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Volumn 13, Issue 12, 2014, Pages 1489-1500

The HIV-1 gp120 V1V2 loop: Structure, function and importance for vaccine development

Author keywords

Efficacy; gp120; HIV vaccine; Neutralizing antibodies; Nonneutralizing antibodies; RV144; V1V2 loop

Indexed keywords

ERDOSTEINE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN G ANTIBODY; NEUTRALIZING ANTIBODY; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84909633945     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.2014.951335     Document Type: Review
Times cited : (27)

References (112)
  • 1
    • 0025696633 scopus 로고
    • Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1
    • Javaherian K, Langlois AJ, LaRosa GJ, et al. Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1. Science 1990;250(4987):1590-3
    • (1990) Science , vol.250 , Issue.4987 , pp. 1590-1593
    • Javaherian, K.1    Langlois, A.J.2    LaRosa, G.J.3
  • 2
    • 84880714310 scopus 로고    scopus 로고
    • A brief history of the global effort to develop a preventive HIV vaccine
    • Esparza J. A brief history of the global effort to develop a preventive HIV vaccine. Vaccine 2013;31(35):3502-18
    • (2013) Vaccine , vol.31 , Issue.35 , pp. 3502-3518
    • Esparza, J.1
  • 3
    • 0025331727 scopus 로고
    • Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160
    • Berman PW, Gregory TJ, Riddle L, et al. Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature 1990;345(6276):622-5
    • (1990) Nature , vol.345 , Issue.6276 , pp. 622-625
    • Berman, P.W.1    Gregory, T.J.2    Riddle, L.3
  • 4
    • 19144365910 scopus 로고    scopus 로고
    • Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1
    • The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group
    • Mascola JR, Snyder SW, Weislow OS, et al. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group. Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. J Infect Dis 1996;173(2):340-8
    • (1996) J Infect Dis , vol.173 , Issue.2 , pp. 340-348
    • Mascola, J.R.1    Snyder, S.W.2    Weislow, O.S.3
  • 5
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn NM, Forthal DN, Harro CD, et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis 2005; 191(5):654-65
    • (2005) J Infect Dis , vol.191 , Issue.5 , pp. 654-665
    • Flynn, N.M.1    Forthal, D.N.2    Harro, C.D.3
  • 6
    • 13944250922 scopus 로고    scopus 로고
    • Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial
    • Gilbert PB, Peterson ML, Follmann D, et al. Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial. J Infect Dis 2005;191(5):666-77
    • (2005) J Infect Dis , vol.191 , Issue.5 , pp. 666-677
    • Gilbert, P.B.1    Peterson, M.L.2    Follmann, D.3
  • 7
    • 34248168722 scopus 로고    scopus 로고
    • Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    • Forthal DN, Gilbert PB, Landucci G, Phan T. Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. J Immunol 2007;178(10):6596-603
    • (2007) J Immunol , vol.178 , Issue.10 , pp. 6596-6603
    • Forthal, D.N.1    Gilbert, P.B.2    Landucci, G.3    Phan, T.4
  • 8
    • 33845433434 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
    • Pitisuttithum P, Gilbert P, Gurwith M, et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 2006;194(12):1661-71
    • (2006) J Infect Dis , vol.194 , Issue.12 , pp. 1661-1671
    • Pitisuttithum, P.1    Gilbert, P.2    Gurwith, M.3
  • 9
    • 1342332108 scopus 로고    scopus 로고
    • Public health. A sound rationale needed for phase III HIV-1 vaccine trials
    • Burton DR, Desrosiers RC, Doms RW, et al. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science 2004;303(5656):316
    • (2004) Science , vol.303 , Issue.5656 , pp. 316
    • Burton, D.R.1    Desrosiers, R.C.2    Doms, R.W.3
  • 10
    • 0025292252 scopus 로고
    • Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells
    • Leonard CK, Spellman MW, Riddle L, et al. Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells. J Biol Chem 1990; 265(18):10373-82
    • (1990) J Biol Chem , vol.265 , Issue.18 , pp. 10373-10382
    • Leonard, C.K.1    Spellman, M.W.2    Riddle, L.3
  • 11
    • 73349094086 scopus 로고    scopus 로고
    • Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
    • Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009;361(23):2209-20
    • (2009) N Engl J Med , vol.361 , Issue.23 , pp. 2209-2220
    • Rerks-Ngarm, S.1    Pitisuttithum, P.2    Nitayaphan, S.3
  • 12
    • 79953019952 scopus 로고    scopus 로고
    • Statistical interpretation of the RV144 HIV vaccine efficacy trial in Thailand: A case study for statistical issues in efficacy trials
    • Gilbert PB, Berger JO, Stablein D, et al. Statistical interpretation of the RV144 HIV vaccine efficacy trial in Thailand: a case study for statistical issues in efficacy trials. J Infect Dis 2011;203(7):969-75
    • (2011) J Infect Dis , vol.203 , Issue.7 , pp. 969-975
    • Gilbert, P.B.1    Berger, J.O.2    Stablein, D.3
  • 13
    • 84859393693 scopus 로고    scopus 로고
    • Immune-correlates analysis of an HIV-1 vaccine efficacy trial
    • Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 2012;366(14):1275-86
    • (2012) N Engl J Med , vol.366 , Issue.14 , pp. 1275-1286
    • Haynes, B.F.1    Gilbert, P.B.2    McElrath, M.J.3
  • 14
    • 84861057293 scopus 로고    scopus 로고
    • Nomenclature for immune correlates of protection after vaccination
    • Plotkin SA, Gilbert PB. Nomenclature for immune correlates of protection after vaccination. Clin Infect Dis 2012;54(11):1615-17
    • (2012) Clin Infect Dis , vol.54 , Issue.11 , pp. 1615-1617
    • Plotkin, S.A.1    Gilbert, P.B.2
  • 15
    • 84888984130 scopus 로고    scopus 로고
    • HIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine development
    • Rao M, Peachman KK, Kim J, et al. HIV-1 variable loop 2 and its importance in HIV-1 infection and vaccine development. Curr HIV Res 2013;11(5):427-38
    • (2013) Curr HIV Res , vol.11 , Issue.5 , pp. 427-438
    • Rao, M.1    Peachman, K.K.2    Kim, J.3
  • 16
    • 83455254775 scopus 로고    scopus 로고
    • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
    • McLellan JS, Pancera M, Carrico C, et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature 2011;480(7377):336-43
    • (2011) Nature , vol.480 , Issue.7377 , pp. 336-343
    • McLellan, J.S.1    Pancera, M.2    Carrico, C.3
  • 17
    • 78651241895 scopus 로고    scopus 로고
    • Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: Strain-dependent variation in quaternary structure
    • White TA, Bartesaghi A, Borgnia MJ, et al. Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure. PLoS Pathog 2010; 6(12):e1001249
    • (2010) PLoS Pathog , vol.6 , Issue.12 , pp. e1001249
    • White, T.A.1    Bartesaghi, A.2    Borgnia, M.J.3
  • 18
    • 78650426126 scopus 로고    scopus 로고
    • Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure
    • Wu SR, Loving R, Lindqvist B, et al. Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure. Proc Natl Acad Sci USA 2010; 107(44):18844-9
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.44 , pp. 18844-18849
    • Wu, S.R.1    Loving, R.2    Lindqvist, B.3
  • 19
    • 84890858459 scopus 로고    scopus 로고
    • Crystal structure of a soluble cleaved HIV-1 envelope trimer
    • Julien JP, Cupo A, Sok D, et al. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science 2013; 342(6165):1477-83
    • (2013) Science , vol.342 , Issue.6165 , pp. 1477-1483
    • Julien, J.P.1    Cupo, A.2    Sok, D.3
  • 20
    • 77954100808 scopus 로고    scopus 로고
    • Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design
    • Zolla-Pazner S, Cardozo T. Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design. Nat Rev Immunol 2010;10(7):527-35
    • (2010) Nat Rev Immunol , vol.10 , Issue.7 , pp. 527-535
    • Zolla-Pazner, S.1    Cardozo, T.2
  • 21
    • 0030812563 scopus 로고    scopus 로고
    • Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein
    • Cao J, Sullivan N, Desjardin E, et al. Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein. J Virol 1997; 71(12):9808-12
    • (1997) J Virol , vol.71 , Issue.12 , pp. 9808-9812
    • Cao, J.1    Sullivan, N.2    Desjardin, E.3
  • 22
    • 13844302894 scopus 로고    scopus 로고
    • Structure of an unliganded simian immunodeficiency virus gp120 core
    • Chen B, Vogan EM, Gong H, et al. Structure of an unliganded simian immunodeficiency virus gp120 core. Nature 2005;433(7028):834-41
    • (2005) Nature , vol.433 , Issue.7028 , pp. 834-841
    • Chen, B.1    Vogan, E.M.2    Gong, H.3
  • 23
    • 84881006882 scopus 로고    scopus 로고
    • HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry
    • Yuan T, Li J, Zhang MY. HIV-1 envelope glycoprotein variable loops are indispensable for envelope structural integrity and virus entry. PLoS One 2013;8(8):e69789
    • (2013) PLoS One , vol.8 , Issue.8 , pp. e69789
    • Yuan, T.1    Li, J.2    Zhang, M.Y.3
  • 24
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong PD, Wyatt R, Robinson J, et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998;393(6686):648-59
    • (1998) Nature , vol.393 , Issue.6686 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3
  • 25
    • 0035100868 scopus 로고    scopus 로고
    • Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/ V2 variable loops
    • Kolchinsky P, Kiprilov E, Bartley P, et al. Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/ V2 variable loops. J Virol 2001;75(7):3435-43
    • (2001) J Virol , vol.75 , Issue.7 , pp. 3435-3443
    • Kolchinsky, P.1    Kiprilov, E.2    Bartley, P.3
  • 26
    • 21644446614 scopus 로고    scopus 로고
    • The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner
    • Saunders CJ, McCaffrey RA, Zharkikh I, et al. The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner. J Virol 2005;79(14):9069-80
    • (2005) J Virol , vol.79 , Issue.14 , pp. 9069-9080
    • Saunders, C.J.1    McCaffrey, R.A.2    Zharkikh, I.3
  • 27
    • 84883488052 scopus 로고    scopus 로고
    • The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry
    • Cardaci S, Soster M, Bussolino F, Marchio S. The V1/V2 loop of HIV-1 gp120 is necessary for Tat binding and consequent modulation of virus entry. FEBS Lett 2013;587(18):2943-51
    • (2013) FEBS Lett , vol.587 , Issue.18 , pp. 2943-2951
    • Cardaci, S.1    Soster, M.2    Bussolino, F.3    Marchio, S.4
  • 28
    • 12144289425 scopus 로고    scopus 로고
    • Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission
    • Derdeyn CA, Decker JM, Bibollet-Ruche F, et al. Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission. Science 2004; 303(5666):2019-22
    • (2004) Science , vol.303 , Issue.5666 , pp. 2019-2022
    • Derdeyn, C.A.1    Decker, J.M.2    Bibollet-Ruche, F.3
  • 29
    • 18144397438 scopus 로고    scopus 로고
    • Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
    • Chohan B, Lang D, Sagar M, et al. Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels. J Virol 2005;79(10):6528-31
    • (2005) J Virol , vol.79 , Issue.10 , pp. 6528-6531
    • Chohan, B.1    Lang, D.2    Sagar, M.3
  • 30
    • 80053452761 scopus 로고    scopus 로고
    • Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections
    • Gnanakaran S, Bhattacharya T, Daniels M, et al. Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. PLoS Pathog 2011;7(9): e1002209
    • (2011) PLoS Pathog , vol.7 , Issue.9 , pp. e1002209
    • Gnanakaran, S.1    Bhattacharya, T.2    Daniels, M.3
  • 31
    • 18144429071 scopus 로고    scopus 로고
    • Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B
    • Frost SD, Liu Y, Pond SL, et al. Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B. J Virol 2005;79(10):6523-7
    • (2005) J Virol , vol.79 , Issue.10 , pp. 6523-6527
    • Frost, S.D.1    Liu, Y.2    Pond, S.L.3
  • 32
    • 59249096215 scopus 로고    scopus 로고
    • Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1
    • Haaland RE, Hawkins PA, Salazar-Gonzalez J, et al. Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1. PLoS Pathog 2009;5(1):e1000274
    • (2009) PLoS Pathog , vol.5 , Issue.1 , pp. e1000274
    • Haaland, R.E.1    Hawkins, P.A.2    Salazar-Gonzalez, J.3
  • 33
    • 70349695689 scopus 로고    scopus 로고
    • Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways
    • Rong R, Li B, Lynch RM, et al. Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways. PLoS Pathog 2009;5(9):e1000594
    • (2009) PLoS Pathog , vol.5 , Issue.9 , pp. e1000594
    • Rong, R.1    Li, B.2    Lynch, R.M.3
  • 34
    • 34249940652 scopus 로고    scopus 로고
    • Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
    • Gray ES, Moore PL, Choge IA, et al. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. J Virol 2007; 81(12):6187-96
    • (2007) J Virol , vol.81 , Issue.12 , pp. 6187-6196
    • Gray, E.S.1    Moore, P.L.2    Choge, I.A.3
  • 35
    • 78651237643 scopus 로고    scopus 로고
    • HIV-1 envelope subregion length variation during disease progression
    • Curlin ME, Zioni R, Hawes SE, et al. HIV-1 envelope subregion length variation during disease progression. PLoS Pathog 2010;6(12):e1001228
    • (2010) PLoS Pathog , vol.6 , Issue.12 , pp. e1001228
    • Curlin, M.E.1    Zioni, R.2    Hawes, S.E.3
  • 36
    • 84862828547 scopus 로고    scopus 로고
    • Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals
    • Gorny MK, Pan R, Williams C, et al. Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals. Virology 2012;427(2):198-207
    • (2012) Virology , vol.427 , Issue.2 , pp. 198-207
    • Gorny, M.K.1    Pan, R.2    Williams, C.3
  • 37
    • 84887270287 scopus 로고    scopus 로고
    • Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes
    • Wibmer CK, Bhiman JN, Gray ES, et al. Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes. PLoS Pathog 2013;9(10):e1003738
    • (2013) PLoS Pathog , vol.9 , Issue.10 , pp. e1003738
    • Wibmer, C.K.1    Bhiman, J.N.2    Gray, E.S.3
  • 38
    • 79952579682 scopus 로고    scopus 로고
    • Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop
    • Moore PL, Gray ES, Sheward D, et al. Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop. J Virol 2011;85(7):3128-41
    • (2011) J Virol , vol.85 , Issue.7 , pp. 3128-3141
    • Moore, P.L.1    Gray, E.S.2    Sheward, D.3
  • 39
    • 84876333290 scopus 로고    scopus 로고
    • Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies
    • Moore PL, Sheward D, Nonyane M, et al. Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodies. J Virol 2013;87(9):4882-94
    • (2013) J Virol , vol.87 , Issue.9 , pp. 4882-4894
    • Moore, P.L.1    Sheward, D.2    Nonyane, M.3
  • 40
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei X, Decker JM, Wang S, et al. Antibody neutralization and escape by HIV-1. Nature 2003;422(6929):307-12
    • (2003) Nature , vol.422 , Issue.6929 , pp. 307-312
    • Wei, X.1    Decker, J.M.2    Wang, S.3
  • 41
    • 2342644898 scopus 로고    scopus 로고
    • The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection
    • Pinter A, Honnen WJ, He Y, et al. The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection. J Virol 2004;78(10):5205-15
    • (2004) J Virol , vol.78 , Issue.10 , pp. 5205-5215
    • Pinter, A.1    Honnen, W.J.2    He, Y.3
  • 42
    • 79960405099 scopus 로고    scopus 로고
    • Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies
    • van Gils MJ, Bunnik EM, Boeser-Nunnink BD, et al. Longer V1V2 region with increased number of potential N-linked glycosylation sites in the HIV-1 envelope glycoprotein protects against HIV-specific neutralizing antibodies. J Virol 2011;85(14):6986-95
    • (2011) J Virol , vol.85 , Issue.14 , pp. 6986-6995
    • Van Gils, M.J.1    Bunnik, E.M.2    Boeser-Nunnink, B.D.3
  • 43
    • 79952602584 scopus 로고    scopus 로고
    • The V1V2 domain and an N-linked glycosylation site in the V3 loop of the HIV-1 envelope glycoprotein modulate neutralization sensitivity to the human broadly neutralizing antibody 2G12
    • Chaillon A, Braibant M, Moreau T, et al. The V1V2 domain and an N-linked glycosylation site in the V3 loop of the HIV-1 envelope glycoprotein modulate neutralization sensitivity to the human broadly neutralizing antibody 2G12. J Virol 2011;85(7):3642-8
    • (2011) J Virol , vol.85 , Issue.7 , pp. 3642-3648
    • Chaillon, A.1    Braibant, M.2    Moreau, T.3
  • 44
    • 79960346105 scopus 로고    scopus 로고
    • Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies
    • Rusert P, Krarup A, Magnus C, et al. Interaction of the gp120 V1V2 loop with a neighboring gp120 unit shields the HIV envelope trimer against cross-neutralizing antibodies. J Exp Med 2011;208(7): 1419-33
    • (2011) J Exp Med , vol.208 , Issue.7 , pp. 1419-1433
    • Rusert, P.1    Krarup, A.2    Magnus, C.3
  • 45
    • 77957940271 scopus 로고    scopus 로고
    • Mutation at a single position in the V2 domain of the HIV-1 envelope protein confers neutralization sensitivity to a highly neutralization-resistant virus
    • O'Rourke SM, Schweighardt B, Phung P, et al. Mutation at a single position in the V2 domain of the HIV-1 envelope protein confers neutralization sensitivity to a highly neutralization-resistant virus. J Virol 2010; 84(21):11200-9
    • (2010) J Virol , vol.84 , Issue.21 , pp. 11200-11209
    • O'Rourke, S.M.1    Schweighardt, B.2    Phung, P.3
  • 46
    • 84887535227 scopus 로고    scopus 로고
    • Specific sequences commonly found in the V3 domain of HIV-1 subtype C isolates affect the overall conformation of native Env and induce a neutralization-resistant phenotype independent of V1/V2 masking
    • Salomon A, Krachmarov C, Lai Z, et al. Specific sequences commonly found in the V3 domain of HIV-1 subtype C isolates affect the overall conformation of native Env and induce a neutralization-resistant phenotype independent of V1/V2 masking. Virology 2014;448:363-74
    • (2014) Virology , vol.448 , pp. 363-374
    • Salomon, A.1    Krachmarov, C.2    Lai, Z.3
  • 47
    • 84896959968 scopus 로고    scopus 로고
    • Functional implications of the binding mode of a human conformation-dependent V2 monoclonal antibody against HIV
    • Spurrier B, Sampson J, Gorny MK, et al. Functional implications of the binding mode of a human conformation-dependent V2 monoclonal antibody against HIV. J Virol 2014;88(8):4100-12
    • (2014) J Virol , vol.88 , Issue.8 , pp. 4100-4112
    • Spurrier, B.1    Sampson, J.2    Gorny, M.K.3
  • 48
    • 84867653590 scopus 로고    scopus 로고
    • Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2
    • Rolland M, Edlefsen PT, Larsen BB, et al. Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2. Nature 2012;490(7420):417-20
    • (2012) Nature , vol.490 , Issue.7420 , pp. 417-420
    • Rolland, M.1    Edlefsen, P.T.2    Larsen, B.B.3
  • 49
    • 39449098115 scopus 로고    scopus 로고
    • HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
    • Arthos J, Cicala C, Martinelli E, et al. HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 2008;9(3):301-9
    • (2008) Nat Immunol , vol.9 , Issue.3 , pp. 301-309
    • Arthos, J.1    Cicala, C.2    Martinelli, E.3
  • 50
    • 80052403070 scopus 로고    scopus 로고
    • Polymorphisms in the alpha4 integrin of neotropical primates: Insights for binding of natural ligands and HIV-1 gp120 to the human alpha4beta7
    • Darc M, Hait SH, Soares EA, et al. Polymorphisms in the alpha4 integrin of neotropical primates: insights for binding of natural ligands and HIV-1 gp120 to the human alpha4beta7. PLoS One 2011;6(9):e24461
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24461
    • Darc, M.1    Hait, S.H.2    Soares, E.A.3
  • 51
    • 33845532053 scopus 로고    scopus 로고
    • Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    • Brenchley JM, Price DA, Schacker TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 2006;12(12):1365-71
    • (2006) Nat Med , vol.12 , Issue.12 , pp. 1365-1371
    • Brenchley, J.M.1    Price, D.A.2    Schacker, T.W.3
  • 52
    • 79952232940 scopus 로고    scopus 로고
    • The genotype of early-transmitting HIV gp120s promotes alpha (4) beta(7)-reactivity, revealing alpha (4) beta(7) +/CD4+ T cells as key targets in mucosal transmission
    • Nawaz F, Cicala C, Van Ryk D, et al. The genotype of early-transmitting HIV gp120s promotes alpha (4) beta(7)-reactivity, revealing alpha (4) beta(7) +/CD4+ T cells as key targets in mucosal transmission. PLoS Pathog 2011;7(2):e1001301
    • (2011) PLoS Pathog , vol.7 , Issue.2 , pp. e1001301
    • Nawaz, F.1    Cicala, C.2    Van Ryk, D.3
  • 53
    • 79251555316 scopus 로고    scopus 로고
    • Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    • Ansari AA, Reimann KA, Mayne AE, et al. Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol 2011;186(2):1044-59
    • (2011) J Immunol , vol.186 , Issue.2 , pp. 1044-1059
    • Ansari, A.A.1    Reimann, K.A.2    Mayne, A.E.3
  • 54
    • 84862173040 scopus 로고    scopus 로고
    • Monoclonal antibodies to the V2 domain of MN-rgp120: Fine mapping of epitopes and inhibition of alpha4beta7 binding
    • Nakamura GR, Fonseca DP, O'Rourke SM, et al. Monoclonal antibodies to the V2 domain of MN-rgp120: fine mapping of epitopes and inhibition of alpha4beta7 binding. PLoS One 2012;7(6): e39045
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e39045
    • Nakamura, G.R.1    Fonseca, D.P.2    O'Rourke, S.M.3
  • 55
    • 84872809067 scopus 로고    scopus 로고
    • Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
    • Liao HX, Bonsignori M, Alam SM, et al. Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity 2013; 38(1):176-86
    • (2013) Immunity , vol.38 , Issue.1 , pp. 176-186
    • Liao, H.X.1    Bonsignori, M.2    Alam, S.M.3
  • 56
    • 84876867850 scopus 로고    scopus 로고
    • Phenotypic properties of transmitted founder HIV-1
    • Parrish NF, Gao F, Li H, et al. Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci USA 2013;110(17):6626-33
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.17 , pp. 6626-6633
    • Parrish, N.F.1    Gao, F.2    Li, H.3
  • 57
    • 84886425422 scopus 로고    scopus 로고
    • 1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of alpha4beta7 integrin
    • Etemad B, Gonzalez OA, McDonough S, et al.1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of alpha4beta7 integrin. J Acquir Immune Defic Syndr 2013;64(3):249-53
    • (2013) J Acquir Immune Defic Syndr , vol.64 , Issue.3 , pp. 249-253
    • Etemad, B.1    Gonzalez, O.A.2    McDonough, S.3
  • 58
    • 0031023939 scopus 로고    scopus 로고
    • Prevalence of a V2 epitope in clade B primary isolates and its recognition by sera from HIV-1-infected individuals
    • Israel ZR, Gorny MK, Palmer C, et al. Prevalence of a V2 epitope in clade B primary isolates and its recognition by sera from HIV-1-infected individuals. AIDS 1997;11(1):128-30
    • (1997) AIDS , vol.11 , Issue.1 , pp. 128-130
    • Israel, Z.R.1    Gorny, M.K.2    Palmer, C.3
  • 59
    • 84868589536 scopus 로고    scopus 로고
    • The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120
    • Karasavvas N, Billings E, Rao M, et al. The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120. AIDS Res Hum Retroviruses 2012;28(11):1444-57
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.11 , pp. 1444-1457
    • Karasavvas, N.1    Billings, E.2    Rao, M.3
  • 60
    • 0027199489 scopus 로고
    • Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120
    • McKeating JA, Shotton C, Cordell J, et al. Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120. J Virol 1993;67(8):4932-44
    • (1993) J Virol , vol.67 , Issue.8 , pp. 4932-4944
    • McKeating, J.A.1    Shotton, C.2    Cordell, J.3
  • 61
    • 0028097964 scopus 로고
    • Presentation of native epitopes in the V1/ V2 and V3 regions of human immunodeficiency virus type 1 gp120 by fusion glycoproteins containing isolated gp120 domains
    • Kayman SC, Wu Z, Revesz K, et al. Presentation of native epitopes in the V1/ V2 and V3 regions of human immunodeficiency virus type 1 gp120 by fusion glycoproteins containing isolated gp120 domains. J Virol 1994;68(1):400-10
    • (1994) J Virol , vol.68 , Issue.1 , pp. 400-410
    • Kayman, S.C.1    Wu, Z.2    Revesz, K.3
  • 62
    • 16244419386 scopus 로고    scopus 로고
    • Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles
    • Gorny MK, Stamatatos L, Volsky B, et al. Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles. J Virol 2005;79(8):5232-7
    • (2005) J Virol , vol.79 , Issue.8 , pp. 5232-5237
    • Gorny, M.K.1    Stamatatos, L.2    Volsky, B.3
  • 63
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker LM, Phogat SK, Chan-Hui PY, et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 2009; 326(5950):285-9
    • (2009) Science , vol.326 , Issue.5950 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.Y.3
  • 64
    • 80052938385 scopus 로고    scopus 로고
    • Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
    • Bonsignori M, Hwang KK, Chen X, et al. Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. J Virol 2011;85(19): 9998-10009
    • (2011) J Virol , vol.85 , Issue.19 , pp. 9998-10009
    • Bonsignori, M.1    Hwang, K.K.2    Chen, X.3
  • 65
    • 77649318846 scopus 로고    scopus 로고
    • Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals
    • Corti D, Langedijk JP, Hinz A, et al. Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. PLoS One 2010;5(1):e8805
    • (2010) PLoS One , vol.5 , Issue.1 , pp. e8805
    • Corti, D.1    Langedijk, J.P.2    Hinz, A.3
  • 66
    • 84860723906 scopus 로고    scopus 로고
    • Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: Implications for vaccine design
    • Bonsignori M, Montefiori DC, Wu X, et al. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol 2012;86(8):4688-92
    • (2012) J Virol , vol.86 , Issue.8 , pp. 4688-4692
    • Bonsignori, M.1    Montefiori, D.C.2    Wu, X.3
  • 67
    • 84899991983 scopus 로고    scopus 로고
    • Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies
    • Doria-Rose NA, Schramm CA, Gorman J, et al. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature 2014;509(7498):55-62
    • (2014) Nature , vol.509 , Issue.7498 , pp. 55-62
    • Doria-Rose, N.A.1    Schramm, C.A.2    Gorman, J.3
  • 68
    • 84856482137 scopus 로고    scopus 로고
    • Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
    • Barouch DH, Liu J, Li H, et al. Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 2012;482(7383):89-93
    • (2012) Nature , vol.482 , Issue.7383 , pp. 89-93
    • Barouch, D.H.1    Liu, J.2    Li, H.3
  • 69
    • 84892786095 scopus 로고    scopus 로고
    • Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV
    • Roederer M, Keele BF, Schmidt SD, et al. Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV. Nature 2014;505(7484):502-8
    • (2014) Nature , vol.505 , Issue.7484 , pp. 502-508
    • Roederer, M.1    Keele, B.F.2    Schmidt, S.D.3
  • 70
    • 84886778874 scopus 로고    scopus 로고
    • Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys
    • Barouch DH, Stephenson KE, Borducchi EN, et al. Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell 2013;155(3):531-9
    • (2013) Cell , vol.155 , Issue.3 , pp. 531-539
    • Barouch, D.H.1    Stephenson, K.E.2    Borducchi, E.N.3
  • 71
    • 84873033705 scopus 로고    scopus 로고
    • Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV (mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial
    • Pegu P, Vaccari M, Gordon S, et al. Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV (mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial. J Virol 2013;87(3):1708-19
    • (2013) J Virol , vol.87 , Issue.3 , pp. 1708-1719
    • Pegu, P.1    Vaccari, M.2    Gordon, S.3
  • 72
    • 84887177893 scopus 로고    scopus 로고
    • Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial
    • Kijak GH, Tovanabutra S, Rerks-Ngarm S, et al. Molecular evolution of the HIV-1 Thai epidemic between the time of RV144 immunogen selection to the execution of the vaccine efficacy trial. J Virol 2013;87(13):7265-81
    • (2013) J Virol , vol.87 , Issue.13 , pp. 7265-7281
    • Kijak, G.H.1    Tovanabutra, S.2    Rerks-Ngarm, S.3
  • 73
    • 84906685742 scopus 로고    scopus 로고
    • An HIV vaccine for South-East Asia - Opportunities and challenges
    • Pitisuttithum P, Rerks-Ngarm S, O'Connell RJ, et al. An HIV vaccine for South-East Asia - opportunities and challenges. Vaccines 2013;1:348-66
    • (2013) Vaccines , vol.1 , pp. 348-366
    • Pitisuttithum, P.1    Rerks-Ngarm, S.2    O'Connell, R.J.3
  • 74
    • 84895174919 scopus 로고    scopus 로고
    • Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection
    • Zolla-Pazner S, Decamp A, Gilbert PB, et al. Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infection. PLoS One 2014;9(2):e87572
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e87572
    • Zolla-Pazner, S.1    Decamp, A.2    Gilbert, P.B.3
  • 75
    • 84884608718 scopus 로고    scopus 로고
    • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial
    • Gottardo R, Bailer RT, Korber BT, et al. Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. PLoS One 2013;8(9):e75665
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e75665
    • Gottardo, R.1    Bailer, R.T.2    Korber, B.T.3
  • 76
    • 84880310997 scopus 로고    scopus 로고
    • Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees
    • Liu P, Yates NL, Shen X, et al. Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees. J Virol 2013;87(14):7828-36
    • (2013) J Virol , vol.87 , Issue.14 , pp. 7828-7836
    • Liu, P.1    Yates, N.L.2    Shen, X.3
  • 77
    • 84904113226 scopus 로고    scopus 로고
    • HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities
    • Pollara J, Bonsignori M, Moody MA, et al. HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities. J Virol 2014; 88(14):7715-26
    • (2014) J Virol , vol.88 , Issue.14 , pp. 7715-7726
    • Pollara, J.1    Bonsignori, M.2    Moody, M.A.3
  • 78
    • 84867902474 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family
    • Bonsignori M, Pollara J, Moody MA, et al. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol 2012;86(21):11521-32
    • (2012) J Virol , vol.86 , Issue.21 , pp. 11521-11532
    • Bonsignori, M.1    Pollara, J.2    Moody, M.A.3
  • 79
    • 79960342938 scopus 로고    scopus 로고
    • An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum
    • Ferrari G, Pollara J, Kozink D, et al. An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. J Virol 2011;85(14):7029-36
    • (2011) J Virol , vol.85 , Issue.14 , pp. 7029-7036
    • Ferrari, G.1    Pollara, J.2    Kozink, D.3
  • 80
    • 84863754149 scopus 로고    scopus 로고
    • HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages
    • Moody MA, Yates NL, Amos JD, et al. HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages. J Virol 2012; 86(14):7496-507
    • (2012) J Virol , vol.86 , Issue.14 , pp. 7496-7507
    • Moody, M.A.1    Yates, N.L.2    Amos, J.D.3
  • 81
    • 84888991613 scopus 로고    scopus 로고
    • Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses
    • Pollara J, Bonsignori M, Moody MA, et al. Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses. Curr HIV Res 2013;11(5):378-87
    • (2013) Curr HIV Res , vol.11 , Issue.5 , pp. 378-387
    • Pollara, J.1    Bonsignori, M.2    Moody, M.A.3
  • 82
    • 84878430727 scopus 로고    scopus 로고
    • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
    • Tomaras GD, Ferrari G, Shen X, et al. Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proc Natl Acad Sci USA 2013;110(22):9019-24
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.22 , pp. 9019-9024
    • Tomaras, G.D.1    Ferrari, G.2    Shen, X.3
  • 83
    • 84864387259 scopus 로고    scopus 로고
    • A short segment of the HIV-1 gp120 V1/ V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies
    • Doria-Rose NA, Georgiev I, O'Dell S, et al. A short segment of the HIV-1 gp120 V1/ V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies. J Virol 2012;86(15):8319-23
    • (2012) J Virol , vol.86 , Issue.15 , pp. 8319-8323
    • Doria-Rose, N.A.1    Georgiev, I.2    O'Dell, S.3
  • 84
    • 84872514448 scopus 로고    scopus 로고
    • Analysis of V2 antibody responses induced in vaccinees in the ALVAC/ AIDSVAX HIV-1 vaccine efficacy trial
    • Zolla-Pazner S, deCamp AC, Cardozo T, et al. Analysis of V2 antibody responses induced in vaccinees in the ALVAC/ AIDSVAX HIV-1 vaccine efficacy trial. PLoS One 2013;8(1):e53629
    • (2013) PLoS One , vol.8 , Issue.1 , pp. e53629
    • Zolla-Pazner, S.1    DeCamp, A.C.2    Cardozo, T.3
  • 85
    • 4444309788 scopus 로고    scopus 로고
    • Phase I/II study of a candidate vaccine designed against the B and E subtypes of HIV-1
    • Pitisuttithum P, Berman PW, Phonrat B, et al. Phase I/II study of a candidate vaccine designed against the B and E subtypes of HIV-1. J Acquir Immune Defic Syndr 2004;37(1):1160-5
    • (2004) J Acquir Immune Defic Syndr , vol.37 , Issue.1 , pp. 1160-1165
    • Pitisuttithum, P.1    Berman, P.W.2    Phonrat, B.3
  • 86
    • 84861173075 scopus 로고    scopus 로고
    • The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope
    • de Souza MS, Ratto-Kim S, Chuenarom W, et al. The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope. J Immunol 2012;188(10):5166-76
    • (2012) J Immunol , vol.188 , Issue.10 , pp. 5166-5176
    • De Souza, M.S.1    Ratto-Kim, S.2    Chuenarom, W.3
  • 87
    • 38749132973 scopus 로고    scopus 로고
    • An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
    • Harari A, Bart PA, Stohr W, et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med 2008;205(1):63-77
    • (2008) J Exp Med , vol.205 , Issue.1 , pp. 63-77
    • Harari, A.1    Bart, P.A.2    Stohr, W.3
  • 88
    • 84903887355 scopus 로고    scopus 로고
    • Analysis of HLAA∗02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial
    • Gartland AJ, Li S, McNevin J, et al. Analysis of HLAA∗02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial. J Virol 2014; 88(15):8242-55
    • (2014) J Virol , vol.88 , Issue.15 , pp. 8242-8255
    • Gartland, A.J.1    Li, S.2    McNevin, J.3
  • 89
    • 77952678708 scopus 로고    scopus 로고
    • Wide variation in the multiplicity of HIV-1 infection among injection drug users
    • Bar KJ, Li H, Chamberland A, et al. Wide variation in the multiplicity of HIV-1 infection among injection drug users. J Virol 2010;84(12):6241-7
    • (2010) J Virol , vol.84 , Issue.12 , pp. 6241-6247
    • Bar, K.J.1    Li, H.2    Chamberland, A.3
  • 90
    • 84899087118 scopus 로고    scopus 로고
    • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination
    • Yates NL, Liao HX, Fong Y, et al. Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination. Sci Transl Med 2014;6(228):228ra239
    • (2014) Sci Transl Med , vol.6 , Issue.228 , pp. 228ra239
    • Yates, N.L.1    Liao, H.X.2    Fong, Y.3
  • 91
    • 36849011566 scopus 로고    scopus 로고
    • Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3
    • Roussilhon C, Oeuvray C, Muller-Graf C, et al. Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3. PLoS Med 2007;4(11):e320
    • (2007) PLoS Med , vol.4 , Issue.11 , pp. e320
    • Roussilhon, C.1    Oeuvray, C.2    Muller-Graf, C.3
  • 92
    • 84858261915 scopus 로고    scopus 로고
    • Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection
    • Kam YW, Simarmata D, Chow A, et al. Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. J Infect Dis 2012;205(7):1147-54
    • (2012) J Infect Dis , vol.205 , Issue.7 , pp. 1147-1154
    • Kam, Y.W.1    Simarmata, D.2    Chow, A.3
  • 93
    • 84899105650 scopus 로고    scopus 로고
    • Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines
    • Chung AW, Ghebremichael M, Robinson H, et al. Polyfunctional Fc-Effector Profiles Mediated by IgG Subclass Selection Distinguish RV144 and VAX003 Vaccines. Sci Transl Med 2014; 6(228):228ra238
    • (2014) Sci Transl Med , vol.6 , Issue.228 , pp. 228ra238
    • Chung, A.W.1    Ghebremichael, M.2    Robinson, H.3
  • 94
    • 84892450553 scopus 로고    scopus 로고
    • The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys
    • Teigler JE, Phogat S, Franchini G, et al. The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys. J Virol 2014; 88(3):1809-14
    • (2014) J Virol , vol.88 , Issue.3 , pp. 1809-1814
    • Teigler, J.E.1    Phogat, S.2    Franchini, G.3
  • 95
    • 20244375525 scopus 로고    scopus 로고
    • MN and IIIB recombinant glycoprotein 120 vaccine-induced binding antibodies to native envelope glycoprotein of human immunodeficiency virus type 1 primary isolates
    • Gorse GJ, Patel GB, Mandava M, National Institute of Allergy and Infectious Disease Aids Vaccine Evaluation Group. MN and IIIB recombinant glycoprotein 120 vaccine-induced binding antibodies to native envelope glycoprotein of human immunodeficiency virus type 1 primary isolates. AIDS Res Hum Retroviruses 1999; 15(10):921-30
    • (1999) AIDS Res Hum Retroviruses , vol.15 , Issue.10 , pp. 921-930
    • Gorse, G.J.1    Patel, G.B.2    Mandava, M.3
  • 96
    • 77951817919 scopus 로고    scopus 로고
    • IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines
    • Banerjee K, Klasse PJ, Sanders RW, et al. IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines. AIDS Res Hum Retroviruses 2010;26(4): 445-58
    • (2010) AIDS Res Hum Retroviruses , vol.26 , Issue.4 , pp. 445-458
    • Banerjee, K.1    Klasse, P.J.2    Sanders, R.W.3
  • 97
    • 0023735451 scopus 로고
    • IgG subclass response to HIV in relation to antibody-dependent cellular cytotoxicity at different clinical stages
    • Ljunggren K, Broliden PA, Morfeldt-Manson L, et al. IgG subclass response to HIV in relation to antibody-dependent cellular cytotoxicity at different clinical stages. Clin Exp Immunol 1988;73(3):343-7
    • (1988) Clin Exp Immunol , vol.73 , Issue.3 , pp. 343-347
    • Ljunggren, K.1    Broliden, P.A.2    Morfeldt-Manson, L.3
  • 98
    • 34848908400 scopus 로고    scopus 로고
    • A phase 1/2 comparative vaccine trial of the safety and immunogenicity of a CRF01-AE (subtype E) candidate vaccine: ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivalent gp120 (CM235/SF2) boost
    • Thongcharoen P, Suriyanon V, Paris RM, et al. A phase 1/2 comparative vaccine trial of the safety and immunogenicity of a CRF01-AE (subtype E) candidate vaccine: ALVAC-HIV (vCP1521) prime with oligomeric gp160 (92TH023/LAI-DID) or bivalent gp120 (CM235/SF2) boost. J Acquir Immune Defic Syndr 2007;46(1):48-55
    • (2007) J Acquir Immune Defic Syndr , vol.46 , Issue.1 , pp. 48-55
    • Thongcharoen, P.1    Suriyanon, V.2    Paris, R.M.3
  • 99
    • 20244383550 scopus 로고    scopus 로고
    • Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults
    • Nitayaphan S, Pitisuttithum P, Karnasuta C, et al. Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults. J Infect Dis 2004;190(4):702-6
    • (2004) J Infect Dis , vol.190 , Issue.4 , pp. 702-706
    • Nitayaphan, S.1    Pitisuttithum, P.2    Karnasuta, C.3
  • 100
    • 84887865083 scopus 로고    scopus 로고
    • Efficacy trial of a DNA/ rAd5 HIV-1 preventive vaccine
    • Hammer SM, Sobieszczyk ME, Janes H, et al. Efficacy trial of a DNA/ rAd5 HIV-1 preventive vaccine. N Engl J Med 2013;369(22):2083-92
    • (2013) N Engl J Med , vol.369 , Issue.22 , pp. 2083-2092
    • Hammer, S.M.1    Sobieszczyk, M.E.2    Janes, H.3
  • 101
    • 84903562353 scopus 로고    scopus 로고
    • Vaccine induced antibody responses in HVTN 505, a Phase IIb HIV-1 efficacy trial
    • Paper presented at 7-10 October 2013; Barcelona, Spain
    • Tomaras G SX, Seaton K, Janes H, et al. Vaccine induced antibody responses in HVTN 505, a Phase IIb HIV-1 efficacy trial. Paper presented at AIDS Vaccine 2013; 7-10 October 2013; Barcelona, Spain
    • (2013) AIDS Vaccine
    • Tomaras, G.S.X.1    Seaton, K.2    Janes, H.3
  • 102
    • 84909600979 scopus 로고    scopus 로고
    • Genetic and immunological evidence for a role of Env-V3 antibodies in the RV144 trial
    • abstract P03.73 LB Barcelona, Spain; 2013
    • Rolland M EP, Gottardo R, et al. Genetic and immunological evidence for a role of Env-V3 antibodies in the RV144 trial. abstract P03.73 LB AIDS Vaccine 2013; Barcelona, Spain; 2013
    • (2013) AIDS Vaccine
    • Rolland, M.E.P.1    Gottardo, R.2
  • 103
    • 84880816240 scopus 로고    scopus 로고
    • Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2
    • Mayr LM, Cohen S, Spurrier B, et al. Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2. PLoS One 2013;8(7):e70859
    • (2013) PLoS One , vol.8 , Issue.7 , pp. e70859
    • Mayr, L.M.1    Cohen, S.2    Spurrier, B.3
  • 104
    • 84899823551 scopus 로고    scopus 로고
    • Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies
    • Carbonetti S, Oliver BG, Glenn J, et al. Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies. PLoS One 2014;9(1):e86905
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86905
    • Carbonetti, S.1    Oliver, B.G.2    Glenn, J.3
  • 105
    • 84873051328 scopus 로고    scopus 로고
    • Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion
    • Alam SM, Liao HX, Tomaras GD, et al. Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. J Virol 2013; 87(3):1554-68
    • (2013) J Virol , vol.87 , Issue.3 , pp. 1554-1568
    • Alam, S.M.1    Liao, H.X.2    Tomaras, G.D.3
  • 106
    • 84883380519 scopus 로고    scopus 로고
    • Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy
    • Buglione-Corbett R, Pouliot K, Marty-Roix R, et al. Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy. PLoS One 2013;8(9):e74820
    • (2013) PLoS One , vol.8 , Issue.9 , pp. e74820
    • Buglione-Corbett, R.1    Pouliot, K.2    Marty-Roix, R.3
  • 107
    • 0029422476 scopus 로고
    • Selection of potent immunological adjuvants for vaccine construction
    • McElrath MJ. Selection of potent immunological adjuvants for vaccine construction. Semin Cancer Biol 1995;6(6):375-85
    • (1995) Semin Cancer Biol , vol.6 , Issue.6 , pp. 375-385
    • McElrath, M.J.1
  • 108
    • 84909600978 scopus 로고    scopus 로고
    • Potent V2-specific antibodies induced in humans using liposome-encapsulated HIV- 1 gp120 recognize a well-exposed v2 epitope on envelope trimer
    • abstract 2049 Keystone. Banff, Alberta, Canada
    • Rao M OS, Peachman K, et al. Potent V2-specific antibodies induced in humans using liposome-encapsulated HIV- 1 gp120 recognize a well-exposed v2 epitope on envelope trimer. abstract 2049 Keystone. HIV Vaccines: Adaptive Immunity and Beyond; Banff, Alberta, Canada; 2014
    • (2014) HIV Vaccines: Adaptive Immunity and Beyond
    • Rao, M.O.S.1    Peachman, K.2
  • 109
    • 79956073079 scopus 로고    scopus 로고
    • Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells
    • Danner R, Chaudhari SN, Rosenberger J, et al. Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One 2011;6(5):e19826
    • (2011) PLoS One , vol.6 , Issue.5 , pp. e19826
    • Danner, R.1    Chaudhari, S.N.2    Rosenberger, J.3
  • 110
    • 84891651815 scopus 로고    scopus 로고
    • Overcoming current limitations in humanized mouse research
    • Brehm MA, Shultz LD, Luban J, Greiner DL. Overcoming current limitations in humanized mouse research. J Infect Dis 2013;208(Suppl 2):S125-30
    • (2013) J Infect Dis , vol.208 , pp. S125-S130
    • Brehm, M.A.1    Shultz, L.D.2    Luban, J.3    Greiner, D.L.4
  • 112
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 2008;372(9653):1881-93
    • (2008) Lancet , vol.372 , Issue.9653 , pp. 1881-1893
    • Buchbinder, S.P.1    Mehrotra, D.V.2    Duerr, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.