Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease

Journal of Periodontal Research

Volumn 49, Issue 6, 2014, Pages 817-826

  Parachuru, V P B ^a   Coates, D E ^a   Milne, T J ^a   Hussaini, H M ^b   Rich, A M ^a   Seymour, G J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Chronic periodontitis; Forkheadbox P3; Interleukin 17; Regulatory T cells

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 17;

B LYMPHOCYTE; CELL COMMUNICATION; CELL SIZE; CLASSIFICATION; COMPARATIVE STUDY; FEMALE; GINGIVITIS; HUMAN; IMMUNOLOGY; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PALATINE TONSIL; PLASMA CELL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH17 CELL;

ANTIGENS, CD19; ANTIGENS, CD3; B-LYMPHOCYTES; CELL COMMUNICATION; CELL SIZE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GINGIVITIS; HUMANS; INTERLEUKIN-17; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PALATINE TONSIL; PLASMA CELLS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84909950947     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/jre.12169     Document Type: Article

References (43)

1. Seymour GJ, Powell RN, Aitken JF. Experimental gingivitis in humans. A clinical and histologic investigation. J Periodontol 1983;54:522-528.
2. Yamazaki K, Yoshie H, Seymour GJ. T cell regulation of the immune response to infection in periodontal diseases. Histol Histopathol 2003;18:889-896.
3. Gemmell E, Seymour GJ. Immunoregulatory control of Th1/Th2 cytokine profiles in periodontal disease. Periodontol 2000 2004;35:21-41.
4. Yamazaki K, Ohsawa Y, Tabeta K et al. Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients. Infect Immun 2002;70:2492-2501.
5. Harrington LE, Hatton RD, Mangan PR et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-1132.
6. Park H, Li Z, Yang XO et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005;6:1133-1141.
7. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-1164.
8. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008;133:775-787.
9. Cardoso CR, Garlet GP, Moreira AP, Junior WM, Rossi MA, Silva JS. Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. J Leukoc Biol 2008;84:311-318.
10. Nakajima T, Ueki-Maruyama K, Oda T et al. Regulatory T-cells infiltrate periodontal disease tissues. J Dent Res 2005;84:639-643.
11. Okui T, Ito H, Honda T, Amanuma R, Yoshie H, Yamazaki K. Characterization of CD4+ FOXP3+ T-cell clones established from chronic inflammatory lesions. Oral Microbiol Immunol 2008;23:49-54.
12. Dutzan N, Gamonal J, Silva A, Sanz M, Vernal R. Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. J Clin Periodontol 2009;36:396-403.
13. Ito H, Honda T, Domon H et al. Gene expression analysis of the CD4+ T-cell clones derived from gingival tissues of periodontitis patients. Oral Microbiol Immunol 2005;20:382-386.
14. Bettelli E, Oukka M, Kuchroo VK. TH-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007;8:345-350.
15. Stockinger B, Veldhoen M, Martin B. Th17 T cells: linking innate and adaptive immunity. Semin Immunol 2007;19:353-361.
16. Ivanov II, McKenzie BS, Zhou L et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006;126:1121-1133.
17. Fossiez F, Djossou O, Chomarat P et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med 1996;183:2593-2603.
18. Kotake S, Udagawa N, Takahashi N et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 1999;103:1345-1352.
19. Johnson RB, Wood N, Serio FG. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. J Periodontol 2004;75:37-43.
20. Lester SR, Bain JL, Johnson RB, Serio FG. Gingival concentrations of interleukin-23 and -17 at healthy sites and at sites of clinical attachment loss. J Periodontol 2007;78:1545-1550.
21. Oda T, Yoshie H, Yamazaki K. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. Oral Microbiol Immunol 2003;18:30-36.
22. Takahashi K, Azuma T, Motohira H, Kinane DF, Kitetsu S. The potential role of interleukin-17 in the immunopathology of periodontal disease. J Clin Periodontol 2005;32:369-374.
23. Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta Valenzuela M, Gamonal J. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. J Clin Periodontol 2005;32:383-389.
24. Cardoso CR, Garlet GP, Crippa GE et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol 2009;24:1-6.
25. Beklen A, Ainola M, Hukkanen M, Gurgan C, Sorsa T, Konttinen YT. MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis. J Dent Res 2007;86:347-351.
26. Beklen A, Sorsa T, Konttinen YT. Toll-like receptors 2 and 5 in human gingival epithelial cells co-operate with T-cell cytokine interleukin-17. Oral Microbiol Immunol 2009;24:38-42.
27. Mahanonda R, Jitprasertwong P, Sa-Ard-Iam N et al. Effects of IL-17 on human gingival fibroblasts. J Dent Res 2008;87:267-272.
28. Yu JJ, Ruddy MJ, Wong GC et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 2007;109:3794-3802.
29. Lee YK, Turner H, Maynard CL et al. Late developmental plasticity in the T helper 17 lineage. Immunity 2009;30:92-107.
30. Zhu J, Paul WE. Heterogeneity and plasticity of T helper cells. Cell Res 2010;20:4-12.
31. Lexberg MH, Taubner A, Forster A et al. Th memory for interleukin-17 expression is stable in vivo. Eur J Immunol 2008;38:2654-2664.
32. Xu L, Kitani A, Fuss I, Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 2007;178:6725-6729.
33. Yang XO, Nurieva R, Martinez GJ et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008;29:44-56.
34. Page G, Sattler A, Kersten S, Thiel A, Radbruch A, Miossec P. Plasma cell-like morphology of Th1-cytokine-producing cells associated with the loss of CD3 expression. Am J Pathol 2004;164:409-417.
35. Ohyama H, Kato-Kogoe N, Kuhara A et al. The involvement of IL-23 and the Th17 pathway in periodontitis. J Dent Res 2009;88:633-638.
36. Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 2003;170:2106-2112.
37. Lockhart E, Green AM, Flynn JL. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol 2006;177:4662-4669.
38. Rachitskaya AV, Hansen AM, Horai R et al. Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 2008;180:5167-5171.
39. Witowski J, Ksiazek K, Jorres A. Interleukin-17: a mediator of inflammatory responses. Cell Mol Life Sci 2004;61:567-579.
40. Hueber AJ, Asquith DL, Miller AM et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol 2010;184:3336-3340.
41. Tonetti MS, Imboden MA, Lang NP. Neutrophil migration into the gingival sulcus is associated with transepithelial gradients of interleukin-8 and ICAM-1. J Periodontol 1998;69:1139-1147.
42. Lochner M, Peduto L, Cherrier M et al. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 2008;205:1381-1393.
43. Voo KS, Wang YH, Santori FR et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A 2009;106:4793-4798.