Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 21, 2014, Pages 6124-6133

  Liu, Hao Ran ^a   Liu, Xian Jun ^a   Fan, Hao Qun ^a   Tang, Jing Jing ^a   Gao, Xiao Hui ^b   Liu, Wu Kun ^a  

^a HUNAN UNIVERSITY   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

AChE inhibitors; Chalcone derivatives; LogP; Molecular docking

Indexed keywords

1 [4 [2 (DIBUTYLAMINO)ETHOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [2 (DIMETHYLAMINO)ETHOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [2 (DIPROPYLAMINO)ETHOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [3 (DIBUTYLAMINO)PROPOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [3 (DIETHYLAMINO)PROPOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [3 (DIMETHYLAMINO)PROPOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [3 (DIPROPYLAMINO)PROPOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [4 (DIBUTYLAMINO)BUTOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [4 (DIETHYLAMINO)BUTOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [4 (DIMETHYLAMINO)BUTOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [4 (DIPROPYLAMINO)BUTOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [5 (DIBUTYLAMINO)PENTYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [5 (DIETHYLAMINO)PENTYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [5 (DIMETHYLAMINO)PENTYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [5 (DIPROPYLAMINO)PENTYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [6 (DIBUTYLAMINO)HEXYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [6 (DIETHYLAMINO)HEXYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [6 (DIMETHYLAMINO)HEXYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 [6 (DIPROPYLAMINO)HEXYLOXY]PHENYL] 3 PHENYLPROP 2 EN 1 ONE; ACETYLCHOLINESTERASE; CHALCONE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; RIVASTIGMINE; UNCLASSIFIED DRUG; CHALCONE;

ARTICLE; BLOOD BRAIN BARRIER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME KINETIC ASSAY; IC50; IN VIVO STUDY; MOLECULAR DOCKING; ANIMAL; CHEMISTRY; HUMAN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; TORPEDO; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINESTERASE; ANIMALS; BUTYRYLCHOLINESTERASE; CHALCONE; CHOLINESTERASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; KINETICS; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP; TORPEDO;

EID: 84908413582     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.08.033     Document Type: Article

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