Dual-target gene silencing by using long, synthetic siRNA duplexes without triggering antiviral responses

Molecules and Cells

Volumn 27, Issue 6, 2009, Pages 689-695

  Chang, Chan Il ^a   Kang, Hye Suk ^a   Ban, Changill ^b   Kim, Soyoun ^c   Lee, Dong Ki ^a  

^a Sungkyunkwan University   (South Korea)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

Antiviral response; Dual target; Off target effect; RNA interference; siRNA

Indexed keywords

DOUBLE STRANDED RNA; DUAL TARGETED SMALL INTERFERING RNA; INTERFERON; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; INNATE IMMUNITY; INTERFERON INDUCTION; RNA INTERFERENCE; RNA STRUCTURE;

BASE PAIRING; BASE SEQUENCE; GENE SILENCING; HELA CELLS; HUMANS; IMMUNITY, INNATE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HETERODUPLEXES; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; VIRUSES;

EID: 67650293582     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10059-009-0093-0     Document Type: Article

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