메뉴 건너뛰기




Volumn 38, Issue 11, 2010, Pages 3771-3779

Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISC

Author keywords

[No Author keywords available]

Indexed keywords

DICER; DOUBLE STRANDED RNA; RNA INDUCED SILENCING COMPLEX;

EID: 77954350917     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq055     Document Type: Article
Times cited : (24)

References (33)
  • 1
    • 34848828540 scopus 로고    scopus 로고
    • Small RNAs: regulators and guardians of the genome
    • Chu,C.Y. and Rana,T.M. (2007) Small RNAs: regulators and guardians of the genome. J. Cell. Physiol., 213, 412-419.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 412-419
    • Chu, C.Y.1    Rana, T.M.2
  • 2
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21-and 22-nucleotide RNAs
    • Elbashir,S.M., Lendeckel,W. and Tuschl,T. (2001) RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 3
    • 23244435548 scopus 로고    scopus 로고
    • State-of-the-art modified RNAi compounds for therapeutics
    • Carstea,E.D., Hough,S., Wiederholt,K. and Welch,P.J. (2005) State-of-the-art modified RNAi compounds for therapeutics. IDrugs, 8, 642-647.
    • (2005) IDrugs , vol.8 , pp. 642-647
    • Carstea, E.D.1    Hough, S.2    Wiederholt, K.3    Welch, P.J.4
  • 5
    • 36148933567 scopus 로고    scopus 로고
    • Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity
    • Kubo,T., Zhelev,Z., Ohba,H. and Bakalova,R. (2007) Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity. Oligonucleotides, 17, 445-464.
    • (2007) Oligonucleotides , vol.17 , pp. 445-464
    • Kubo, T.1    Zhelev, Z.2    Ohba, H.3    Bakalova, R.4
  • 6
    • 0041331496 scopus 로고    scopus 로고
    • siRNA function in RNAi: a chemical modification analysis
    • Chiu,Y.L. and Rana,T.M. (2003) siRNA function in RNAi: a chemical modification analysis. RNA, 9, 1034-1048.
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.L.1    Rana, T.M.2
  • 10
    • 37549014207 scopus 로고    scopus 로고
    • Argonaute proteins: key players in RNA silencing
    • Hutvagner,G. and Simard,M.J. (2008) Argonaute proteins: key players in RNA silencing. Nat. Rev. Mol. Cell Biol., 9, 22-32.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 22-32
    • Hutvagner, G.1    Simard, M.J.2
  • 13
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy,A.A., Myers,M., Hannon,G.J. and Hammond,S.M. (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev., 16, 2491-2496.
    • (2002) Genes Dev. , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 14
    • 33646050344 scopus 로고    scopus 로고
    • Delivery of short hairpin RNAs-triggers of gene silencing-into mouse embryonic stem cells
    • Schaniel,C., Li,F., Schafer,X.L., Moore,T., Lemischka,I.R. and Paddison,P.J. (2006) Delivery of short hairpin RNAs-triggers of gene silencing-into mouse embryonic stem cells. Nat. Methods, 3, 397-400.
    • (2006) Nat. Methods , vol.3 , pp. 397-400
    • Schaniel, C.1    Li, F.2    Schafer, X.L.3    Moore, T.4    Lemischka, I.R.5    Paddison, P.J.6
  • 15
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in drosophila melanogaster embryo lysate
    • Elbashir,S.M., Martinez,J., Patkaniowska,A., Lendeckel,W. and Tuschl,T. (2001) Functional anatomy of siRNAs for mediating efficient RNAi in drosophila melanogaster embryo lysate. EMBO J., 20, 6877-6888.
    • (2001) EMBO J. , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 16
    • 0025136271 scopus 로고
    • Specificity of restriction endonucleases and DNA modification methyltransferases a review
    • (edition 3)
    • Kessler,C. and Manta,V. (1990) Specificity of restriction endonucleases and DNA modification methyltransferases a review (edition 3). Gene, 92, 1-248.
    • (1990) Gene , vol.92 , pp. 1-248
    • Kessler, C.1    Manta, V.2
  • 17
    • 1342306353 scopus 로고    scopus 로고
    • Effects on RNAi of the tight structure, sequence and position of the targeted region
    • Yoshinari,K., Miyagishi,M. and Taira,K. (2004) Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res., 32, 691-699.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 691-699
    • Yoshinari, K.1    Miyagishi, M.2    Taira, K.3
  • 20
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung,S., Kim,Y.J., Kim,S., Park,H.O. and Choi,Y.C. (2006) Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun., 342, 919-927.
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.O.4    Choi, Y.C.5
  • 21
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen,A., Haley,B. and Zamore,P.D. (2001) ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell, 107, 309-321.
    • (2001) Cell , vol.107 , pp. 309-321
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 22
    • 36148933344 scopus 로고    scopus 로고
    • Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect
    • Kubo,T., Zhelev,Z., Ohba,H. and Bakalova,R. (2008) Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect. Biochem. Biophys. Res. Commun., 365, 54-61.
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 54-61
    • Kubo, T.1    Zhelev, Z.2    Ohba, H.3    Bakalova, R.4
  • 23
    • 40649086065 scopus 로고    scopus 로고
    • Structural and biochemical insights into the dicing mechanism of mouse dicer: a conserved lysine is critical for dsRNA cleavage
    • Du,Z., Lee,J.K., Tjhen,R., Stroud,R.M. and James,T.L. (2008) Structural and biochemical insights into the dicing mechanism of mouse dicer: a conserved lysine is critical for dsRNA cleavage. Proc. Natl Acad. Sci. USA, 105, 2391-2396.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2391-2396
    • Du, Z.1    Lee, J.K.2    Tjhen, R.3    Stroud, R.M.4    James, T.L.5
  • 25
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga,C., Tomari,Y., Shin,C., Bartel,D.P. and Zamore,P.D. (2005) Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell, 123, 607-620.
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 26
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
    • Meister,G., Landthaler,M., Dorsett,Y. and Tuschl,T. (2004) Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA, 10, 544-550.
    • (2004) RNA , vol.10 , pp. 544-550
    • Meister, G.1    Landthaler, M.2    Dorsett, Y.3    Tuschl, T.4
  • 27
    • 0037425583 scopus 로고    scopus 로고
    • Short-interfering-RNA-mediated gene silencing in mammalian cells requires dicer and eIF2C translation initiation factors
    • Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K. (2003) Short-interfering-RNA-mediated gene silencing in mammalian cells requires dicer and eIF2C translation initiation factors. Curr. Biol., 13, 41-46.
    • (2003) Curr. Biol. , vol.13 , pp. 41-46
    • Doi, N.1    Zenno, S.2    Ueda, R.3    Ohki-Hamazaki, H.4    Ui-Tei, K.5    Saigo, K.6
  • 29
    • 34248576287 scopus 로고    scopus 로고
    • RNA helicase A interacts with RISC in human cells and functions in RISC loading
    • Robb,G.B. and Rana,T.M. (2007) RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell, 26, 523-537.
    • (2007) Mol. Cell , vol.26 , pp. 523-537
    • Robb, G.B.1    Rana, T.M.2
  • 32
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang,Y., Sheng,G., Juranek,S., Tuschl,T. and Patel,D.J. (2008) Structure of the guide-strand-containing argonaute silencing complex. Nature, 456, 209-213.
    • (2008) Nature , vol.456 , pp. 209-213
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 33
    • 57749206034 scopus 로고    scopus 로고
    • Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
    • Wang,Y., Juranek,S., Li,H., Sheng,G., Tuschl,T. and Patel,D.J. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature, 456, 921-926.
    • (2008) Nature , vol.456 , pp. 921-926
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Tuschl, T.5    Patel, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.