Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK-Hsp27 Apoptotic Pathway in Oral Cancer Cells

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Chen, Su Feng ^a   Nieh, Shin ^b   Jao, Shu Wen ^b   Liu, Chia Lin ^c   Wu, Chien Hua ^c   Chang, Yun Ching ^c   Yang, Chin Yuh ^d   Lin, Yaoh Shiang ^b,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CISPLATIN; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; QUERCETIN; TUMOR MARKER;

ABCG2 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENICITY; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MDR 1 GENE; MOUSE; MOUTH CANCER; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TUMOR GENE; TUMOR REGRESSION; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DRUG RESISTANCE, NEOPLASM; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MOUTH NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUERCETIN; SPHEROIDS, CELLULAR;

EID: 84869053223     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049275     Document Type: Article

References (36)

1. Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Tasi HT, et al. (2010) Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity. Future Oncol 6: 837-850.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
3. Olasz L, Szabo I, Horvath A, (1988) A combined treatment for advanced oral cavity cancers. Cancer 62: 1267-1274.
4. Lippman SM, Sudbo J, Hong WK, (2005) Oral cancer prevention and the evolution of molecular-targeted drug development. J Clin Oncol 23: 346-356.
5. Hamburger AW, Salmon SE, (1977) Primary bioassay of human tumor stem cells. Science 197: 461-463.
6. Bonnet D, Dick JE, (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737.
7. Clarke MF, (2006) Oncogenes, self-renewal and cancer. Pathol Biol (Paris) 54: 109-111.
8. Dean M, Fojo T, Bates S, (2005) Tumour stem cells and drug resistance. Nat Rev Cancer 5: 275-284.
9. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, et al. (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7: 1028-1034.
10. Fletcher JI, Haber M, Henderson MJ, Norris MD, (2010) ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 10: 147-156.
11. Sengupta S, Mantha AK, Mitra S, Bhakat KK, (2011) Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene 30: 482-493.
12. Lee J, Jiffar T, Kupferman ME, (2012) A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma. PLoS One 7: e30246.
13. Siddik ZH, (2003) Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22: 7265-7279.
14. Wang D, Lippard SJ, (2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4: 307-320.
15. Kuo MT, Chen HH, Song IS, Savaraj N, Ishikawa T, (2007) The roles of copper transporters in cisplatin resistance. Cancer Metastasis Rev 26: 71-83.
16. Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, et al. (2004) Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3: 1543-1549.
17. Chen HH, Yan JJ, Chen WC, Kuo MT, Lai YH, et al. (2012) Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Lung Cancer 75: 228-234.
18. Vogel JL, Parsell DA, Lindquist S, (1995) Heat-shock proteins Hsp104 and Hsp70 reactivate mRNA splicing after heat inactivation. Curr Biol 5: 306-317.
19. Langdon SP, Rabiasz GJ, Hirst GL, King RJ, Hawkins RA, et al. (1995) Expression of the heat shock protein HSP27 in human ovarian cancer. Clin Cancer Res 1: 1603-1609.
20. Nakajima M, Kuwano H, Miyazaki T, Masuda N, Kato H, (2002) Significant correlation between expression of heat shock proteins 27, 70 and lymphocyte infiltration in esophageal squamous cell carcinoma. Cancer Lett 178: 99-106.
21. Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK, et al. (1993) The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 53: 4443-4448.
22. Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, et al. (2009) Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. J Pharmacol Sci 109: 257-264.
23. Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, et al. (2010) Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol 80: 1833-1843.
24. Hsu HS, Lin JH, Huang WC, Hsu TW, Su K, et al. (2011) Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27. Cancer 117: 1516-1528.
25. Chen SF, Chang YC, Nieh S, Liu CL, Yang CY, et al. (2012) Nonadhesive culture system as a model of rapid sphere formation with cancer stem cell properties. PLoS One 7: e31864.
26. Dalerba P, Cho RW, Clarke MF, (2007) Cancer stem cells: models and concepts. Annu Rev Med 58: 267-284.
27. Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, et al. (2009) Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res 69: 5820-5828.
28. Wei L, Liu TT, Wang HH, Hong HM, Yu AL, et al. (2011) Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-kappaB. Breast Cancer Res 13: R101.
29. Yang AD, Fan F, Camp ER, van Buren G, Liu W, et al. (2006) Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 12: 4147-4153.
30. Hsu DS, Lan HY, Huang CH, Tai SK, Chang SY, et al. (2010) Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer. Clin Cancer Res 16: 4561-4571.
31. Cao L, Zhou Y, Zhai B, Liao J, Xu W, et al. (2011) Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol 11: 71.
32. Parcellier A, Schmitt E, Brunet M, Hammann A, Solary E, et al. (2005) Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions. Antioxid Redox Signal 7: 404-413.
33. Soo ET, Yip GW, Lwin ZM, Kumar SD, Bay BH, (2008) Heat shock proteins as novel therapeutic targets in cancer. In Vivo 22: 311-315.
34. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, et al. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037.
35. Tang SN, Singh C, Nall D, Meeker D, Shankar S, et al. (2010) The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition. J Mol Signal 5: 14.
36. Nagai N, Nakai A, Nagata K, (1995) Quercetin suppresses heat shock response by down regulation of HSF1. Biochem Biophys Res Commun 208: 1099-1105.