Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Bastianelli, Giacomo ^a,b   Bouillon, Anthony ^b   Nguyen, Christophe ^c   Le Nguyen, Dung ^c   Nilges, Michael ^a,b   Barale, Jean Christophe ^b  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c SYSDIAG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ECBALLIUM ELATERIUM TRYPSIN INHIBITOR II; SUBTILISIN; SUBTILISIN LIKE 1 PROTEASE; UNCLASSIFIED DRUG; PROTEIN BINDING; PROTOZOAL PROTEIN; SUBTILISIN-LIKE PROTEASE 1, PLASMODIUM FALCIPARUM;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL; PLASMODIUM VIVAX; PROTEIN SECONDARY STRUCTURE; SCORING SYSTEM; SEQUENCE HOMOLOGY; CATALYSIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PLASMODIUM VIVAX MALARIA; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MALARIA, VIVAX; MOLECULAR DOCKING SIMULATION; PLASMODIUM VIVAX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBTILISINS;

EID: 84908650015     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109269     Document Type: Article

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