XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15532-15537

  Lee, Min Goo ^a   Han, Jikhyon ^a   Jeong, Seong In ^a   Her, Nam Gu ^a   Lee, Jin Hee ^a   Ha, Tae Kyu ^a   Kang, Min Ju ^a   Ryu, Byung Kyu ^a   Chi, Sung Gil ^a  

^a Korea University   (South Korea)

Author keywords

HIPK2; P53; Siah2; XAF1; ZNF313

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; E3 UBIQUITIN LIGASE SIAH2; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; PEPTIDES AND PROTEINS; PROLINE; PROTEIN MDM2; PROTEIN P53; SERINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS ASSOCIATED FACTOR 1; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 313; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HIPK2 PROTEIN, HUMAN; ISOPROTEIN; MDM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RNF114 PROTEIN, HUMAN; SEVEN IN ABSENTIA PROTEINS; SIGNAL PEPTIDE; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE; XAF1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL CYCLE ARREST; CELL FATE; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MODULATION; MOLECULAR INTERACTION; POSITIVE FEEDBACK; PROTEIN PHOSPHORYLATION; STRESS; UBIQUITINATION; ZINC FINGER MOTIF; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; HCT116 CELL LINE; METABOLISM; NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; REMISSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; FEEDBACK, PHYSIOLOGICAL; HCT116 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; REMISSION INDUCTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84908434392     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1411746111     Document Type: Article

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