The involvement of IL-23 and the Th 17 pathway in periodontitis

Journal of Dental Research

Volumn 88, Issue 7, 2009, Pages 633-638

  Ohyama, H ^a   Kato Kogoe, N ^a   Kuhara, A ^a   Nishimura, F ^b   Nakasho, K ^a   Yamanegi, K ^a   Yamada, N ^a   Hata, M ^a   Yamane, J ^a   Terada, N ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cellular immune response; IL 12; Interleukin (IL) 23; Periodontitis; Th17

Indexed keywords

GAMMA INTERFERON; IL23R PROTEIN, HUMAN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN RECEPTOR;

ARTICLE; BIOSYNTHESIS; CASE CONTROL STUDY; CD4+ T LYMPHOCYTE; CHRONIC PERIODONTITIS; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; POLYMERASE CHAIN REACTION;

CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC PERIODONTITIS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-17; INTERLEUKIN-23; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12;

EID: 68249143144     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/0022034509339889     Document Type: Article

References (34)

1. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, et al. (2007). Phenotypic and functional features of human Th17 cells. J Exp Med 204:1849-1861.
2. Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, Frappart L, et al. (1999). Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42:963-970.
3. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, et al. (2007). The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566-569.
4. Ebersole JL, Taubman MA (1994). The protective nature of host responses in periodontal diseases. Periodontal 2000 5:112-141.
5. Gemmell E, Yamazaki K, Seymour GJ (2007). The role of T cells in periodontal disease: homeostasis and autoimmunity. Periodontal 2000 43:14-40.
6. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6:1123-1132.
7. Harrington LE, Mangan PR, Weaver CT (2006). Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 18:349-356.
8. + Th cells that cause autoimmune arthritis. J Exp Med 204:41-47.
9. Kirkham BW, Lassere MN, Edmonds JP, Juhasz KM, Bird RA, Lee CS, et al. (2006). Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort). Arthritis Rheum 54:1122-1131.
10. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, et al. (1999). IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345-1352.
11. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, et al. (2005). IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 20:233-240.
12. Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y (2003). IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 100:5986-5990.
13. Nakajima T, Ueki-Maruyama K, Oda T, Ohsawa Y, Ito H, Seymour GJ, et al. (2005). Regulatory T-cells infiltrate periodontal disease tissues. J Dent Res 84:639-643.
14. Ohyama H, Ogata K, Takeuchi K, Namisato M, Fukutomi Y, Nishimura F, et al. (2005). Polymorphism of the 5′ flanking region of the IL-12 receptor β2 gene partially determines the clinical types of leprosy through impaired transcriptional activity. J Clin Pathol 58:740-743.
15. Ohyama H, Kato-Kogoe N, Nishimura F, Takeuchi-Hatanaka K, Matsushita S, Yamanegi K, et al. (2008). Differential effects of polymorphisms in the 5′ flanking region of ILI 2RB2 on NK and T cell activity. J Interferon Cytokine Res 28:563-569.
16. Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. (2000). Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715-725.
17. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (2002). A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168:5699-5708.
18. Piskin G, Sylva-Steenland RM, Bos JD, Teunissen MB (2006). In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol 176:1908-1915.
19. Roberts FA, McCaffery KA, Michalek SM (1997). Profile of cytokine mRNA expression in chronic adult periodontitis. JDent Res 76:1833-1839.
20. Rogge L, Papi A, Presky DH, Biffi M, Minetti LJ, Miotto D, et al. (1999). Antibodies to the IL-12 receptor β2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol 162:3926-3932.
21. Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, et al. (2006). Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203: 2673-2682.
22. Shaker OG, Moustafa W, Essmat S, Abdel-Halim M, E1-Komy M. (2006). The role of interleukin-12 in the pathogenesis of psoriasis. Clin Biochem 39:119-125.
23. Snyderman R, McCarty GA (1982). Analogous mechanism of tissue destruction in rheumatoid arthritis and periodontal disease. In: Host-parasite interactions in periodontal diseases. Genco RJ, Mergenhagen SE, editors. Washington, DC: American Society for Microbiology, pp. 354-362.
24. H2 hypothesis of T cell-mediated tissue damage. Nat Med 13:139-145;
25. erratum in Nat Med 13:385, 2007.
26. Takahashi K, Azuma T, Motohira H, Kinane DF, Kitetsu S (2005). The potential role of interleukin-17 in the immunopathology of periodontal disease. J Clin Periodontal 32:369-374.
27. Takayanagi H, Ogasawara K, Hida S, Chiba T, Murata S, Sato K, et al. (2000). T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 408:600-605.
28. Takeichi O, Haber J, Kawai T, Smith DJ, Mora I, Taubman MA (2000). Cytokine profiles of T-lymphocytes from gingival tissues with pathological pocketing. J Dent Res 79:1548-1555.
29. Takeuchi-Hatanaka K, Ohyama H, Nishimura F, Kato-Kogoe N, Soga Y, Matsushita S, et al. (2008). Polymorphisms in the 5′ flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population. J Clin Periodontal 35:317-323.
30. Teng YT (2003). The role of acquired immunity and periodontal disease progression. Crit Rev Oral Biol Med 14:237-252.
31. Tokoro Y, Matsuki Y, Yamamoto T, Suzuki T, Hara K (1997). Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. Clin Exp Immunol 107:166-174.
32. Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta Valenzuela M, Gamonal J (2005). Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis. J Clin Periodontal 32:383-389.
33. Yamazaki K, Nakajima T, Gemmell E, Polak B, Seymour GJ, Hara K (1994). IL-4- and IL-6-producing cells in human periodontal disease tissue. J Oral Pathol Med 23:347-353.
34. reg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum 56:4104-4112.