The Route of HIV Escape from Immune Response Targeting Multiple Sites Is Determined by the Cost-Benefit Tradeoff of Escape Mutations

PLoS Computational Biology

Volumn 10, Issue 10, 2014, Pages

  Batorsky, Rebecca ^a,b   Sergeev, Rinat A ^a,c   Rouzine, Igor M ^a,d  

^a TUFTS UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COST BENEFIT ANALYSIS; DISEASES; FORECASTING; IMMUNE SYSTEM; MOLECULES; VIRUSES;

COST-BENEFIT TRADEOFFS; COST/BENEFIT; CYTOTOXIC T LYMPHOCYTES; FITNESS COSTS; IMMUNE RESPONSE; INFECTED CELLS; MAJOR FACTORS; POSITIVE CORRELATIONS; SELECTION PRESSURES; VIRAL REPLICATION;

EPITOPES;

EPITOPE; HLA ANTIGEN;

ANTIGEN MEDIATED CLONAL SELECTION; ANTIGEN RECOGNITION; ARTICLE; CORRELATIONAL STUDY; CYTOTOXIC T LYMPHOCYTE; GROWTH RATE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE CLONE; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; NONHUMAN; STEADY STATE; STRUCTURAL GENE; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS LOAD; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN; BIOLOGY; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; MUTATION; PHYSIOLOGY; REPRODUCTIVE FITNESS; VIROLOGY;

COMPUTATIONAL BIOLOGY; GENETIC FITNESS; HIV INFECTIONS; HIV-1; HUMANS; MUTATION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84908350583     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003878     Document Type: Article

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