Desmosomal interactome in keratinocytes: A systems biology approach leading to an understanding of the pathogenesis of skin disease

Cellular and Molecular Life Sciences

Volumn 66, Issue 21, 2009, Pages 3517-3533

  Cirillo, Nicola ^a   Prime, Stephen S ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Adhesome; Desmosome; Keratinocytes; Pemphigus vulgaris; Plakophilin 3; Systems biology

Indexed keywords

ADAPTOR PROTEIN; CYTOSKELETON PROTEIN; DESMOCOLLIN; DESMOGLEIN 1; DESMOGLEIN 2; DESMOGLEIN 3; DESMOPLAKIN; DISPASE; IMMUNOGLOBULIN G; MEMBRANE PROTEIN; PHOSPHATASE; PHOSPHOTRANSFERASE; PLAKOGLOBIN; PLAKOPHILIN; PLAKOPHILIN 3; PROTEIN KINASE; PROTEINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ACANTHOLYSIS; AMINO ACID SEQUENCE; ARTICLE; CELL ADHESION; CELL CULTURE; CELL INTERACTION; CONTROLLED STUDY; DESMOSOMAL INTERACTOME; DESMOSOME; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; KERATINOCYTE; PATHOGENESIS; PEMPHIGUS VULGARIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SYSTEMS BIOLOGY; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL ADHESION; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DESMOSOMES; HUMANS; KERATINOCYTES; MEMBRANE PROTEINS; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MODELS, BIOLOGICAL; PEMPHIGUS; PROTEIN BINDING; SKIN DISEASES; SYSTEMS BIOLOGY;

EID: 70349878700     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0139-7     Document Type: Article

References (40)

1. FJ Bruggeman HV Westerhoff 2007 The nature of systems biology Trends Microbiol 15 45 50 17113776 10.1016/j.tim.2006.11.003 (Pubitemid 46043550)
2. EL Hess 1970 Origins of molecular biology Science 168 664 669 4908914 10.1126/science.168.3932.664
3. E Almaas 2007 Biological impacts and context of network theory J Exp Biol 210 1548 1558 17449819 10.1242/jeb.003731 (Pubitemid 46841959)
4. S Ramaswamy KN Ross ES Lander TR Golub 2003 A molecular signature of metastasis in primary solid tumors Nat Genet 33 49 54 12469122 10.1038/ng1060 (Pubitemid 36068681)
5. S Ramaswamy 2007 Rational design of cancer-drug combinations N Engl J Med 357 299 300 17634467 10.1056/NEJMcibr072593 (Pubitemid 47080397)
6. EC Baechler FM Batliwalla G Karypis PM Gaffney WA Ortmann KJ Espe KB Shark WJ Grande KM Hughes V Kapur PK Gregersen TW Behrens 2003 Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Proc Natl Acad Sci USA 100 2610 2615 12604793 10.1073/pnas.0337679100 (Pubitemid 36297546)
7. WJ Nelson 2008 Regulation of cell-cell adhesion by the cadherin-catenin complex Biochem Soc Trans 36 149 155 18363555 10.1042/BST0360149 (Pubitemid 351570584)
8. BD Angst C Marcozzi AI Magee 2001 The cadherin superfamily: diversity in form and function J Cell Sci 114 629 641 11171368
9. Cirillo N (2009) Pathophysiology of the desmosome. Research Signpost, Kerala, India
10. D Garrod M Chidgey 2008 Desmosome structure, composition and function Biochim Biophys Acta 1778 572 587 17854763 10.1016/j.bbamem.2007.07.014 (Pubitemid 351317796)
11. Miera A, Foshay K, Stewart A, Gallicano GI (2009) Development of a sticky situation: the role of the desmosome in epidermal morphogenesis. In: Cirillo N (ed) Pathophysiology of the desmosome. Research Signpost, Kerala, pp 33-61
12. AS Payne Y Hanakawa M Amagai JR Stanley 2004 Desmosomes and disease: pemphigus and bullous impetigo Curr Opin Cell Biol 16 536 543 15363804 10.1016/j.ceb.2004.07.006 (Pubitemid 39201238)
13. KJ Green CL Simpson 2007 Desmosomes: new perspectives on a classic J Invest Dermatol 127 2499 2515 17934502 10.1038/sj.jid.5701015 (Pubitemid 47585074)
14. A Lanza N Cirillo F Femiano F Gombos 2006 How does acantholysis occur in pemphigus vulgaris: a critical review J Cutan Pathol 33 401 412 16776715 10.1111/j.0303-6987.2006.00523.x (Pubitemid 43865298)
15. J Waschke 2008 The desmosome and pemphigus Histochem Cell Biol 130 21 54 18386043 10.1007/s00418-008-0420-0
16. R Zaidel-Bar S Itzkovitz A Ma'ayan R Iyengar B Geiger 2007 Functional atlas of the integrin adhesome Nat Cell Biol 9 858 867 17671451 10.1038/ncb0807-858 (Pubitemid 47190436)
17. L Paris G Bazzoni 2008 The protein interaction network of the epithelial junctional complex: a system-level analysis Mol Biol Cell 19 5409 5421 18923145 10.1091/mbc.E08-05-0477
18. P Shannon A Markiel O Ozier NS Baliga JT Wang D Ramage N Amin B Schwikowski T Ideker 2003 Cytoscape: a software environment for integrated models of biomolecular interaction networks Genome Res 13 2498 2504 14597658 10.1101/gr.1239303 (Pubitemid 37428274)
19. Pieroni E, de la Fuente van Bentem S, Mancosu G, Capobianco E, Hirt H, de la Fuente A (2008) Protein networking: insights into global functional organization of proteomes. Proteomics 8:799-816
20. R Albert H Jeong AL Barabasi 2000 Error and attack tolerance of complex networks Nature 406 378 382 10935628 10.1038/35019019 (Pubitemid 30625551)
21. A Lanza N Cirillo R Rossiello M Rienzo L Cutillo A Casamassimi F de Nigris C Schiano L Rossiello F Femiano F Gombos C Napoli 2008 Evidence of key role of Cdk2 overexpression in pemphigus vulgaris J Biol Chem 283 8736 8745 18199752 10.1074/jbc.M702186200
22. N Cirillo M Lanza A De Rosa F Femiano F Gombos A Lanza 2008 At least three phosphorylation events induced by pemphigus vulgaris sera are pathogenically involved in keratinocyte acantholysis Int J Immunopathol Pharmacol 21 189 195 18336745
23. N Cirillo F Gombos A Lanza 2007 Pemphigus vulgaris immunoglobulin G can recognize a 130 000 MW antigen other than desmoglein 3 on peripheral blood mononuclear cell surface Immunology 121 377 382 17386081 10.1111/j.1365-2567. 2007.02585.x (Pubitemid 46817359)
24. P Boukamp RT Petrussevska D Breitkreutz J Hornung A Markham NE Fusenig 1988 Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line J Cell Biol 106 761 771 2450098 10.1083/jcb.106.3.761
25. E Calautti S Cabodi PL Stein M Hatzfeld N Kedersha GP Dotto 1998 Tyrosine phosphorylation and Src-family kinases control keratinocyte cell-cell adhesion J Cell Biol 141 1449 1465 9628900 10.1083/jcb.141.6.1449 (Pubitemid 28289919)
26. N Cirillo M Lanza F Femiano GM Gaeta A De Rosa F Gombos A Lanza 2007 If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concause J Cell Physiol 212 563 567 17474087 10.1002/jcp.21111 (Pubitemid 47267524)
27. N Cirillo M Lanza A De Rosa M Cammarota A La Gatta F Gombos A Lanza 2008 The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery J Cell Biochem 103 598 606 17559062 10.1002/jcb.21431 (Pubitemid 351171930)
28. A Lanza R Santoro A De Rosa GM Gaeta F Gombos N Cirillo 2007 Inhibition of protein phosphorylation, but not synthesis nor lysosomal degradation, prevents keratinocyte adhesion loss induced by pemphigus vulgaris serum J Stomatol Invest 1 25 32
29. HH Bragulla DG Homberger 2009 Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia J Anat 214 516 559 19422428 10.1111/j.1469-7580.2009.01066.x
30. M Hesse ED Watson T Schwaluk TM Magin 2005 Rescue of keratin 18/19 doubly deficient mice using aggregation with tetraploid embryos Eur J Cell Biol 84 355 361 15819413 10.1016/j.ejcb.2004.12.014 (Pubitemid 40353074)
31. J Waschke 2008 Direct interference with desmoglein binding in pemphigus J Stomatol Invest 2 53 55
32. T Sklyarova S Bonné P D'Hooge G Denecker S Goossens R De Rycke G Borgonie M Bösl F van Roy J van Hengel 2008 Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation J Invest Dermatol 128 1375 1385 18079750 10.1038/sj.jid.5701189 (Pubitemid 351693184)
33. VT Nguyen J Arredondo AI Chernyavsky Y Kitajima M Pittelkow SA Grando 2004 Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes J Biol Chem 279 2135 2146 14600150 10.1074/jbc.M309000200 (Pubitemid 38084487)
34. A Stellavato N Cirillo 2007 Fate of desmoglein 3 in oral pemphigus vulgaris: an RT-PCR study of cell adhesion molecules J Stomatol Invest 1 63 68
35. R Caldelari A de Bruin D Baumann MM Suter C Bierkamp V Balmer E Müller 2001 A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris J Cell Biol 153 823 834 11352942 10.1083/jcb.153.4.823 (Pubitemid 34286113)
36. L Williamson NA Raess R Caldelari A Zakher A de Bruin H Posthaus R Bolli T Hunziker MM Suter EJ Müller 2006 Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin EMBO J 25 3298 3309 16871158 10.1038/sj.emboj.7601224 (Pubitemid 44141788)
37. P Berkowitz P Hu S Warren Z Liu LA Diaz DS Rubenstein 2006 p38MAPK inhibition prevents disease in pemphigus vulgaris mice Proc Natl Acad Sci USA 103 12855 12860 16908851 10.1073/pnas.0602973103 (Pubitemid 44298651)
38. VT Nguyen AI Chernyavsky J Arredondo D Bercovich A Orr-Urtreger DE Vetter J Wess AL Beaudet Y Kitajima SA Grando 2004 Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes Exp Cell Res 294 534 549 15023540 10.1016/j.yexcr.2003.12.010 (Pubitemid 38326750)
39. AI Chernyavsky J Arredondo Y Kitajima M Sato-Nagai SA Grando 2007 Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens J Biol Chem 282 13804 13812 17344213 10.1074/jbc.M611365200 (Pubitemid 47100562)
40. AI Chernyavsky J Arredondo T Piser E Karlsson SA Grando 2008 Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis J Biol Chem 283 3401 3408 18073210 10.1074/jbc.M704956200