Subcellular transport of EKLF and switch-on of murine adult βmaj globin gene transcription

Molecular and Cellular Biology

Volumn 27, Issue 6, 2007, Pages 2309-2323

  Shyu, Yu Chiau ^a   Lee, Tung Liang ^a,b   Wen, Shau Ching ^a   Chen, Hsin ^a   Hsiao, Wei Yuan ^a   Chen, Xin ^a,c   Hwang, JauLang ^a   Shen, Che Kun James ^a,b  

^a INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^b NATIONAL DEFENSE UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFOXIDE; ERYTHROID KRUPPEL LIKE FACTOR; HEMOGLOBIN BETA CHAIN; HEXAMETHYLENEBISACETAMIDE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN SC35; REGULATOR PROTEIN; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; EMBRYO; ERYTHROID CELL; ERYTHROLEUKEMIA CELL; FEMALE; FETUS; FETUS LIVER; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE LOCUS; GENE REPRESSION; GENE SILENCING; GENE SWITCHING; GLOBIN GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR IMPORT; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; TRANSIENT TRANSFECTION;

AGING; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; ERYTHROID CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLOBINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER; MICE; PROMOTER REGIONS (GENETICS); PROTEIN TRANSPORT; RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

MAMMALIA; MURINAE;

EID: 33947249119     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01875-06     Document Type: Article

References (60)

1. Anguita, E., J. Hughes, C. Heyworth, G. A. Blobel, W. G. Wood, and D. R. Higgs. 2004. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 23:2841-2852.
2. Baron, M. H. 2003. Embryonic origins of mammalian hematopoiesis. Exp. Hematol. 31:1160-1169.
3. Bieker, J. J. 2005. Probing the onset and regulation of erythroid cell-specific gene expression. Mt. Sinai J. Med. 72:333-338.
4. Brown, J. M., J. Leach, J. E. Reittie, A. Atzberger, J. Lee-Prudhoe, W. G. Wood, D. R. Higgs, F. J. Iborra, and V. J. Buckle. 2006. Coregulated human globin genes are frequently in spatial proximity when active. J. Cell Biol. 172:177-187.
5. Bulger, M., and M. Groudine. 1999. Looping versus linking: toward a model for long-distance gene activation. Genes Dev. 13:2465-2477.
6. Chen, H. J., C. L. Hwong, C. H. Wang, and J. Hwang. 2000. Degradation of DNA topoisomerase I by a novel trypsin-like serine protease in proliferating human T lymphocytes. J. Biol. Chem. 275:13109-13117.
7. Chen, L. F., and W. C. Greene. 2004. Shaping the nuclear action of NF-κB. Nat. Rev. Mol. Cell Biol. 5:392-401.
8. Crabtree, G. R., and E. N. Olson. 2002. NFAT signaling: choreographing the social lives of cells. Cell 109(Suppl.):S67-S79.
9. Daftari, P., N. R. Gawa, and C. K. Shen. 1999. Distinction between AP1 and NF-E2 factor-binding at specific chromatin regions in mammalian cells. Oncogene 18:5482-5486.
10. de Laat, W., and F. Grosveld. 2003. Spatial organization of gene expression: the active chromatin hub. Chromosome Res. 11:447-459.
11. Drissen, R., R. J. Palstra, N. Gillemans, E. Splinter, F. Grosveld, S. Philipsen, and W. de Laat. 2004. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 18: 2485-2490.
12. Engel, J. D., and K. Tanimoto. 2000. Looping, linking, and chromatin activity: new insights into beta-globin locus regulation. Cell 100:499-502.
13. Fantoni, A., A. Bank, and P. A. Marks. 1967. Globin composition and synthesis of hemoglobins in developing fetal mice erythroid cells. Science 157:1327-1329.
14. Francastel, C., W. Magis, and M. Groudine. 2001. Nuclear relocation of a transactivator subunit precedes target gene activation. Proc. Natl. Acad. Sci. USA 98:12120-12125.
15. Fraser, P., and F. Grosveld. 1998. Locus control regions, chromatin activation and transcription. Curr. Opin. Cell Biol. 10:361-365.
16. Geyer, R. K., Z. K. Yu, and C. G. Maki. 2000. The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat. Cell Biol. 2:569-573.
17. Haar, J. L., and G. A. Ackerman. 1971. A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse. Anat. Rec. 170:199-223.
18. Hodge, D., E. Coghill, J. Keys, T. Maguire, B. Hartmann, A. McDowall, M. Weiss, S. Grimmond, and A. Perkins. 2006. A global role for EKLF in definitive and primitive erythropoiesis. Blood 107:3359-3370.
19. Hsu, C. T., C. Y. Ting, C. J. Ting, T. Y. Chen, C. P. Lin, J. Whang-Peng, and J. Hwang. 2000. Vaccination against gonadotropin-releasing hormone (GnRH) using toxin receptor-binding domain-conjugated GnRH repeats. Cancer Res 60:3701-3705.
20. Im, H., J. A. Grass, K. D. Johnson, S. I. Kim, M. E. Boyer, A. N. Imbalzano, J. J. Bieker, and E. H. Bresnick. 2005. Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region. Proc. Natl. Acad. Sci. USA 102:17065-17070.
21. Jahn, C. L., C. A. Hutchison III, S. J. Phillips, S. Weaver, N. L. Haigwood, C. F. Voliva, and M. H. Edgell. 1980. DNA sequence organization of the beta-globin complex in the BALB/c mouse. Cell 21:159-168.
22. Johnson, K. D., H. M. Christensen, B. Zhao, and E. H. Bresnick. 2001. Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter. Mol. Cell 8:465-471.
23. Kadam, S., G. S. McAlpine, M. L. Phelan, R. E. Kingston, K. A. Jones, and B. M. Emerson. 2000. Functional selectivity of recombinant mammalian SWI/SNF subunits. Genes Dev. 14:2441-2451.
24. Kiekhaefer, C. M., J. A. Grass, K. D. Johnson, M. E. Boyer, and E. H. Bresnick. 2002. Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain. Proc. Natl. Acad. Sci. USA 99:14309-14314.
25. Kim, A., and A. Dean. 2004. Developmental stage differences in chromatin subdomains of the beta-globin locus. Proc. Natl. Acad. Sci. USA 101:7028-7033.
26. Kingsley, P. D., J. Malik, R. L. Emerson, T. P. Bushnell, K. E. McGrath, L. A. Bloedorn, M. Bulger, and J. Palis. 2006. " Maturational" globin switching in primary primitive erythroid cells. Blood 107:1665-1672.
27. Kochel, I., and L. Strzadala. 2004. [FK506-binding proteins in the regulation of transcription factors activity in T cells]. Postepy Hig Med. Dosw. 58:118-127. (In Polish.) (Online.)
28. Köster, M., S. Lykke-Andersen, Y. A. Elnakady, K. Gerth, P. Washausen, G. Hofle, F. Sasse, J. Kjems, and H. Hauser. 2003. Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Exp. Cell Res. 286:321-331.
29. Leder, A., H. I. Miller, D. H. Hamer, J. G. Seidman, B. Norman, M. Sullivan, and P. Leder. 1978. Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proc. Natl. Acad. Sci. USA 75:6187-6191.
30. Li, Q., K. R. Peterson, X. Fang, and G. Stamatoyannopoulos. 2002. Locus control regions. Blood 100:3077-3086.
31. Li, Y. C., C. Lee, D. Sanoudou, T. H. Hseu, S. Y. Li, and C. C. Lin. 2000. Interstitial colocalization of two cervid satellite DNAs involved in the genesis of the Indian muntjac karyotype. Chromosome Res. 8:363-373.
32. Liu, J. J., S. C. Hou, and C. K. Shen. 2003. Erythroid gene suppression by NF-κB. J. Biol. Chem. 278:19534-19540.
33. McMorrow, T., A. van den Wijngaard, A. Wollenschlaeger, M. van de Corput, K. Monkhorst, T. Trimborn, P. Fraser, M. van Lohuizen, T. Jenuwein, M. Djabali, S. Philipsen, F. Grosveld, and E. Milot. 2000. Activation of the beta globin locus by transcription factors and chromatin modifiers. EMBO J. 19:4986-4996.
34. Miller, I. J., and J. J. Bieker. 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol. Cell. Biol. 13:2776-2786.
35. Nudel, U., J. E. Salmon, M. Terada, A. Bank, R. A. Rifkind, and P. A. Marks. 1977. Differential effects of chemical inducers on expression of beta globin genes in murine erythroleukemia cells. Proc. Natl. Acad. Sci. USA 74:1100-1104.
36. Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and F. Grosveld. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316-318.
37. Osborne, C. S., L. Chakalova, K. E. Brown, D. Carter, A. Horton, E. Debrand, B. Goyenechea, J. A. Mitchell, S. Lopes, W. Reik, and P. Fraser. 2004. Active genes dynamically colocalize to shared sites of ongoing transcription. Nat. Genet. 36:1065-1071.
38. Palis, J., S. Robertson, M. Kennedy, C. Wall, and G. Keller. 1999. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126:5073-5084.
39. Pandya, K., and T. M. Townes. 2002. Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. J. Biol. Chem. 277:16304-16312.
40. Perkins, A. C., K. M. Gaensler, and S. H. Orkin. 1996. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proc. Natl. Acad. Sci. USA 93:12267-12271.
41. Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature 375:318-322.
42. Quadrini, K. J., and J. J. Bieker. 2002. Kruppel-like zinc fingers bind to nuclear import proteins and are required for efficient nuclear localization of erythroid Kruppel-like factor. J. Biol. Chem. 277:32243-32252.
43. Saitoh, H., R. Pu, M. Cavenagh, and M. Dasso. 1997. RanBP2 associates with Ubc9p and a modified form of RanGAP1. Proc. Natl. Acad. Sci. USA 94:3736-3741.
44. Sawado, T., J. Halow, M. A. Bender, and M. Groudine. 2003. The beta-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation. Genes Dev. 17:1009-1018.
45. Sawado, T., K. Igarashi, and M. Groudine. 2001. Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter. Proc. Natl. Acad. Sci. USA 98:10226-10231.
46. Shiels, C., S. A. Islam, R. Vatcheva, P. Sasieni, M. J. Stemberg, P. S. Freemont, and D. Sheer. 2001. PML bodies associate specifically with the MHC gene cluster in interphase nuclei. J. Cell Sci. 114:3705-3716.
47. Shyu, Y.-C., T.-L. Lee, C.-Y. Ting, S.-C. Wen, L.-J. Hsieh, Y.-C. Li, J.-L. Hwang, C.-C. Lin, and C.-K. J. Shen. 2005. Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus. Mol. Cell. Biol. 25:10365-10378.
48. Shyu, Y. C., S. C. Wen, T. L. Lee, X. Chen, C. T. Hsu, H. Chen, R. L. Chen, J. L. Hwang, and C. K. Shen. 2006. Chromatin-binding in vivo of the erythroid kruppel-like factor, EKLF, in the murine globin loci. Cell Res. 16: 347-355.
49. Southwood, C. M., K. M. Downs, and J. J. Bieker. 1996. Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev. Dyn. 206:248-259.
50. Strunze, S., L. C. Trotman, K. Boucke, and U. F. Greber. 2005. Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export. Mol. Biol. Cell 16:2999-3009.
51. Surinya, K. H., T. C. Cox, and B. K. May. 1997. Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene. Identification of promoter elements and role of regulatory proteins. J. Biol. Chem. 272: 26585-26594.
52. Terui, Y., N. Saad, S. Jia, F. McKeon, and J. Yuan. 2004. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J. Biol. Chem. 279:28257-28265.
53. Tewari, R., N. Gillemans, M. Wijgerde, B. Nuez, M. von Lindern, F. Grosveld, and S. Philipsen. 1998. Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the beta-globin locus control region. EMBO J. 17:2334-2341.
54. Trimborn, T., J. Gribnau, F. Grosveld, and P. Fraser. 1999. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev. 13:112-124.
55. Vieira, K. F., P. P. Levings, M. A. Hill, V. J. Crusselle, S. H. Kang, J. D. Engel, and J. Hungert. 2004. Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro. J. Biol. Chem. 279:50350-50357.
56. Whitelaw, E., S. F. Tsai, P. Hogben, and S. H. Orkin. 1990. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse. Mol. Cell. Biol. 10:6596-6606.
57. Whitney, J. B., III. 1977. Differential control of the synthesis of two hemoglobin beta chains in normal mice. Cell 12:863-871.
58. Wijgerde, M., J. Gribnau, T. Trimborn, B. Nuez, S. Philipsen, F. Grosveld, and P. Fraser. 1996. The role of EKLF in human beta-globin gene competition. Genes Dev. 10:2894-2902.
59. Zhou, D., K. M. Pawlik, J. Ren, C. W. Sun, and T. M. Townes. 2006. Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development. J. Biol. Chem. 281:16052-16057.
60. Zhou, D., J. X. Ren, T. M. Ryan, N. P. Higgins, and T. M. Townes. 2004. Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. Nucleic Acids Res. 32:e128.