Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome

Brain

Volumn 137, Issue 6, 2014, Pages 1701-1715

  Reid, Christopher A ^a   Leaw, Bryan ^a   Richards, Kay L ^a   Richardson, Robert ^a   Wimmer, Verena ^a   Yu, Christiaan ^a   Hill Yardin, Elisa L ^a   Lerche, Holger ^b,c   Scheffer, Ingrid E ^a   Berkovic, Samuel F ^a   Petrou, Steven ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

action potentials; beta1 subunit; Dravet syndrome; epileptic encephalopathy; sodium channel

Indexed keywords

4 AMINOBUTYRIC ACID; DIAZEPAM; LAMOTRIGINE; RETIGABINE; STIRIPENTOL; VOLTAGE GATED SODIUM CHANNEL BETA 1 SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DENDRITE; DRUG EFFICACY; FEMALE; HIPPOCAMPAL CA1 REGION; HOMOZYGOTE; INTERNEURON; MALE; MOUSE; MUTANT MOUSE STRAIN; NERVE CELL EXCITABILITY; NERVE POTENTIAL; NEUROPROTECTION; NONHUMAN; PATCH CLAMP TECHNIQUE; PHENOTYPE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SUBICULUM; SYNAPSE;

ACTION POTENTIALS; BETA1 SUBUNIT; DRAVET SYNDROME; EPILEPTIC ENCEPHALOPATHY; SODIUM CHANNEL;

ACTION POTENTIALS; ANIMALS; DENDRITES; DISEASE MODELS, ANIMAL; EPILEPSIES, MYOCLONIC; MICE; MICE, INBRED C57BL; MUTATION; NEURONS; VOLTAGE-GATED SODIUM CHANNEL BETA-1 SUBUNIT;

EID: 84901449954     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awu077     Document Type: Article

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