Efficient intracellular delivery and multiple-target gene silencing triggered by tripodal RNA based nanoparticles: A promising approach in liver-specific RNAi delivery

Journal of Controlled Release

Volumn 196, Issue , 2014, Pages 28-36

  Sajeesh, S ^a   Lee, Tae Yeon ^a   Kim, Joon Ki ^a   Son, Da Seul ^a   Hong, Sun Woo ^a   Kim, Soohyun ^a   Yun, Wan Soo ^a   Kim, Soyoun ^b   Chang, Chanil ^c   Li, Chiang ^d   Lee, Dong Ki ^a  

^a Sungkyunkwan University   (South Korea)

^b Dongguk University   (South Korea)

^c BMT Inc   (South Korea)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Liver targeting; Nanoparticles; Polyethyleneimine; RNA interference; Tripodal interfering RNA (tiRNA)

Indexed keywords

INTRACELLULAR DELIVERY; LIVER TARGETING; POLYETHYLENEIMINE; RNA INTERFERENCE; TARGET GENES; TRIPODAL-INTERFERING RNA (TIRNA);

NANOPARTICLES;

APOLIPOPROTEIN B; GALACTOSE; NANOPARTICLE; POLYETHYLENEIMINE; RNA; SINGLE STRANDED RNA; SMALL INTERFERING RNA; TRIPODAL INTERFERING RNA; UNCLASSIFIED DRUG; CYTOKINE; IMMUNOLOGICAL ADJUVANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; FEMALE; GENE SILENCING; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER; MOUSE; MOUSE MODEL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEIC ACID STRUCTURE; PARTICLE SIZE; RNA INTERFERENCE; RNA STRUCTURE; SINGLE DRUG DOSE; STATIC ELECTRICITY; ZETA POTENTIAL; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; TISSUE DISTRIBUTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; DRUG DELIVERY SYSTEMS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HELA CELLS; HUMANS; LIVER; MICE; MICE, INBRED C57BL; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84908191349     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.09.016     Document Type: Article

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