Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion

British Journal of Cancer

Volumn 111, Issue 6, 2014, Pages 1230-1237

  Hassona, Y ^a,b   Cirillo, N ^c,d   Heesom, K ^a   Parkinson, E K ^e   Prime, S S ^a,e  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF JORDAN   (Jordan)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Education and Health   (Italy)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

cancer associated fibroblasts; cellcell adhesion; head and neck cancer; invasion; matrix metalloproteinases; oral squamous cell carcinoma; TGF

Indexed keywords

COLLAGEN GEL; GELATINASE A; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN; INTERSTITIAL COLLAGENASE; NEUTRALIZING ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN; PROTEIN P53;

ARTICLE; CELL ADHESION; CELL AGING; CELL COUNT; CELL INVASION; ENZYME RELEASE; FIBROBLAST; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MASS SPECTROMETRY; NEOPLASM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY; CELL CULTURE; CELL MOTION; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; MOUTH TUMOR; PARACRINE SIGNALING; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; SECRETION (PROCESS); SQUAMOUS CELL CARCINOMA; TWO DIMENSIONAL GEL ELECTROPHORESIS;

CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL AGING; CELL MOVEMENT; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FIBROBLASTS; HUMANS; KERATINOCYTES; MASS SPECTROMETRY; MATRIX METALLOPROTEINASE 2; MOUTH NEOPLASMS; PARACRINE COMMUNICATION; PHENOTYPE; PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84908360918     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.438     Document Type: Article

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