Synthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone-thiosemicarbazones with tautomerizable methylene group

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 228-238

  Marković, Violeta ^a   Janićijević, Ana ^a   Stanojković, Tatjana ^b   Kolundžija, Branka ^b   Sladić, Dušan ^c   Vujčić, Miroslava ^d   Janović, Barbara ^c   Joksović, Ljubinka ^a   Djurdjević, Predrag T ^a   Todorović, Nina ^d   Trifunović, Snežana ^c   Joksović, Milan D ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

^b INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

^d UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Anthraquinone; Cytotoxicity; DNA binding studies; Tautomerism; Thiosemicarbazone

Indexed keywords

ANTHRAQUINONE DERIVATIVE; CASPASE 3; CASPASE 8; CASPASE 9; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 (2 CARBAMOTHIOYLHYDRAZONO)BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (BUTYLCARBAMOTHIOYL)HYDRAZONO] BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (CYCLOHEXYLCARBAMOTHIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (FURAN 2 YLMETHYLCARBAMO THIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (HEXYLCARBAMOTHIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (P TOLYLCARBAMOTHIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (PHENYLCARBAMOTHIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (PYRIDIN 3 YLMETHYLCARBAMO THIOYL)HYDRAZONO]BUTANOATE; ETHYL 4 (9,10 DIOXO 9,10 DIHYDROANTHRACEN 1 YL) 4 OXO 2 [2 (THIOPHEN 2 YLMETHYL CARBAMOTHIOYL)HYDRAZONO]BUTANOATE; PLASMID DNA; THIOSEMICARBAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL STRAIN K 562; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; TAUTOMERIZATION;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BINDING SITES; CATTLE; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HELA CELLS; HUMANS; K562 CELLS; METHANE; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES;

EID: 84877040246     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.071     Document Type: Article

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