Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation

Toxicology

Volumn 206, Issue 1, 2005, Pages 17-31

  Okahashi, Noriko ^a   Sano, Masashi ^b   Miyata, Kaori ^a   Tamano, Seiko ^b   Higuchi, Hashihiro ^a   Kamita, Yusuke ^a   Seki, Takaki ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b Daiyukai Research Institute for Medical Science   (Japan)

Author keywords

Anti androgen; Endocrine disrupter; Fenitrothion; o,o Dimethyl o (4 nitro m tolyl) phosphorothioate; Organophosphate insecticide; Reproductive study

Indexed keywords

CHOLINESTERASE; FERNITROTHION; ORGANOPHOSPHATE INSECTICIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BREAST AREOLA; CONTROLLED STUDY; DIET; ENDOCRINE SYSTEM; ENVIRONMENT; ENZYME ACTIVITY; EXPOSURE; FEMALE; HISTOPATHOLOGY; LACTATION; MALE; MATING; MATURATION; NONHUMAN; OBSERVATION; ORGAN WEIGHT; PARENT; PREGNANCY; PRIORITY JOURNAL; PROGENY; PUBERTY; RAT; REPRODUCTIVE TOXICITY; SENSITIVITY ANALYSIS; SPERM; WEANING;

ACETYLCHOLINESTERASE; ADMINISTRATION, ORAL; ANIMALS; BRAIN; ENDOCRINE SYSTEM; FEMALE; FENITROTHION; INSECTICIDES; MALE; NIPPLES; ORGAN SIZE; OVARIAN FOLLICLE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, INBRED STRAINS; SEXUAL MATURATION; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; VAGINA;

ANIMALIA;

EID: 10044229462     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.04.020     Document Type: Article

References (33)

1. J. Ashby, and P.A. Lefevre The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators J. Appl. Toxicol. 20 2000 35 47
2. A.B. Astroff, K.J. Freshwater, and D.A. Eigenberg Comparative organophosphate-induced effects observed in adult and neonatal Sprague-Dawley rats during the conduct of multigeneration toxicity studies Reprod. Toxicol. 12 1998 619 645
3. T.J. Bucci, B. Bolon, A.R. Warbritton, J.J. Chen, and J.J. Heindel Influence of sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies Reprod. Toxicol. 11 1997 689 696
4. C.W. Dunnett A multiple comparison procedure for comparing several means with a control J. Am. Stat. Assoc. 50 1955 1096 11121
5. L.E. Gray Jr., J. Ostby, V. Wilson, C. Lambright, K. Bobseine, P. Hartig, A. Hotchkiss, C. Wolf, J. Furr, M. Price, L. Parks, R.L. Cooper, T.E. Stoker, S.C. Laws, S.J. Degitz, K.M. Jensen, M.D. Kahl, J.J. Korte, E.A. Makynen, J.E. Tietge, and G.T. Ankley Xenoendocrine disrupters-tiered screening and testing: filling key data gaps Toxicology 181-182 2002 371 382
6. P.W. Harvey, and I. Johnson Approaches to the assessment of toxicity data with endpoints related to endocrine disruption J. Appl. Toxicol. 22 2002 241 247
7. J.J. Heindel Oocyte quantitation and ovarian histology G. Daston C.A. Kimmel An Evaluation and Interpretation of Reproductive Endpoints for Human Health Risk Assessment 1999 ILSI Press Washington, DC 57 74
8. R.R. Holson, B. Gough, P. Sullivan, T. Badger, and D.M. Sheehan Prenatal dexamethasone or stress but not ACTH or corticosterone alter sexual behavior in male rats Neurotoxicol. Teratol. 17 4 1995 393 401
9. JMPR, 2000. Pesticide residues in food 2000: FENITROTHION (First draft prepared by U. Mueller), pp. 133-180.
10. W.R. Kelce, C.R. Lambright, L.E. Gray Jr., and K.P. Roberts Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism Toxicol. Appl. Pharmacol. 142 1 1997 192 200
11. G.I. Keshet, and M. Weinstock Maternal naltrexone prevents morphological and behavioral alterations induced in rats by prenatal stress Pharmacol. Biochem. Behav. 50 3 1995 413 419
12. T. Kunimatsu, T. Yamada, K. Ose, O. Sunami, Y. Kamita, Y. Okuno, T. Seki, and I. Nakatsuka Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays Regul. Toxicol. Pharmacol. 35 2002 227 237
13. E. Mylchreest, D.G. Wallace, R.C. Cattley, and P.M.D. Foster Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation Toxicol Sci. 55 2000 143 151
14. T. Shono, T. Imajima, O. Zakaria, and S. Suita Does maternal stress induce abnormal descent of the testis in prepubertal rats? BJU Int. 84 1999 353 356
15. P. Sohoni, P.A. Lefevre, J. Ashby, and J.P. Sumpter Possible androgenic/anti-androgenic activity of the insecticide fenitrothion J. Appl. Toxicol. 21 3 2001 173 178
16. P. Sohoni, and J.P. Sumpter Several environmental oestrogens are also anti-androgens J. Endocrinol. 158 1998 327 339
17. R.G.D. Steel A multiple comparison rank sum test: treatments verses control Biometrics 15 1959 560 572
18. J.T. Stevens, A. Tobia, J.C. Lamb IV, C. Tellone, and F. O'Neal FIFRA Subdivision F testing Guidelines: are these tests adequate to detect potential hormonal activity for crop protection chemicals? J. Toxicol. Environ. Health. 50 1997 415 431
19. T.E. Stoker, L.G. Parks, L.E. Gray, and R.L. Cooper Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee Crit. Rev. Toxicol. 30 2 2000 197 252
20. O. Sunami, T. Kunimatsu, T. Yamada, S. Yabushita, T. Sukata, K. Miyata, Y. Kamita, Y. Okuno, T. Seki, I. Nakatsuka, and M. Matsuo Evaluation of a 5-day Hershberger assay using young mature male rats: methyltestosterone and p,p′-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo J. Toxicol. Sci. 25 2000 403 415
21. H. Tamura, S.C. Maness, K. Reischmann, D.C. Dorman, L.E. Gray, and K.W. Gaido Androgen receptor antagonism by the organophosphate insecticide fenitrothion Toxicol. Sci. 60 2001 56 62
22. H. Tamura, H. Yoshikawa, K.W. Gaido, S.M. Ross, R.K. DeLisle, W.J. Welsh, and A.M. Richard Interaction of organophosphate pesticides and related compounds with the androgen receptor Environ. Health. Perspect. 111 4 2003 545 552
23. K.J. Turner, N.J. Barlow, M.F. Struve, D.G. Wallace, K.W. Gaido, D.C. Dorman, and P.M. Foster Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat Toxicol. Sci. 68 2002 174 183
24. US EPA, 1994. HED chapter of the registration eligibility decision document for fenitrothion.
25. US EPA, 1998. EDSTAC Final Report. http://www.epa.gov/scipoly/oscpendo/ history/finalrpt.htm.
26. US EPA, 2000a. Responses to public comments on the office of pesticide program's science policy: The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorus and Carbamate Pesticides.
27. USEPA, 2000b. The Use of Data on Cholinesterase Inhibition for Risk Assessments of Organophosphorous and Carbamate Pesticides.
28. I.L. Ward, and K.E. Stehm Prenatal stress feminizes juvenile play patterns in male rats Physiol. Behav. 50 3 1991 601 605
29. I.L. Ward, O.B. Ward, R.J. Winn, and D. Bielawski Male and female sexual behavior potential of male rats prenatally exposed to the influence of alcohol, stress, or both factors Behav. Neurosci. 108 6 1994 1188 1195
30. WHO, 1992. Fenitrothion. In: Environmental Health Criteria, p. 133.
31. WHO JMPR. 1999. FAO/WHO Joint Meeting on Pesticide Residues. Report of the 1998FAO/WHO Joint Meeting on Pesticide Residues. Food and Agricultural Organization-United Nations. Rome, Italy.
32. M.T. Williams, M.B. Hennessy, and H.N. Davis Stress during pregnancy alters rat offspring morphology and ultrasonic vocalizations Physiol. Behav. 63 3 1998 337 343
33. B.J. Winer Statistical Principles in Experimental Design 1971 McGraw-Hill New York