Anthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative evaluation and DNA-interaction studies

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 401-410

  Marković, Violeta ^a   Debeljak, Nevena ^a   Stanojković, Tatjana ^b   Kolundžija, Branka ^b   Sladić, Dušan ^c   Vujčić, Miroslava ^d   Janović, Barbara ^d   Tanić, Nikola ^e   Perović, Milka ^e   Tešić, Vesna ^e   Antić, Jadranka ^f   Joksović, Milan D ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

^b INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

^d Institute for Chemistry   (Serbia)

^e UNIVERSITY OF BELGRADE   (Serbia)

^f CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Anthraquinone; Apoptosis; Chalcone; Cytotoxicity; DNA study

Indexed keywords

1 (3 2 TOLYLACRYLOYL)ANTHRACENE 9,10 DIONE; 1 (3 3 TOLYLACRYLOYL)ANTHRACENE 9,10 DIONE; 1 (3 4 TOLYLACRYLOYL)ANTHRACENE 9,10 DIONE; 1 (3 PHENYLACRYLOYL)ANTHRACENE 9,10 DIONE; 1 [3 (4 CHLOROPHENYL)ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 (3 OXO 3 2 TOLYLPROP 1 ENYL)PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 (3 OXO 3 3 TOLYLPROP 1 ENYL)PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 (3 OXO 3 4 TOLYLPROP 1 ENYL)PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 (3 OXO 3 PHENYLPROP 1 ENYL)PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (2 FLUOROPHENYL) 3 OXOPROP 1 ENYL)PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (2 METHOXYPHENYL) 3 OXOPROP 1 ENYL]PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (2 NITROPHENYL) 3 OXOPROP 1 ENYL]PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (3 METHOXYPHENYL) 3 OXOPROP 1 ENYL]PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (4 FLUOROPHENYL) 3 OXOPROP 1 ENYL]PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; 1 [3 [4 [3 (4 METHOXYPHENYL) 3 OXOPROP 1 ENYL]PHENYL]ACRYLOYL]ANTHRACENE 9,10 DIONE; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CISPLATIN; UNCLASSIFIED DRUG; CALF THYMUS DNA; DNA;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL LINE; CELL ADHESION; CELL COUNT; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG STRUCTURE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; BINDING SITE; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; FIBROBLAST; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHALCONES; DNA; FIBROBLASTS; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908368917     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.10.055     Document Type: Article

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