Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 106-117

  Rubinstein, Moran ^a   Westenbroek, Ruth E ^a   Yu, Frank H ^a   Jones, Christina J ^a   Scheuer, Todd ^a   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Action potential threshold; Dravet Syndrome; Epilepsy; Excitatory post synaptic potential amplification; Interneuron; NaV1.1; Sodium channels

Indexed keywords

SODIUM CHANNEL NAV1.1; LIDOCAINE; QX-314; SCN1A PROTEIN, MOUSE; SODIUM CHANNEL BLOCKING AGENT;

129 MOUSE; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; C57BL 6 MOUSE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE MODEL; DISEASE SEVERITY; FEBRILE CONVULSION; FOREBRAIN; GABAERGIC SYSTEM; GENE AMPLIFICATION; GENE DELETION; GENE MUTATION; GENETIC DISORDER; GENETIC MODEL; GENOTYPE PHENOTYPE CORRELATION; HAPLOINSUFFICIENCY; HIPPOCAMPAL CA1 REGION; INTERNEURON; MALE; MOUSE; MYOCLONUS SEIZURE; NAV1.1 GENE; NERVE CELL EXCITABILITY; NERVE CELL LESION; NERVE POTENTIAL; NEUROMODULATION; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PREMATURE MORTALITY; PROTEIN DEFECT; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; SEIZURE THRESHOLD; SEVERE MYOCLONIC EPILEPSY IN INFANCY; STRAIN DIFFERENCE; STRATUM ORIENS; SYMPTOM; SYNAPTIC POTENTIAL; ACTION POTENTIAL; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BIOPHYSICS; C57BL MOUSE; CONDITIONING; CYTOLOGY; DRUG EFFECTS; EPILEPSIES, MYOCLONIC; EXCITATORY POSTSYNAPTIC POTENTIAL; FEAR; GENETICS; HIPPOCAMPUS; IN VITRO STUDY; MUTATION; NERVE CELL INHIBITION; NEWBORN; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; THERMOTHERAPY; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICAL PROCESSES; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; EPILEPSIES, MYOCLONIC; EXCITATORY POSTSYNAPTIC POTENTIALS; FEAR; HIPPOCAMPUS; HYPERTHERMIA, INDUCED; IN VITRO TECHNIQUES; LIDOCAINE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; NEURAL INHIBITION; SODIUM CHANNEL BLOCKERS;

EID: 84908544395     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.017     Document Type: Article

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