TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell

Molecular and Cellular Biochemistry

Volumn 371, Issue 1-2, 2012, Pages 177-186

  Meng, Qingbing ^a   Zheng, Minqian ^a   Liu, Hongbing ^a   Song, Changzhi ^a   Zhang, Wensheng ^a   Yan, Juan ^a   Qin, Ling ^a   Liu, Xiaolan ^a  

^a Yancheng City No1 People's Hospital   (China)

Author keywords

Invasion; Osteosarcoma; RNA interference; TRAF6

Indexed keywords

CASPASE 3; CRYSTAL VIOLET; CYCLIN D1; CYTOMEGALOVIRUS ANTIGEN PP65; GELATINASE B; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; BONE TISSUE; CANCER INVASION; CARCINOGENESIS; CELL INVASION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG METASTASIS; MALE; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRESCHOOL CHILD; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SCHOOL CHILD; SIGNAL TRANSDUCTION; TISSUES; TUMOR VOLUME; WESTERN BLOTTING;

ADOLESCENT; ADULT; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHILD; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; NEOPLASM INVASIVENESS; OSTEOSARCOMA; RNA INTERFERENCE; RNA, MESSENGER; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84868537497     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1434-4     Document Type: Article

References (43)

1. PosthumaDeBoer J, Witlox MA, Kaspers GJ, van Royen BJ (2011) Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature. Clin Exp Metastasis 28:493-503
2. Bielack SS, Carrle D, Hardes J, Schuck A, Paulussen M (2008) Bone tumors in adolescents and young adults. Curr Treat Options Oncol 9:67-80
3. Harting MT, Blakely ML (2006) Management of osteosarcoma pulmonary metastases. Semin Pediatr Surg 15:25-29
4. Zwaga T, Bovee JV, Kroon HM (2008) Osteosarcoma of the femur with skip, lymph node, and lung metastases. Radiographics 28:277-283
5. Shen A, Zhang Y, Yang H, Xu R, Huang G (2012) Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. J Surg Oncol 105:830-834
6. Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E (2004) Defining the epithelial stem cell niche in skin. Science 303:359-363
7. Spradling A, Drummond-Barbosa D, Kai T (2001) Stem cells find their niche. Nature 414:98-104
8. Bradley JR, Pober JS (2001) Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20:6482-6491
9. Wixted JH, Rothstein JL, Eisenlohr LC (2012) Identification of functionally distinct TRAF proinflammatory and phosphatidylinositol 3-kinase/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (PI3K/MEK) transforming activities emanating from RET/PTC fusion oncoprotein. J Biol Chem 287:3691-3703
10. Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T (2000) Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp Cell Res 254:14-24
11. Rothe M, Wong SC, Henzel WJ, Goeddel DV (1994) A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-692
12. Avila M, Martinez-Juarez A, Ibarra-Sanchez A, Gonzalez-Espinosa C (2012) Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells. Innate Immun 18:648-660
13. Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (1996) TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci USA 93:9437-9442
14. Ishida T, Mizushima S, Azuma S, Kobayashi N, Tojo T, Suzuki K, Aizawa S, Watanabe T, Mosialos G, Kieff E et al (1996) Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem 271:28745-28748
15. Xu LG, Li LY, Shu HB (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem 279:17278-17282
16. Xu Y, Cheng G, Baltimore D (1996) Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity 5:407-415
17. Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (1995) Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J Biol Chem 270:25715-25721
18. Takeuchi M, Rothe M, Goeddel DV (1996) Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J Biol Chem 271:19935-19942
19. Soni V, Cahir-McFarland E, Kieff E (2007) LMP1 TRAFficking activates growth and survival pathways. Adv Exp Med Biol 597:173-187
20. Rothe M, Sarma V, Dixit VM, Goeddel DV (1995) TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 269:1424-1427
21. Landstrom M (2010) The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol 42:585-589
22. Lee SY, Choi Y (2007) TRAF1 and its biological functions. Adv Exp Med Biol 597:25-31
23. Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T et al (1999) Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4:353-362
24. Chung JY, Park YC, Ye H, Wu H (2002) All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci 115:679-688
25. Vaiopoulos AG, Papachroni KK, Papavassiliou AG (2010) Colon carcinogenesis: learning from NF-kappaB and AP-1. Int J Biochem Cell Biol 42:1061-1065
26. Cooper SJ, Bowden GT (2007) Ultraviolet B regulation of transcription factor families: roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis. Curr Cancer Drug Targets 7:325-334
27. King CG, Kobayashi T, Cejas PJ, Kim T, Yoon K, Kim GK, Chiffoleau E, Hickman SP, Walsh PT, Turka LA et al (2006) TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 12:1088-1092
28. Lamothe B, Webster WK, Gopinathan A, Besse A, Campos AD, Darnay BG (2007) TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun 359:1044-1049
29. Poblenz AT, Jacoby JJ, Singh S, Darnay BG (2007) Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides. Biochem Biophys Res Commun 359:510-515
30. Ramachandran C, Rodriguez S, Ramachandran R, Raveendran Nair PK, Fonseca H, Khatib Z, Escalon E, Melnick SJ (2005) Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res 25:3293-3302
31. Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M, Tsao MS, Lam S, Gazdar AF, Lam WL et al (2011) TRAF6 is an amplified oncogene bridging the RAS and NF-kappaB pathways in human lung cancer. J Clin Invest 121:4095-4105
32. Ma T, Wang N, Su Z, Chen L, Zhu N, Ma C, Chen X, Chen H (2011) Characterization of apoptosis and proliferation in esophageal carcinoma EC109 cells following siRNA-induced down-regulation of TRAF6. Mol Cell Biochem 352:77-85
33. Liu H, Tamashiro S, Baritaki S, Penichet M, Yu Y, Chen H, Berenson J, Bonavida B (2012) TRAF6 activation in multiple myeloma: a potential therapeutic target. Clin Lymphoma Myeloma Leuk 12:155-163
34. Chaudhry SI, Hooper S, Nye E, Williamson P, Harrington K, Sahai E (2012) Autocrine IL-1beta-TRAF6 signalling promotes squamous cell carcinoma invasion through paracrine TNFalpha signalling to carcinoma-associated fibroblasts. Oncogene. doi: 10.1038/onc.2012.1091onc201291
35. Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 153:106-120
36. Ben-David D, Livne E, Reznick AZ (2012) The involvement of oxidants and NF-kappaB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Inflamm Res 61:673-688
37. Wang SJ, Sun B, Pan SH, Chen H, Kong R, Li J, Xue DB, Bai XW, Jiang HC (2010) Experimental study of the function and mechanism combining dihydroartemisinin and gemcitabine in treating pancreatic cancer. Zhonghua Wai Ke Za Zhi 48:530-534
38. Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B (2012) Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in pancreatic cancer both in vitro and in vivo. J Cancer Res Clin Oncol 138:785-797
39. Ilvesaro JM, Merrell MA, Li L, Wakchoure S, Graves D, Brooks S, Rahko E, Jukkola-Vuorinen A, Vuopala KS, Harris KW et al (2008) Toll-like receptor 9 mediates CpG oligonucleotide-induced cellular invasion. Mol Cancer Res 6:1534-1543
40. Starska K, Forma E, Brys M, Glowacka E, Lewy-Trenda I, Lukomski M, Krajewska WM (2012) The expression of TLR pathway molecules in peripheral blood mononuclear cells and their relationship with tumor invasion and cytokine secretion in laryngeal carcinoma. Adv Med Sci 57:124-135
41. Chen YY, Chiang SY, Lin JG, Ma YS, Liao CL, Weng SW, Lai TY, Chung JG (2010) Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int J Oncol 36:1113-1120
42. Kim A, Kim MJ, Yang Y, Kim JW, Yeom YI, Lim JS (2009) Suppression of NF-kappaB activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells. Carcinogenesis 30:927-936
43. Argast GM, Krueger JS, Thomson S, Sujka-Kwok I, Carey K, Silva S, O'Connor M, Mercado P, Mulford IJ, Young GD et al (2011) Inducible expression of TGFbeta, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model. Clin Exp Metastasis 28:593-614