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Volumn 30, Issue 11, 2014, Pages 1350-1360

Regenerative Cell and Tissue-based Therapies for Pulmonary Arterial Hypertension

Author keywords

[No Author keywords available]

Indexed keywords

ALLOTRANSPLANTATION; BIOLOGICAL THERAPY; CLINICAL TRIAL (TOPIC); ENDOTHELIAL PROGENITOR CELL; EX VIVO STUDY; HUMAN; LUNG PARENCHYMA; LUNG TRANSPLANTATION; MESENCHYMAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; PULMONARY HYPERTENSION; REGENERATIVE MEDICINE; REVIEW; TISSUE ENGINEERING; TISSUE SCAFFOLD; CYTOLOGY; FAMILIAL PRIMARY PULMONARY HYPERTENSION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; PATHOLOGY; PROCEDURES;

EID: 84908479834     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2014.08.022     Document Type: Review
Times cited : (23)

References (95)
  • 1
    • 84890738424 scopus 로고    scopus 로고
    • Updated clinical classification of pulmonary hypertension
    • Simonneau G., Gatzoulis M.A., Adatia I., et al. Updated clinical classification of pulmonary hypertension. JAm Coll Cardiol 2013, 62:D34-D41.
    • (2013) JAm Coll Cardiol , vol.62 , pp. D34-D41
    • Simonneau, G.1    Gatzoulis, M.A.2    Adatia, I.3
  • 2
    • 77952234421 scopus 로고    scopus 로고
    • Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies
    • Archer S.L., Weir E.K., Wilkins M.R. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 2010, 121:2045-2066.
    • (2010) Circulation , vol.121 , pp. 2045-2066
    • Archer, S.L.1    Weir, E.K.2    Wilkins, M.R.3
  • 3
    • 5344233478 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension
    • Farber H.W., Loscalzo J. Pulmonary arterial hypertension. New Engl J Med 2004, 351:1655-1665.
    • (2004) New Engl J Med , vol.351 , pp. 1655-1665
    • Farber, H.W.1    Loscalzo, J.2
  • 4
    • 1642453778 scopus 로고    scopus 로고
    • Endothelial dysfunction in pulmonary hypertension
    • Budhiraja R., Tuder R.M., Hassoun P.M. Endothelial dysfunction in pulmonary hypertension. Circulation 2004, 109:159-165.
    • (2004) Circulation , vol.109 , pp. 159-165
    • Budhiraja, R.1    Tuder, R.M.2    Hassoun, P.M.3
  • 5
    • 73949089232 scopus 로고    scopus 로고
    • Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
    • Sakao S., Tatsumi K., Voelkel N.F. Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation. Respir Res 2009, 10:95.
    • (2009) Respir Res , vol.10 , pp. 95
    • Sakao, S.1    Tatsumi, K.2    Voelkel, N.F.3
  • 6
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
    • Tuder R.M., Cool C.D., Geraci M.W., et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999, 159:1925-1932.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Geraci, M.W.3
  • 7
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A., Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. New Engl J Med 1995, 333:214-221.
    • (1995) New Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 8
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman B.W., McPherson C.D., Newman J.H., et al. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. New Engl J Med 1992, 327:70-75.
    • (1992) New Engl J Med , vol.327 , pp. 70-75
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 9
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A., Yanagisawa M., Langleben D., et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. New Engl J Med 1993, 328:1732-1739.
    • (1993) New Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3
  • 10
    • 77649337086 scopus 로고    scopus 로고
    • Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials
    • Jurasz P., Courtman D., Babaie S., Stewart D.J. Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials. Pharmacol Ther 2010, 126:1-8.
    • (2010) Pharmacol Ther , vol.126 , pp. 1-8
    • Jurasz, P.1    Courtman, D.2    Babaie, S.3    Stewart, D.J.4
  • 11
    • 77954243018 scopus 로고    scopus 로고
    • Formation of plexiform lesions in experimental severe pulmonary arterial hypertension
    • Abe K., Toba M., Alzoubi A., et al. Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation 2010, 121:2747-2754.
    • (2010) Circulation , vol.121 , pp. 2747-2754
    • Abe, K.1    Toba, M.2    Alzoubi, A.3
  • 12
    • 66549127501 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association
    • McLaughlin V.V., Archer S.L., Badesch D.B., et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association. Circulation 2009, 119:2250-2294.
    • (2009) Circulation , vol.119 , pp. 2250-2294
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 13
    • 77951961897 scopus 로고    scopus 로고
    • Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation
    • Thenappan T., Shah S.J., Rich S., et al. Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation. Eur Respir J 2010, 35:1079-1087.
    • (2010) Eur Respir J , vol.35 , pp. 1079-1087
    • Thenappan, T.1    Shah, S.J.2    Rich, S.3
  • 14
    • 0035195281 scopus 로고    scopus 로고
    • ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species
    • Wedgwood S., Dettman R.W., Black S.M. ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 2001, 281:L1058-L1067.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L1058-L1067
    • Wedgwood, S.1    Dettman, R.W.2    Black, S.M.3
  • 15
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    • Knoepfler P.S. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009, 27:1050-1056.
    • (2009) Stem Cells , vol.27 , pp. 1050-1056
    • Knoepfler, P.S.1
  • 16
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T., Murohara T., Sullivan A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 17
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997, 386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 18
    • 0032528555 scopus 로고    scopus 로고
    • Evidence for circulating bone marrow-derived endothelial cells
    • Shi Q., Rafii S., Wu M.H., et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 1998, 92:362-367.
    • (1998) Blood , vol.92 , pp. 362-367
    • Shi, Q.1    Rafii, S.2    Wu, M.H.3
  • 19
    • 54449093958 scopus 로고    scopus 로고
    • Isolation and characterization of endothelial progenitor cells from human blood
    • Chapter 2:Unit 2C.1
    • Mead L.E., Prater D., Yoder M.C., Ingram D.A. Isolation and characterization of endothelial progenitor cells from human blood. Curr Protoc Stem Cell Biol 2008, Chapter 2:Unit 2C.1.
    • (2008) Curr Protoc Stem Cell Biol
    • Mead, L.E.1    Prater, D.2    Yoder, M.C.3    Ingram, D.A.4
  • 20
    • 51649099800 scopus 로고    scopus 로고
    • Assessing identity, phenotype, and fate of endothelial progenitor cells
    • Hirschi K.K., Ingram D.A., Yoder M.C. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008, 28:1584-1595.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1584-1595
    • Hirschi, K.K.1    Ingram, D.A.2    Yoder, M.C.3
  • 22
    • 23944518957 scopus 로고    scopus 로고
    • Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells
    • Ingram D.A., Caplice N.M., Yoder M.C. Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. Blood 2005, 106:1525-1531.
    • (2005) Blood , vol.106 , pp. 1525-1531
    • Ingram, D.A.1    Caplice, N.M.2    Yoder, M.C.3
  • 23
    • 84874300952 scopus 로고    scopus 로고
    • Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow
    • Tura O., Skinner E.M., Barclay G.R., et al. Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow. Stem Cells 2013, 31:338-348.
    • (2013) Stem Cells , vol.31 , pp. 338-348
    • Tura, O.1    Skinner, E.M.2    Barclay, G.R.3
  • 24
    • 84858658108 scopus 로고    scopus 로고
    • Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells
    • Mund J.A., Estes M.L., Yoder M.C., Ingram D.A., Case J. Flow cytometric identification and functional characterization of immature and mature circulating endothelial cells. Arterioscler Thromb Vasc Biol 2012, 32:1045-1053.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1045-1053
    • Mund, J.A.1    Estes, M.L.2    Yoder, M.C.3    Ingram, D.A.4    Case, J.5
  • 25
    • 67849095429 scopus 로고    scopus 로고
    • Defining human endothelial progenitor cells
    • Yoder M.C. Defining human endothelial progenitor cells. JThromb Haemost 2009, 7(suppl 1):49-52.
    • (2009) JThromb Haemost , vol.7 , pp. 49-52
    • Yoder, M.C.1
  • 26
    • 1042291152 scopus 로고    scopus 로고
    • Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis
    • Hur J., Yoon C.H., Kim H.S., et al. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler Thromb Vasc Biol 2004, 24:288-293.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 288-293
    • Hur, J.1    Yoon, C.H.2    Kim, H.S.3
  • 27
    • 79960408013 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells and respiratory disease
    • Jones C.P., Rankin S.M. Bone marrow-derived stem cells and respiratory disease. Chest 2011, 140:205-211.
    • (2011) Chest , vol.140 , pp. 205-211
    • Jones, C.P.1    Rankin, S.M.2
  • 28
    • 77952065242 scopus 로고    scopus 로고
    • Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities
    • Medina R.J., O'Neill C.L., Sweeney M., et al. Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med Genomics 2010, 3:18.
    • (2010) BMC Med Genomics , vol.3 , pp. 18
    • Medina, R.J.1    O'Neill, C.L.2    Sweeney, M.3
  • 29
    • 24944526542 scopus 로고    scopus 로고
    • Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases
    • Yoon C.H., Hur J., Park K.W., et al. Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases. Circulation 2005, 112:1618-1627.
    • (2005) Circulation , vol.112 , pp. 1618-1627
    • Yoon, C.H.1    Hur, J.2    Park, K.W.3
  • 30
    • 7244242362 scopus 로고    scopus 로고
    • Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    • Ingram D.A., Mead L.E., Tanaka H., et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004, 104:2752-2760.
    • (2004) Blood , vol.104 , pp. 2752-2760
    • Ingram, D.A.1    Mead, L.E.2    Tanaka, H.3
  • 31
    • 33847348148 scopus 로고    scopus 로고
    • Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    • Yoder M.C., Mead L.E., Prater D., et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007, 109:1801-1809.
    • (2007) Blood , vol.109 , pp. 1801-1809
    • Yoder, M.C.1    Mead, L.E.2    Prater, D.3
  • 32
    • 84893098832 scopus 로고    scopus 로고
    • Targeted delivery of genes to endothelial cells and cell- and gene-based therapy in pulmonary vascular diseases
    • Suen C.M., Mei S.H., Kugathasan L., Stewart D.J. Targeted delivery of genes to endothelial cells and cell- and gene-based therapy in pulmonary vascular diseases. Compr Physiol 2013, 3:1749-1779.
    • (2013) Compr Physiol , vol.3 , pp. 1749-1779
    • Suen, C.M.1    Mei, S.H.2    Kugathasan, L.3    Stewart, D.J.4
  • 33
    • 14844360656 scopus 로고    scopus 로고
    • Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease
    • Zhao Y.D., Courtman D.W., Deng Y., et al. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005, 96:442-450.
    • (2005) Circ Res , vol.96 , pp. 442-450
    • Zhao, Y.D.1    Courtman, D.W.2    Deng, Y.3
  • 34
    • 78049388103 scopus 로고    scopus 로고
    • Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension
    • Ormiston M.L., Deng Y., Stewart D.J., Courtman D.W. Innate immunity in the therapeutic actions of endothelial progenitor cells in pulmonary hypertension. Am J Respir Cell Mol Biol 2010, 43:546-554.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 546-554
    • Ormiston, M.L.1    Deng, Y.2    Stewart, D.J.3    Courtman, D.W.4
  • 35
    • 67349206322 scopus 로고    scopus 로고
    • Role of paracrine factors in stem and progenitor cell-mediated cardiac repair and tissue fibrosis
    • Burchfield J.S., Dimmeler S. Role of paracrine factors in stem and progenitor cell-mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair 2008, 1:4.
    • (2008) Fibrogenesis Tissue Repair , vol.1 , pp. 4
    • Burchfield, J.S.1    Dimmeler, S.2
  • 36
    • 37549026759 scopus 로고    scopus 로고
    • Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
    • Cho H.J., Lee N., Lee J.Y., et al. Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart. JExp Med 2007, 204:3257-3269.
    • (2007) JExp Med , vol.204 , pp. 3257-3269
    • Cho, H.J.1    Lee, N.2    Lee, J.Y.3
  • 37
    • 26844525184 scopus 로고    scopus 로고
    • Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
    • Urbich C., Aicher A., Heeschen C., et al. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. JMol Cell Cardiol 2005, 39:733-742.
    • (2005) JMol Cell Cardiol , vol.39 , pp. 733-742
    • Urbich, C.1    Aicher, A.2    Heeschen, C.3
  • 38
    • 84901427745 scopus 로고    scopus 로고
    • Existence, functional impairment, and lung repair potential of endothelial colony-forming cells in oxygen-induced arrested alveolar growth
    • Alphonse R.S., Vadivel A., Fung M., et al. Existence, functional impairment, and lung repair potential of endothelial colony-forming cells in oxygen-induced arrested alveolar growth. Circulation 2014, 129:2144-2157.
    • (2014) Circulation , vol.129 , pp. 2144-2157
    • Alphonse, R.S.1    Vadivel, A.2    Fung, M.3
  • 39
    • 34047108549 scopus 로고    scopus 로고
    • Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial
    • Wang X.X., Zhang F.R., Shang Y.P., et al. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. JAm Coll Cardiol 2007, 49:1566-1571.
    • (2007) JAm Coll Cardiol , vol.49 , pp. 1566-1571
    • Wang, X.X.1    Zhang, F.R.2    Shang, Y.P.3
  • 40
    • 49349116828 scopus 로고    scopus 로고
    • Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: open-label pilot study
    • Zhu J.H., Wang X.X., Zhang F.R., et al. Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: open-label pilot study. Pediatr Transplant 2008, 12:650-655.
    • (2008) Pediatr Transplant , vol.12 , pp. 650-655
    • Zhu, J.H.1    Wang, X.X.2    Zhang, F.R.3
  • 41
    • 79959959289 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with circulating angiogenic cells
    • Mirsky R., Jahn S., Koskenvuo J.W., et al. Treatment of pulmonary arterial hypertension with circulating angiogenic cells. Am J Physiol Lung Cell Mol Physiol 2011, 301:L12-L19.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.301 , pp. L12-L19
    • Mirsky, R.1    Jahn, S.2    Koskenvuo, J.W.3
  • 42
    • 0035975944 scopus 로고    scopus 로고
    • Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension
    • Campbell A.I., Zhao Y., Sandhu R., Stewart D.J. Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension. Circulation 2001, 104:2242-2248.
    • (2001) Circulation , vol.104 , pp. 2242-2248
    • Campbell, A.I.1    Zhao, Y.2    Sandhu, R.3    Stewart, D.J.4
  • 43
    • 33746838551 scopus 로고    scopus 로고
    • Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer
    • Zhao Y.D., Courtman D.W., Ng D.S., et al. Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer. Am J Respir Cell Mol Biol 2006, 35:182-189.
    • (2006) Am J Respir Cell Mol Biol , vol.35 , pp. 182-189
    • Zhao, Y.D.1    Courtman, D.W.2    Ng, D.S.3
  • 44
    • 0038554221 scopus 로고    scopus 로고
    • Protective role of angiopoietin-1 in experimental pulmonary hypertension
    • Zhao Y.D., Campbell A.I., Robb M., Ng D., Stewart D.J. Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res 2003, 92:984-991.
    • (2003) Circ Res , vol.92 , pp. 984-991
    • Zhao, Y.D.1    Campbell, A.I.2    Robb, M.3    Ng, D.4    Stewart, D.J.5
  • 45
    • 0042433541 scopus 로고    scopus 로고
    • Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    • Nagaya N., Kangawa K., Kanda M., et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation 2003, 108:889-895.
    • (2003) Circulation , vol.108 , pp. 889-895
    • Nagaya, N.1    Kangawa, K.2    Kanda, M.3
  • 46
    • 34447570619 scopus 로고    scopus 로고
    • Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension
    • Zhao Q., Liu Z., Wang Z., et al. Effect of prepro-calcitonin gene-related peptide-expressing endothelial progenitor cells on pulmonary hypertension. Ann Thorac Surg 2007, 84:544-552.
    • (2007) Ann Thorac Surg , vol.84 , pp. 544-552
    • Zhao, Q.1    Liu, Z.2    Wang, Z.3
  • 47
    • 0033219861 scopus 로고    scopus 로고
    • Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits monocrotaline-induced pulmonary hypertension
    • Campbell A.I., Kuliszewski M.A., Stewart D.J. Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits monocrotaline-induced pulmonary hypertension. Am J Respir Cell Mol Biol 1999, 21:567-575.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 567-575
    • Campbell, A.I.1    Kuliszewski, M.A.2    Stewart, D.J.3
  • 48
    • 84877268495 scopus 로고    scopus 로고
    • Therapeutic effect of eNOS-transfected endothelial progenitor cells on hemodynamic pulmonary arterial hypertension
    • Wei L., Zhu W., Xia L., et al. Therapeutic effect of eNOS-transfected endothelial progenitor cells on hemodynamic pulmonary arterial hypertension. Hypertens Res 2013, 36:414-421.
    • (2013) Hypertens Res , vol.36 , pp. 414-421
    • Wei, L.1    Zhu, W.2    Xia, L.3
  • 49
    • 84868091993 scopus 로고    scopus 로고
    • Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials
    • Lalu M.M., McIntyre L., Pugliese C., et al. Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One 2012, 7:e47559.
    • (2012) PLoS One , vol.7 , pp. e47559
    • Lalu, M.M.1    McIntyre, L.2    Pugliese, C.3
  • 50
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M., Le Blanc K., Mueller I., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006, 8:315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 51
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 52
    • 55049092713 scopus 로고    scopus 로고
    • In search of the invivo identity of mesenchymal stem cells
    • da Silva Meirelles L., Caplan A.I., Nardi N.B. In search of the invivo identity of mesenchymal stem cells. Stem Cells 2008, 26:2287-2299.
    • (2008) Stem Cells , vol.26 , pp. 2287-2299
    • da Silva Meirelles, L.1    Caplan, A.I.2    Nardi, N.B.3
  • 53
    • 34147131808 scopus 로고    scopus 로고
    • Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts
    • Lama V.N., Smith L., Badri L., et al. Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. JClin Invest 2007, 117:989-996.
    • (2007) JClin Invest , vol.117 , pp. 989-996
    • Lama, V.N.1    Smith, L.2    Badri, L.3
  • 54
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L., Chagastelles P.C., Nardi N.B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. JCell Sci 2006, 119:2204-2213.
    • (2006) JCell Sci , vol.119 , pp. 2204-2213
    • da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 55
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath S.H., Levy O., Inamdar M.S., Karp J.M. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012, 10:244-258.
    • (2012) Cell Stem Cell , vol.10 , pp. 244-258
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3    Karp, J.M.4
  • 56
    • 33846980821 scopus 로고    scopus 로고
    • Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction
    • Baber S.R., Deng W., Master R.G., et al. Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol 2007, 292:H1120-H1128.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. H1120-H1128
    • Baber, S.R.1    Deng, W.2    Master, R.G.3
  • 57
    • 58149379244 scopus 로고    scopus 로고
    • Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells
    • Leiker M., Suzuki G., Iyer V.S., Canty J.M., Lee T. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells. Cell Transplant 2008, 17:911-922.
    • (2008) Cell Transplant , vol.17 , pp. 911-922
    • Leiker, M.1    Suzuki, G.2    Iyer, V.S.3    Canty, J.M.4    Lee, T.5
  • 58
    • 84881092225 scopus 로고    scopus 로고
    • Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal
    • Krampera M., Galipeau J., Shi Y., et al. Immunological characterization of multipotent mesenchymal stromal cells-The International Society for Cellular Therapy (ISCT) working proposal. Cytotherapy 2013, 15:1054-1061.
    • (2013) Cytotherapy , vol.15 , pp. 1054-1061
    • Krampera, M.1    Galipeau, J.2    Shi, Y.3
  • 59
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren G., Zhang L., Zhao X., et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008, 2:141-150.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3
  • 61
    • 33747186449 scopus 로고    scopus 로고
    • Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension
    • Kanki-Horimoto S., Horimoto H., Mieno S., et al. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 2006, 114:I181-I185.
    • (2006) Circulation , vol.114 , pp. I181-I185
    • Kanki-Horimoto, S.1    Horimoto, H.2    Mieno, S.3
  • 62
    • 70350439907 scopus 로고    scopus 로고
    • Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension
    • Umar S., de Visser Y.P., Steendijk P., et al. Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension. Am J Physiol Heart Circ Physiol 2009, 297:H1606-H1616.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H1606-H1616
    • Umar, S.1    de Visser, Y.P.2    Steendijk, P.3
  • 63
    • 84860833322 scopus 로고    scopus 로고
    • Implantation of mesenchymal stem cells improves right ventricular impairments caused by experimental pulmonary hypertension
    • Luan Y., Zhang Z.H., Wei D.E., et al. Implantation of mesenchymal stem cells improves right ventricular impairments caused by experimental pulmonary hypertension. Am J Med Sci 2012, 343:402-406.
    • (2012) Am J Med Sci , vol.343 , pp. 402-406
    • Luan, Y.1    Zhang, Z.H.2    Wei, D.E.3
  • 64
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee C., Mitsialis S.A., Aslam M., et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 2012, 126:2601-2611.
    • (2012) Circulation , vol.126 , pp. 2601-2611
    • Lee, C.1    Mitsialis, S.A.2    Aslam, M.3
  • 65
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H., Ekstrom K., Bossios A., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3
  • 66
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov A.V., Magdaleno S., Setterquist R., Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta 2012, 1820:940-948.
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4
  • 67
    • 77952771680 scopus 로고    scopus 로고
    • Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats
    • Takemiya K., Kai H., Yasukawa H., et al. Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats. Basic Res Cardiol 2010, 105:409-417.
    • (2010) Basic Res Cardiol , vol.105 , pp. 409-417
    • Takemiya, K.1    Kai, H.2    Yasukawa, H.3
  • 68
    • 79951819303 scopus 로고    scopus 로고
    • Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension
    • Liang O.D., Mitsialis S.A., Chang M.S., et al. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells 2011, 29:99-107.
    • (2011) Stem Cells , vol.29 , pp. 99-107
    • Liang, O.D.1    Mitsialis, S.A.2    Chang, M.S.3
  • 69
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 2001, 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 70
    • 84866689845 scopus 로고    scopus 로고
    • Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis
    • Waterman R.S., Henkle S.L., Betancourt A.M. Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis. PLoS One 2012, 7:e45590.
    • (2012) PLoS One , vol.7 , pp. e45590
    • Waterman, R.S.1    Henkle, S.L.2    Betancourt, A.M.3
  • 71
    • 84894521405 scopus 로고    scopus 로고
    • The toll-like receptor 3 ligand, poly(I: C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143
    • Zhao X., Liu D., Gong W., et al. The toll-like receptor 3 ligand, poly(I: C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143. Stem Cells 2014, 32:521-533.
    • (2014) Stem Cells , vol.32 , pp. 521-533
    • Zhao, X.1    Liu, D.2    Gong, W.3
  • 72
    • 55049084643 scopus 로고    scopus 로고
    • Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells
    • Rosova I., Dao M., Capoccia B., Link D., Nolta J.A. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 2008, 26:2173-2182.
    • (2008) Stem Cells , vol.26 , pp. 2173-2182
    • Rosova, I.1    Dao, M.2    Capoccia, B.3    Link, D.4    Nolta, J.A.5
  • 73
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 74
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita K., Ichisaka T., Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007, 448:313-317.
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 75
    • 80053412471 scopus 로고    scopus 로고
    • Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells
    • Li Z., Hu S., Ghosh Z., Han Z., Wu J.C. Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells. Stem Cells Dev 2011, 20:1701-1710.
    • (2011) Stem Cells Dev , vol.20 , pp. 1701-1710
    • Li, Z.1    Hu, S.2    Ghosh, Z.3    Han, Z.4    Wu, J.C.5
  • 76
    • 84874592081 scopus 로고    scopus 로고
    • Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells
    • Lai W.H., Ho J.C., Chan Y.C., et al. Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells. PLoS One 2013, 8:e57876.
    • (2013) PLoS One , vol.8 , pp. e57876
    • Lai, W.H.1    Ho, J.C.2    Chan, Y.C.3
  • 77
    • 84865286051 scopus 로고    scopus 로고
    • Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels
    • Margariti A., Winkler B., Karamariti E., et al. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. Proc Natl Acad Sci U S A 2012, 109:13793-13798.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 13793-13798
    • Margariti, A.1    Winkler, B.2    Karamariti, E.3
  • 78
    • 85002614032 scopus 로고    scopus 로고
    • Combining induced pluripotent stem cell with next generation sequencing technology to gain new insights into pathobiology and treatment of pulmonary arterial hypertension
    • Rabinovitch M. Combining induced pluripotent stem cell with next generation sequencing technology to gain new insights into pathobiology and treatment of pulmonary arterial hypertension. Pulm Circ 2013, 3:153-155.
    • (2013) Pulm Circ , vol.3 , pp. 153-155
    • Rabinovitch, M.1
  • 79
    • 84881366718 scopus 로고    scopus 로고
    • Functional vascular endothelium derived from human induced pluripotent stem cells
    • Adams W.J., Zhang Y., Cloutier J., et al. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports 2013, 1:105-113.
    • (2013) Stem Cell Reports , vol.1 , pp. 105-113
    • Adams, W.J.1    Zhang, Y.2    Cloutier, J.3
  • 80
    • 84901592333 scopus 로고    scopus 로고
    • Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension
    • Lavoie J.R., Ormiston M.L., Perez-Iratxeta C., et al. Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension. Circulation 2014, 129:2125-2135.
    • (2014) Circulation , vol.129 , pp. 2125-2135
    • Lavoie, J.R.1    Ormiston, M.L.2    Perez-Iratxeta, C.3
  • 81
    • 79951672622 scopus 로고    scopus 로고
    • Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication
    • Sirois I., Raymond M.A., Brassard N., et al. Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication. Cell Death Differ 2011, 18:549-562.
    • (2011) Cell Death Differ , vol.18 , pp. 549-562
    • Sirois, I.1    Raymond, M.A.2    Brassard, N.3
  • 82
    • 33645658329 scopus 로고    scopus 로고
    • Accessed August 1
    • U.S. Department of Health and Human Services. Organ Procurement and Transplantation Network. Available at: . Accessed August 1,2014. http://optn.transplant.hrsa.gov.
    • (2014) Organ Procurement and Transplantation Network
  • 83
    • 58549115473 scopus 로고    scopus 로고
    • Medical complications of lung transplantation
    • Lyu D.M., Zamora M.R. Medical complications of lung transplantation. Proc Am Thorac Soc 2009, 6:101-107.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 101-107
    • Lyu, D.M.1    Zamora, M.R.2
  • 84
    • 84880815189 scopus 로고    scopus 로고
    • Can stem cells be used to generate new lungs? Exvivo lung bioengineering with decellularized whole lung scaffolds
    • Wagner D.E., Bonvillain R.W., Jensen T., et al. Can stem cells be used to generate new lungs? Exvivo lung bioengineering with decellularized whole lung scaffolds. Respirology 2013, 18:895-911.
    • (2013) Respirology , vol.18 , pp. 895-911
    • Wagner, D.E.1    Bonvillain, R.W.2    Jensen, T.3
  • 85
    • 77955422758 scopus 로고    scopus 로고
    • Regeneration and orthotopic transplantation of a bioartificial lung
    • Ott H.C., Clippinger B., Conrad C., et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med 2010, 16:927-933.
    • (2010) Nat Med , vol.16 , pp. 927-933
    • Ott, H.C.1    Clippinger, B.2    Conrad, C.3
  • 86
    • 57349176894 scopus 로고    scopus 로고
    • Clinical transplantation of a tissue-engineered airway
    • Macchiarini P., Jungebluth P., Go T., et al. Clinical transplantation of a tissue-engineered airway. Lancet 2008, 372:2023-2030.
    • (2008) Lancet , vol.372 , pp. 2023-2030
    • Macchiarini, P.1    Jungebluth, P.2    Go, T.3
  • 87
    • 84892598869 scopus 로고    scopus 로고
    • The first tissue-engineered airway transplantation: 5-year follow-up results
    • Gonfiotti A., Jaus M.O., Barale D., et al. The first tissue-engineered airway transplantation: 5-year follow-up results. Lancet 2014, 383:238-244.
    • (2014) Lancet , vol.383 , pp. 238-244
    • Gonfiotti, A.1    Jaus, M.O.2    Barale, D.3
  • 88
    • 79960351640 scopus 로고    scopus 로고
    • Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds
    • Badylak S.F., Taylor D., Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng 2011, 13:27-53.
    • (2011) Annu Rev Biomed Eng , vol.13 , pp. 27-53
    • Badylak, S.F.1    Taylor, D.2    Uygun, K.3
  • 89
    • 0030041083 scopus 로고    scopus 로고
    • Extracellular matrix biology in the lung
    • Dunsmore S.E., Rannels D.E. Extracellular matrix biology in the lung. Am J Physiol 1996, 270:L3-27.
    • (1996) Am J Physiol , vol.270 , pp. L3-27
    • Dunsmore, S.E.1    Rannels, D.E.2
  • 90
    • 84855374148 scopus 로고    scopus 로고
    • Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells
    • Daly A.B., Wallis J.M., Borg Z.D., et al. Initial binding and recellularization of decellularized mouse lung scaffolds with bone marrow-derived mesenchymal stromal cells. Tissue Eng Part A 2012, 18:1-16.
    • (2012) Tissue Eng Part A , vol.18 , pp. 1-16
    • Daly, A.B.1    Wallis, J.M.2    Borg, Z.D.3
  • 91
    • 84886750797 scopus 로고    scopus 로고
    • Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix
    • Ghaedi M., Calle E.A., Mendez J.J., et al. Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix. JClin Invest 2013, 123:4950-4962.
    • (2013) JClin Invest , vol.123 , pp. 4950-4962
    • Ghaedi, M.1    Calle, E.A.2    Mendez, J.J.3
  • 92
    • 77955115175 scopus 로고    scopus 로고
    • Tissue-engineered lungs for invivo implantation
    • Petersen T.H., Calle E.A., Zhao L., et al. Tissue-engineered lungs for invivo implantation. Science 2010, 329:538-541.
    • (2010) Science , vol.329 , pp. 538-541
    • Petersen, T.H.1    Calle, E.A.2    Zhao, L.3
  • 93
    • 84899870907 scopus 로고    scopus 로고
    • Hypertensive rat lungs retain hallmarks of vascular disease upon decellularization but support the growth of mesenchymal stem cells
    • Scarritt M.E., Bonvillain R.W., Burkett B.J., et al. Hypertensive rat lungs retain hallmarks of vascular disease upon decellularization but support the growth of mesenchymal stem cells. Tissue Eng Part A 2014, 20:1426-1443.
    • (2014) Tissue Eng Part A , vol.20 , pp. 1426-1443
    • Scarritt, M.E.1    Bonvillain, R.W.2    Burkett, B.J.3
  • 94
    • 80052786772 scopus 로고    scopus 로고
    • Enhanced invivo function of bioartificial lungs in rats
    • [discussion: 6]
    • Song J.J., Kim S.S., Liu Z., et al. Enhanced invivo function of bioartificial lungs in rats. Ann Thorac Surg 2011, 92:998-1005. [discussion: 6].
    • (2011) Ann Thorac Surg , vol.92 , pp. 998-1005
    • Song, J.J.1    Kim, S.S.2    Liu, Z.3
  • 95
    • 84894376025 scopus 로고    scopus 로고
    • Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale
    • Gilpin S.E., Guyette J.P., Gonzalez G., et al. Perfusion decellularization of human and porcine lungs: bringing the matrix to clinical scale. JHeart Lung Transplant 2014, 33:298-308.
    • (2014) JHeart Lung Transplant , vol.33 , pp. 298-308
    • Gilpin, S.E.1    Guyette, J.P.2    Gonzalez, G.3


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