HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation

PLoS Pathogens

Volumn 10, Issue 10, 2014, Pages

  Choi, Young Bong ^a   Harhaj, Edward William ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CELL PROTEIN; GLUTATHIONE TRANSFERASE; I KAPPA B KINASE; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; LATENT MEMBRANE PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN MCL 1; PROTEOME; TAX PROTEIN; TOLL LIKE RECEPTOR; TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; VOLTAGE DEPENDENT ANION CHANNEL 1; LYSINE; MCL1 PROTEIN, HUMAN; MCL1 PROTEIN, MOUSE; POLYUBIQUITIN; TAX PROTEIN, HUMAN T-LYMPHOTROPHIC VIRUS 1;

APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL IMMORTALIZATION; CELL SURVIVAL; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRION; PLASMID; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RNA ISOLATION; UBIQUITINATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; DNA DAMAGE; HUMAN T-LYMPHOTROPIC VIRUS 1; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES;

HUMAN T-LYMPHOTROPIC VIRUS 1;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LYSINE; MASS SPECTROMETRY; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NF-KAPPA B; POLYUBIQUITIN; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84908244416     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004458     Document Type: Article

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