Curcumin suppresses metastasis via Sp-1, FAK inhibition, and E-cadherin upregulation in colorectal cancer

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Chen, Chun Chieh ^a,b   Sureshbabul, Munisamy ^a,b   Chen, Huei Wen ^a,b   Lin, Yu Shuang ^a   Lee, Jen Yi ^a   Hong, Qi Sheng ^a,b   Yang, Ya Chien ^a,c   Yu, Sung Liang ^a,b,c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; CD24 ANTIGEN; CURCUMIN; CYCLIN D3; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; HISTONE DEACETYLASE 4; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN; PROTEIN ADEM 10; PROTEIN EPHB2; PROTEIN KINASE B; PROTEIN SEPP 1; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRUCTURE; CELL VIABILITY; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG MECHANISM; ENVIRONMENTAL STRESS; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TUMOR GROWTH; UPREGULATION;

EID: 84881535929     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/541695     Document Type: Article

References (52)

1. Siegel R., Naishadham D., Jemal A., Cancer statistics, 2012. CA Cancer Journal for Clinicians 2012 62 1 10 29 2-s2.0-84855792427 10.3322/caac.20138
2. Chiang C.-J., Chen Y.-C., Chen C.-J., You S.-L., Lai M.-S., Cancer trends in Taiwan. Japanese Journal of Clinical Oncology 2010 40 10 897 904 2-s2.0-77957696225 10.1093/jjco/hyq057
3. Pourhoseingholi M. A., Increased burden of colorectal cancer in Asia. The World Journal of Gastrointestinal Oncology 2012 4 68 70 10.4251/wjgo.v4.i4.68
4. Leber M. F., Efferth T., Molecular principles of cancer invasion and metastasis. International Journal of Oncology 2009 34 4 881 895 2-s2.0-67649421096 10.3892/ijo-00000214
5. Shi Q., Le X., Abbruzzese J. L., Peng Z., Qian C.-N., Tang H., Xiong Q., Wang B., Li X.-C., Xie K., Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. Cancer Research 2001 61 10 4143 4154 2-s2.0-0035872399 (Pubitemid 32720983)
6. Zannetti A., Del Vecchio S., Carriero M. V., Fonti R., Franco P., Botti G., D'Aiuto G., Stoppelli M. P., Salvatore M., Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma. Cancer Research 2000 60 6 1546 1551 2-s2.0-0034653737 (Pubitemid 30183423)
7. Kitadai Y., Yasui W., Yokozaki H., Kuniyasu H., Haruma K., Kajiyama G., Tahara E., The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas. Biochemical and Biophysical Research Communications 1992 189 3 1342 1348 2-s2.0-0027048516 10.1016/0006-291X(92)90221-6 (Pubitemid 23041306)
8. Schlaepfer D. D., Hauck C. R., Sieg D. J., Signaling through focal adhesion kinase. Progress in Biophysics and Molecular Biology 1999 71 3-4 435 478 2-s2.0-0032894567 10.1016/S0079-6107(98)00052-2 (Pubitemid 29156312)
9. Shen T.-L., Guan J.-L., Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. The FEBS Letters 2001 499 1-2 176 181 2-s2.0-0035875975 10.1016/S0014-5793(01)02545-5 (Pubitemid 32539344)
10. Yu Q., Stamenkovic I., Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF- β and promotes tumor invasion and angiogenesis. Genes and Development 2000 14 2 163 176 2-s2.0-0034650486 (Pubitemid 30070982)
11. van Roy F., Berx G., The cell-cell adhesion molecule E-cadherin. Cellular and Molecular Life Sciences 2008 65 23 3756 3788 2-s2.0-57349114162 10.1007/s00018-008-8281-1
12. Davie J. R., He S., Li L., Sekhavat A., Espino P., Drobic B., Dunn K. L., Sun J.-M., Chen H. Y., Yu J., Pritchard S., Wang X., Nuclear organization and chromatin dynamics-Sp1, Sp3 and histone deacetylases. Advances in Enzyme Regulation 2008 48 1 189 208 2-s2.0-51349134563 10.1016/j.advenzreg.2007.11.016
13. Chen H.-M., Pahl H. L., Scheibe R. J., Zhang D.-E., Tenen D. G., The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity. Journal of Biological Chemistry 1993 268 11 8230 8239 2-s2.0-0027416753 (Pubitemid 23120411)
14. Wang X., Urvalek A. M., Liu J., Zhao J., Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells. Journal of Biological Chemistry 2008 283 20 13934 13942 2-s2.0-46649092797 10.1074/jbc.M709300200
15. Waby J. S., Chirakkal H., Yu C., Griffiths G. J., Benson R. S. P., Bingle C. D., Corfe B. M., Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line. Molecular Cancer 2010 9, article 275 2-s2.0-77957917520 10.1186/1476-4598-9-275
16. Cox B. D., Natarajan M., Stettner M. R., Gladson C. L., New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. Journal of Cellular Biochemistry 2006 99 1 36 52 2-s2.0-33748068089 10.1002/jcb.20956 (Pubitemid 44297948)
17. Baumann P., Thiele W., Cremers N., Muppala S., Krachulec J., Diefenbacher M., Kassel O., Mudduluru G., Allgayer H., Frame M., Sleeman J. P., CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion. Cellular and Molecular Life Sciences 2012 69 3 435 448 2-s2.0-84856209716 10.1007/s00018-011-0756-9
18. Christofori G., New signals from the invasive front. Nature 2006 441 7092 444 450 2-s2.0-33745297408 10.1038/nature04872 (Pubitemid 44050139)
19. Bretz N. P., Salnikov A. V., Perne C., CD24 controls Src/STAT3 activity in human tumors. Cellular and Molecular Life Sciences 2012 69 3863 3879
20. Ye P., Nadkarni M. A., Hunter N., Regulation of E-cadherin and TGF- β 3 expression by CD24 in cultured oral epithelial cells. Biochemical and Biophysical Research Communications 2006 349 1 229 235 2-s2.0-33748300738 10.1016/j.bbrc.2006.08.033 (Pubitemid 44331786)
21. Chen X., Wang Y., Xia H., Wang Q., Jiang X., Lin Z., Ma Y., Yang Y., Hu M., Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis. Molecular Biology Reports 2012 39 6707 6714 2-s2.0-84856423642 10.1007/s11033-012-1494-2
22. Orsulic S., Huber O., Aberle H., Arnold S., Kemler R., E-cadherin binding prevents β -catenin nuclear localization and β -catenin/LEF-1- mediated transactivation. Journal of Cell Science 1999 112 8 1237 1245 2-s2.0-0032891720 (Pubitemid 29218912)
23. Gupta S. C., Prasad S., Kim J. H., Patchva S., Webb L. J., Priyadarsini I. K., Aggarwal B. B., Multitargeting by curcumin as revealed by molecular interaction studies. Natural Product Reports 2011 28 12 1937 1955 2-s2.0-81355142057 10.1039/c1np00051a
24. Kuttan R., Bhanumathy P., Nirmala K., George M. C., Potential anticancer activity of turmeric (Curcuma longa). Cancer Letters 1985 29 2 197 202 2-s2.0-0022357855 (Pubitemid 16175818)
25. Ruby A. J., Kuttan G., Dinesh Babu K., Rajasekharan K. N., Kuttan R., Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters 1995 94 1 79 83 2-s2.0-0029648973
26. Chen H., Zhang Z.-S., Zhang Y.-L., Zhou D.-Y., Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Research 1999 19 5 3675 3680 2-s2.0-0032763091
27. Chen H.-W., Lee J.-Y., Huang J.-Y., Wang C.-C., Chen W.-J., Su S.-F., Huang C.-W., Ho C.-C., Chen J. J. W., Tsai M.-F., Yu S.-L., Yang P.-C., Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Research 2008 68 18 7428 7438 2-s2.0-54749152839 10.1158/0008-5472.CAN-07-6734
28. Lee J.-Y., Lee Y.-M., Chang G.-C., Yu S.-L., Hsieh W.-Y., Chen J. J. W., Chen H.-W., Yang P.-C., Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy. PLoS ONE 2011 6 8 2-s2.0-80051746642 10.1371/journal.pone.0023756 e23756
29. Lin H.-J., Su C.-C., Lu H.-F., Yang J.-S., Hsu S.-C., Ip S.-W., Wu J.-J., Li Y.-C., Ho C.-C., Wu C.-C., Chung J.-G., Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho a and Rock-1 gene expression. Oncology Reports 2010 23 3 665 670 2-s2.0-77349086587 10.3892/or-00000682
30. Shishodia S., Singh T., Chaturvedi M. M., Modulation of transcription factors by curcumin. Advances in Experimental Medicine and Biology 2007 595 127 148 2-s2.0-34347226317 10.1007/978-0-387-46401-5-4
31. Leupold J. H., Yang H.-S., Colburn N. H., Asangani I., Post S., Allgayer H., Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene 2007 26 31 4550 4562 2-s2.0-34447270490 10.1038/sj.onc.1210234 (Pubitemid 47039134)
32. Cho S.-G., Yi Z., Pang X., Yi T., Wang Y., Luo J., Wu Z., Li D., Liu M., Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation. Cancer Research 2009 69 17 7062 7070 2-s2.0-70149121279 10.1158/0008-5472.CAN-09-0476
33. Chadalapaka G., Jutooru I., Chintharlapalli S., Papineni S., Smith R. III, Li X., Safe S., Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research 2008 68 13 5345 5354 2-s2.0-48549085442 10.1158/0008-5472.CAN-07-6805
34. Aigner S., Ramos C. L., Hafezi-Moghadam A., Lawrence M. B., Friederichs J., Altevogt P., Ley K., CD24 mediates rolling of breast carcinoma cellson P-selectin. The FASEB Journal 1998 12 12 1241 1251 2-s2.0-0031715514 (Pubitemid 28418954)
35. Lou Z., O'Reilly S., Liang H., Maher V. M., Sleight S. D., McCormick J. J., Down-regulation of overexpression Sp1 protein in human fibrosarcoma cell lines inhibits tumor formation. Cancer Research 2005 65 3 1007 1017 2-s2.0-13444267281 (Pubitemid 40216463)
36. Yamamoto D., Sonoda Y., Hasegawa M., Funakoshi-Tago M., Aizu-Yokota E., Kasahara T., FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathways. Cellular Signalling 2003 15 6 575 583 2-s2.0-0037409464 10.1016/S0898-6568(02)00142-0 (Pubitemid 36385163)
37. McLean G. W., Komiyama N. H., Serrels B., Asano H., Reynolds L., Conti F., Hodivala-Dilke K., Metzger D., Chambon P., Grant S. G. N., Frame M. C., Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes and Development 2004 18 24 2998 3003 2-s2.0-10644280092 10.1101/gad.316304 (Pubitemid 39658168)
38. Lee J. W., Kim Y. H., Park H. B., Xu L.-H., Cance W. G., Block J. A., Scully S. P., The C-terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines. Journal of Orthopaedic Research 2003 21 6 1071 1080 2-s2.0-0142148134 10.1016/S0736-0266(03)00101-3 (Pubitemid 37322389)
39. Calalb M. B., Polte T. R., Hanks S. K., Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Molecular and Cellular Biology 1995 15 2 954 963 2-s2.0-0028877919
40. Schlaepfer D. D., Hunter T., Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Molecular and Cellular Biology 1996 16 5623 5633 (Pubitemid 26315082)
41. Leu T.-H., Su S. L., Chuang Y.-C., Maa M.-C., Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity. Biochemical Pharmacology 2003 66 12 2323 2331 2-s2.0-0344962391 10.1016/j.bcp.2003.08.017 (Pubitemid 37456740)
42. Kim D., Kim S.-J., Kang S.-S., Jin E.-J., Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells. Experimental and Molecular Medicine 2009 41 9 656 664 2-s2.0-70349473076 10.3858/emm.2009.41.9.072
43. Ilic D., Furuta Y., Suda T., Atsumi T., Fujimoto J., Ikawa Y., Yamamoto T., Aizawa S., Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells. Biochemical and Biophysical Research Communications 1995 209 1 300 309 2-s2.0-0028924161 10.1006/bbrc.1995.1503
44. Tamura M., Gu J., Takino T., Yamada K. M., Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130(Cas). Cancer Research 1999 59 2 442 449 2-s2.0-0033556443 (Pubitemid 29048881)
45. Sood P. K., Nahar U., Nehru B., Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brain. Neurotoxicity Research 2011 20 4 351 361 2-s2.0-80053894222 10.1007/s12640-011-9249-8
46. Wang L., Liu R., Li D., A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosis. American Journal of Translational Research 2012 4 347 356
47. Torres V. A., Tapia J. C., Rodriguez D. A., Lladser A., Arredondo C., Leyton L., Quest A. F. G., E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced β -catenin-Tcf/Lef- dependent transcription. Molecular and Cellular Biology 2007 27 21 7703 7717 2-s2.0-35649009855 10.1128/MCB.01991-06 (Pubitemid 350033675)
48. Sundram V., Chauhan S. C., Ebeling M., Jaggi M., Curcumin attenuates β -catenin signaling in prostate cancer cells through activation of protein kinase D1. PLoS ONE 2012 7 4 2-s2.0-84859868412 10.1371/journal.pone.0035368 e35368
49. Wong T.-S., Chan W.-S., Li C.-H., Liu R. W.-M., Tang W. W.-Y., Tsao S.-W., Tsang R. K.-Y., Ho W.-K., Wei W. I., Chan J. Y.-W., Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Research 2010 30 7 2851 2856 2-s2.0-77955822805
50. Lee J. M., Dedhar S., Kalluri R., Thompson E. W., The epithelial-mesenchymal transition: new insights in signaling, development, and disease. Journal of Cell Biology 2006 172 7 973 981 2-s2.0-33645302628 10.1083/jcb.200601018
51. Huang T., Chen Z., Fang L., Curcumin inhibits LPS-induced EMT through downregulation of NF-kappaB-Snail signaling in breast cancer cells. Oncology Reports 2013 29 117 124
52. Jungert K., Buck A., von Wichert G., Adler G., König A., Buchholz M., Gress T. M., Ellenrieder V., Sp1 is required for transforming growth factor- β -induced mesenchymal transition and migration in pancreatic cancer cells. Cancer Research 2007 67 4 1563 1570 2-s2.0-33847736187 10.1158/0008-5472.CAN-06-1670 (Pubitemid 46383380)