Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/V2 variable loops

Journal of Virology

Volumn 75, Issue 7, 2001, Pages 3435-3443

  Kolchinsky, P ^a   Kiprilov, E ^a   Bartley, P ^a   Rubinstein, R ^a   Sodroski, J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCAN; GLYCOPROTEIN GP 120; MONOCLONAL ANTIBODY; VIRUS GLYCOPROTEIN;

ARTICLE; CAPILLARY ENDOTHELIUM; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENDOTHELIUM CELL; GLYCOSYLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS ENVELOPE; VIRUS ISOLATION; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; CELL LINE; GLYCOSYLATION; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 0035100868     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.7.3435-3443.2001     Document Type: Article

References (82)

1. CC-CKR5: A RANTES, MIP-1a. MIP-1b receptor as a fusion cofactor for macrophage-tropic HIV-1
2. Identification of the major envelope glycoprotein product of HTLV-III
3. Receptor-mediated activation of immunodeficiency viruses in viral fusion
4. Enhancement of SIV infection with soluble receptor molecules
5. Isolation of a T-lymphocyte retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS)
6. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR5 co-receptor
7. Soluble CD4 and dextran sulfate mediate release of gp120 from HIV-1: Implications for clinical trials
8. Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)
9. Core structure of gp41 from HIV envelope glycoprotein
10. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry
11. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
12. Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: Induction and enhancement by soluble CD4
13. HIV-2, the West African AIDS virus
14. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
15. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
16. A soluble form of CD4 (T4) protein inhibits AIDS virus infection
17. Identification of a major co-receptor for primary isolates of HIV-1
18. Conformational transitions in CD4 due to complexation with HIV-envelope glycoprotein gp120
19. The simian immunodeficiency viruses
20. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
21. + cells is mediated by the chemokine receptor CC-CKR-5
22. Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent phenotype
23. Structure-function relationships of the HIV-1 envelope V3 loop tropism determinant: Evidence for two distinct conformations
24. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain
25. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4
26. Tyrosine sulfation of the amino-terminus of CCR5 facilitates HIV-1 entry
27. A tyrosine-sulfated peptide based on the N-terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry
28. Acquired immunodeficiency syndrome: Epidemiologic, clinical, immunologic, and therapeutic considerations
29. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
30. HIV infection is blocked in vitro by recombinant soluble CD4
31. Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120
32. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
33. Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120
34. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants
35. Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope glycoprotein
36. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
37. Serological identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III
38. Morphometric analysis of recombinant soluble CD4-mediated release of the envelope glycoprotein gp120 from HIV-1
39. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
40. Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication
41. Numbering positions in HIV relative to HXB2
42. Structure of an HIV-1 gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing antibody
43. Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions for coreceptor specificity
44. Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells
45. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III
46. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
47. mac239)
48. CD4-independent binding of SIV gp120 to rhesus CCR5
49. Dissociation of gp120 from HIV-1 virions induced by soluble CD4
50. Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation
51. Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4
52. Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein
53. Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies
54. Effects of mutations in constant regions 3 and 4 of envelope of simian immunodeficiency virus
55. Energetics of the HIV gp120-CD4 binding reaction
56. Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding
57. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
58. Fine definition of a conserved CCR5-binding region on human immunodeficiency virus type 1 gp120 glycoprotein
59. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients
60. Epitope exposure on functional, oligomeric HIV-1 gp41 molecules
61. Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding
62. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding
63. Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells
64. Enhancement of infectivity of a non-syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1
65. Blocking of HIV-1 infectivity by a soluble secreted form of the CD4 antigen
66. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
67. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
68. The HIV 'A' (sor) gene product is essential for virus infectivity
69. Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
70. CD4-induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: Consequences for virus entry and neutralization
71. Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events
72. Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
73. Soluble CD4 molecules neutralize human immunodeficiency virus type 1
74. CD4-dependent, antibody-sensitive interactions between HIV-1 and its coreceptor CCR5
75. Atomic structure of the ectodomain from gp41
76. Human immunodeficiency virus type 1 envelope gp120 is cleaved after incubation with recombinant soluble CD4
77. Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1
78. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
79. Functional and immunological characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions
80. Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
81. The antigenic structure of the human immunodeficiency virus gp120 envelope glycoprotein