Preferential inactivation of SCN1A in parvalbumin interneurons increases seizure susceptibility

Neurobiology of Disease

Volumn 49, Issue 1, 2013, Pages 211-220

  Dutton, Stacey B ^a   Makinson, Christopher D ^a   Papale, Ligia A ^a   Shankar, Anupama ^a   Balakrishnan, Bindu ^a   Nakazawa, Kazu ^b   Escayg, Andrew ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Epilepsy; Interneurons; Ion channels; Pyramidal neurons; SCN1A

Indexed keywords

PARVALBUMIN; SODIUM CHANNEL NAV1.1; TRANSCRIPTION FACTOR EMX1; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CAMK2A PROTEIN, MOUSE; FLUROTHYL; SCN1A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; HETEROZYGOSITY; HIPPOCAMPUS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERNEURON; MALE; MOUSE; NEOCORTEX; NERVE CELL EXCITABILITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; SEIZURE; SEIZURE THRESHOLD; 129 MOUSE; ANIMAL; C57BL MOUSE; DEFICIENCY; FEBRILE CONVULSION; FEVER; GENETICS; METABOLISM; NERVE CELL INHIBITION; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE SUSCEPTIBILITY; FEVER; FLUROTHYL; HIPPOCAMPUS; INTERNEURONS; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; NAV1.1 VOLTAGE-GATED SODIUM CHANNEL; NEOCORTEX; NEURAL INHIBITION; PARVALBUMINS; PYRAMIDAL CELLS; SEIZURES; SEIZURES, FEBRILE;

EID: 84868666590     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.08.012     Document Type: Article

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