Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 7, 2010, Pages 3117-3122

  Nishikawa, Keizo ^a   Nakashima, Tomoki ^a,b   Hayashi, Mikihito ^a   Fukunaga, Takanobu ^a   Kato, Shigeaki ^b,c   Kodama, Tatsuhiko ^d   Takahashi, Satoru ^e   Calame, Kathryn ^f   Takayanagi, Hiroshi ^a,b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e UNIVERSITY OF TSUKUBA   (Japan)

^f Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

B lymphocyte induced maturation protein 1; Bone; Nuclear factor of activated T cells c1; Osteoclastogenesis; Transcription

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAFB; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE; GENE OVEREXPRESSION; GENE REPRESSION; HOMEOSTASIS; LRF8 GENE; MOUSE; NONHUMAN; OSTEOCLAST; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; FLOW CYTOMETRY; IMMUNOBLOTTING; INTERFERON REGULATORY FACTORS; MAFB TRANSCRIPTION FACTOR; MICE; MICE, MUTANT STRAINS; NFATC TRANSCRIPTION FACTORS; OLIGONUCLEOTIDES; OSTEOCLASTS; POLYMERASE CHAIN REACTION; RANK LIGAND; REGULATORY ELEMENTS, TRANSCRIPTIONAL; REPRESSOR PROTEINS; RNA INTERFERENCE; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSCRIPTION FACTORS;

MUS;

EID: 77649262903     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912779107     Document Type: Article

References (40)

1. Takayanagi H (2007) Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7:292-304.
2. Lorenzo J, Horowitz M, Choi Y (2008) Osteoimmunology: Interactions of the bone and immune system. Endocr Rev 29:403-440.
3. Goldring SR, Gravallese EM (2000) Mechanisms of bone loss in inflammatory arthritis: Diagnosis and therapeutic implications. Arthritis Res 2:33-37.
4. Kong YY, et al. (1999) Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402:304-309.
5. Takayanagi H, et al. (2000) T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 408:600-605.
6. Rodan GA, Martin TJ (2000) Therapeutic approaches to bone diseases. Science 289: 1508-1514.
7. Theill LE, Boyle WJ, Penninger JM (2002) RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 20:795-823.
8. Xing L, Schwarz EM, Boyce BF (2005) Osteoclast precursors, RANKL/RANK, and immunology. Immunol Rev 208:19-29.
9. Ross FP, Teitelbaum SL (2005) α/β3 and macrophage colony-stimulating factor: Partners in osteoclast biology. Immunol Rev 208:88-105.
10. Kobayashi N, et al. (2001) Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J 20:1271-1280.
11. Wagner EF, Eferl R (2005) Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208:126-140.
12. Asagiri M, et al. (2005) Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202:1261-1269.
13. Takayanagi H, et al. (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3:889-901.
14. Koga T, et al. (2004) Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428:758-763.
15. Mócsai A, et al. (2004) The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci USA 101:6158-6163.
16. Shinohara M, et al. (2008) Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132:794-806.
17. Winslow MM, et al. (2006) Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell 10:771-782.
18. Aliprantis AO, et al. (2008) NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118:3775-3789.
19. Yagi M, et al. (2007) Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J Bone Miner Res 22:992-1001.
20. Kim K, Lee SH, Ha Kim J, Choi Y, Kim N (2008) NFATc1 induces osteoclast fusion via upregulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DCSTAMP). Mol Endocrinol 22:176-185.
21. Lee SH, et al. (2006) v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med 12:1403-1409.
22. Zhao B, et al. (2009) Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 15:1066-1071.
23. Kim K, et al. (2007) MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood 109:3253-3259.
24. Martins G, Calame K (2008) Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 26:133-169.
25. Shapiro-ShelefM, et al. (2003) Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19:607-620.
26. Kanamori M, et al. (2004) A genome-wide and nonredundant mouse transcription factor database. Biochem Biophys Res Commun 322:787-793.
27. Eisen MB, Spellman PT, Brown PO, Botstein D (1998) Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
28. Bozec A, et al. (2008) Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature 454:221-225.
29. Ishii KA, et al. (2009) Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med 15:259-266.
30. Chang DH, Angelin-Duclos C, Calame K (2000) BLIMP-1: Trigger for differentiation of myeloid lineage. Nat Immunol 1:169-176.
31. Alvarez M, Rhodes SJ, Bidwell JP (2003) Context-dependent transcription: All politics is local. Gene 313:43-57.
32. Kessler DS (1997) Siamois is required for formation of Spemann's organizer. Proc Natl Acad Sci USA 94:13017-13022.
33. Nakamura T, et al. (2007) Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell 130:811-823.
34. Nutt SL, Heavey B, Rolink AG, Busslinger M (1999) Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556-562.
35. Tamura T, Nagamura-Inoue T, Shmeltzer Z, Kuwata T, Ozato K (2000) ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Immunity 13:155-165.
36. Moriguchi T, et al. (2006) MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol 26:5715-5727.
37. Tunyaplin C, et al. (2004) Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J Immunol 173:1158-1165.
38. Morita S, Kojima T, Kitamura T (2000) Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 7:1063-1066.
39. Sato S, et al. (2005) Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6:1087-1095.
40. Nishikawa K, et al. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Mol Cell Biol 23:8295-8305.