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Volumn 58, Issue 10, 2014, Pages 2001-2013

Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
[No Author Info available]

Author keywords

Chemoprevention; Prostate cancer; RNA sequencing; Specificity protein 1; Sulforaphane

Indexed keywords

ANTINEOPLASTIC AGENT; ISOTHIOCYANIC ACID DERIVATIVE; SMALL INTERFERING RNA; SP1 PROTEIN, HUMAN; SULFORAFAN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTOME; TUMOR PROTEIN;

EID: 84908428951     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400269     Document Type: Article
Times cited : (26)

References (46)
  • 1
    • 84908458999 scopus 로고    scopus 로고
    • Cancer Fact Sheet: Prostate Cancer
    • International Agency for Research on Cancer, GLOBOCAN, Cancer Fact Sheet: Prostate Cancer, 2010.
    • (2010) GLOBOCAN
  • 2
    • 0003397692 scopus 로고    scopus 로고
    • Atlanta:American Cancer Society Press
    • American Cancer Society, Cancer Facts & Figures 2012. Atlanta:American Cancer Society Press, 2012.
    • (2012) Cancer Facts & Figures 2012
  • 3
    • 84856235306 scopus 로고    scopus 로고
    • Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis
    • Liu, B., Mao, Q., Cao, M., Xie, L., Cruciferous vegetables intake and risk of prostate cancer: a meta-analysis. Int. J. Urol. 2012, 19, 134-141.
    • (2012) Int. J. Urol. , vol.19 , pp. 134-141
    • Liu, B.1    Mao, Q.2    Cao, M.3    Xie, L.4
  • 4
    • 34047136753 scopus 로고    scopus 로고
    • Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    • Higdon, J. V., Delage, B., Williams, D. E., Dashwood, R. H., Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol. Res. 2007, 55, 224-236.
    • (2007) Pharmacol. Res. , vol.55 , pp. 224-236
    • Higdon, J.V.1    Delage, B.2    Williams, D.E.3    Dashwood, R.H.4
  • 5
    • 62449233418 scopus 로고    scopus 로고
    • Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    • Singh, S. V., Warin, R., Xiao, D., Powolny, A. A. et al., Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res. 2009, 69, 2117-2125.
    • (2009) Cancer Res. , vol.69 , pp. 2117-2125
    • Singh, S.V.1    Warin, R.2    Xiao, D.3    Powolny, A.A.4
  • 6
    • 84857918033 scopus 로고    scopus 로고
    • Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles
    • Agyeman, A. S., Chaerkady, R., Shaw, P. G., Davidson, N. E. et al., Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res. Treat. 2012, 132, 175-187.
    • (2012) Breast Cancer Res. Treat. , vol.132 , pp. 175-187
    • Agyeman, A.S.1    Chaerkady, R.2    Shaw, P.G.3    Davidson, N.E.4
  • 7
    • 58849084204 scopus 로고    scopus 로고
    • Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells
    • Bhamre, S., Sahoo, D., Tibshirani, R., Dill, D. L. et al., Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. Prostate 2009, 69, 181-190.
    • (2009) Prostate , vol.69 , pp. 181-190
    • Bhamre, S.1    Sahoo, D.2    Tibshirani, R.3    Dill, D.L.4
  • 8
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotidemicroarray
    • Thimmulappa, R. K., Mai, K. H., Srisuma, S., Kensler, T. W. et al., Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotidemicroarray. Cancer Res. 2002, 62, 5196-5203.
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4
  • 9
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    • Hu, R., Xu, C., Shen, G., Jain, M. R. et al., Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett. 2006, 243, 170-192.
    • (2006) Cancer Lett. , vol.243 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3    Jain, M.R.4
  • 10
    • 79959742774 scopus 로고    scopus 로고
    • Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells
    • Clarke, J. D., Hsu, A., Yu, Z., Dashwood, R. H. et al., Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. Mol. Nutr. Food Res. 2011, 55, 999-1009.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 999-1009
    • Clarke, J.D.1    Hsu, A.2    Yu, Z.3    Dashwood, R.H.4
  • 11
    • 84869082989 scopus 로고    scopus 로고
    • Promoter demethylation of cyclin D2 by sulforaphane in prostate cancer cells
    • Hsu, A., Wong, C. P., Yu, Z., Williams, D. E. et al., Promoter demethylation of cyclin D2 by sulforaphane in prostate cancer cells. Clin. Epigenetics 2011, 3, 3.
    • (2011) Clin. Epigenetics , vol.3 , pp. 3
    • Hsu, A.1    Wong, C.P.2    Yu, Z.3    Williams, D.E.4
  • 12
    • 72249122960 scopus 로고    scopus 로고
    • Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    • Ho, E., Clarke, J. D., Dashwood, R. H., Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr. 2009, 139, 2393-2396.
    • (2009) J Nutr. , vol.139 , pp. 2393-2396
    • Ho, E.1    Clarke, J.D.2    Dashwood, R.H.3
  • 13
    • 3042688047 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
    • Hu, R., Hebbar, V., Kim, B. R., Chen, C. et al., In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther. 2004, 310, 263-271.
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 263-271
    • Hu, R.1    Hebbar, V.2    Kim, B.R.3    Chen, C.4
  • 14
    • 33846094115 scopus 로고    scopus 로고
    • Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice
    • Khor, T. O., Hu, R., Shen, G., Jeong, W. S. et al., Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharm. Drug. Dispos. 2006, 27, 407-420.
    • (2006) Biopharm. Drug. Dispos. , vol.27 , pp. 407-420
    • Khor, T.O.1    Hu, R.2    Shen, G.3    Jeong, W.S.4
  • 15
    • 77955079408 scopus 로고    scopus 로고
    • Sulforaphane- and phenethyl isothiocyanateinduced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression
    • Gross-Steinmeyer, K., Stapleton, P. L., Tracy, J. H., Bammler, T. K. et al., Sulforaphane- and phenethyl isothiocyanateinduced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol. Sci. 2010, 116, 422-432.
    • (2010) Toxicol. Sci. , vol.116 , pp. 422-432
    • Gross-Steinmeyer, K.1    Stapleton, P.L.2    Tracy, J.H.3    Bammler, T.K.4
  • 17
    • 80053610809 scopus 로고    scopus 로고
    • GENE-counter: a computational pipeline for the analysis of RNA-Seq data for gene expression differences
    • Cumbie, J. S., Kimbrel, J. A., Di, Y., Schafer, D. W. et al., GENE-counter: a computational pipeline for the analysis of RNA-Seq data for gene expression differences. PLoS One 2011, 6, e25279.
    • (2011) PLoS One , vol.6
    • Cumbie, J.S.1    Kimbrel, J.A.2    Di, Y.3    Schafer, D.W.4
  • 18
    • 78651476339 scopus 로고    scopus 로고
    • Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
    • Pflueger, D., Terry, S., Sboner, A., Habegger, L. et al., Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing. Genome Res. 2011, 21, 56-67.
    • (2011) Genome Res. , vol.21 , pp. 56-67
    • Pflueger, D.1    Terry, S.2    Sboner, A.3    Habegger, L.4
  • 19
    • 62049085786 scopus 로고    scopus 로고
    • Transcriptome sequencing to detect gene fusions in cancer
    • Maher, C. A., Kumar-Sinha, C., Cao, X., Kalyana-Sundaram, S. et al., Transcriptome sequencing to detect gene fusions in cancer. Nature 2009, 458, 97-101.
    • (2009) Nature , vol.458 , pp. 97-101
    • Maher, C.A.1    Kumar-Sinha, C.2    Cao, X.3    Kalyana-Sundaram, S.4
  • 20
    • 83555173511 scopus 로고    scopus 로고
    • Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    • Clarke, J. D., Hsu, A., Williams, D. E., Dashwood, R. H. et al., Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. Pharm Res. 2011, 28, 3171-3179.
    • (2011) Pharm Res. , vol.28 , pp. 3171-3179
    • Clarke, J.D.1    Hsu, A.2    Williams, D.E.3    Dashwood, R.H.4
  • 21
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    • Myzak, M. C., Hardin, K., Wang, R., Dashwood, R. H. et al., Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis 2006, 27, 811-819.
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4
  • 22
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    • Myzak, M. C., Karplus, P. A., Chung, F. L., Dashwood, R. H., A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer. Res. 2004, 64, 5767-5774.
    • (2004) Cancer. Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 23
    • 84859885816 scopus 로고    scopus 로고
    • Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
    • Trapnell, C., Roberts, A., Goff, L., Pertea, G. et al., Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 2012, 7, 562-578.
    • (2012) Nat. Protoc. , vol.7 , pp. 562-578
    • Trapnell, C.1    Roberts, A.2    Goff, L.3    Pertea, G.4
  • 24
    • 84865429801 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
    • Beaver, L.M., Yu, T.W., Sokolowski, E. I., Williams, D. E. et al., 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol. Appl. Pharmacol. 2012, 263, 345-351.
    • (2012) Toxicol. Appl. Pharmacol. , vol.263 , pp. 345-351
    • Beaver, L.M.1    Yu, T.W.2    Sokolowski, E.I.3    Williams, D.E.4
  • 25
    • 34247493236 scopus 로고    scopus 로고
    • Matplotlib: a 2D graphics environment
    • Hunter, J. D., Matplotlib: a 2D graphics environment. Comput. Sci. Eng. 2007, 9, 90-95.
    • (2007) Comput. Sci. Eng. , vol.9 , pp. 90-95
    • Hunter, J.D.1
  • 26
    • 56449107474 scopus 로고    scopus 로고
    • BioVenn-a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams
    • Hulsen, T., de Vlieg, J., Alkema, W., BioVenn-a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 2008, 9, 488.
    • (2008) BMC Genomics , vol.9 , pp. 488
    • Hulsen, T.1    de Vlieg, J.2    Alkema, W.3
  • 27
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da, W., Sherman, B. T., Lempicki, R. A., Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4, 44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 28
    • 84875404794 scopus 로고    scopus 로고
    • The UCSC Genome Browser database: extensions and updates 2013
    • Meyer, L. R., Zweig, A. S., Hinrichs, A. S., Karolchik, D. et al., The UCSC Genome Browser database: extensions and updates 2013. Nucleic Acids Res. 2013, 41, D64-D69.
    • (2013) Nucleic Acids Res. , vol.41 , pp. D64-D69
    • Meyer, L.R.1    Zweig, A.S.2    Hinrichs, A.S.3    Karolchik, D.4
  • 29
    • 33644876958 scopus 로고    scopus 로고
    • TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes
    • Matys, V., Kel-Margoulis, O. V., Fricke, E., Liebich, I. et al., TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic Acids Res. 2006, 34, D108-D110.
    • (2006) Nucleic Acids Res. , vol.34 , pp. D108-D110
    • Matys, V.1    Kel-Margoulis, O.V.2    Fricke, E.3    Liebich, I.4
  • 30
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C. et al., Initial sequencing and analysis of the human genome. Nature 2001, 409, 860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3    Nusbaum, C.4
  • 31
    • 60249084250 scopus 로고    scopus 로고
    • Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophages
    • Wong, C. P., Bray, T. M., Ho, E., Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophages. Cancer Lett. 2009, 276, 38-46.
    • (2009) Cancer Lett. , vol.276 , pp. 38-46
    • Wong, C.P.1    Bray, T.M.2    Ho, E.3
  • 32
    • 80051975232 scopus 로고    scopus 로고
    • Targeting Sp1 transcription factors in prostate cancer therapy
    • Sankpal, U. T., Goodison, S., Abdelrahim, M., Basha, R., Targeting Sp1 transcription factors in prostate cancer therapy. Med. Chem. 2011, 7, 518-525.
    • (2011) Med. Chem. , vol.7 , pp. 518-525
    • Sankpal, U.T.1    Goodison, S.2    Abdelrahim, M.3    Basha, R.4
  • 33
    • 69449098702 scopus 로고    scopus 로고
    • Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure
    • Chambers, K. F., Bacon, J. R., Kemsley, E. K., Mills, R. D. et al., Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure. Prostate 2009, 69, 1411-1421.
    • (2009) Prostate , vol.69 , pp. 1411-1421
    • Chambers, K.F.1    Bacon, J.R.2    Kemsley, E.K.3    Mills, R.D.4
  • 34
    • 77954409309 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer
    • Traka, M. H., Spinks, C. A., Doleman, J. F., Melchini, A. et al., The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer. Mol. Cancer 2010, 9, 189.
    • (2010) Mol. Cancer , vol.9 , pp. 189
    • Traka, M.H.1    Spinks, C.A.2    Doleman, J.F.3    Melchini, A.4
  • 35
    • 84870052576 scopus 로고    scopus 로고
    • Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate
    • Melchini, A., Needs, P. W., Mithen, R. F., Traka, M. H., Enhanced in vitro biological activity of synthetic 2-(2-pyridyl) ethyl isothiocyanate compared to natural 4-(methylsulfinyl) butyl isothiocyanate. J. Med. Chem. 2012, 55, 9682-9692.
    • (2012) J. Med. Chem. , vol.55 , pp. 9682-9692
    • Melchini, A.1    Needs, P.W.2    Mithen, R.F.3    Traka, M.H.4
  • 36
    • 77956611413 scopus 로고    scopus 로고
    • The role of Sp1 and Sp3 in normal and cancer cell biology
    • Li, L., Davie, J. R., The role of Sp1 and Sp3 in normal and cancer cell biology. Ann. Anat. 2010, 192, 275-283.
    • (2010) Ann. Anat. , vol.192 , pp. 275-283
    • Li, L.1    Davie, J.R.2
  • 37
    • 84866397957 scopus 로고    scopus 로고
    • Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence
    • Bedolla, R. G., Gong, J., Prihoda, T. J., Yeh, I. T. et al., Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. PLoS One 2012, 7, e44917.
    • (2012) PLoS One , vol.7 , pp. e44917
    • Bedolla, R.G.1    Gong, J.2    Prihoda, T.J.3    Yeh, I.T.4
  • 38
    • 73549120404 scopus 로고    scopus 로고
    • Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
    • Lu, S., Archer, M. C., Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. Int. J. Cancer 2010, 126, 416-425.
    • (2010) Int. J. Cancer , vol.126 , pp. 416-425
    • Lu, S.1    Archer, M.C.2
  • 39
    • 84860871238 scopus 로고    scopus 로고
    • Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent
    • Chew, Y. C., Adhikary, G., Wilson, G. M., Xu, W. et al., Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J. Biol. Chem. 2012, 287, 16168-16178.
    • (2012) J. Biol. Chem. , vol.287 , pp. 16168-16178
    • Chew, Y.C.1    Adhikary, G.2    Wilson, G.M.3    Xu, W.4
  • 40
    • 0034611606 scopus 로고    scopus 로고
    • Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells
    • Ren, F., Zhang, S., Mitchell, S. H., Butler, R. et al., Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells. Oncogene 2000, 19, 1924-1932.
    • (2000) Oncogene , vol.19 , pp. 1924-1932
    • Ren, F.1    Zhang, S.2    Mitchell, S.H.3    Butler, R.4
  • 41
    • 34047261665 scopus 로고    scopus 로고
    • Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    • Chintharlapalli, S., Papineni, S., Ramaiah, S. K., Safe, S., Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res. 2007, 67, 2816-2823.
    • (2007) Cancer Res. , vol.67 , pp. 2816-2823
    • Chintharlapalli, S.1    Papineni, S.2    Ramaiah, S.K.3    Safe, S.4
  • 42
    • 59049096024 scopus 로고    scopus 로고
    • Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression
    • Willoughby, J. A. Sr., Sundar, S. N., Cheung, M., Tin, A. S. et al., Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression. J. Biol. Chem. 2009, 284, 2203-2213.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2203-2213
    • Willoughby Sr., J.A.1    Sundar, S.N.2    Cheung, M.3    Tin, A.S.4
  • 43
    • 33749560635 scopus 로고    scopus 로고
    • Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate
    • Wang, L. G., Liu, X. M., Chiao, J. W., Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate. Carcinogenesis 2006, 27, 2124-2132.
    • (2006) Carcinogenesis , vol.27 , pp. 2124-2132
    • Wang, L.G.1    Liu, X.M.2    Chiao, J.W.3
  • 44
    • 0035933895 scopus 로고    scopus 로고
    • Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter
    • Cram, E. J., Liu, B. D., Bjeldanes, L. F., Firestone, G. L., Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J Biol. Chem. 2001, 276, 22332-22340.
    • (2001) J Biol. Chem. , vol.276 , pp. 22332-22340
    • Cram, E.J.1    Liu, B.D.2    Bjeldanes, L.F.3    Firestone, G.L.4
  • 45
    • 0035984590 scopus 로고    scopus 로고
    • 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1- mediated activation of p21(WAF1/CIP1) expression
    • Hong, C., Kim, H. A., Firestone, G. L., Bjeldanes, L. F., 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1- mediated activation of p21(WAF1/CIP1) expression. Carcinogenesis 2002, 23, 1297-1305.
    • (2002) Carcinogenesis , vol.23 , pp. 1297-1305
    • Hong, C.1    Kim, H.A.2    Firestone, G.L.3    Bjeldanes, L.F.4
  • 46
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie, J. R., Inhibition of histone deacetylase activity by butyrate. J. Nutr. 2003, 133, 2485S-2493.
    • (2003) J. Nutr. , vol.133 , pp. 2485S-2493
    • Davie, J.R.1


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