메뉴 건너뛰기




Volumn 12, Issue 6, 2008, Pages 650-655

Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-label pilot study

Author keywords

Cell transplantation; Endothelial progenitor cells; Idiopathic pulmonary arterial hypertension; Pediatrics; Stem cells; Transplantation

Indexed keywords

ADOLESCENT; ARTICLE; AUTOLOGOUS ENDOTHELIAL PROGENITOR CELL TRANSPLANTATION; CLINICAL ARTICLE; EXERCISE; EXERCISE TEST; FEASIBILITY STUDY; FEMALE; HEART CATHETERIZATION; HUMAN; IDIOPATHIC DISEASE; LUNG HEMODYNAMICS; MALE; PATIENT SAFETY; PILOT STUDY; PULMONARY HYPERTENSION; SCHOOL CHILD; SIX MINUTE WALK DISTANCE TEST; STEM CELL TRANSPLANTATION; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 49349116828     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2007.00863.x     Document Type: Article
Times cited : (115)

References (38)
  • 1
    • 0025837793 scopus 로고
    • Survival in patients with primary pulmonary hypertension. Results from a national prospective registry
    • D'Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 1991: 115: 343 349.
    • (1991) Ann Intern Med , vol.115 , pp. 343-349
    • D'Alonzo, G.E.1    Barst, R.J.2    Ayres, S.M.3
  • 2
    • 20344370254 scopus 로고    scopus 로고
    • Idiopathic pulmonary arterial hypertension in children
    • Rosenzweig EB, Barst RJ. Idiopathic pulmonary arterial hypertension in children. Curr Opin Pediatr 2005: 17: 372 380.
    • (2005) Curr Opin Pediatr , vol.17 , pp. 372-380
    • Rosenzweig, E.B.1    Barst, R.J.2
  • 3
    • 0026632785 scopus 로고
    • The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension
    • Rich S, Kaufmann E, Levy PS. The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med 1992: 327: 76 81.
    • (1992) N Engl J Med , vol.327 , pp. 76-81
    • Rich, S.1    Kaufmann, E.2    Levy, P.S.3
  • 4
    • 0021367046 scopus 로고
    • Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin)
    • Higenbottam T, Wheeldon PW, Wallwork J. Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet 1984: 1: 1046 1047.
    • (1984) Lancet , vol.1 , pp. 1046-1047
    • Higenbottam, T.1    Wheeldon, P.W.2    Wallwork, J.3
  • 5
    • 0028597038 scopus 로고
    • Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin
    • Barst RJ, Rubin LJ, McGoon MD, et al. Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin. Ann Intern Med 1994: 121: 409 415.
    • (1994) Ann Intern Med , vol.121 , pp. 409-415
    • Barst, R.J.1    Rubin, L.J.2    McGoon, M.D.3
  • 7
    • 0042433541 scopus 로고    scopus 로고
    • Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    • Nagaya N, Kangawa K, Kanda M, et al. Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation 2003: 108: 889 895.
    • (2003) Circulation , vol.108 , pp. 889-895
    • Nagaya, N.1    Kangawa, K.2    Kanda, M.3
  • 8
    • 14844360656 scopus 로고    scopus 로고
    • Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease
    • Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang O, Stewart DJ. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005: 96: 442 450.
    • (2005) Circ Res , vol.96 , pp. 442-450
    • Zhao, Y.D.1    Courtman, D.W.2    Deng, Y.3    Kugathasan, L.4    Zhang, O.5    Stewart, D.J.6
  • 9
    • 3042732877 scopus 로고    scopus 로고
    • Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs
    • Takahashi M, Nakamura T, Toba T, Kaiwara N, Kato H, Shimizu Y. Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs. Tissue Eng 2004: 10: 771 779.
    • (2004) Tissue Eng , vol.10 , pp. 771-779
    • Takahashi, M.1    Nakamura, T.2    Toba, T.3    Kaiwara, N.4    Kato, H.5    Shimizu, Y.6
  • 10
    • 0037055666 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomised controlled trial
    • Tateishi-Yuyama E, Matsubara H, Murohara T, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomised controlled trial. Lancet 2002: 360: 427 435.
    • (2002) Lancet , vol.360 , pp. 427-435
    • Tateishi-Yuyama, E.1    Matsubara, H.2    Murohara, T.3
  • 11
    • 0037044406 scopus 로고    scopus 로고
    • Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    • Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002: 106: 1913 1918.
    • (2002) Circulation , vol.106 , pp. 1913-1918
    • Strauer, B.E.1    Brehm, M.2    Zeus, T.3
  • 12
    • 0037058848 scopus 로고    scopus 로고
    • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI)
    • Assmus B, Schachinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 2002: 106: 3009 3017.
    • (2002) Circulation , vol.106 , pp. 3009-3017
    • Assmus, B.1    Schachinger, V.2    Teupe, C.3
  • 13
    • 5644236574 scopus 로고    scopus 로고
    • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOPCARE-AMI Trial
    • Schachinger V, Assmus B, Britten MB, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 2004: 44: 1690 1699.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1690-1699
    • Schachinger, V.1    Assmus, B.2    Britten, M.B.3
  • 14
    • 34047108549 scopus 로고    scopus 로고
    • Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: A pilot randomized controlled trial
    • Wang XX, Zhang FR, Shang YP, et al. Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: A pilot randomized controlled trial. J Am Coll Cardiol 2007: 49: 1566 1571.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1566-1571
    • Wang, X.X.1    Zhang, F.R.2    Shang, Y.P.3
  • 15
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension: A national prospective study
    • Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension: A national prospective study. Ann Intern Med 1987: 107: 216 223.
    • (1987) Ann Intern Med , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 16
    • 0036644465 scopus 로고    scopus 로고
    • ATS statement: Guidelines for the six-minute walk test
    • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories.
    • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002: 166: 111 117.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 111-117
  • 17
    • 0034724335 scopus 로고    scopus 로고
    • Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
    • Kalka C, Masuda H, Takahashi T, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A 2000: 97: 3422 3427.
    • (2000) Proc Natl Acad Sci U S a , vol.97 , pp. 3422-3427
    • Kalka, C.1    Masuda, H.2    Takahashi, T.3
  • 18
    • 10744230139 scopus 로고    scopus 로고
    • Effects of homocysteine on number and activity of endothelial progenitor cells from peripheral blood
    • Chen JZ, Zhu JH, Wang XX, et al. Effects of homocysteine on number and activity of endothelial progenitor cells from peripheral blood. J Mol Cell Cardiol 2004: 36: 233 239.
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 233-239
    • Chen, J.Z.1    Zhu, J.H.2    Wang, X.X.3
  • 19
    • 0022646182 scopus 로고
    • Effect of long term oxygen treatment at home in children with pulmonary vascular disease
    • Bowyer JJ, Busst CM, Denison DM, Shinebourne EA. Effect of long term oxygen treatment at home in children with pulmonary vascular disease. Br Heart J 1986: 55: 385 390.
    • (1986) Br Heart J , vol.55 , pp. 385-390
    • Bowyer, J.J.1    Busst, C.M.2    Denison, D.M.3    Shinebourne, E.A.4
  • 20
    • 17044415276 scopus 로고    scopus 로고
    • Safety and efficacy of Sildenafil therapy in children with pulmonary hypertension
    • Karatza AA, Bush A, Magee AG. Safety and efficacy of Sildenafil therapy in children with pulmonary hypertension. Int J Cardiol 2005: 100: 267 273.
    • (2005) Int J Cardiol , vol.100 , pp. 267-273
    • Karatza, A.A.1    Bush, A.2    Magee, A.G.3
  • 22
    • 0030802871 scopus 로고    scopus 로고
    • Hemodynamic data and survival in children with pulmonary hypertension
    • Clabby ML, Canter CE, Moller JH, Bridges ND. Hemodynamic data and survival in children with pulmonary hypertension. J Am Coll Cardiol 1997: 30: 554 560.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 554-560
    • Clabby, M.L.1    Canter, C.E.2    Moller, J.H.3    Bridges, N.D.4
  • 23
    • 0031455622 scopus 로고    scopus 로고
    • The Registry of the International Society of Heart and Lung Transplantation: First official pediatric report - 1997
    • Boucek MM, Novick RJ, Bennett LE, Fiol B, Keck BM, Hosenpud JD. The Registry of the International Society of Heart and Lung Transplantation: First official pediatric report - 1997. J Heart Lung Transplant 1997: 16: 1189 1206.
    • (1997) J Heart Lung Transplant , vol.16 , pp. 1189-1206
    • Boucek, M.M.1    Novick, R.J.2    Bennett, L.E.3    Fiol, B.4    Keck, B.M.5    Hosenpud, J.D.6
  • 24
    • 0037623284 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet 2003: 361: 1533 1544.
    • (2003) Lancet , vol.361 , pp. 1533-1544
    • Runo, J.R.1    Loyd, J.E.2
  • 26
    • 0037434561 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
    • Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003: 348: 593 600.
    • (2003) N Engl J Med , vol.348 , pp. 593-600
    • Hill, J.M.1    Zalos, G.2    Halcox, J.P.3
  • 27
    • 0037173080 scopus 로고    scopus 로고
    • Statin therapy accelerate reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells
    • Walter DH, Rittig K, Bahlmann FH, et al. Statin therapy accelerate reendothelialization: A novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 2002: 105: 3017 3024.
    • (2002) Circulation , vol.105 , pp. 3017-3024
    • Walter, D.H.1    Rittig, K.2    Bahlmann, F.H.3
  • 28
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative endothelial progenitor cells for angiogenesis
    • Asahara T, Murohara T, Sullivan A, et al. Isolation of putative endothelial progenitor cells for angiogenesis. Science 1997: 275: 964 967.
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 29
    • 12944253116 scopus 로고    scopus 로고
    • Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors
    • Peichev M, Naiyer AJ, Pereira D, et al. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 2000: 95: 952 958.
    • (2000) Blood , vol.95 , pp. 952-958
    • Peichev, M.1    Naiyer, A.J.2    Pereira, D.3
  • 30
    • 0035793330 scopus 로고    scopus 로고
    • Vascular trauma induces rapid but transient mobilization of VEGFR2+AC133+ endothelial precursor cells
    • Gill M, Dias S, Hattori K, et al. Vascular trauma induces rapid but transient mobilization of VEGFR2+AC133+ endothelial precursor cells. Circ Res 2001: 88: 167 174.
    • (2001) Circ Res , vol.88 , pp. 167-174
    • Gill, M.1    Dias, S.2    Hattori, K.3
  • 31
    • 0033986273 scopus 로고    scopus 로고
    • Circulating endothelial precursors: Mystery, reality, and promise
    • Rafii S. Circulating endothelial precursors: Mystery, reality, and promise. J Clin Invest 2000: 105: 17 19.
    • (2000) J Clin Invest , vol.105 , pp. 17-19
    • Rafii, S.1
  • 33
    • 0034129573 scopus 로고    scopus 로고
    • Transplanted cord blood-derived endothelial progenitor cells augment postnatal neovascularization
    • Murohara T, Ikeda H, Duan J, et al. Transplanted cord blood-derived endothelial progenitor cells augment postnatal neovascularization. J Clin Invest 2000: 105: 1527 1536.
    • (2000) J Clin Invest , vol.105 , pp. 1527-1536
    • Murohara, T.1    Ikeda, H.2    Duan, J.3
  • 34
    • 0035044085 scopus 로고    scopus 로고
    • Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    • Kocher AA, Schuster MD, Szabolcs MJ, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001: 7: 430 436.
    • (2001) Nat Med , vol.7 , pp. 430-436
    • Kocher, A.A.1    Schuster, M.D.2    Szabolcs, M.J.3
  • 35
    • 0032945433 scopus 로고    scopus 로고
    • Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
    • Takahashi T, Kalka C, Masuda H, et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999: 5: 434 438.
    • (1999) Nat Med , vol.5 , pp. 434-438
    • Takahashi, T.1    Kalka, C.2    Masuda, H.3
  • 36
    • 0038814333 scopus 로고    scopus 로고
    • Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling
    • Aicher A, Brenner W, Zuhayra M, et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003: 107: 2134 2139.
    • (2003) Circulation , vol.107 , pp. 2134-2139
    • Aicher, A.1    Brenner, W.2    Zuhayra, M.3
  • 37
    • 11144247257 scopus 로고    scopus 로고
    • Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model
    • Anderson SA, Glod J, Arbab AS, et al. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood 2005: 105: 420 425.
    • (2005) Blood , vol.105 , pp. 420-425
    • Anderson, S.A.1    Glod, J.2    Arbab, A.S.3
  • 38
    • 33748069125 scopus 로고    scopus 로고
    • Is stem cell therapy ready for patients? Stem cell therapy for cardiac repair ready for the next step
    • Boyle AJ, Schulman SP, Hare JM. Is stem cell therapy ready for patients? Stem cell therapy for cardiac repair ready for the next step. Circulation 2006: 114: 339 352.
    • (2006) Circulation , vol.114 , pp. 339-352
    • Boyle, A.J.1    Schulman, S.P.2    Hare, J.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.