Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs -1 and -2) in fibroblasts are early indictors of oral sub-mucous fibrosis and ageing

Journal of Oral Pathology and Medicine

Volumn 41, Issue 6, 2012, Pages 454-462

  Pitiyage, Gayani N ^a   Lim, Kue P ^b   Gemenitzidis, Emilios ^a   Teh, Muy Teck ^a   Waseem, Ahmad ^a   Prime, Stephen S ^b   Tilakaratne, Wanninayake M ^c   Fortune, Farida ^a   Parkinson, E K ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF PERADENIYA   (Sri Lanka)

Author keywords

Fibroblast; Fibrosis; Metalloproteinases; Senescence; Transforming growth factor

Indexed keywords

TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; FIBROBLAST; HUMAN; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; MOUTH DISEASE; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL AGING; CELL CULTURE TECHNIQUES; COLLAGEN TYPE I; CULTURE MEDIA, CONDITIONED; DNA DAMAGE; EPITHELIUM; FIBROBLASTS; HUMANS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MESODERM; MIDDLE AGED; ORAL SUBMUCOUS FIBROSIS; PROTEASE INHIBITORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFORMING GROWTH FACTOR BETA1; YOUNG ADULT;

EID: 84863491358     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2012.01129.x     Document Type: Article

References (22)

1. Rajalalitha P, Vali S. Molecular pathogenesis of oral submucous fibrosis - a collagen metabolic disorder. J Oral Pathol Med 2005; 34: 321-8.
2. Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol 2006; 42: 561-8.
3. Harvey W, Scutt A, Meghji S, Canniff JP. Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. Arch Oral Biol 1986; 31: 45-9.
4. Scutt A, Meghji S, Harvey W. Stimulation of human fibroblast collagen synthesis in vitro by gamma-aminobutyric acid. Biochem Pharmacol 1987; 36: 1333-5.
5. Scutt A, Meghji S, Canniff JP, Harvey W. Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis. Experientia 1987; 43: 391-3.
6. Trivedy CR, Warnakulasuriya KA, Peters TJ, Senkus R, Hazarey VK, Johnson NW. Raised tissue copper levels in oral submucous fibrosis. J Oral Pathol Med 2000; 29: 241-8.
7. Shieh TY, Yang JF. Collagenase activity in oral submucous fibrosis. Proc Natl Sci Counc Repub China B 1992; 16: 106-10.
8. Pillai R, Balaram P, Reddiar KS. Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer. Cancer 1992; 69: 2011-20.
9. Haque MF, Harris M, Meghji S, Barrett AW. Immunolocalization of cytokines and growth factors in oral submucous fibrosis. Cytokine 1998; 10: 713-9.
10. Chang YC, Yang SF, Lai CC, Liu JY, Hsieh YS. Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures. J Periodontal Res 2002; 37: 196-203.
11. Hsu M, Peled ZM, Chin GS, Liu W, Longaker MT. Ontogeny of expression of transforming growth factor-beta 1 (TGF-beta 1), TGF-beta 3, and TGF-beta receptors I and II in fetal rat fibroblasts and skin. Plast Reconstr Surg 2001; 107: 1787-94; discussion 95-6.
12. Ghosh AK. Factors involved in the regulation of type I collagen gene expression: implication in fibrosis. Exp Biol Med (Maywood) 2002; 227: 301-14.
13. Kuo MY, Chen HM, Hahn LJ, Hsieh CC, Chiang CP. Collagen biosynthesis in human oral submucous fibrosis fibroblast cultures. J Dent Res 1995; 74: 1783-8.
14. Pitiyage GN, Slijepcevic P, Gabrani A, et al. Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases. J Pathol 2011; 223: 604-17.
15. Coppe JP, Patil CK, Rodier F, et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6: 2853-68.
16. Jun JI, Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 2010; 12: 676-85.
17. Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134: 657-67.
18. Munro J, Steeghs K, Morrison V, Ireland H, Parkinson EK. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres. Oncogene 2001; 20: 3541-52.
19. Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993; 73: 713-24.
20. Rodier F, Coppe JP, Patil CK, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11: 973-9.
21. Fahey MS, Paterson IC, Stone A, et al. Dysregulation of autocrine TGF-beta isoform production and ligand responses in human tumour-derived and Ha-ras-transfected keratinocytes and fibroblasts. Br J Cancer 1996; 74: 1074-80.
22. Moutasim KA, Jenei V, Sapienza K, et al. Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol 2011; 223: 366-77.