Polymorphisms in the α4 integrin of neotropical primates: Insights for binding of natural ligands and HIV-1 gp120 to the human α4β7

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Darc, Mirela ^a,b   Hait, Sabrina H ^a,b   Soares, Esmeralda A ^b   Cicala, Claudia ^c   Seuanez, Hector N ^a,b   Machado, Elizabeth S ^a   Arthos, James A ^c   Soares, Marcelo A ^a,b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 BETA7 INTEGRIN; ALPHA4 INTEGRIN; GLYCOPROTEIN GP 120; INTEGRIN; MAGNESIUM ION; MANGANESE; MONOCLONAL ANTIBODY; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; INTEGRIN ALPHA4BETA7; LIGAND;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ARTICLE; ATELIDAE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CEBIDAE; DNA DETERMINATION; EXON; GENE AMPLIFICATION; GENOTYPE; HUMAN; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PITHECIIDAE; PRIMATE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; ANIMAL; CATTLE; CELL STRAIN HEK293; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PLATYRRHINI; PROTEIN BINDING;

HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMATES;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; GENOTYPE; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HUMANS; INTEGRINS; LIGANDS; MICE; PLATYRRHINI; POLYMORPHISM, GENETIC; PROTEIN BINDING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 80052403070     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024461     Document Type: Article

References (38)

1. Mittelbrunn M, Molina A, Escribese MM, Yanez-Mo M, Escudero E, et al. (2004) VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses. Proc Natl Acad Sci U S A 101: 11058-11063.
2. Desgrosellier JS, Cheresh DA, (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9-22.
3. Triantafilou K, Takada Y, Triantafilou M, (2001) Mechanisms of integrin-mediated virus attachment and internalization process. Crit Rev Immunol 21: 311-322.
4. Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, et al. (2008) HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 9: 301-309.
5. Graham KL, Fleming FE, Halasz P, Hewish MJ, Nagesha HS, et al. (2005) Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands. J Gen Virol 86: 3397-3408.
6. Dorner M, Zucol F, Alessi D, Haerle SK, Bossart W, et al. (2010) beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection. J Virol 84: 6667-6677.
7. Hynes RO, (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
8. Pender SL, Salmela MT, Monteleone G, Schnapp D, McKenzie C, et al. (2000) Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype. Am J Pathol 157: 1955-1962.
9. Pulido R, Elices MJ, Campanero MR, Osborn L, Schiffer S, et al. (1991) Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J Biol Chem 266: 10241-10245.
10. Schiffer SG, Hemler ME, Lobb RR, Tizard R, Osborn L, (1995) Molecular mapping of functional antibody binding sites of alpha 4 integrin. J Biol Chem 270: 14270-14273.
11. Budde ML, Lhost JJ, Dudley DM, Rakasz EG, O'Connor DH, (2010) Integrin alpha4beta7 is downregulated on the surfaces of simian immunodeficiency virus SIVmac239-infected cells. J Virol 84: 6344-6351.
12. Kader M, Bixler S, Roederer M, Veazey R, Mattapallil JJ, (2009) CD4 T cell subsets in the mucosa are CD28+Ki-67-HLA-DR-CD69+ but show differential infection based on alpha4beta7 receptor expression during acute SIV infection. J Med Primatol 38 (Suppl 1): 24-31.
13. Reeves RK, Evans TI, Gillis J, Johnson RP, (2010) Simian immunodeficiency virus infection induces expansion of alpha4beta7+ and cytotoxic CD56+ NK cells. J Virol 84: 8959-8963.
14. Ansari AA, Reimann KA, Mayne AE, Takahashi Y, Stephenson ST, et al. (2011) Blocking of {alpha}4{beta}7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Immunol 186: 1044-1059.
15. Mummidi S, Bamshad M, Ahuja SS, Gonzalez E, Feuillet PM, et al. (2000) Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus. J Biol Chem 275: 18946-18961.
16. Ribeiro IP, Schrago CG, Soares EA, Pissinatti A, Seuanez HN, et al. (2005) CCR5 chemokine receptor gene evolution in New World monkeys (Platyrrhini, Primates): implication on resistance to lentiviruses. Infect Genet Evol 5: 271-280.
17. Zubair S, Metzenberg S, (2000) CXCR4 homologues of gibbon ape, African green monkey, squirrel monkey, and cotton-top marmoset. AIDS Res Hum Retroviruses 16: 1179-1182.
18. Maillard PV, Ecco G, Ortiz M, Trono D, (2010) The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain. J Virol 84: 5790-5801.
19. Pacheco B, Finzi A, McGee-Estrada K, Sodroski J, (2010) Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins. J Virol 84: 4095-4099.
20. Ribeiro IP, Menezes AN, Moreira MA, Bonvicino CR, Seuanez HN, et al. (2005) Evolution of cyclophilin A and TRIMCyp retrotransposition in New World primates. J Virol 79: 14998-15003.
21. Sayah DM, Sokolskaja E, Berthoux L, Luban J, (2004) Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature 430: 569-573.
22. Soares EA, Menezes AN, Schrago CG, Moreira MA, Bonvicino CR, et al. (2010) Evolution of TRIM5alpha B30.2 (SPRY) domain in New World primates. Infect Genet Evol 10: 246-253.
23. Perez-Caballero D, Soll SJ, Bieniasz PD, (2008) Evidence for restriction of ancient primate gammaretroviruses by APOBEC3 but not TRIM5alpha proteins. PLoS Pathog 4: e1000181.
24. Sawyer SL, Emerman M, Malik HS, (2004) Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G. PLoS Biol 2: E275.
25. Wong SK, Connole M, Sullivan JS, Choe H, Carville A, et al. (2009) A New World primate deficient in tetherin-mediated restriction of human immunodeficiency virus type 1. J Virol 83: 8771-8780.
26. Hall TA, (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nuclei Acids Symposium Series 41: 95-98.
27. DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, et al. (1987) Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cell Biol 7: 379-387.
28. Nawaz F, Cicala C, van Ryk D, Block KE, Jelicic K, et al. (2011) The Genotype of Early-Transmitting HIV gp120s Promotes High α4β7-Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission. PLoS Pathog 7: e1001301.
29. Perelman P, Johnson W, Roos C, Seuanez HN, Horvath JE, et al. (2011) A molecular phylogeny of living primates. PLoS Genetics 7: e1001342.
30. Day ES, Osborn L, Whitty A, (2002) Effect of divalent cations on the affinity and selectivity of alpha4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2+ activation of integrin alpha4beta1 confers a distinct ligand specificity. Cell Commun Adhes 9: 205-219.
31. Coisne C, Mao W, Engelhardt B, (2009) Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J Immunol 182: 5909-5913.
32. Engelhardt B, Kappos L, (2008) Natalizumab: targeting alpha4-integrins in multiple sclerosis. Neurodegener Dis 5: 16-22.
33. Colombel JF, Peyrin-Biroulet L, (2006) Natalizumab: a promising treatment for Crohn's disease. Expert Rev Clin Immunol 2: 677-689.
34. Edula RG, Picco MF, (2009) An evidence-based review of natalizumab therapy in the management of Crohn's disease. Ther Clin Risk Manag 5: 935-942.
35. Nguyen K, Sylvain NR, Bunnell SC, (2008) T cell costimulation via the integrin VLA-4 inhibits the actin-dependent centralization of signaling microclusters containing the adaptor SLP-76. Immunity 28: 810-821.
36. Wang J, Springer TA, (1998) Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses. Immunol Rev 163: 197-215.
37. Raymond S, Delobel P, Mavigner M, Cazabat M, Souyris C, et al. (2008) Correlation between genotypic predictions based on V3 sequences and phenotypic determination of HIV-1 tropism. Aids 22: F11-16.
38. Schneider H, Canavez FC, Sampaio I, Moreira MA, Tagliaro CH, et al. (2001) Can molecular data place each neotropical monkey in its own branch? Chromosoma 109: 515-523.