Fenitrothion alters sperm characteristics in rats: Ameliorating effects of palm oil tocotrienol-rich fraction

Experimental Animals

Volumn 63, Issue 4, 2014, Pages 383-393

  Taib, Izatus Shima ^a   Budin, Siti Balkis ^a   Ghazali, Ahmad Rohi ^a   Jayusman, Putri Ayu ^a   Mohamed, Jamaludin ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

Author keywords

Antioxidant; Organophosphate; Oxidative stress; Spermatozoa; Vitamin E

Indexed keywords

ALPHA TOCOTRIENOL; CORN OIL; FENITROTHION; GLUTATHIONE; MALONALDEHYDE; PALM OIL; PROTEIN; PROTEIN CARBONYL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ANTIOXIDANT; INSECTICIDE; VEGETABLE OIL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATTENUATION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; EPIDIDYMIS TAIL; FLUORESCENCE MICROSCOPY; LD 50; MALE; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; RAT; SEMEN ANALYSIS; SPERM QUALITY; SPERMATOZOON COUNT; SPERMATOZOON HEAD; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; VITAMIN SUPPLEMENTATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; ORAL DRUG ADMINISTRATION; PROTEIN CARBONYLATION; SPERMATOZOON; SPERMATOZOON CAPACITATION; SPRAGUE DAWLEY RAT;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; DNA DAMAGE; FENITROTHION; GLUTATHIONE; INSECTICIDES; MALE; MALONDIALDEHYDE; PLANT OILS; PROTEIN CARBONYLATION; RATS, SPRAGUE-DAWLEY; SPERM CAPACITATION; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TOCOTRIENOLS;

EID: 84908317548     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Ahmad, N.S., Khalid, B.A., Luke, D.A., and Ima Nirwana, S. 2005. Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone. Clin. Exp. Pharmacol. Physiol. 32: 761–770.
2. Aitken, R.J. and De Iuliis, G.N. 2010. On the possible origins of dna damage in human spermatozoa. Mol. Hum. Re-prod. 16: 3–13.
3. ben Abdallah, F., Fetoui, h., zribi, n., Fakfakh, F., and Ammar-Keskes, L. 2012. Antioxidant supplementations in vitro improve rat sperm parameters and enhance antioxidant enzyme activities against dimethoate-induced sperm damages. Andrologia 44: 272–279.
4. bebb, R.a., anawalt, b.d., Christensen, R.b., Paulsen, C.a., bremner, W.J., and matsumoto, a.m. 1996. Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach. J. Clin. Endocrinol. Metab. 81: 757–762.
5. beyer, W.F. Jr. and Fridovich, I. 1987. Assaying for super-oxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem. 161: 559–566.
6. budin, S.b., han, C.m., Jayusman, P.a., and Taib, I.S. 2012. Tocotrienol rich fraction prevents fenitrothion induced pancreatic damage by restoring antioxidant status. Pak. J. Biol. Sci. 15: 517–523.
7. budin, S.b., han, K.J., Jayusman, P.a., Taib, I.S., Ghazali, a.R., and mohamed, J. 2013. Antioxidant activity of Toco-trienol Rich Fraction Prevents Fenitrothion-induced Renal damage in Rats. J. Toxicol. Pathol. 26: 111–118.
8. budin, S.b., othman, F., louis, S.R., bakar, m.a., das, S., and mohamed, J. 2009. The effects of palm oil tocotrienol-rich fraction supplementation on biochemical parameters, oxidative stress and the vascular wall of streptozotocin-in-duced diabetic rats. Clinics (Sao Paulo) 64: 235–244.
9. burruel, V.R., Raabe, o.G., overstreet, J.W., Wilson, b.W., and Wiley, l.m. 2000. Paternal effects from methamidophos administration in mice. Toxicol. Appl. Pharmacol. 165: 148–157.
10. Chin, S.F., hamid, n.a.a., latiff, a.a., zakaria, z., mazlan, m., yusof, y.a.m., Karim, a.a., Ibahim, J., hamid, z., and ngah, W.z.W. 2008. Reduction of dna damage in older healthy adults by Tri e Tocotrienol supplementation. Nutrition 24: 1–10.
11. dizdaroglu, m., nackerdien, z., Chao, b.C., Gajewski, e., and Rao, G. 1991. Chemical nature of in vivo dna base damage in hydrogen peroxide-treated mammalian cells. Arch. Biochem. Biophys. 285: 388–390.
12. ecobichon, d.J., ozere, R.l., Reid, e., and Crocker, J.F.S. 1977. Acute fenitrothion poisoning. Can. Med. Assoc. J. 116: 377–379.
13. eitsuka, T., nakagawa, K., and miyazawa, T. 2006. Down-regulation of telomerase activity in dld-1 human colorectal adenocarcinoma cells by tocotrienol. Biochem. Biophys. Res. Commun. 348: 170–175.
14. elhalwagy, m.e.a., darwish, n.S., and zaher, e.m. 2008. Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide. Pestic. Biochem. Physiol. 91: 81–89.
15. ellman, G.l. 1959. Tissue sulfhydryl groups. Arch. Bio-chem. Biophys. 82: 70–77.
16. elmazoudy, R.h., attia, a.a., and el-Shenawy, n.S. 2011. Protective role of propolis against reproductive toxicity of chlorpyrifos in male rats. Pestic. Biochem. Physiol. 101: 175–181.
17. hughes, C.m., lewis, S.e., mcKelvey-martin, V.J., and Thompson, W. 1996. A comparison of baseline and induced dna damage in human spermatozoa from fertile and infertile men, using a modifed comet assay. Mol. Hum. Reprod. 2: 613–619.
18. Kamalakkannan, n. and Prince, P.S. 2003. Hypoglycaemic effect of water extracts of aegle marmelos fruits in strep-tozotocin diabetic rats. J. Ethnopharmacol. 87: 207–210.
19. Khanna, S., Patel, V., Rink, C., Roy, S., and Sen, C.K. 2005. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein defcient mice. Free Radic. Biol. Med. 39: 1310–1319.
20. Khanna, S., Roy, S., Ryu, h., bahadduri, P., Swaan, P.W., Ratan, R.R., and Sen, C.K. 2003. Molecular basis of vitamin e action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J. Biol. Chem. 278: 43508–43515.
21. Klinefelter, G.R., Strader, l.F., Suarez, J.d., and Roberts, n.l. 2002. Bromochloroacetic acid exerts qualitative effects on rat sperm: implications for a novel biomarker. Toxicol. Sci. 68: 164–173.
22. Krishnamoorthy, G., Venkataraman, P., arunkumar, a., Vignesh, R.C., aruldhas, m.m., and arunakaran, J. 2007. Ameliorative effect of vitamins (alpha-tocopherol and ascorbic acid) on PCb (aroclor 1254) induced oxidative stress in rat epididymal sperm. Reprod. Toxicol. 23: 239–245.
23. levine, R.l., Garland, d., oliver, C.n., amici, a., Climent, I., lenz, a.G., ahn, b.W., Shaltiel, S., and Stadtman, e.R. 1990. Determination of carbonyl content in oxidatively mod-ifed proteins. Methods Enzymol. 186: 464–478.
24. lowry, o.h., Rosebrough, n.J., Farr, a.l., and Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265–275.
25. Lukaszewicz-Hussain, A. 2010. Role of oxidative stress in organophosphate insecticide toxicity - Short review. Pestic. Biochem. Physiol. 98: 145–150.
26. matough, F.a., budin, S.b., hamid, z.a., louis, S.R., al-wahaibi, n., and mohamed, J. 2012. Palm vitamin e reduces oxidative stress, and physical and morphological alterations of erythrocyte membranes in streptozotocin-induced diabetic rats. Oxid. Antioxid. Med. Sci. 1: 59–68.
27. meeker, J.d., Singh, n.P., Ryan, l., duty, S.m., barr, d.b., herrick, R.F., bennett, d.h., and hauser, R. 2004. Urinary levels of insecticide metabolites and dna damage in human sperm. Hum. Reprod. 19: 2573–2580.
28. Milatovic, d., Gupta, R.C., and Aschner, M. 2006. Anticho-linesterase toxicity and oxidative stress. Scientifc World-Journal 6: 295–310.
29. okahashi, n., Sano, m., miyata, K., Tamano, S., higuchi, h., Kamita, y., and Seki, T. 2005. Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation. Toxicology 206: 17–31.
30. okamura, a., Kamijima, m., ohtani, K., yamanoshita, o., nakamura, d., Ito, y., miyata, m., ueyama, J., Suzuki, T., Imai, R., Takagi, K., and nakajima, T. 2009. Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophos-phorus pesticides in rats. J. Occup. Health 51: 478–487.
31. okamura, a., Kamijima, m., Shibata, e., ohtani, K., Takagi, K., ueyama, J., Watanabe, y., omura, m., Wang, h., Ichiha-ra, G., Kondo, T., and nakajima, T. 2005. A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats. Toxicology 213: 129–137.
32. Packer, l., Weber, S.u., and Rimbach, G. 2001. Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J. Nutr. 131: 369S–373S.
33. Padungtod, C., hassold, T.J., millie, e., Ryan, l.m., Sav-itz, d.a., Christiani, d.C., and Xu, X. 1999. Sperm aneu-ploidy among Chinese pesticide factory workers: scoring by the FISh method. Am. J. Ind. Med. 36: 230–238.
34. Pérez-herrera, n., Polanco-minaya, h., Salazar-arredondo, e., Solís-heredia, m.J., hernández-ochoa, I., Rojas-García, e., alvarado-mejía, J., borja-aburto, V.h., and Quintanilla-Vega, B. 2008. Pon1Q192R genetic polymorphism modi-fes organophosphorous pesticide effects on semen quality and dna integrity in agricultural workers from southern mexico. Toxicol. Appl. Pharmacol. 230: 261–268.
35. Piña-Guzmán, b., Solís-heredia, m.J., Rojas-García, a.e., urióstegui-acosta, m., and Quintanilla-Vega, B. 2006. Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress. Toxicol. Appl. Pharmacol. 216: 216–224.
36. Sakai, m., okabe, m., Tachibana, h., and Yamada, K. 2006. Apoptosis induction by gamma-tocotrienol in human hepa-toma hep3b cells. J. Nutr. Biochem. 17: 672–676.
37. Sarabia, l., maurer, I., and Bustos-Obregón, E. 2009. Mela-tonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm dna. Ecotoxicol. Environ. Saf. 72: 663–668.
38. Seed, J., Chapin, R.e., Clegg, e.d., dostal, l.a., Foote, R.h., hurtt, m.e., Klinefelter, G.R., makris, S.l., Perreault, S.d., Schrader, S., Seyler, d., Sprando, R., Treinen, K.a., Veeramachaneni, d.n., and Wise, l.d. 1996. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. IlSI Risk Science Institute expert Working Group on Sperm evaluation. Reprod. Toxicol. 10: 237–244.
39. Sen, C.K., Khanna, S., and Roy, S. 2006. Tocotrienols: Vitamin e beyond tocopherols. Life Sci. 78: 2088–2098.
40. Serbinova, e., Kagan, V., han, d., and Packer, L. 1991. Free radical recycling and intramembrane mobility in the antioxi-dant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic. Biol. Med. 10: 263–275.
41. Shibata, a., nakagawa, K., Sookwong, P., Tsuzuki, T., oika-wa, S., and miyazawa, T. 2008. Tumor anti-angiogenic effect and mechanism of action of delta-tocotrienol. Biochem. Pharmacol. 76: 330–339.
42. Sikka, S.C. 2004. Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J. Androl. 25: 5–18.
43. Stocks, J. and dormandy, T.l. 1971. The autoxidation of human red cell lipids induced by hydrogen peroxide. Br. J. Haematol. 20: 95–111.
44. Taib, I.S., budin, S.b., Ghazali, a.R., Jayusman, P.a., louis, S.R., and mohamed, J. 2013. Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male Sprague-dawley rats. Clinics (Sao Paulo) 68: 93–100.
45. Tamura, h., maness, S.C., Reischmann, K., dorman, d.C., Gray, l.e., and Gaido, K.W. 2001. Androgen receptor antagonism by the organophosphate insecticide fenitrothion. Toxicol. Sci. 60: 56–62.
46. Traber, m.G. and atkinson, J. 2007. Vitamin E, antioxidant and nothing more. Free Radic. Biol. Med. 43: 4–15.
47. Trivedi, P., Kushwaha, S., Tripathi, d., and Jena, G. 2010. Evaluation of male germ cell toxicity in rats: Correlation between sperm head morphology and sperm comet assay. Mutat. Res-Gen. Toxicol. En. 703: 115–121.
48. uygun, u., Koksel, h., and Atli, A. 2005. Residue levels of malathion and its metabolites and fenitrothion in post-harvest treatment wheat during storage, milling and baking. Food Chem. 92: 643–647.
49. uzun, F.G., Kalender, S., Durak, D., Demir, F., and Kalender, Y. 2009. Malathion-induced testicular toxicity in male rats and the protective effect of vitamins C and e. Food Chem. Toxicol. 47: 1903–1908.
50. uzunhisarcikli, m., Kalender, y., dirican, K., Kalender, S., ogutcu, a., and buyukkomurcu, F. 2007. Acute, subacute and subchronic administration of methyl parathion-induced testicular damage in male rats and protective role of vitamins C and e. Pestic. Biochem. Physiol. 87: 115–122.
51. Valko, m., Rhodes, C.J., moncol, J., Izakovic, m., and Mazur, m. 2006. Free radicals, metals and antioxidants in oxida-tive stress-induced cancer. Chem. Biol. Interact. 160: 1–40.
52. Villaverde, J., hildebrandt, a., martínez, e., lacorte, S., morillo, e., maqueda, C., Viana, P., and Barceló, D. 2008. Priority pesticides and their degradation products in river sediments from Portugal. Sci. Total Environ. 390: 507–513.
53. Wyrobek, a. and bruce, W. 1975. Chemical induction of sperm abnormalities in mice. P. Natl. Acad. Sci-Biol. 72: 4425–4429.
54. yap, W.n., zaiden, n., Tan, y.l., ngoh, C.P., zhang, X.W., Wong, y.C., ling, m.T., and yap, y.l. 2010. Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. Cancer Lett. 291: 187–199.
55. yucra, S., Rubio, J., Gasco, m., Gonzales, C., Steenland, K., and Gonzales, G.F. 2006. Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers. Int. J. Oc-cup. Environ. Health 12: 355–361.