Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

Haematologica

Volumn 99, Issue 11, 2014, Pages 1677-1685

  Trakarnsanga, Kongtana ^a,c   Wilson, Marieangela C ^a   Lau, Winnie ^a   Singleton, Belinda K ^b   Parsons, Steve F ^b   Sakuntanaga, Punthita ^a   Kurita, Ryo ^d   Nakamura, Yukio ^d   Anstee, David J ^b   Frayne, Jan ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c MAHIDOL UNIVERSITY   (Thailand)

^d RIKEN BIORESOURCE CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN EPSILON CHAIN; HEMOGLOBIN GAMMA A; HEMOGLOBIN GAMMA G; HEMOGLOBIN MU CHAIN; HEMOGLOBIN THETA CHAIN; HEMOGLOBIN ZETA CHAIN; KRUPPEL LIKE FACTOR 1; PROTEIN BCL 11 XL; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BCL11A PROTEIN, HUMAN; CARRIER PROTEIN; ERYTHROID KRUPPEL-LIKE FACTOR; HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; KRUPPEL LIKE FACTOR; NUCLEAR PROTEIN;

ARTICLE; CD34 SELECTION; CELL DIFFERENTIATION; CELL LABELING; CONTROLLED STUDY; ERYTHROID CELL; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LENTIVIRINAE; MASS SPECTROMETRY; PHENOTYPE; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PROTEIN DETERMINATION; PROTEIN INDUCTION; QUANTITATIVE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL CORD BLOOD; WESTERN BLOTTING; ADULT STEM CELL; CELL LINE; CYTOLOGY; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL; K562 CELL LINE; METABOLISM;

ADULT STEM CELLS; BETA-GLOBINS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; EPSILON-GLOBINS; ERYTHROID CELLS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; K562 CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHENOTYPE; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 84908409973     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.110155     Document Type: Article

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