Synthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 274-282

  Tseng, Chih Hua ^a   Chen, Yeh Long ^a   Hsu, Chih Yao ^a   Chen, Tzu Chiang ^a   Cheng, Chih Mei ^a   Tso, Hsien Cheng ^a   Lu, Yan Jia ^a   Tzeng, Cherng Chyi ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

3 Phenylquinolinylchalcones; Antiproliferative activities; Chalcone derivatives

Indexed keywords

1 (1H INDOL 3 YL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (2 AMINO 4 METHYLPYRIMIDIN 5 YL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (2,4 DIMETHOXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (2,6 DIMETHOXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (3 AMINOTHIOPHEN 2 YL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (3,4 DIMETHOXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2YL]PROP 2 EN 1 ONE; 1 (3,5 DIMETHOXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (4 AMINOPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2YL]PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (4 HYDROXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (4 METHOXYPHENYL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (5 BROMOTHIOPHEN 2 YL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL]PROP 2 EN 1 ONE; 3 (4 METHOXYPHENYL)QUINOLINE 2 CARBALDEHYDE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 (1H PYRROL 2 YLL)PROP 2 EN 1 ONE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 (PYRIDIN 2 YL)PROP 2 EN 1 ONE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 (THIOPHEN 3 YL)PROP 2 EN 1 ONE; 3 [3 (4 METHOXYPHENYL)QUINOLIN 2 YL] 1 PHENYLPROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; CASPASE 3; CHALCONE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TOPOTECAN; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION;

BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHALCONE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOLINES;

EID: 84870682188     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.027     Document Type: Article

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