Gene expression analysis of the CD4+ T-cell clones derived from gingival tissues of periodontitis patients

Oral Microbiology and Immunology

Volumn 20, Issue 6, 2005, Pages 382-386

  Ito, H ^b   Honda, T ^a,b   Domon, H ^a,b   Oda, T ^b   Okui, T ^a,b   Amanuma, R ^a,b   Nakajima, T ^c   Yamazaki, Kazuhisa ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

Author keywords

Gene expression; Periodontitis; T cell clones

Indexed keywords

BASILIXIMAB; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; IMMOBILIZED ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY CD3; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BLOOD; CONTROLLED STUDY; GENE EXPRESSION; GINGIVA; HUMAN; LYMPHOCYTE CLONE; LYMPHOCYTIC INFILTRATION; MOLECULE; PERIODONTITIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TISSUE INJURY;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GINGIVA; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-4; PERIODONTITIS; RECEPTORS, INTERLEUKIN-2; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 27644585833     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2005.00241.x     Document Type: Article

References (20)

1. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003: 198: 1875-1886.
2. - T cells through Foxp3 induction and down-regulation of SmadV. J Immunol 2004: 172: 5149-5153.
3. + regulatory T cells. Nat Immunol 2003: 4: 330-336.
4. + T cells isolated from inflamed human gingival tissues. Clin Exp Immunol 1996: 103: 422-428.
5. Gemmell E, Carter CL, Grieco DA, Sugarman PB, Seymour GJ. P. gingivalis-specific T-cell lines produce Th1 and Th2 cytokines. J Dent Res 2002: 81: 303-307.
6. Gemmell E, Grieco DA, Cullinan MP, Westerman B, Seymour GJ. Antigen-specific T-cell receptor Vβ expression in Porphyromonas gingivalis-specific T-cell lines. Oral Microbiol Immunol 1998: 13: 355-361.
7. Gemmell E, Woodford V, Seymour GJ. Characterization of T lymphocyte clones derived from Porphyromonas gingivalis infected subjects. J Periodontal Res 1996: 31: 47-56.
8. Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response. Crit Rev Oral Biol Med 2002: 13: 17-34.
9. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003: 299: 1057-1061.
10. + T regulatory cells in humans. Hum Immunol 2005: 66: 13-20.
11. Oda T, Yoshie H, Yamazaki K. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-κB ligand in vitro. Oral Microbiol Immunol 2003: 18: 30-36.
12. Okada H, Murakami S, Kitamura M, Nozaki T, Kusumoto Y, Hirano H, et al. Diagnostic strategies of periodontitis based on the molecular mechanisms of periodontal tissue destruction. Oral Dis 1996: 2: 87-95.
13. pos T cells by human mature autologous dendritic cells. Eur J Immunol 2004: 34: 762-772.
14. - T cells. J Clin Invest 2003: 112: 1437-1443.
15. Wassenaar A, Reinhardus C, Thepen T, Abraham-Inpijn L, Kievits F. Cloning, characterization, and antigen specificity of T-lymphocyte subsets extracted from gingival tissue of chronic adult periodontitis patients. Infect Immun 1995: 63: 2147-2153.
16. + T cell clones from peripheral blood of a chronic adult periodontitis patient. Clin Exp Immunol 1998: 113: 105-110.
17. + regulatory T cells. Int Immunol 2004: 16: 1643-1656.
18. Yamazaki K, Nakajima T, Gemmell E, Kjeldsen M, Seymour GJ, Hara K. Biased expression of T cell receptor Vβ genes in periodontitis patients. Clin Exp Immunol 1996: 106: 329-335.
19. Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol 1995: 99: 384-391.
20. Yamazaki K, Ohsawa Y, Tabeta K, Ito H, Ueki K, Oda T, et al. Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients. Infect Immun 2002: 70: 2492-2501.