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Volumn 13, Issue 9, 2013, Pages 957-962

Regulation of EMT by Notch signaling pathway in tumor progression

Author keywords

Cancer; MiRNA; Natural compound; Notch; Oncogene; Tumor suppressor gene

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; DELTA LIKE 4 LIGAND; FIBRONECTIN; GAMMA SECRETASE; JAGGED 2; JAGGED1; MATRIX METALLOPROTEINASE; MICRORNA; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR ZEB1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 84890828010     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/15680096113136660101     Document Type: Review
Times cited : (77)

References (65)
  • 2
    • 79955460636 scopus 로고    scopus 로고
    • Notch signalling in solid tumours: A little bit of everything but not all the time
    • Ranganathan, P.; Weaver, K. L.; Capobianco, A. J. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat. Rev. Cancer 2011, 11, 338-351.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 338-351
    • Ranganathan, P.1    Weaver, K.L.2    Capobianco, A.J.3
  • 3
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu, R.; Efeyan, A.; Sabatini, D. M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12, 21-35.
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 4
    • 80955181031 scopus 로고    scopus 로고
    • The Hedgehog's tale: Developing strategies for targeting cancer
    • Ng, J. M.; Curran, T. The Hedgehog's tale: developing strategies for targeting cancer. Nat. Rev. Cancer 2011, 11, 493-501.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 5
    • 84860217431 scopus 로고    scopus 로고
    • The functions and regulation of the PTEN tumour suppressor
    • Song, M. S.; Salmena, L.; Pandolfi, P. P. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 2012, 13, 283-296.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 283-296
    • Song, M.S.1    Salmena, L.2    Pandolfi, P.P.3
  • 6
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P.; Cheng, H.; Roberts, T. M.; Zhao, J. J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 2009, 8, 627-644.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 7
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus, A.; Birchmeier, W. Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 2008, 8, 387-398.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 8
    • 0142259346 scopus 로고    scopus 로고
    • The role of Notch in tumorigenesis: Oncogene or tumour suppressor?
    • Radtke, F.; Raj, K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat. Rev. Cancer 2003, 3, 756-767.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 756-767
    • Radtke, F.1    Raj, K.2
  • 9
    • 77953523118 scopus 로고    scopus 로고
    • The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness
    • Wang, Z.; Li, Y.; Kong, D.; Sarkar, F. H. The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness. Curr. Drug Targets 2010, 11, 745-751.
    • (2010) Curr. Drug Targets , vol.11 , pp. 745-751
    • Wang, Z.1    Li, Y.2    Kong, D.3    Sarkar, F.H.4
  • 10
    • 13244298117 scopus 로고    scopus 로고
    • Notch and epithelial-mesenchyme transition in development and tumor progression: Another turn of the screw
    • Grego-Bessa, J.; Diez, J.; Timmerman, L.; de, la. Pompa. J. L. Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle 2004, 3, 718-721.
    • (2004) Cell Cycle , vol.3 , pp. 718-721
    • Grego-Bessa, J.1    Diez, J.2    Timmerman, L.3    de la Pompa, J.L.4
  • 12
    • 58149174376 scopus 로고    scopus 로고
    • Exploitation of the Notch signaling pathway as a novel target for cancer therapy
    • Wang, Z.; Li, Y.; Banerjee, S.; Sarkar, F. H. Exploitation of the Notch signaling pathway as a novel target for cancer therapy. Anticancer Res. 2008, 28, 3621-3630.
    • (2008) Anticancer Res. , vol.28 , pp. 3621-3630
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 13
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • Wang, Z.; Li, Y.; Banerjee, S.; Sarkar, F. H. Emerging role of Notch in stem cells and cancer. Cancer Lett. 2009, 279, 8-12.
    • (2009) Cancer Lett. , vol.279 , pp. 8-12
    • Wang, Z.1    Li, Y.2    Banerjee, S.3    Sarkar, F.H.4
  • 14
    • 77951884078 scopus 로고    scopus 로고
    • Cross-talk between miRNA and Notch signaling pathways in tumor development and progression
    • Wang, Z.; Li, Y.; Kong, D.; Ahmad, A.; Banerjee, S.; Sarkar, F. H. Cross-talk between miRNA and Notch signaling pathways in tumor development and progression. Cancer Lett. 2010, 292, 141-148.
    • (2010) Cancer Lett. , vol.292 , pp. 141-148
    • Wang, Z.1    Li, Y.2    Kong, D.3    Ahmad, A.4    Banerjee, S.5    Sarkar, F.H.6
  • 17
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan, R.; Ilagan, M. X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137, 216-233.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 18
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • Miele, L. Notch signaling. Clin. Cancer Res. 2006, 12, 1074-1079.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1074-1079
    • Miele, L.1
  • 19
    • 84870954822 scopus 로고    scopus 로고
    • Epigenetic silencing of Notch signaling in gastrointestinal cancers
    • Piazzi, G.; Bazzoli, F.; Ricciardiello, L. Epigenetic silencing of Notch signaling in gastrointestinal cancers. Cell Cycle 2012, 11, 4323-4327.
    • (2012) Cell Cycle , vol.11 , pp. 4323-4327
    • Piazzi, G.1    Bazzoli, F.2    Ricciardiello, L.3
  • 22
    • 84859482643 scopus 로고    scopus 로고
    • Notch signaling and intestinal cancer
    • Guilmeau, S. Notch signaling and intestinal cancer. Adv. Exp. Med. Biol. 2012, 727, 272-288.
    • (2012) Adv. Exp. Med. Biol. , vol.727 , pp. 272-288
    • Guilmeau, S.1
  • 23
    • 84859484455 scopus 로고    scopus 로고
    • Notch-signaling and nonmelanoma skin cancer: An ancient friend, revisited
    • Reichrath, J; Reichrath, S. Notch-signaling and nonmelanoma skin cancer: an ancient friend, revisited. Adv. Exp. Med. Biol. 2012, 727, 265-271.
    • (2012) Adv. Exp. Med. Biol. , vol.727 , pp. 265-271
    • Reichrath, J.1    Reichrath, S.2
  • 24
    • 84859506935 scopus 로고    scopus 로고
    • Notch signaling and malignant melanoma
    • Muller, C. S. Notch signaling and malignant melanoma. Adv. Exp. Med. Biol. 2012, 727, 258-264.
    • (2012) Adv. Exp. Med. Biol. , vol.727 , pp. 258-264
    • Muller, C.S.1
  • 25
    • 84859482094 scopus 로고    scopus 로고
    • Notch signaling and breast cancer
    • Reedijk, M. Notch signaling and breast cancer. Adv. Exp. Med. Biol. 2012, 727, 241-257.
    • (2012) Adv. Exp. Med. Biol. , vol.727 , pp. 241-257
    • Reedijk, M.1
  • 26
    • 78951481235 scopus 로고    scopus 로고
    • Role of Notch and its oncogenic signaling crosstalk in breast cancer
    • Guo, S.; Liu, M.; Gonzalez-Perez, R. R. Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim. Biophys. Acta. 2011, 1815, 197-213.
    • (2011) Biochim. Biophys. Acta. , vol.1815 , pp. 197-213
    • Guo, S.1    Liu, M.2    Gonzalez-Perez, R.R.3
  • 27
    • 84856008970 scopus 로고    scopus 로고
    • Notch signalling in cancer progression and bone metastasis
    • Sethi, N.; Kang, Y. Notch signalling in cancer progression and bone metastasis. Br. J. Cancer 2011, 105, 1805-1810.
    • (2011) Br. J. Cancer , vol.105 , pp. 1805-1810
    • Sethi, N.1    Kang, Y.2
  • 28
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De, Craene. B.; Berx, G. Regulatory networks defining EMT during cancer initiation and progression. Nat. Rev. Cancer 2013, 13, 97-110.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 97-110
    • De, C.B.1    Berx, G.2
  • 29
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery, J. P.; Acloque, H.; Huang, R. Y.; Nieto, M. A. Epithelialmesenchymal transitions in development and disease. Cell 2009, 139, 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 31
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang, Y.; Massague, J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 2004, 118, 277-279.
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 32
    • 77957571588 scopus 로고    scopus 로고
    • The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer
    • Sarkar, F. H.; Li, Y.; Wang, Z.; Kong, D. The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer. Cancer Metastasis Rev. 2010, 29, 383-394.
    • (2010) Cancer Metastasis Rev. , vol.29 , pp. 383-394
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 34
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabineresistant pancreatic cancer.;ells is linked with activation of the notch signaling pathway
    • Wang, Z.; Li, Y.; Kong, D.; Banerjee, S.; Ahmad, A.; Azmi, A. S.; Ali, S.; Abbruzzese, J. L.; Gallick, G. E.; Sarkar, F. H. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabineresistant pancreatic cancer.;ells is linked with activation of the notch signaling pathway. Cancer Res. 2009, 69, 2400-2407.
    • (2009) Cancer Res. , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 35
    • 84859095585 scopus 로고    scopus 로고
    • Activation of Notch-1 enhances epithelialmesenchymal transition in gefitinib-acquired resistant lung cancer cells
    • Xie, M.; Zhang, L.; He, C. S.; Xu, F.; Liu, J. L.; Hu, Z. H.; Zhao, L. P.; Tian, Y. Activation of Notch-1 enhances epithelialmesenchymal transition in gefitinib-acquired resistant lung cancer cells. J. Cell. Biochem. 2012, 113, 1501-1513.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 1501-1513
    • Xie, M.1    Zhang, L.2    He, C.S.3    Xu, F.4    Liu, J.L.5    Hu, Z.H.6    Zhao, L.P.7    Tian, Y.8
  • 36
    • 79151479321 scopus 로고    scopus 로고
    • Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways
    • Ahmad, A.; Wang, Z.; Kong, D.; Ali, R.; Ali, S.; Banerjee, S.; Sarkar, F. H. Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways. Breast Cancer Res, Treat. 2011, 126, 15-25.
    • (2011) Breast Cancer Res, Treat. , vol.126 , pp. 15-25
    • Ahmad, A.1    Wang, Z.2    Kong, D.3    Ali, R.4    Ali, S.5    Banerjee, S.6    Sarkar, F.H.7
  • 37
    • 48649098427 scopus 로고    scopus 로고
    • Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells
    • Kong, D.; Wang, Z.; Sarkar, S. H.; Li, Y.; Banerjee, S.; Saliganan, A.; Kim, H. R.; Cher, M. L.; Sarkar, F. H. Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells. Stem Cells 2008, 26, 1425-1435.
    • (2008) Stem Cells , vol.26 , pp. 1425-1435
    • Kong, D.1    Wang, Z.2    Sarkar, S.H.3    Li, Y.4    Banerjee, S.5    Saliganan, A.6    Kim, H.R.7    Cher, M.L.8    Sarkar, F.H.9
  • 38
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao, B.; Wang, Z.; Ali, S.; Kong, D.; Li, Y.; Ahmad, A.; Banerjee, S.; Azmi, A. S.; Miele, L.; Sarkar, F. H. Notch-1 induces epithelialmesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett. 2011, 307, 26-36.
    • (2011) Cancer Lett. , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Li, Y.5    Ahmad, A.6    Banerjee, S.7    Azmi, A.S.8    Miele, L.9    Sarkar, F.H.10
  • 39
    • 36349006961 scopus 로고    scopus 로고
    • Development and characterization of gemcitabineresistant pancreatic tumor cells
    • Shah, A. N.; Summy, J. M.; Zhang, J.; Park, S. I.; Parikh, N. U.; Gallick, G. E. Development and characterization of gemcitabineresistant pancreatic tumor cells. Ann. Surg. Oncol. 2007, 14, 3629-3637.
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 3629-3637
    • Shah, A.N.1    Summy, J.M.2    Zhang, J.3    Park, S.I.4    Parikh, N.U.5    Gallick, G.E.6
  • 41
    • 45849139695 scopus 로고    scopus 로고
    • Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes
    • Huang, Y.; Hoque, M. O.; Wu, F.; Trink, B.; Sidransky, D.; Ratovitski, E. A. Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes. Cell Cycle 2008, 7, 1613-1622.
    • (2008) Cell Cycle , vol.7 , pp. 1613-1622
    • Huang, Y.1    Hoque, M.O.2    Wu, F.3    Trink, B.4    Sidransky, D.5    Ratovitski, E.A.6
  • 42
    • 79960385475 scopus 로고    scopus 로고
    • Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer
    • Gungor, C.; Zander, H.; Effenberger, K. E.; Vashist, Y. K.; Kalinina, T.; Izbicki, J. R.; Yekebas, E.; Bockhorn, M. Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer. Cancer Res. 2011, 71, 5009-5019.
    • (2011) Cancer Res. , vol.71 , pp. 5009-5019
    • Gungor, C.1    Zander, H.2    Effenberger, K.E.3    Vashist, Y.K.4    Kalinina, T.5    Izbicki, J.R.6    Yekebas, E.7    Bockhorn, M.8
  • 43
    • 84859270591 scopus 로고    scopus 로고
    • Notch signaling mediates TGF-beta1-induced epithelialmesenchymal transition through the induction of Snai1
    • Matsuno, Y.; Coelho, A. L.; Jarai, G.; Westwick, J.; Hogaboam, C. M. Notch signaling mediates TGF-beta1-induced epithelialmesenchymal transition through the induction of Snai1. Int. J. Biochem. Cell Biol. 2012, 44, 776-789.
    • (2012) Int. J. Biochem. Cell Biol. , vol.44 , pp. 776-789
    • Matsuno, Y.1    Coelho, A.L.2    Jarai, G.3    Westwick, J.4    Hogaboam, C.M.5
  • 44
    • 84867068023 scopus 로고    scopus 로고
    • Inhibition of Notch signaling by a gamma-secretase inhibitor attenuates hepatic fibrosis in rats
    • Chen, Y.; Zheng, S.; Qi, D.; Zheng, S.; Guo, J.; Zhang, S.; Weng, Z. Inhibition of Notch signaling by a gamma-secretase inhibitor attenuates hepatic fibrosis in rats. PLoS One 2012, 7, e46512.
    • (2012) PLoS One , vol.7
    • Chen, Y.1    Zheng, S.2    Qi, D.3    Zheng, S.4    Guo, J.5    Zhang, S.6    Weng, Z.7
  • 45
    • 84879106039 scopus 로고    scopus 로고
    • Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells
    • Gupta, N.; Xu, Z.; El-Sehemy, A.; Steed, H.; Fu, Y. Notch3 induces epithelial-mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells. Gynecol. Oncol. 2013.
    • (2013) Gynecol. Oncol.
    • Gupta, N.1    Xu, Z.2    El-Sehemy, A.3    Steed, H.4    Fu, Y.5
  • 49
    • 84872869354 scopus 로고    scopus 로고
    • Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer
    • Kang, M.; Jiang. B.; Xu, B.; Lu, W.; Guo, Q.; Xie, Q.; Zhang, B.; Dong, X.; Chen, D.; Wu, Y. Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer. Cancer Lett. 2013, 330, 11-21.
    • (2013) Cancer Lett. , vol.330 , pp. 11-21
    • Kang, M.1    Jiang, B.2    Xu, B.3    Lu, W.4    Guo, Q.5    Xie, Q.6    Zhang, B.7    Dong, X.8    Chen, D.9    Wu, Y.10
  • 50
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-tomesenchymal transition
    • Zavadil, J.; Cermak, L.; Soto-Nieves, N.; Bottinger, E. P. Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-tomesenchymal transition. EMBO J. 2004, 23, 1155-1165.
    • (2004) EMBO J. , vol.23 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 51
    • 77957790485 scopus 로고    scopus 로고
    • Jagged/Notch signalling is required for a subset of TGFbeta1 responses in human kidney epithelial cells
    • Nyhan, K. C.; Faherty, N.; Murray, G.; Cooey, L. B.; Godson, C.; Crean, J. K.; Brazil, D. P. Jagged/Notch signalling is required for a subset of TGFbeta1 responses in human kidney epithelial cells. Biochim. Biophys. Acta. 2010, 1803, 1386-1395.
    • (2010) Biochim. Biophys. Acta. , vol.1803 , pp. 1386-1395
    • Nyhan, K.C.1    Faherty, N.2    Murray, G.3    Cooey, L.B.4    Godson, C.5    Crean, J.K.6    Brazil, D.P.7
  • 52
    • 36549010842 scopus 로고    scopus 로고
    • Jagged1-mediated Notch activation induces epithelialto-mesenchymal transition through Slug-induced repression of Ecadherin
    • Leong, K. G.; Niessen, K.; Kulic, I.; Raouf, A.; Eaves, C.; Pollet, I.; Karsan, A. Jagged1-mediated Notch activation induces epithelialto-mesenchymal transition through Slug-induced repression of Ecadherin. J. Exp. Med. 2007, 204, 2935-2948.
    • (2007) J. Exp. Med. , vol.204 , pp. 2935-2948
    • Leong, K.G.1    Niessen, K.2    Kulic, I.3    Raouf, A.4    Eaves, C.5    Pollet, I.6    Karsan, A.7
  • 53
    • 75549083984 scopus 로고    scopus 로고
    • Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
    • Chen, J.; Imanaka, N.; Griffin, J. D. Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br. J. Cancer 2010, 102, 351-360.
    • (2010) Br. J. Cancer , vol.102 , pp. 351-360
    • Chen, J.1    Imanaka, N.2    Griffin, J.D.3
  • 60
    • 84879422834 scopus 로고    scopus 로고
    • Notch inhibitors for cancer treatment
    • Espinoza, I.; Miele, L. Notch inhibitors for cancer treatment. Pharmacol. Ther. 2013, 139(2), 95-110
    • (2013) Pharmacol. Ther. , vol.139 , Issue.2 , pp. 95-110
    • Espinoza, I.1    Miele, L.2
  • 61
    • 84867687369 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by gamma-secretase inhibitor IX
    • Palagani, V.; El, Khatib. M.; Kossatz, U.; Bozko, P.; Müller, M. R.; Manns, M. P.; Krech, T.; Malek, N. P.; Plentz, R. R. Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by gamma-secretase inhibitor IX. PLoS One 2012, 7, e46514.
    • (2012) PLoS One , vol.7
    • Palagani, V.1    El Khatib, M.2    Kossatz, U.3    Bozko, P.4    Müller, M.R.5    Manns, M.P.6    Krech, T.7    Malek, N.P.8    Plentz, R.R.9
  • 62
    • 84859496041 scopus 로고    scopus 로고
    • Notch inhibition as a promising new approach to cancer therapy
    • Purow, B. Notch inhibition as a promising new approach to cancer therapy. Adv. Exp. Med. Biol. 2012, 727, 305-319.
    • (2012) Adv. Exp. Med. Biol. , vol.727 , pp. 305-319
    • Purow, B.1
  • 63
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • Wang, Z.; Zhang, Y.; Banerjee, S.; Li, Y.; Sarkar, F. H. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006, 106, 2503-2513.
    • (2006) Cancer , vol.106 , pp. 2503-2513
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 64
    • 33645064160 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells
    • Wang, Z.; Zhang, Y.; Banerjee, S.; Li, Y.; Sarkar, F. H. Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int. J. Cancer 2006, 118, 1930-1936.
    • (2006) Int. J. Cancer , vol.118 , pp. 1930-1936
    • Wang, Z.1    Zhang, Y.2    Banerjee, S.3    Li, Y.4    Sarkar, F.H.5
  • 65
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li, Y.; VandenBoom, T. G. 2nd.; Kong, D.; Wang, Z.; Ali, S.; Philip, P. A.; Sarkar, F. H. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res. 2009, 69, 6704-6712.
    • (2009) Cancer Res. , vol.69 , pp. 6704-6712
    • Li, Y.1    VandenBoom 2nd, T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6    Sarkar, F.H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.