Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 29-40

  Abonia, Rodrigo ^a   Insuasty, Daniel ^a   Castillo, Juan ^a   Insuasty, Braulio ^a   Quiroga, Jairo ^a   Nogueras, Manuel ^b   Cobo, Justo ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

Acetophenones; Anti tumor agents; Chalcones; Claisen Schmidt condensation; Quinoline 2 one derivatives

Indexed keywords

2 (2 OXO 1,2 DIHYDROQUINOLIN 3 YLMETHYLENE)INDAN 1,3 DIONE; 2,2' [(2 OXO 1,2 DIHYDROQUINOLIN 3 YL)METHYLENE]BIS(3 HYDROXY 5,5 DIMETHYLCYCLOHEX 2 ENONE); 3 (3 OXO 3 PHENYLPROP 1 EN 1 YL)QUINOLIN 2(1H) ONE; 3 (4 CHLOROPHENYL) 5 (2 OXO 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDROPYRAZOLO 1 CARBOTHIOAMIDE; 3 (4 METHOXYPHENYL) 5 (2 OXO 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDROPYRAZOLO 1 CARBOTHIOAMIDE; 3 [3 (4 BROMOPHENYL) 1 HYDROXY 3 OXOPROPYL]QUINOLIN 2(1H) ONE; 3 [3 (4 BROMOPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (4 CHLOROPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (4 FLUOROPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (4 HYDROXYPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (4 METHOXYPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (4 NITROPHENYL) 1 HYDROXY 3 OXOPROPYL]QUINOLIN 2(1H) ONE; 3 [3 (4 NITROPHENYL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 (BENZO[D][1,3]DIOXOL 5 YL) 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 [(1,1 BIPHENYL) 4 YL] 3 OXOPROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3 [3 OXO 3 (4 TOLYL)PROP 1 EN 1 YL]QUINOLIN 2(1H) ONE; 3,3' (3 OXOPENTA 1,4 DIENE 1,5 DIYL)BIS[QUINOLIN 2(1H) ONE]; 3,3',1,4 PHENYLENEBIS(3 OXOPROP 1 ENE 3,1 DIYL)BIS[QUINOLIN 2(1H) ONE]; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; QUINOLINE 2 ONE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CLAISEN CONDENSATION; CLAISEN SCHMIDT CONDENSATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; GI 50; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; NUDE MOUSE; REACTION ANALYSIS; SINGLE DRUG DOSE; TOXICITY TESTING;

ACETOPHENONES; ALDEHYDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; DIOXANES; HYDROXIDES; INHIBITORY CONCENTRATION 50; LETHAL DOSE 50; MICE; MICE, NUDE; POTASSIUM COMPOUNDS; QUINOLINES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867002944     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.039     Document Type: Article

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