Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A

Science

Volumn 322, Issue 5909, 2008, Pages 1839-1842

  Sankaran, Vijay G ^a,b   Menne, Tobias F ^a   Xu, Jian ^a   Akie, Thomas E ^a   Lettre, Guillaume ^a,c   Van Handel, Ben ^d   Mikkola, Hanna K A ^d   Hirschhorn, Joel N ^a,c   Cantor, Alan B ^a   Orkin, Stuart H ^a,b,e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; HEMOGLOBIN F; ONCOPROTEIN; PROTEIN BCL11A; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BLOOD SYSTEM DISORDER; DEVELOPMENTAL STAGE; GENE EXPRESSION; GENETIC ANALYSIS; HEMOGLOBIN; HOMINID;

AMINO ACID SEQUENCE; ARTICLE; BETA THALASSEMIA; DOWN REGULATION; ERYTHROID CELL; EXON; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLOBIN GENE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SICKLE CELL ANEMIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BETA-GLOBINS; CARRIER PROTEINS; CELL LINE, TUMOR; CELLS, CULTURED; DOWN-REGULATION; ERYTHROBLASTS; ERYTHROID CELLS; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HEMOGLOBINOPATHIES; HISTONE DEACETYLASES; HUMANS; K562 CELLS; MICE; MULTIGENE FAMILY; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ISOFORMS; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 57849083996     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1165409     Document Type: Article

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