Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats

Basic Research in Cardiology

Volumn 105, Issue 3, 2010, Pages 409-417

  Takemiya, Kiyoko ^a   Kai, Hisashi ^a   Yasukawa, Hideo ^a   Tahara, Nobuhiro ^a   Kato, Seiya ^a,b   Imaizumi, Tsutomu ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF THE RYUKYUS   (Japan)

Author keywords

Gene therapy; Mesenchymal stem cell; Pulmonary hypertension

Indexed keywords

GREEN FLUORESCENT PROTEIN; INDIUM 111; MONOCROTALINE; PROSTACYCLIN; PROSTACYCLIN SYNTHASE; 6 OXOPROSTAGLANDIN F1 ALPHA; CYTOCHROME P450; ISOMERASE;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKENING; ARTICLE; BONE MARROW CULTURE; CONTROLLED STUDY; DRUG EFFICACY; EXPRESSION VECTOR; GENE TARGETING; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HEART RIGHT VENTRICLE HYPERTROPHY; ISOTOPE LABELING; LEWIS RAT; MALE; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; NONHUMAN; PROGNOSIS; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; STEM CELL GENE THERAPY; SURVIVAL RATE; ANIMAL; CYTOLOGY; DISEASE MODEL; GENE THERAPY; GENETICS; LUNG; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; TREATMENT OUTCOME;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; EPOPROSTENOL; GENE THERAPY; HYPERTENSION, PULMONARY; INTRAMOLECULAR OXIDOREDUCTASES; LUNG; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; RATS; RATS, INBRED LEW; TRANSDUCTION, GENETIC; TREATMENT OUTCOME;

EID: 77952771680     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-009-0065-8     Document Type: Article

References (33)

1. Abedin M, Tintut Y, Demer LL (2004) Mesenchymal stem cells and the artery wall. Circ Res 95:671-676 (Pubitemid 39331926)
2. Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellara A, Morecki S, Andolfi G, Tabucchi A, Carlucci F, Marinello E, Cattaneo F, Vai S, Servida P, Miniero R, Roncaralo MG, Bordignon C (2002) Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 296:2410-2413 (Pubitemid 34734219)
3. Baksh D, Song L, Tuan RS (2004) Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8:301-316 (Pubitemid 44145494)
4. Campbell AI, Kuliszewski MA, Stewart DJ (1999) Cell-based gene transfer to the pulmonary vasculature: endothelial nitric oxide synthase overexpression inhibits monocrotaline-induced pulmonary hypertension. Am J Respir Cell Mol Biol 21:567-575
5. Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A (2000) Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288:669-672 (Pubitemid 30241569)
6. Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Graves BM, Loyd JE (1992) An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 327:70-75
7. Correia-Pinto J, Henriques-Coelho T, Roncon-Albuquerque R Jr, Lourenço AP, Melo-Rocha G, Vasques-Nóvoa F, Gillebert TC, Leite-Moreira AF (2009) Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotalineinduced pulmonary hypertension. Basic Res Cardiol 104:535-575
8. Gao J, Dennis JE, Muzic RF, Lundberg M, Caplan AI (2001) The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 169:12-20 (Pubitemid 32437040)
9. Halkos ME, Zhao Z-Q, Kerendi F, Wang N-P, Jiang R, Schmarkey LS, Martin BJ, Quyyumi AA, Few WL, Kin H, Guyton RA, Vnten-Johansen J (2008) Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction. Basic Res Cardiol 103:525-536
10. Hirschi KK, Goodell MA (2002) Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells. Gene Ther 9:648-652 (Pubitemid 34567494)
11. Humbert M, Sitbon O, Simonneau G (2004) Treatment of pulmonary arterial hypertension. N Engl J Med 351:1425-1436
12. Inoue S, Popp FC, Koehl GE, Piso P, Schlitt HJ, Geissler EK, Dahlke MH (2006) Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 81:1589-1595 (Pubitemid 43890897)
13. Kanki-Horimoto S, Horimoto H, Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T (2006) Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 114:1181-1185
14. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A (2001) Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 128:5181-5188
15. Lambert RR, Vaessen RJ, Waterhof N, Stienen GJM (2007) Right ventricular hypertrophy causes impairment of leftventricular diastolic function in the rat. Basic Res Cardiol 102:19-27
16. Lappin PB, Ross KL, King LE, Fraker PJ, Roth RA (1998) The response of pulmonary vascular endothelial cells to monocrataline pyrrole: cell proliferation and DNA synthesis in vitro and in vivo. Toxicol Appl Pharmacol 150:37-48
17. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW (2000) Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 6:1282-1286
18. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ (2003) Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 9:1195-1201 (Pubitemid 37173705)
19. Mullane KM, Dusting GJ, Salmon JA, Moneada S, Vane JR (1979) Biotransformation and cardiovascular effects of arachidonic acid in the dog. Eur J Pharmacol 54:217-228 (Pubitemid 9201064)
20. Nagaya N, Kangawa K, Kanda M, Uematsu M, Horio T, Fukuyama N, Hino J, Harada-Shiba M, Okumura H, Tabata Y, Mochizuki N, Chiba Y, Nishioka K, Miyatake K, Asahara T, Hara H, Mori H (2003) Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation 108:889-895 (Pubitemid 37022134)
21. Nagaya N, Yokoyama C, Kyotani S, Shimonishi M, Morishita R, Uematsu M, Nishikimi T, Nakanishi N, Ogihara T, Yamagishi M, Miyatake K, Kaneda Y, Tanabe T (2000) Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Circulation 102:2005-2010
22. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147 (Pubitemid 29282067)
23. Pittenger MF, Martin BJ (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 95:9-20 (Pubitemid 38931831)
24. Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL (2005) Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 33:145-152 (Pubitemid 41473051)
25. Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM (2002) Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109:1291-1302 (Pubitemid 34546893)
26. Suhara H, Sawa Y, Fukushima N, Kagisaki K, Yokoyama C, Tanabe T, Ohtake S, Matsuda H (2002) Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. J Thorac Cardiovasc Surg 123:855-861
27. Tahara N, Kai H, Niiyama H, Mori T, Sugi Y, Takayama N, Yasukawa H, Numaguchi Y, Matsui H, Okumura K, Imaizumi T (2004) Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Hum Gene Ther 15:1270-1278 (Pubitemid 40052438)
28. Tone Y, Inoue H, Hara S, Yokoyama C, Hatae T, Oida H, Narumiya S, Shigemoto R, Yukawa S, Tanabe T (1997) The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase. Eur J Cell Biol 72:268-277 (Pubitemid 27117133)
29. Tuder RM, Cool CD, Geraci MW, Wang J, Abman SH, Wright L, Badesch D, Voelkel NF (1999) Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 159:1925-1932 (Pubitemid 29275065)
30. Vane JR, Anggard EE, Botting RM (1990) Regulatory functions of the vascular endothelium. N Engl J Med 323:27-36
31. Vonk MC, van Dijk AP, Heijdra YF, van der Heijden HF, Bredie SJ, van den Hoogen FH (2005) Pulmonary hypertension: its diagnosis and management, a multidisciplinary approach. Neth J Med 63:193-198
32. Wang XX, Zhang FR, Shang YP, Zhu JH, Xie XD, Tao QM, Zhu JH, Chen JZ (2007) Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J Am Coll Cardiol 49:1566-1571
33. Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, Stewart DJ (2005) Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 96:442-450 (Pubitemid 40354538)