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Volumn 5, Issue 6, 2002, Pages 224-233

Fitness of drug resistant HIV-1: Methodology and clinical implications

Author keywords

Drug resistance; Fitness; HIV; Replication capacity

Indexed keywords

ANTIRETROVIRUS AGENT;

EID: 0036971250     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-7646(02)00123-1     Document Type: Review
Times cited : (79)

References (84)
  • 1
    • 0035941384 scopus 로고    scopus 로고
    • Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy
    • Antinori, A., Liuzzi, G., Cingolani, A., Bertoli, A., Di Giambenedetto, S., Trotta, M.P., Rizzo, M.G., Girardi, E., De Luca, A., Perno, C.F., 2001. Drug-resistant mutants of HIV-1 in patients exhibiting increasing CD4 cell count despite virological failure of highly active antiretroviral therapy. AIDS 15, 2325-2327.
    • (2001) AIDS , vol.15 , pp. 2325-2327
    • Antinori, A.1    Liuzzi, G.2    Cingolani, A.3    Bertoli, A.4    Di Giambenedetto, S.5    Trotta, M.P.6    Rizzo, M.G.7    Girardi, E.8    De Luca, A.9    Perno, C.F.10
  • 2
    • 0033863784 scopus 로고    scopus 로고
    • Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture
    • Archer, R.H., Dykes, C., Gerondelis, P., Lloyd, A., Fay, P., Reichman, R.C., Bambara, R.A., Demeter, L.M., 2000. Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture. J. Virol. 74, 8390-8401.
    • (2000) J. Virol. , vol.74 , pp. 8390-8401
    • Archer, R.H.1    Dykes, C.2    Gerondelis, P.3    Lloyd, A.4    Fay, P.5    Reichman, R.C.6    Bambara, R.A.7    Demeter, L.M.8
  • 4
    • 0032869255 scopus 로고    scopus 로고
    • HIV-1 evolution under pressure of protease inhibitors: Climbing the stairs of viral fitness
    • Berkhout, B., 1999a. HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness. J. Biomed. Sci. 6, 298-305.
    • (1999) J. Biomed. Sci. , vol.6 , pp. 298-305
    • Berkhout, B.1
  • 5
    • 0033081160 scopus 로고    scopus 로고
    • Proposed alternatives for the use of anti-HIV drugs
    • Berkhout, B., 1999b. Proposed alternatives for the use of anti-HIV drugs. Drug Resist. Updat. 2, 69-70.
    • (1999) Drug Resist. Updat. , vol.2 , pp. 69-70
    • Berkhout, B.1
  • 6
    • 0035958763 scopus 로고    scopus 로고
    • Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy
    • Birk, M., Svedhem, V., Sonnerborg, A., 2001. Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy. AIDS 15, 1359-1368.
    • (2001) AIDS , vol.15 , pp. 1359-1368
    • Birk, M.1    Svedhem, V.2    Sonnerborg, A.3
  • 7
    • 0031884993 scopus 로고    scopus 로고
    • In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection
    • Blaak, H., Brouwer, M., Ran, L.J., de Wolf, F., Schuitemaker, H., 1998. In vitro replication kinetics of human immunodeficiency virus type 1 (HIV-1) variants in relation to virus load in long-term survivors of HIV-1 infection. J. Infect. Dis. 177, 600-610.
    • (1998) J. Infect. Dis. , vol.177 , pp. 600-610
    • Blaak, H.1    Brouwer, M.2    Ran, L.J.3    De Wolf, F.4    Schuitemaker, H.5
  • 8
    • 0035104646 scopus 로고    scopus 로고
    • Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1
    • Bleiber, G., Munoz, M., Ciuffi, A., Meylan, P., Telenti, A., 2001. Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1. J. Virol. 75, 3291-3300.
    • (2001) J. Virol. , vol.75 , pp. 3291-3300
    • Bleiber, G.1    Munoz, M.2    Ciuffi, A.3    Meylan, P.4    Telenti, A.5
  • 9
    • 0030065565 scopus 로고    scopus 로고
    • Resistance of human immunodeficiency virus type 1 to protease inhibitors: Selection of resistance mutations in the presence and absence of the drug
    • Borman, A.M., Paulous, S., Clavel, F., 1996. Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J. Gen. Virol. 77, 419-426.
    • (1996) J. Gen. Virol. , vol.77 , pp. 419-426
    • Borman, A.M.1    Paulous, S.2    Clavel, F.3
  • 11
    • 0034565934 scopus 로고    scopus 로고
    • HIV drug resistance and viral fitness
    • Clavel, F., Race, E., Mammano, F., 2000. HIV drug resistance and viral fitness. Adv. Pharmacol. 49, 41-66.
    • (2000) Adv. Pharmacol. , vol.49 , pp. 41-66
    • Clavel, F.1    Race, E.2    Mammano, F.3
  • 12
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin, J.M., 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 13
    • 0031015475 scopus 로고    scopus 로고
    • Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors
    • Croteau, G., Doyon, L., Thibeault, D., McKercher, G., Pilote, L., Lamarre, D., 1997. Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J. Virol. 71, 1089-1096.
    • (1997) J. Virol. , vol.71 , pp. 1089-1096
    • Croteau, G.1    Doyon, L.2    Thibeault, D.3    McKercher, G.4    Pilote, L.5    Lamarre, D.6
  • 14
    • 0035158709 scopus 로고    scopus 로고
    • Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus
    • De Ronde, A., van Dooren, M., van Der, H.L., Bouwhuis, D., de Rooij, E., van Gemen, B., de Boer, R., Goudsmit, J., 2001. Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus. J. Virol. 75, 595-602.
    • (2001) J. Virol. , vol.75 , pp. 595-602
    • De Ronde, A.1    Van Dooren, M.2    Van Der, H.L.3    Bouwhuis, D.4    De Rooij, E.5    Van Gemen, B.6    De Boer, R.7    Goudsmit, J.8
  • 15
    • 0034456413 scopus 로고    scopus 로고
    • Determinants of virological response to antiretroviral therapy: Implications for long-term strategies
    • Deeks, S.G., 2000. Determinants of virological response to antiretroviral therapy: implications for long-term strategies. Clin. Infect. Dis. 30 (Suppl. 2), S177-S184.
    • (2000) Clin. Infect. Dis. , vol.30 , Issue.SUPPL. 2
    • Deeks, S.G.1
  • 16
    • 0035281213 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance
    • Deeks, S.G., 2001. International perspectives on antiretroviral resistance. Nonnucleoside reverse transcriptase inhibitor resistance. J. Acquir. Immune. Defic. Syndr. 26 (Suppl. 1), S25-S33.
    • (2001) J. Acquir. Immune. Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Deeks, S.G.1
  • 17
    • 0034070773 scopus 로고    scopus 로고
    • Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection
    • Deeks, S.G., Barbour, J.D., Martin, J.N., Swanson, M.S., Grant, R.M., 2000. Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection. J. Infect. Dis. 181, 946-953.
    • (2000) J. Infect. Dis. , vol.181 , pp. 946-953
    • Deeks, S.G.1    Barbour, J.D.2    Martin, J.N.3    Swanson, M.S.4    Grant, R.M.5
  • 19
    • 0034867418 scopus 로고    scopus 로고
    • Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations
    • Devereux, H.L., Emery, V.C., Johnson, M.A., Loveday, C., 2001. Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations. J. Med. Virol. 65, 218-224.
    • (2001) J. Med. Virol. , vol.65 , pp. 218-224
    • Devereux, H.L.1    Emery, V.C.2    Johnson, M.A.3    Loveday, C.4
  • 20
    • 0034691650 scopus 로고    scopus 로고
    • Substantial correlation between HIV type 1 drug-associated resistance mutations in plasma and peripheral blood mononuclear cells in treatment-experienced patients
    • Devereux, H.L., Loveday, C., Youle, M., Sabin, C.A., Burke, A., Johnson, M., 2000. Substantial correlation between HIV type 1 drug-associated resistance mutations in plasma and peripheral blood mononuclear cells in treatment-experienced patients. AIDS Res. Hum. Retroviruses 16, 1025-1030.
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 1025-1030
    • Devereux, H.L.1    Loveday, C.2    Youle, M.3    Sabin, C.A.4    Burke, A.5    Johnson, M.6
  • 21
    • 0034630910 scopus 로고    scopus 로고
    • Viruses at the edge of adaptation
    • Domingo, E., 2000. Viruses at the edge of adaptation. Virology 270, 251-253.
    • (2000) Virology , vol.270 , pp. 251-253
    • Domingo, E.1
  • 22
    • 0002482572 scopus 로고    scopus 로고
    • Viral quasispecies and fitness variations
    • Domingo, E., Webster, R., Holland, J. (Eds.), Academic Press, San Diego
    • Domingo, E., Escarmis, C., Menendez-Arias, L., Holland, J., 1999. Viral quasispecies and fitness variations. In: Domingo, E., Webster, R., Holland, J. (Eds.), Origin and Evolution of Viruses. Academic Press, San Diego, pp. 141-161.
    • (1999) Origin and Evolution of Viruses , pp. 141-161
    • Domingo, E.1    Escarmis, C.2    Menendez-Arias, L.3    Holland, J.4
  • 23
    • 0030747157 scopus 로고    scopus 로고
    • RNA virus mutations and fitness for survival
    • Domingo, E., Holland, J.J., 1997. RNA virus mutations and fitness for survival. Annu. Rev. Microbiol. 51, 151-178.
    • (1997) Annu. Rev. Microbiol. , vol.51 , pp. 151-178
    • Domingo, E.1    Holland, J.J.2
  • 24
    • 0029899093 scopus 로고    scopus 로고
    • Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
    • Doyon, L., Croteau, G., Thibeault, D., Poulin, F., Pilote, L., Lamarre, D., 1996. Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J. Virol. 70, 3763-3769.
    • (1996) J. Virol. , vol.70 , pp. 3763-3769
    • Doyon, L.1    Croteau, G.2    Thibeault, D.3    Poulin, F.4    Pilote, L.5    Lamarre, D.6
  • 25
    • 0031950370 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type I associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy
    • Eastman, P.S., Mittler, J., Kelso, R., Gee, C., Boyer, E., Kolberg, J., Urdea, M., Leonard, J.M., Norbeck, D.W., Mo, H., Markowitz, M., 1998. Genotypic changes in human immunodeficiency virus type I associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. J. Virol. 72, 5154-5164.
    • (1998) J. Virol. , vol.72 , pp. 5154-5164
    • Eastman, P.S.1    Mittler, J.2    Kelso, R.3    Gee, C.4    Boyer, E.5    Kolberg, J.6    Urdea, M.7    Leonard, J.M.8    Norbeck, D.W.9    Mo, H.10    Markowitz, M.11
  • 26
    • 0029067916 scopus 로고
    • Comparison of selective polymerase chain reaction primers and differential probe hybridization of polymerase chain reaction products for determination of relative amounts of codon 215 mutant and wild-type HIV-1 populations
    • Eastman, P.S., Urdea, M., Besemer, D., Stempien, M., Kolberg, J., 1995. Comparison of selective polymerase chain reaction primers and differential probe hybridization of polymerase chain reaction products for determination of relative amounts of codon 215 mutant and wild-type HIV-1 populations. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 9, 264-273.
    • (1995) J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. , vol.9 , pp. 264-273
    • Eastman, P.S.1    Urdea, M.2    Besemer, D.3    Stempien, M.4    Kolberg, J.5
  • 27
    • 0033819048 scopus 로고    scopus 로고
    • Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1
    • Garcia-Lerma, J.G., Gerrish, P.J., Wright, A.C., Qari, S.H., Heneine, W., 2000. Evidence of a role for the Q151L mutation and the viral background in development of multiple dideoxynucleoside-resistant human immunodeficiency virus type 1. J. Virol. 74, 9339-9346.
    • (2000) J. Virol. , vol.74 , pp. 9339-9346
    • Garcia-Lerma, J.G.1    Gerrish, P.J.2    Wright, A.C.3    Qari, S.H.4    Heneine, W.5
  • 28
    • 0032993043 scopus 로고    scopus 로고
    • The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5′-end- and DNA 3′-end-directed RNase H activities
    • Gerondelis, P., Archer, R.H., Palaniappan, C., Reichman, R.C., Fay, P.J., Bambara, R.A., Demeter, L.M., 1999. The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5′-end- and DNA 3′-end-directed RNase H activities. J. Virol. 73, 5803-5813.
    • (1999) J. Virol. , vol.73 , pp. 5803-5813
    • Gerondelis, P.1    Archer, R.H.2    Palaniappan, C.3    Reichman, R.C.4    Fay, P.J.5    Bambara, R.A.6    Demeter, L.M.7
  • 29
    • 0030926277 scopus 로고    scopus 로고
    • Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215
    • Goudsmit, J., De Ronde, A., de Rooij, E., de Boer, R., 1997. Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215. J. Virol. 71, 4479-4484.
    • (1997) J. Virol. , vol.71 , pp. 4479-4484
    • Goudsmit, J.1    De Ronde, A.2    De Rooij, E.3    De Boer, R.4
  • 30
    • 0030011523 scopus 로고    scopus 로고
    • Human immunodeficiency virus fitness in vivo: Calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase
    • Goudsmit, J., De Ronde, A., Ho, D.D., Perelson, A.S., 1996. Human immunodeficiency virus fitness in vivo: calculations based on a single zidovudine resistance mutation at codon 215 of reverse transcriptase. J. Virol. 70 (8), 5662-5664.
    • (1996) J. Virol. , vol.70 , Issue.8 , pp. 5662-5664
    • Goudsmit, J.1    De Ronde, A.2    Ho, D.D.3    Perelson, A.S.4
  • 33
    • 0031958266 scopus 로고    scopus 로고
    • Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro
    • Harrigan, P.R., Bloor, S., Larder, B.A., 1998. Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro. J. Virol. 72, 3773-3778.
    • (1998) J. Virol. , vol.72 , pp. 3773-3778
    • Harrigan, P.R.1    Bloor, S.2    Larder, B.A.3
  • 34
    • 0029798237 scopus 로고    scopus 로고
    • Nevirapineresistant human immunodeficiency virus: Kinetics of replication and estimated prevalence in untreated patients
    • Havlir, D.V., Eastman, S., Gamst, A., Richman, D.D., 1996. Nevirapineresistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients. J. Virol. 70, 7894-7899.
    • (1996) J. Virol. , vol.70 , pp. 7894-7899
    • Havlir, D.V.1    Eastman, S.2    Gamst, A.3    Richman, D.D.4
  • 37
  • 38
    • 0026070176 scopus 로고
    • Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses
    • Holland, J.J., de la Torre, J.C., Clarke, D.K., Duarte, E., 1991. Quantitation of relative fitness and great adaptability of clonal populations of RNA viruses. J. Virol. 65, 2960-2967.
    • (1991) J. Virol. , vol.65 , pp. 2960-2967
    • Holland, J.J.1    De la Torre, J.C.2    Clarke, D.K.3    Duarte, E.4
  • 39
    • 0036135710 scopus 로고    scopus 로고
    • In vitro analysis of HIV-1 resistance to nevirapine and fitness determination of resistant variants
    • Iglesias-Ussel, M.D., Casado, C., Yuste, E., Olivares, I., Lopez-Galindez, C., 2002. In vitro analysis of HIV-1 resistance to nevirapine and fitness determination of resistant variants. J. Gen. Virol. 83, 93-101.
    • (2002) J. Gen. Virol. , vol.83 , pp. 93-101
    • Iglesias-Ussel, M.D.1    Casado, C.2    Yuste, E.3    Olivares, I.4    Lopez-Galindez, C.5
  • 40
    • 0034469498 scopus 로고    scopus 로고
    • Relative replication fitness of a high-level 3′-azido-3′-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr → Gly) at codon 69
    • Imamichi, T., Berg, S.C., Imamichi, H., Lopez, J.C., Metcalf, J.A., Falloon, J., Lane, H.C., 2000. Relative replication fitness of a high-level 3′-azido-3′-deoxythymidine-resistant variant of human immunodeficiency virus type 1 possessing an amino acid deletion at codon 67 and a novel substitution (Thr → Gly) at codon 69. J. Virol. 74, 10958-10964.
    • (2000) J. Virol. , vol.74 , pp. 10958-10964
    • Imamichi, T.1    Berg, S.C.2    Imamichi, H.3    Lopez, J.C.4    Metcalf, J.A.5    Falloon, J.6    Lane, H.C.7
  • 41
    • 0035088519 scopus 로고    scopus 로고
    • Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles
    • Imamichi, T., Murphy, M.A., Imamichi, H., Lane, H.C., 2001. Amino acid deletion at codon 67 and Thr-to-Gly change at codon 69 of human immunodeficiency virus type 1 reverse transcriptase confer novel drug resistance profiles. J. Virol. 75, 3988-3992.
    • (2001) J. Virol. , vol.75 , pp. 3988-3992
    • Imamichi, T.1    Murphy, M.A.2    Imamichi, H.3    Lane, H.C.4
  • 42
    • 0028085161 scopus 로고
    • Recombinant virus assay: A rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates
    • Kellam, P., Larder, B.A., 1994. Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates. Antimicrob. Agents Chemother. 38, 23-30.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 23-30
    • Kellam, P.1    Larder, B.A.2
  • 43
    • 0036655272 scopus 로고    scopus 로고
    • Origin of human immunodeficiency virus type 1 quasispecies emerging after antiretroviral treatment interruption in patients with therapeutic failure
    • Kijak, G.H., Simon, V., Balfe, P., Vanderhoeven, J., Pampuro, S.E., Zala, C., Ochoa, C., Cahn, P., Markowitz, M., Salomon, H., 2002. Origin of human immunodeficiency virus type 1 quasispecies emerging after antiretroviral treatment interruption in patients with therapeutic failure. J. Virol. 76, 7000-7009.
    • (2002) J. Virol. , vol.76 , pp. 7000-7009
    • Kijak, G.H.1    Simon, V.2    Balfe, P.3    Vanderhoeven, J.4    Pampuro, S.E.5    Zala, C.6    Ochoa, C.7    Cahn, P.8    Markowitz, M.9    Salomon, H.10
  • 44
    • 0033064963 scopus 로고    scopus 로고
    • Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay
    • Kosalaraksa, P., Kavlick, M.F., Maroun, V., Le, R., Mitsuya, H., 1999. Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an in vitro competitive HIV-1 replication assay. J. Virol. 73, 5356-5363.
    • (1999) J. Virol. , vol.73 , pp. 5356-5363
    • Kosalaraksa, P.1    Kavlick, M.F.2    Maroun, V.3    Le, R.4    Mitsuya, H.5
  • 46
    • 0035281108 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance
    • Loveday, C., 2001. International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance. J. Acquir. Immune. Defic. Syndr. 26 (Suppl. 1), S10-S24.
    • (2001) J. Acquir. Immune. Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Loveday, C.1
  • 47
    • 0035330599 scopus 로고    scopus 로고
    • A novel recombinant marker virus assay for comparing the relative fitness of HIV-1 reverse transcriptase variants
    • Lu, J., Kuritzkes, D.R., 2001. A novel recombinant marker virus assay for comparing the relative fitness of HIV-1 reverse transcriptase variants. J. Acquir. Immune. Defic. Syndr. 27, 7-13.
    • (2001) J. Acquir. Immune. Defic. Syndr. , vol.27 , pp. 7-13
    • Lu, J.1    Kuritzkes, D.R.2
  • 48
    • 0031948662 scopus 로고    scopus 로고
    • Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
    • Maeda, Y., Venzon, D.J., Mitsuya, H., 1998. Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. J. Infect. Dis. 177, 1207-1213.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1207-1213
    • Maeda, Y.1    Venzon, D.J.2    Mitsuya, H.3
  • 49
    • 0031846317 scopus 로고    scopus 로고
    • Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
    • Mammano, F., Petit, C., Clavel, F., 1998. Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients. J. Virol. 72, 7632-7637.
    • (1998) J. Virol. , vol.72 , pp. 7632-7637
    • Mammano, F.1    Petit, C.2    Clavel, F.3
  • 50
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and in the presence of drug
    • Mammano, F., Trouplin, V., Zennou, V., Clavel, F., 2000. Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J. Virol. 74, 8524-8531.
    • (2000) J. Virol. , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 51
    • 0028854676 scopus 로고
    • Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz, M., Mo, H., Kempf, D.J., Norbeck, D.W., Bhat, T.N., Erickson, J.W., Ho, D.D., 1995. Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69, 701-706.
    • (1995) J. Virol. , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3    Norbeck, D.W.4    Bhat, T.N.5    Erickson, J.W.6    Ho, D.D.7
  • 52
    • 0034734783 scopus 로고    scopus 로고
    • Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants
    • Martinez-Picado, J., Savara, A.V., Shi, L., Sutton, L., D'aquila, R.T., 2000. Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants. Virology 275, 318-322.
    • (2000) Virology , vol.275 , pp. 318-322
    • Martinez-Picado, J.1    Savara, A.V.2    Shi, L.3    Sutton, L.4    D'aquila, R.T.5
  • 53
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado, J., Savara, A.V., Sutton, L., D'aquila, R.T., 1999. Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J. Virol. 73, 3744-3752.
    • (1999) J. Virol. , vol.73 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3    D'aquila, R.T.4
  • 54
    • 0036642406 scopus 로고    scopus 로고
    • Reduced levels of CD4 cell spontaneous apoptosis in human immunodeficiency virus-infected patients with discordant response to protease inhibitors
    • Meroni, L., Varchetta, S., Manganaro, D., Gatti, N., Riva, A., Monforte, A., Galli, M., 2002. Reduced levels of CD4 cell spontaneous apoptosis in human immunodeficiency virus-infected patients with discordant response to protease inhibitors. J. Infect. Dis. 186, 143-144.
    • (2002) J. Infect. Dis. , vol.186 , pp. 143-144
    • Meroni, L.1    Varchetta, S.2    Manganaro, D.3    Gatti, N.4    Riva, A.5    Monforte, A.6    Galli, M.7
  • 55
    • 0035280944 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance. Resistance to protease inhibitors
    • Miller, V., 2001a. International perspectives on antiretroviral resistance. Resistance to protease inhibitors. J. Acquir. Immune. Defic. Syndr. 26 (Suppl. 1), S34-S50.
    • (2001) J. Acquir. Immune. Defic. Syndr. , vol.26 , Issue.SUPPL. 1
    • Miller, V.1
  • 56
    • 0035146527 scopus 로고    scopus 로고
    • Structured treatment interruptions in antiretroviral management of HIV-1
    • Miller, V., 2001b. Structured treatment interruptions in antiretroviral management of HIV-1. Curr. Opin. Infect. Dis. 14, 29-37.
    • (2001) Curr. Opin. Infect. Dis. , vol.14 , pp. 29-37
    • Miller, V.1
  • 57
    • 0033865498 scopus 로고    scopus 로고
    • Patterns of changes in human immunodeficiency virus type 1 V3 sequence populations late in infection
    • Nelson, J.A., Baribaud, F., Edwards, T., Swanstrom, R., 2000. Patterns of changes in human immunodeficiency virus type 1 V3 sequence populations late in infection. J. Virol. 74, 8494-8501.
    • (2000) J. Virol. , vol.74 , pp. 8494-8501
    • Nelson, J.A.1    Baribaud, F.2    Edwards, T.3    Swanstrom, R.4
  • 58
    • 0035141001 scopus 로고    scopus 로고
    • Implications of antiretroviral resistance on viral fitness
    • Nijhuis, M., Deeks, S., Boucher, C., 2001. Implications of antiretroviral resistance on viral fitness. Curr. Opin. Infect. Dis. 14, 23-28.
    • (2001) Curr. Opin. Infect. Dis. , vol.14 , pp. 23-28
    • Nijhuis, M.1    Deeks, S.2    Boucher, C.3
  • 59
    • 0032804864 scopus 로고    scopus 로고
    • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
    • Nijhuis, M., Schuurman, R., de Jong, D., Erickson, J., Gustchina, E., Albert, J., Schipper, P., Gulnik, S., Boucher, C.A., 1999. Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. AIDS 13, 2349-2359.
    • (1999) AIDS , vol.13 , pp. 2349-2359
    • Nijhuis, M.1    Schuurman, R.2    De Jong, D.3    Erickson, J.4    Gustchina, E.5    Albert, J.6    Schipper, P.7    Gulnik, S.8    Boucher, C.A.9
  • 61
  • 64
    • 0034040118 scopus 로고    scopus 로고
    • Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
    • Pierson, T., McArthur, J., Siliciano, R.F., 2000. Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu. Rev. Immunol. 18, 665-708.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 665-708
    • Pierson, T.1    McArthur, J.2    Siliciano, R.F.3
  • 65
    • 0035341522 scopus 로고    scopus 로고
    • Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen
    • Piketty, C., Weiss, L., Thomas, E, Mohamed, A.S., Belec, L., Kazatchkine, M.D., 2001. Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. J. Infect. Dis. 183, 1328-1335.
    • (2001) J. Infect. Dis. , vol.183 , pp. 1328-1335
    • Piketty, C.1    Weiss, L.2    Thomas, E.3    Mohamed, A.S.4    Belec, L.5    Kazatchkine, M.D.6
  • 67
    • 0001769435 scopus 로고    scopus 로고
    • HIV-1 fitness: Implications for drug resistance, disease progression, and global epidemic evolution
    • Kuiken, C., Foley, B., Hahn, B., Marx, P., McCutchan, F., Mellors, J., Wolinsky, S., Korber, B. (Eds.), Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM
    • Quiñones-Mateu, M.E., Arts, E.J., 2001. HIV-1 fitness: implications for drug resistance, disease progression, and global epidemic evolution. In: Kuiken, C., Foley, B., Hahn, B., Marx, P., McCutchan, F., Mellors, J., Wolinsky, S., Korber, B. (Eds.), HIV Sequence Compendium 2001, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, pp. 134-170.
    • (2001) HIV Sequence Compendium 2001 , pp. 134-170
    • Quiñones-Mateu, M.E.1    Arts, E.J.2
  • 70
    • 0031571885 scopus 로고    scopus 로고
    • Population dynamics studies of wild-type and drug-resistant mutant HIV in mixed infections
    • Rayner, M.M., Cordova, B., Jackson, D.A., 1997. Population dynamics studies of wild-type and drug-resistant mutant HIV in mixed infections. Virology 236, 85-94.
    • (1997) Virology , vol.236 , pp. 85-94
    • Rayner, M.M.1    Cordova, B.2    Jackson, D.A.3
  • 71
    • 0035793118 scopus 로고    scopus 로고
    • A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics
    • Resch, W., Parkin, N., Stuelke, E.L., Watkins, T., Swanstrom, R., 2001. A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics. Proc. Natl. Acad. Sci. U.S.A. 98, 176-181.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 176-181
    • Resch, W.1    Parkin, N.2    Stuelke, E.L.3    Watkins, T.4    Swanstrom, R.5
  • 72
    • 0036337934 scopus 로고    scopus 로고
    • Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly
    • Resch, W., Ziermann, R., Parkin, N., Gamamik, A., Swanstrom, R., 2002. Nelfinavir-resistant, amprenavir-hypersusceptible strains of human immunodeficiency virus type 1 carrying an N88S mutation in protease have reduced infectivity, reduced replication capacity, and reduced fitness and process the Gag polyprotein precursor aberrantly. J. Virol. 76, 8659-8666.
    • (2002) J. Virol. , vol.76 , pp. 8659-8666
    • Resch, W.1    Ziermann, R.2    Parkin, N.3    Gamamik, A.4    Swanstrom, R.5
  • 73
    • 0037016482 scopus 로고    scopus 로고
    • Discordant immunological response in HIV-positive patients on non-nucleoside reverse transcriptase inhibitor-based regimens
    • Ripamonti, D., Arici, C., Maggiolo, F., Finazzi, M.G., Suter, F., 2002. Discordant immunological response in HIV-positive patients on non-nucleoside reverse transcriptase inhibitor-based regimens. AIDS 16, 130-131.
    • (2002) AIDS , vol.16 , pp. 130-131
    • Ripamonti, D.1    Arici, C.2    Maggiolo, F.3    Finazzi, M.G.4    Suter, F.5
  • 74
    • 0034632745 scopus 로고    scopus 로고
    • HIV type 1 protease cleavage site mutations and viral fitness: Implications for drug susceptibility phenotyping assays
    • Robinson, L.H., Myers, R.E., Snowden, B.W., Tisdale, M., Blair, E.D., 2000. HIV type 1 protease cleavage site mutations and viral fitness: implications for drug susceptibility phenotyping assays. AIDS Res. Hum. Retroviruses 16, 1149-1156.
    • (2000) AIDS Res. Hum. Retroviruses , vol.16 , pp. 1149-1156
    • Robinson, L.H.1    Myers, R.E.2    Snowden, B.W.3    Tisdale, M.4    Blair, E.D.5
  • 76
    • 0030768138 scopus 로고    scopus 로고
    • Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation
    • published erratum appears in J Virol 1998 Apr;72(4):3504
    • Sharma, P.L., Crumpacker, C.S., 1997. Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation [published erratum appears in J Virol 1998 Apr;72(4):3504]. J. Virol. 71, 8846-8851.
    • (1997) J. Virol. , vol.71 , pp. 8846-8851
    • Sharma, P.L.1    Crumpacker, C.S.2
  • 77
    • 0032875344 scopus 로고    scopus 로고
    • Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: A comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val
    • Sharma, P.L., Crumpacker, C.S., 1999. Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val. J. Virol. 73, 8448-8456.
    • (1999) J. Virol. , vol.73 , pp. 8448-8456
    • Sharma, P.L.1    Crumpacker, C.S.2
  • 78
    • 0030816830 scopus 로고    scopus 로고
    • A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors
    • Shi, C., Mellors, J.W., 1997. A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors. Antimicrob. Agents Chemother. 41, 2781-2785.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2781-2785
    • Shi, C.1    Mellors, J.W.2
  • 80
    • 0033389039 scopus 로고    scopus 로고
    • Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype
    • Verhofstede, C., Wanzeele, F.V., Van Der, G.B., De Cabooter, N., Plum, J., 1999. Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype. AIDS 13, 2541-2546.
    • (1999) AIDS , vol.13 , pp. 2541-2546
    • Verhofstede, C.1    Wanzeele, F.V.2    Van Der, G.B.3    De Cabooter, N.4    Plum, J.5
  • 83
    • 0031977656 scopus 로고    scopus 로고
    • Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants
    • Yerly, S., Rakik, A., De Loes, S.K., Hirschel, B., Descamps, D., Brun-Vezinet, F., Perrin, L., 1998. Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants. J. Virol. 72, 3520-3523.
    • (1998) J. Virol. , vol.72 , pp. 3520-3523
    • Yerly, S.1    Rakik, A.2    De Loes, S.K.3    Hirschel, B.4    Descamps, D.5    Brun-Vezinet, F.6    Perrin, L.7


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