-
1
-
-
84655161946
-
HIF1a and HIF2a: Sibling rivalry in hypoxic tumour growth and progression
-
Keith B, Johnson RS, Simon MC. HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 2011;12: 9-22.
-
(2011)
Nat Rev Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson WR, Hay MP. Targeting hypoxia in cancer therapy. Nat Rev Cancer 2011;11:393-410.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
4
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
5
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002;29:15-8.
-
(2002)
Semin Oncol
, vol.29
, pp. 15-18
-
-
Folkman, J.1
-
6
-
-
84863338304
-
Ubiquitination in signaling to and activation of IKK
-
Chen ZJ. Ubiquitination in signaling to and activation of IKK. Immunol Rev 2012;246:95-106.
-
(2012)
Immunol Rev
, vol.246
, pp. 95-106
-
-
Chen, Z.J.1
-
7
-
-
67650744586
-
The role of ubiquitin in NF-kB regulatory pathways
-
Skaug B, Jiang X, Chen ZJ. The role of ubiquitin in NF-kB regulatory pathways. Annu Rev Biochem 2009;78:769-96.
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 769-796
-
-
Skaug, B.1
Jiang, X.2
Chen, Z.J.3
-
8
-
-
20344368856
-
Role of TRAF6 in the immune system
-
Choi Y. Role of TRAF6 in the immune system. Adv Exp Med Biol 2005; 560:77-82.
-
(2005)
Adv Exp Med Biol
, vol.560
, pp. 77-82
-
-
Choi, Y.1
-
9
-
-
0035475338
-
Tumor necrosis factor receptor-associated factors (TRAFs)
-
Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 2001;20:6482-91.
-
(2001)
Oncogene
, vol.20
, pp. 6482-6491
-
-
Bradley, J.R.1
Pober, J.S.2
-
10
-
-
35348829146
-
Roles of TRAF6 in CD40 signaling
-
Hostager BS. Roles of TRAF6 in CD40 signaling. Immunol Res 2007;39:105-14.
-
(2007)
Immunol Res
, vol.39
, pp. 105-114
-
-
Hostager, B.S.1
-
11
-
-
84934443656
-
TRAFs in RANK signaling
-
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ. TRAFs in RANK signaling. Adv Exp Med Biol 2007;597:152-9.
-
(2007)
Adv Exp Med Biol
, vol.597
, pp. 152-159
-
-
Darnay, B.G.1
Besse, A.2
Poblenz, A.T.3
Lamothe, B.4
Jacoby, J.J.5
-
12
-
-
73849121794
-
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
-
Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med 2010;16:49-58.
-
(2010)
Nat Med
, vol.16
, pp. 49-58
-
-
Starczynowski, D.T.1
Kuchenbauer, F.2
Argiropoulos, B.3
Sung, S.4
Morin, R.5
Muranyi, A.6
-
13
-
-
77249119762
-
The landscape of somatic copynumber alteration across human cancers
-
Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copynumber alteration across human cancers. Nature 2010;463:899-905.
-
(2010)
Nature
, vol.463
, pp. 899-905
-
-
Beroukhim, R.1
Mermel, C.H.2
Porter, D.3
Wei, G.4
Raychaudhuri, S.5
Donovan, J.6
-
14
-
-
80053389114
-
TRAF6 is an amplified oncogene bridging the RAS and NF-kB pathways in human lung cancer
-
Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M, et al. TRAF6 is an amplified oncogene bridging the RAS and NF-kB pathways in human lung cancer. J Clin Invest 2011;121: 4095-105.
-
(2011)
J Clin Invest
, vol.121
, pp. 4095-4105
-
-
Starczynowski, D.T.1
Lockwood, W.W.2
Delehouzee, S.3
Chari, R.4
Wegrzyn, J.5
Fuller, M.6
-
15
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
17
-
-
77956526505
-
TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alphasynuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains
-
Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, et al. TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alphasynuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. Hum Mol Genet 2010;19:3759-70.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3759-3770
-
-
Zucchelli, S.1
Codrich, M.2
Marcuzzi, F.3
Pinto, M.4
Vilotti, S.5
Biagioli, M.6
-
18
-
-
33947506493
-
Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of i kappa B kinase activation
-
Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem 2007;282:4102-12.
-
(2007)
J Biol Chem
, vol.282
, pp. 4102-4112
-
-
Lamothe, B.1
Besse, A.2
Campos, A.D.3
Webster, W.K.4
Wu, H.5
Darnay, B.G.6
-
19
-
-
84859994526
-
PVHL mediates K63- linked ubiquitination of nCLU
-
Xue J, Lv DD, Jiao S, Zhao WT, Li XB, Sun H, et al. pVHL mediates K63- linked ubiquitination of nCLU. PLoS ONE 2012;7:e35848.
-
(2012)
PLoS ONE
, vol.7
-
-
Xue, J.1
Lv, D.D.2
Jiao, S.3
Zhao, W.T.4
Li, X.B.5
Sun, H.6
-
20
-
-
33846842258
-
Chrysin inhibits expression of HIF-1a through reducing HIF-1a stability and inhibiting its protein synthesis
-
Fu BB, Xue J, Li ZD, Shi X, Jiang BH, Fang J. Chrysin inhibits expression of HIF-1a through reducing HIF-1a stability and inhibiting its protein synthesis. Mol Cancer Ther 2007;6:220-6.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 220-226
-
-
Fu, B.B.1
Xue, J.2
Li, Z.D.3
Shi, X.4
Jiang, B.H.5
Fang, J.6
-
21
-
-
75149150805
-
Prolyl hydroxylase-3 is downregulated in colorectal cancer cells and inhibits IKKb, independent of hydroxylase activity
-
Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J. Prolyl hydroxylase-3 is downregulated in colorectal cancer cells and inhibits IKKb, independent of hydroxylase activity. Gastroenterology 2010;138: 606-15.
-
(2010)
Gastroenterology
, vol.138
, pp. 606-615
-
-
Xue, J.1
Li, X.2
Jiao, S.3
Wei, Y.4
Wu, G.5
Fang, J.6
-
22
-
-
57349181198
-
Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase
-
Hu XW, Meng D, Fang J. Apigenin inhibited migration and invasion of human ovarian cancer A2780 cells through focal adhesion kinase. Carcinogenesis 2008;29:2369-76.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2369-2376
-
-
Hu, X.W.1
Meng, D.2
Fang, J.3
-
23
-
-
77950473770
-
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia- inducible factor (HIF)-1a but not HIF-2a
-
Luo W, Zhong J, Chang R, Hu H, Pandey A, Gregg Semenza L. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia- inducible factor (HIF)-1a but not HIF-2a. J Biol Chem 2010;285: 3651-63.
-
(2010)
J Biol Chem
, vol.285
, pp. 3651-3663
-
-
Luo, W.1
Zhong, J.2
Chang, R.3
Hu, H.4
Pandey, A.5
Gregg Semenza, L.6
-
24
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O (2)-independent and HSP90 inhibitor-induced degradation of HIF- 1alpha
-
Liu YV, Baek JH, Zhang H, Diez R, Cole RN, Semenza GL. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O (2)-independent and HSP90 inhibitor-induced degradation of HIF- 1alpha. Mol Cell 2007;25:207-17.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
25
-
-
0347334750
-
IL-1beta-mediated upregulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-mediated upregulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003;17:2115-7.
-
(2003)
FASEB J
, vol.17
, pp. 2115-2117
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
26
-
-
44849100198
-
NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a
-
Rius J,GumaM, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1a. Nature 2008;453:807-12.
-
(2008)
Nature
, vol.453
, pp. 807-812
-
-
Rius, J.1
Guma, M.2
Schachtrup, C.3
Akassoglou, K.4
Zinkernagel, A.S.5
Nizet, V.6
-
27
-
-
76249086685
-
CD40 ligand-induced carcinoma cell death: A balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals
-
Elmetwali T, Young LS, Palmer DH. CD40 ligand-induced carcinoma cell death: a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals. J Immunol 2010;184:1111-20.
-
(2010)
J Immunol
, vol.184
, pp. 1111-1120
-
-
Elmetwali, T.1
Young, L.S.2
Palmer, D.H.3
-
28
-
-
0034326624
-
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
-
Zapata JM, Krajewska M, Krajewski S, Krajewski S, Kitada S, Welsh K, et al. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol 2000;165:5084-96.
-
(2000)
J Immunol
, vol.165
, pp. 5084-5096
-
-
Zapata, J.M.1
Krajewska, M.2
Krajewski, S.3
Krajewski, S.4
Kitada, S.5
Welsh, K.6
-
29
-
-
84855201584
-
Renal cell carcinoma: Resistance to therapy, role of apoptosis, and the prognostic and therapeutic target potential of TRAF proteins
-
Rajandram R, Bennett NC, Morais C, Johnson DW, Gobe GC. Renal cell carcinoma: resistance to therapy, role of apoptosis, and the prognostic and therapeutic target potential of TRAF proteins. Med Hypotheses 2012;78:330-6.
-
(2012)
Med Hypotheses
, vol.78
, pp. 330-336
-
-
Rajandram, R.1
Bennett, N.C.2
Morais, C.3
Johnson, D.W.4
Gobe, G.C.5
-
30
-
-
77149164456
-
The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential
-
Starska K, Forma E, Lewy-Trenda I, Stasikowska O, Brys M, Krajewska WM, et al. The expression of SOCS1 and TLR4-NFkappaB pathway molecules in neoplastic cells as potential. Folia Histochem Cytobiol 2009;47:401-10.
-
(2009)
Folia Histochem Cytobiol
, vol.47
, pp. 401-410
-
-
Starska, K.1
Forma, E.2
Lewy-Trenda, I.3
Stasikowska, O.4
Brys, M.5
Krajewska, W.M.6
-
31
-
-
33644838832
-
MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells
-
Hirata Y, Ohmae T, Shibata W, Maeda S, Ogura K, Yoshida H, et al. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. J Immunol 2006;176:3796-803.
-
(2006)
J Immunol
, vol.176
, pp. 3796-3803
-
-
Hirata, Y.1
Ohmae, T.2
Shibata, W.3
Maeda, S.4
Ogura, K.5
Yoshida, H.6
-
32
-
-
79952716229
-
Contribution of IL-17-producing gammadeltaTcells to the efficacy of anticancer chemotherapy
-
Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, et al. Contribution of IL-17-producing gammadeltaTcells to the efficacy of anticancer chemotherapy. J Exp Med 2011;208:491-503.
-
(2011)
J Exp Med
, vol.208
, pp. 491-503
-
-
Ma, Y.1
Aymeric, L.2
Locher, C.3
Mattarollo, S.R.4
Delahaye, N.F.5
Pereira, P.6
-
33
-
-
79959252739
-
Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6
-
Ma T, Wang N, Su Z, Chen L, Zhu N, Ma C, et al. Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6. Mol Cell Biochem 2011b;352:77-85.
-
(2011)
Mol Cell Biochem
, vol.352
, pp. 77-85
-
-
Ma, T.1
Wang, N.2
Su, Z.3
Chen, L.4
Zhu, N.5
Ma, C.6
-
34
-
-
0037073695
-
Induction of hypoxia-inducible factor 1a by transcriptional and translational mechanisms
-
Page EL, Robitaille GA, Pouyssegur J, Richard DE. Induction of hypoxia-inducible factor 1a by transcriptional and translational mechanisms. J Biol Chem 2002;277:48403-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 48403-48409
-
-
Page, E.L.1
Robitaille, G.A.2
Pouyssegur, J.3
Richard, D.E.4
-
35
-
-
23144449583
-
Delivery of ubiquitinated substrates to proteinunfolding machines
-
Elsasser S, Finley D. Delivery of ubiquitinated substrates to proteinunfolding machines. Nat Cell Biol 2005;7:742-9.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 742-749
-
-
Elsasser, S.1
Finley, D.2
-
36
-
-
69549116880
-
The E3 ligase TRAF6 regulates AKT ubiquitination and activation
-
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, et al. The E3 ligase TRAF6 regulates AKT ubiquitination and activation. Science 2009;325:1134-8.
-
(2009)
Science
, vol.325
, pp. 1134-1138
-
-
Yang, W.L.1
Wang, J.2
Chan, C.H.3
Lee, S.W.4
Campos, A.D.5
Lamothe, B.6
-
37
-
-
84874105225
-
Pro-angiogenic activity of TLRs and NLRs: A novel link between Gut microbiota and intestinal angiogenesis
-
Schirbel A, Kessler S, Rieder F, West G, Rebert N, Asosingh K, et al. Pro-angiogenic activity of TLRs and NLRs: a novel link between Gut microbiota and intestinal angiogenesis. Gastroenterology 2013;144: 613-23.
-
(2013)
Gastroenterology
, vol.144
, pp. 613-623
-
-
Schirbel, A.1
Kessler, S.2
Rieder, F.3
West, G.4
Rebert, N.5
Asosingh, K.6
-
38
-
-
84875683676
-
TNF receptorassociated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells
-
Peng Z, Shuangzhu Y, Yongjie J, Xinjun Z, Ying L. TNF receptorassociated factor 6 regulates proliferation, apoptosis, and invasion of glioma cells. Mol Cell Biochem 2013;377:87-96.
-
(2013)
Mol Cell Biochem
, vol.377
, pp. 87-96
-
-
Peng, Z.1
Shuangzhu, Y.2
Yongjie, J.3
Xinjun, Z.4
Ying, L.5
|