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Volumn 35, Issue 4, 2014, Pages 494-511

Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: Insight from animal models

Author keywords

Androgens; Gonadotropin releasing hormone neurons; Polycystic ovary syndrome; Prenatal androgenization

Indexed keywords

ESTRADIOL; ESTROGEN; GONADORELIN; LUTEINIZING HORMONE; PROGESTERONE; TESTOSTERONE;

EID: 84908161108     PISSN: 00913022     EISSN: 10956808     Source Type: Journal    
DOI: 10.1016/j.yfrne.2014.04.002     Document Type: Review
Times cited : (45)

References (162)
  • 1
    • 0031979511 scopus 로고    scopus 로고
    • Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys
    • Abbott D.H., Dumesic D.A., Eisner J.R., Colman R.J., Kemnitz J.W. Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys. Trends Endocrinol. Metab. (TEM) 1998, 9:62-67.
    • (1998) Trends Endocrinol. Metab. (TEM) , vol.9 , pp. 62-67
    • Abbott, D.H.1    Dumesic, D.A.2    Eisner, J.R.3    Colman, R.J.4    Kemnitz, J.W.5
  • 2
    • 0036313064 scopus 로고    scopus 로고
    • Developmental origin of polycystic ovary syndrome - a hypothesis
    • Abbott D.H., Dumesic D.A., Franks S. Developmental origin of polycystic ovary syndrome - a hypothesis. J. Endocrinol. 2002, 174:1-5.
    • (2002) J. Endocrinol. , vol.174 , pp. 1-5
    • Abbott, D.H.1    Dumesic, D.A.2    Franks, S.3
  • 3
    • 21244500111 scopus 로고    scopus 로고
    • Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?
    • Abbott D.H., Barnett D.K., Bruns C.M., Dumesic D.A. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?. Hum. Reprod. Update 2005, 11:357-374. 10.1093/humupd/dmi013.
    • (2005) Hum. Reprod. Update , vol.11 , pp. 357-374
    • Abbott, D.H.1    Barnett, D.K.2    Bruns, C.M.3    Dumesic, D.A.4
  • 4
    • 45849113338 scopus 로고    scopus 로고
    • Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys
    • Abbott D.H., Barnett D.K., Levine J.E., Padmanabhan V., Dumesic D.A., Jacoris S., Tarantal A.F. Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys. Biol. Reprod. 2008, 79:154-163. 10.1095/biolreprod.108.067702.
    • (2008) Biol. Reprod. , vol.79 , pp. 154-163
    • Abbott, D.H.1    Barnett, D.K.2    Levine, J.E.3    Padmanabhan, V.4    Dumesic, D.A.5    Jacoris, S.6    Tarantal, A.F.7
  • 5
    • 69349084968 scopus 로고    scopus 로고
    • Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys
    • Abbott D.H., Tarantal A.F., Dumesic D.A. Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am. J. Primatol. 2009, 71:776-784. 10.1002/ajp.20679.
    • (2009) Am. J. Primatol. , vol.71 , pp. 776-784
    • Abbott, D.H.1    Tarantal, A.F.2    Dumesic, D.A.3
  • 7
    • 24944439023 scopus 로고    scopus 로고
    • Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons
    • Abe H., Terasawa E. Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons. Endocrinology 2005, 146:4312-4320. 10.1210/en.2005-0435.
    • (2005) Endocrinology , vol.146 , pp. 4312-4320
    • Abe, H.1    Terasawa, E.2
  • 8
    • 84861326656 scopus 로고    scopus 로고
    • Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep
    • Abi Salloum B., Herkimer C., Lee J.S., Veiga-Lopez A., Padmanabhan V. Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep. Endocrinology 2012, 153:2813-2822. 10.1210/en.2011-2074.
    • (2012) Endocrinology , vol.153 , pp. 2813-2822
    • Abi Salloum, B.1    Herkimer, C.2    Lee, J.S.3    Veiga-Lopez, A.4    Padmanabhan, V.5
  • 9
    • 77952747569 scopus 로고    scopus 로고
    • Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels
    • Anderson H., Fogel N., Grebe S.K., Singh R.J., Taylor R.L., Dunaif A. Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels. J. Clin. Endocrinol. Metab. 2010, 95:2180-2186. 10.1210/jc.2009-2651.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , pp. 2180-2186
    • Anderson, H.1    Fogel, N.2    Grebe, S.K.3    Singh, R.J.4    Taylor, R.L.5    Dunaif, A.6
  • 11
    • 0028099876 scopus 로고
    • Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women
    • Barnes R.B., Rosenfield R.L., Ehrmann D.A., Cara J.F., Cuttler L., Levitsky L.L., Rosenthal I.M. Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. J. Clin. Endocrinol. Metab. 1994, 79:1328-1333. 10.1210/jcem.79.5.7962325.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 1328-1333
    • Barnes, R.B.1    Rosenfield, R.L.2    Ehrmann, D.A.3    Cara, J.F.4    Cuttler, L.5    Levitsky, L.L.6    Rosenthal, I.M.7
  • 12
    • 84908189740 scopus 로고    scopus 로고
    • Developmental Resistance to Progesterone Negative Feedback in Hyperandrogenemic Adolescent Girls: Evidence for the Evolution of GnRH Pulse Patterns through Puberty.
    • 94th Meeting of the Endocrine Society. Abstract SUN-35.
    • Beller, J., Abshire, M., Burt Solorzano, C., Collins, J., McCartney, C., Marshall, J., 2012. Developmental Resistance to Progesterone Negative Feedback in Hyperandrogenemic Adolescent Girls: Evidence for the Evolution of GnRH Pulse Patterns through Puberty. 94th Meeting of the Endocrine Society. Abstract SUN-35.
    • (2012)
    • Beller, J.1    Abshire, M.2    Burt, S.C.3    Collins, J.4    McCartney, C.5    Marshall, J.6
  • 13
    • 0037387354 scopus 로고    scopus 로고
    • Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep
    • Birch R.A., Padmanabhan V., Foster D.L., Unsworth W.P., Robinson J.E. Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep. Endocrinology 2003, 144:1426-1434.
    • (2003) Endocrinology , vol.144 , pp. 1426-1434
    • Birch, R.A.1    Padmanabhan, V.2    Foster, D.L.3    Unsworth, W.P.4    Robinson, J.E.5
  • 14
    • 67650269904 scopus 로고    scopus 로고
    • Modulation of gonadotropin-releasing hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls - implications for regulation of pubertal maturation
    • Blank S.K., McCartney C.R., Chhabra S., Helm K.D., Eagleson C.A., Chang R.J., Marshall J.C. Modulation of gonadotropin-releasing hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls - implications for regulation of pubertal maturation. J. Clin. Endocrinol. Metab. 2009, 94:2360-2366. 10.1210/jc.2008-2606.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 2360-2366
    • Blank, S.K.1    McCartney, C.R.2    Chhabra, S.3    Helm, K.D.4    Eagleson, C.A.5    Chang, R.J.6    Marshall, J.C.7
  • 15
    • 73949110359 scopus 로고    scopus 로고
    • Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by high-fat diet in mice
    • Brill D.S., Moenter S.M. Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by high-fat diet in mice. Biol. Reprod. 2009, 81:1093-1098. 10.1095/biolreprod.109.079301.
    • (2009) Biol. Reprod. , vol.81 , pp. 1093-1098
    • Brill, D.S.1    Moenter, S.M.2
  • 18
    • 0030046710 scopus 로고    scopus 로고
    • Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability
    • Bucholtz D.C., Vidwans N.M., Herbosa C.G., Schillo K.K., Foster D.L. Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability. Endocrinology 1996, 137:601-607.
    • (1996) Endocrinology , vol.137 , pp. 601-607
    • Bucholtz, D.C.1    Vidwans, N.M.2    Herbosa, C.G.3    Schillo, K.K.4    Foster, D.L.5
  • 19
    • 0034457255 scopus 로고    scopus 로고
    • Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors
    • Chappell P.E., Levine J.E. Stimulation of gonadotropin-releasing hormone surges by estrogen. I. Role of hypothalamic progesterone receptors. Endocrinology 2000, 141:1477-1485.
    • (2000) Endocrinology , vol.141 , pp. 1477-1485
    • Chappell, P.E.1    Levine, J.E.2
  • 20
    • 0033305055 scopus 로고    scopus 로고
    • Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice
    • Chappell P.E., Schneider J.S., Kim P., Xu M., Lydon J.P., O'Malley B.W., Levine J.E. Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology 1999, 140:3653-3658.
    • (1999) Endocrinology , vol.140 , pp. 3653-3658
    • Chappell, P.E.1    Schneider, J.S.2    Kim, P.3    Xu, M.4    Lydon, J.P.5    O'Malley, B.W.6    Levine, J.E.7
  • 21
    • 68549092941 scopus 로고    scopus 로고
    • GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways
    • Chen P., Moenter S.M. GABAergic transmission to gonadotropin-releasing hormone (GnRH) neurons is regulated by GnRH in a concentration-dependent manner engaging multiple signaling pathways. J. Neurosci. Off. J. Soc. Neurosci. 2009, 29:9809-9818. 10.1523/JNEUROSCI.2509-09.2009.
    • (2009) J. Neurosci. Off. J. Soc. Neurosci. , vol.29 , pp. 9809-9818
    • Chen, P.1    Moenter, S.M.2
  • 22
    • 73649083725 scopus 로고    scopus 로고
    • The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep
    • Cheng G., Coolen L.M., Padmanabhan V., Goodman R.L., Lehman M.N. The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep. Endocrinology 2010, 151:301-311. 10.1210/en.2009-0541.
    • (2010) Endocrinology , vol.151 , pp. 301-311
    • Cheng, G.1    Coolen, L.M.2    Padmanabhan, V.3    Goodman, R.L.4    Lehman, M.N.5
  • 23
    • 18844383658 scopus 로고    scopus 로고
    • Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls
    • Chhabra S., McCartney C.R., Yoo R.Y., Eagleson C.A., Chang R.J., Marshall J.C. Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls. J. Clin. Endocrinol. Metab. 2005, 90:2810-2815. 10.1210/jc.2004-2359.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 2810-2815
    • Chhabra, S.1    McCartney, C.R.2    Yoo, R.Y.3    Eagleson, C.A.4    Chang, R.J.5    Marshall, J.C.6
  • 24
    • 27344437865 scopus 로고    scopus 로고
    • Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity
    • Christian C.A., Mobley J.L., Moenter S.M. Diurnal and estradiol-dependent changes in gonadotropin-releasing hormone neuron firing activity. Proc. Natl. Acad. Sci. USA 2005, 102:15682-15687. 10.1073/pnas.0504270102.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15682-15687
    • Christian, C.A.1    Mobley, J.L.2    Moenter, S.M.3
  • 25
    • 32544457993 scopus 로고    scopus 로고
    • Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance
    • Coviello A.D., Legro R.S., Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J. Clin. Endocrinol. Metab. 2006, 91:492-497. 10.1210/jc.2005-1666.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 492-497
    • Coviello, A.D.1    Legro, R.S.2    Dunaif, A.3
  • 27
    • 33745203112 scopus 로고    scopus 로고
    • Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome
    • De Zegher F., Ibáñez L. Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome. Fertil. Steril. 2006, 86(Suppl. 1):S4-S5. 10.1016/j.fertnstert.2006.03.013.
    • (2006) Fertil. Steril. , vol.86 , pp. S4-S5
    • De Zegher, F.1    Ibáñez, L.2
  • 28
    • 12244253710 scopus 로고    scopus 로고
    • Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons
    • DeFazio R.A., Heger S., Ojeda S.R., Moenter S.M. Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons. Mol. Endocrinol. 2002, 16:2872-2891.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2872-2891
    • DeFazio, R.A.1    Heger, S.2    Ojeda, S.R.3    Moenter, S.M.4
  • 30
    • 84870986039 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications
    • Diamanti-Kandarakis E., Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr. Rev. 2012, 33:981-1030. 10.1210/er.2011-1034.
    • (2012) Endocr. Rev. , vol.33 , pp. 981-1030
    • Diamanti-Kandarakis, E.1    Dunaif, A.2
  • 32
    • 84891901197 scopus 로고    scopus 로고
    • Cancer risk and PCOS
    • Dumesic D.A., Lobo R.A. Cancer risk and PCOS. Steroids 2013, 78:782-785. 10.1016/j.steroids.2013.04.004.
    • (2013) Steroids , vol.78 , pp. 782-785
    • Dumesic, D.A.1    Lobo, R.A.2
  • 33
    • 0036959732 scopus 로고    scopus 로고
    • Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization
    • Dumesic D.A., Schramm R.D., Peterson E., Paprocki A.M., Zhou R., Abbott D.H. Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization. J. Clin. Endocrinol. Metab. 2002, 87:1111-1119.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1111-1119
    • Dumesic, D.A.1    Schramm, R.D.2    Peterson, E.3    Paprocki, A.M.4    Zhou, R.5    Abbott, D.H.6
  • 34
    • 0031028152 scopus 로고    scopus 로고
    • Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood
    • Dumesic D.A., Abbott D.H., Eisner J.R., Goy R.W. Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood. Fertil. Steril. 1997, 67:155-163.
    • (1997) Fertil. Steril. , vol.67 , pp. 155-163
    • Dumesic, D.A.1    Abbott, D.H.2    Eisner, J.R.3    Goy, R.W.4
  • 35
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 1997, 18:774-800.
    • (1997) Endocr. Rev. , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 36
    • 0034523425 scopus 로고    scopus 로고
    • Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
    • Eagleson C.A., Gingrich M.B., Pastor C.L., Arora T.K., Burt C.M., Evans W.S., Marshall J.C. Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J. Clin. Endocrinol. Metab. 2000, 85:4047-4052.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 4047-4052
    • Eagleson, C.A.1    Gingrich, M.B.2    Pastor, C.L.3    Arora, T.K.4    Burt, C.M.5    Evans, W.S.6    Marshall, J.C.7
  • 37
    • 0034454040 scopus 로고    scopus 로고
    • Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys
    • Eisner J.R., Dumesic D.A., Kemnitz J.W., Abbott D.H. Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys. J. Clin. Endocrinol. Metab. 2000, 85:1206-1210.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 1206-1210
    • Eisner, J.R.1    Dumesic, D.A.2    Kemnitz, J.W.3    Abbott, D.H.4
  • 38
    • 0036151008 scopus 로고    scopus 로고
    • Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess
    • Eisner J.R., Barnett M.A., Dumesic D.A., Abbott D.H. Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess. Fertil. Steril. 2002, 77:167-172.
    • (2002) Fertil. Steril. , vol.77 , pp. 167-172
    • Eisner, J.R.1    Barnett, M.A.2    Dumesic, D.A.3    Abbott, D.H.4
  • 39
    • 0038654779 scopus 로고    scopus 로고
    • Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation
    • Eisner J.R., Dumesic D.A., Kemnitz J.W., Colman R.J., Abbott D.H. Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation. Obes. Res. 2003, 11:279-286. 10.1038/oby.2003.42.
    • (2003) Obes. Res. , vol.11 , pp. 279-286
    • Eisner, J.R.1    Dumesic, D.A.2    Kemnitz, J.W.3    Colman, R.J.4    Abbott, D.H.5
  • 41
    • 28244436487 scopus 로고    scopus 로고
    • Effects of experimental hyperandrogenemia on the female rat reproductive axis: suppression of progesterone-receptor messenger RNA expression in the brain and blockade of luteinizing hormone surges
    • Foecking E.M., Levine J.E. Effects of experimental hyperandrogenemia on the female rat reproductive axis: suppression of progesterone-receptor messenger RNA expression in the brain and blockade of luteinizing hormone surges. Gend. Med. 2005, 2:155-165.
    • (2005) Gend. Med. , vol.2 , pp. 155-165
    • Foecking, E.M.1    Levine, J.E.2
  • 42
    • 18844378644 scopus 로고    scopus 로고
    • Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator
    • Foecking E.M., Szabo M., Schwartz N.B., Levine J.E. Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator. Biol. Reprod. 2005, 72:1475-1483. 10.1095/biolreprod.105.039800.
    • (2005) Biol. Reprod. , vol.72 , pp. 1475-1483
    • Foecking, E.M.1    Szabo, M.2    Schwartz, N.B.3    Levine, J.E.4
  • 44
    • 0347986534 scopus 로고    scopus 로고
    • Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome
    • Genazzani A.D., Battaglia C., Malavasi B., Strucchi C., Tortolani F., Gamba O. Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil. Steril. 2004, 81:114-119.
    • (2004) Fertil. Steril. , vol.81 , pp. 114-119
    • Genazzani, A.D.1    Battaglia, C.2    Malavasi, B.3    Strucchi, C.4    Tortolani, F.5    Gamba, O.6
  • 46
    • 0028029753 scopus 로고
    • Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries
    • Gilling-Smith C., Willis D.S., Beard R.W., Franks S. Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J. Clin. Endocrinol. Metab. 1994, 79:1158-1165.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 1158-1165
    • Gilling-Smith, C.1    Willis, D.S.2    Beard, R.W.3    Franks, S.4
  • 47
    • 84867598389 scopus 로고    scopus 로고
    • Fast scan cyclic voltammetry as a novel method for detection of real-time gonadotropin-releasing hormone release in mouse brain slices
    • Glanowska K.M., Venton B.J., Moenter S.M. Fast scan cyclic voltammetry as a novel method for detection of real-time gonadotropin-releasing hormone release in mouse brain slices. J. Neurosci. Off. J. Soc. Neurosci. 2012, 32:14664-14669. 10.1523/JNEUROSCI.1303-12.2012.
    • (2012) J. Neurosci. Off. J. Soc. Neurosci. , vol.32 , pp. 14664-14669
    • Glanowska, K.M.1    Venton, B.J.2    Moenter, S.M.3
  • 49
    • 84867810739 scopus 로고    scopus 로고
    • Kisspeptin neurons from mice to men: similarities and differences
    • Goodman R.L., Lehman M.N. Kisspeptin neurons from mice to men: similarities and differences. Endocrinology 2012, 153:5105-5118. 10.1210/en.2012-1550.
    • (2012) Endocrinology , vol.153 , pp. 5105-5118
    • Goodman, R.L.1    Lehman, M.N.2
  • 50
    • 2542422831 scopus 로고    scopus 로고
    • Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep
    • Goodman R.L., Coolen L.M., Anderson G.M., Hardy S.L., Valent M., Connors J.M., Fitzgerald M.E., Lehman M.N. Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep. Endocrinology 2004, 145:2959-2967. 10.1210/en.2003-1305.
    • (2004) Endocrinology , vol.145 , pp. 2959-2967
    • Goodman, R.L.1    Coolen, L.M.2    Anderson, G.M.3    Hardy, S.L.4    Valent, M.5    Connors, J.M.6    Fitzgerald, M.E.7    Lehman, M.N.8
  • 51
    • 0015464871 scopus 로고
    • Gonadal hormones and behavior of normal and pseudohermaphroditic nonhuman female primates
    • Goy R.W., Resko J.A. Gonadal hormones and behavior of normal and pseudohermaphroditic nonhuman female primates. Recent Prog. Horm. Res. 1972, 28:707-733.
    • (1972) Recent Prog. Horm. Res. , vol.28 , pp. 707-733
    • Goy, R.W.1    Resko, J.A.2
  • 52
    • 33645221142 scopus 로고    scopus 로고
    • Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals
    • (discussion 105-108)
    • Gray L.E., Wilson V.S., Stoker T., Lambright C., Furr J., Noriega N., Howdeshell K., Ankley G.T., Guillette L. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Int. J. Androl. 2006, 29:96-104. (discussion 105-108). 10.1111/j.1365-2605.2005.00636.x.
    • (2006) Int. J. Androl. , vol.29 , pp. 96-104
    • Gray, L.E.1    Wilson, V.S.2    Stoker, T.3    Lambright, C.4    Furr, J.5    Noriega, N.6    Howdeshell, K.7    Ankley, G.T.8    Guillette, L.9
  • 53
    • 0023003363 scopus 로고
    • Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction
    • Grenman S., Rönnemaa T., Irjala K., Kaihola H.L., Grönroos M. Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. J. Clin. Endocrinol. Metab. 1986, 63:1257-1261.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 1257-1261
    • Grenman, S.1    Rönnemaa, T.2    Irjala, K.3    Kaihola, H.L.4    Grönroos, M.5
  • 54
    • 0021990692 scopus 로고
    • Alterations in the onset of ovulatory failure and gonadotropin secretion following steroid administration to lightly androgenized female rats
    • Handa R.J., Gorski R.A. Alterations in the onset of ovulatory failure and gonadotropin secretion following steroid administration to lightly androgenized female rats. Biol. Reprod. 1985, 32:248-256.
    • (1985) Biol. Reprod. , vol.32 , pp. 248-256
    • Handa, R.J.1    Gorski, R.A.2
  • 55
    • 0033608404 scopus 로고    scopus 로고
    • Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat
    • He D., Funabashi T., Sano A., Uemura T., Minaguchi H., Kimura F. Effects of glucose and related substrates on the recovery of the electrical activity of gonadotropin-releasing hormone pulse generator which is decreased by insulin-induced hypoglycemia in the estrogen-primed ovariectomized rat. Brain Res. 1999, 820:71-76.
    • (1999) Brain Res. , vol.820 , pp. 71-76
    • He, D.1    Funabashi, T.2    Sano, A.3    Uemura, T.4    Minaguchi, H.5    Kimura, F.6
  • 56
    • 79959228560 scopus 로고    scopus 로고
    • Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotrophin-releasing hormone neurones: towards an emerging consensus
    • Herbison A.E., Moenter S.M. Depolarising and hyperpolarising actions of GABA(A) receptor activation on gonadotrophin-releasing hormone neurones: towards an emerging consensus. J. Neuroendocrinol. 2011, 23:557-569. 10.1111/j.1365-2826.2011.02145.x.
    • (2011) J. Neuroendocrinol. , vol.23 , pp. 557-569
    • Herbison, A.E.1    Moenter, S.M.2
  • 57
    • 0029775865 scopus 로고    scopus 로고
    • Sexual differentiation of the surge mode of gonadotropin secretion: prenatal androgens abolish the gonadotropin-releasing hormone surge in the sheep
    • Herbosa C.G., Dahl G.E., Evans N.P., Pelt J., Wood R.I., Foster D.L. Sexual differentiation of the surge mode of gonadotropin secretion: prenatal androgens abolish the gonadotropin-releasing hormone surge in the sheep. J. Neuroendocrinol. 1996, 8:627-633.
    • (1996) J. Neuroendocrinol. , vol.8 , pp. 627-633
    • Herbosa, C.G.1    Dahl, G.E.2    Evans, N.P.3    Pelt, J.4    Wood, R.I.5    Foster, D.L.6
  • 58
    • 79955376303 scopus 로고    scopus 로고
    • Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary
    • Hogg K., McNeilly A.S., Duncan W.C. Prenatal androgen exposure leads to alterations in gene and protein expression in the ovine fetal ovary. Endocrinology 2011, 152:2048-2059. 10.1210/en.2010-1219.
    • (2011) Endocrinology , vol.152 , pp. 2048-2059
    • Hogg, K.1    McNeilly, A.S.2    Duncan, W.C.3
  • 59
    • 84455188274 scopus 로고    scopus 로고
    • Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome
    • Hogg K., Young J.M., Oliver E.M., Souza C.J., McNeilly A.S., Duncan W.C. Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome. Endocrinology 2012, 153:450-461. 10.1210/en.2011-1607.
    • (2012) Endocrinology , vol.153 , pp. 450-461
    • Hogg, K.1    Young, J.M.2    Oliver, E.M.3    Souza, C.J.4    McNeilly, A.S.5    Duncan, W.C.6
  • 60
    • 57349185737 scopus 로고    scopus 로고
    • Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels
    • Huang W., Acosta-Martínez M., Horton T.H., Levine J.E. Fasting-induced suppression of LH secretion does not require activation of ATP-sensitive potassium channels. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E1439-E1446. 10.1152/ajpendo.90615.2008.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295 , pp. E1439-E1446
    • Huang, W.1    Acosta-Martínez, M.2    Horton, T.H.3    Levine, J.E.4
  • 61
    • 33749992707 scopus 로고    scopus 로고
    • Genomic and post-genomic approaches to polycystic ovary syndrome-progress so far: mini review
    • Hughes C., Elgasim M., Layfield R., Atiomo W. Genomic and post-genomic approaches to polycystic ovary syndrome-progress so far: mini review. Hum. Reprod. Oxf. Engl. 2006, 21:2766-2775. 10.1093/humrep/del222.
    • (2006) Hum. Reprod. Oxf. Engl. , vol.21 , pp. 2766-2775
    • Hughes, C.1    Elgasim, M.2    Layfield, R.3    Atiomo, W.4
  • 62
    • 0345337250 scopus 로고    scopus 로고
    • Insulin resistance, premature adrenarche, and a risk of the Polycystic Ovary Syndrome (PCOS)
    • Ibáñez L., Potau N., Carrascosa A. Insulin resistance, premature adrenarche, and a risk of the Polycystic Ovary Syndrome (PCOS). Trends Endocrinol. Metab. (TEM) 1998, 9:72-77.
    • (1998) Trends Endocrinol. Metab. (TEM) , vol.9 , pp. 72-77
    • Ibáñez, L.1    Potau, N.2    Carrascosa, A.3
  • 63
    • 0035724946 scopus 로고    scopus 로고
    • Polycystic ovary syndrome after precocious pubarche: ontogeny of the low-birthweight effect
    • Ibáñez L., Valls C., Potau N., Marcos M.V., de Zegher F. Polycystic ovary syndrome after precocious pubarche: ontogeny of the low-birthweight effect. Clin. Endocrinol. (Oxf.) 2001, 55:667-672.
    • (2001) Clin. Endocrinol. (Oxf.) , vol.55 , pp. 667-672
    • Ibáñez, L.1    Valls, C.2    Potau, N.3    Marcos, M.V.4    de Zegher, F.5
  • 64
    • 0346171340 scopus 로고    scopus 로고
    • Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome
    • Ibáñez L., Ferrer A., Ong K., Amin R., Dunger D., de Zegher F. Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome. J. Pediatr. 2004, 144:23-29. 10.1016/j.jpeds.2003.08.015.
    • (2004) J. Pediatr. , vol.144 , pp. 23-29
    • Ibáñez, L.1    Ferrer, A.2    Ong, K.3    Amin, R.4    Dunger, D.5    de Zegher, F.6
  • 65
    • 79961225521 scopus 로고    scopus 로고
    • Early metformin therapy (age 8-12years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence
    • Ibáñez L., López-Bermejo A., Díaz M., Marcos M.V., de Zegher F. Early metformin therapy (age 8-12years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence. J. Clin. Endocrinol. Metab. 2011, 96:E1262-1267. 10.1210/jc.2011-0555.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. E1262-1267
    • Ibáñez, L.1    López-Bermejo, A.2    Díaz, M.3    Marcos, M.V.4    de Zegher, F.5
  • 66
    • 66449092943 scopus 로고    scopus 로고
    • Organizational actions of postnatal estradiol in female sheep treated prenatally with testosterone: programming of prepubertal neuroendocrine function and the onset of puberty
    • Jackson L.M., Timmer K.M., Foster D.L. Organizational actions of postnatal estradiol in female sheep treated prenatally with testosterone: programming of prepubertal neuroendocrine function and the onset of puberty. Endocrinology 2009, 150:2317-2324. 10.1210/en.2008-1307.
    • (2009) Endocrinology , vol.150 , pp. 2317-2324
    • Jackson, L.M.1    Timmer, K.M.2    Foster, D.L.3
  • 67
    • 84875856637 scopus 로고    scopus 로고
    • Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep
    • Jackson L.M., Mytinger A., Roberts E.K., Lee T.M., Foster D.L., Padmanabhan V., Jansen H.T. Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep. Endocrinology 2013, 154:1612-1623. 10.1210/en.2012-1613.
    • (2013) Endocrinology , vol.154 , pp. 1612-1623
    • Jackson, L.M.1    Mytinger, A.2    Roberts, E.K.3    Lee, T.M.4    Foster, D.L.5    Padmanabhan, V.6    Jansen, H.T.7
  • 69
    • 80054904105 scopus 로고    scopus 로고
    • Developmental programming: reproductive endocrinopathies in the adult female sheep after prenatal testosterone treatment are reflected in altered ontogeny of GnRH afferents
    • Jansen H.T., Hershey J., Mytinger A., Foster D.L., Padmanabhan V. Developmental programming: reproductive endocrinopathies in the adult female sheep after prenatal testosterone treatment are reflected in altered ontogeny of GnRH afferents. Endocrinology 2011, 152:4288-4297. 10.1210/en.2011-0117.
    • (2011) Endocrinology , vol.152 , pp. 4288-4297
    • Jansen, H.T.1    Hershey, J.2    Mytinger, A.3    Foster, D.L.4    Padmanabhan, V.5
  • 71
    • 0015911884 scopus 로고
    • Sexual differentiation of pituitary function: apparent difference between primates and rodents
    • Karsch F.J., Dierschke D.J., Knobil E. Sexual differentiation of pituitary function: apparent difference between primates and rodents. Science 1973, 179:484-486.
    • (1973) Science , vol.179 , pp. 484-486
    • Karsch, F.J.1    Dierschke, D.J.2    Knobil, E.3
  • 72
    • 67749086524 scopus 로고    scopus 로고
    • The role of insulin-sensitizing agents in the treatment of polycystic ovary syndrome
    • Katsiki N., Georgiadou E., Hatzitolios A.I. The role of insulin-sensitizing agents in the treatment of polycystic ovary syndrome. Drugs 2009, 69:1417-1431. 10.2165/00003495-200969110-00002.
    • (2009) Drugs , vol.69 , pp. 1417-1431
    • Katsiki, N.1    Georgiadou, E.2    Hatzitolios, A.I.3
  • 73
    • 77953916840 scopus 로고    scopus 로고
    • Coming of age in the kisspeptin era: sex differences, development, and puberty
    • Kauffman A.S. Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol. Cell. Endocrinol. 2010, 324:51-63. 10.1016/j.mce.2010.01.017.
    • (2010) Mol. Cell. Endocrinol. , vol.324 , pp. 51-63
    • Kauffman, A.S.1
  • 74
    • 84874427907 scopus 로고    scopus 로고
    • Rapid direct action of estradiol in GnRH neurons: findings and implications
    • Kenealy B.P., Terasawa E. Rapid direct action of estradiol in GnRH neurons: findings and implications. Front. Endocrinol. 2011, 2:106. 10.3389/fendo.2011.00106.
    • (2011) Front. Endocrinol. , vol.2 , pp. 106
    • Kenealy, B.P.1    Terasawa, E.2
  • 75
    • 0032780179 scopus 로고    scopus 로고
    • Prenatal testosterone masculinizes synaptic input to gonadotropin-releasing hormone neurons in sheep
    • Kim S.J., Foster D.L., Wood R.I. Prenatal testosterone masculinizes synaptic input to gonadotropin-releasing hormone neurons in sheep. Biol. Reprod. 1999, 61:599-605.
    • (1999) Biol. Reprod. , vol.61 , pp. 599-605
    • Kim, S.J.1    Foster, D.L.2    Wood, R.I.3
  • 77
    • 79958105230 scopus 로고    scopus 로고
    • Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis
    • Kjerulff L.E., Sanchez-Ramos L., Duffy D. Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis. Am. J. Obstet. Gynecol. 2011, 204(558):e1-e6. 10.1016/j.ajog.2011.03.021.
    • (2011) Am. J. Obstet. Gynecol. , vol.204 , Issue.558 , pp. e1-e6
    • Kjerulff, L.E.1    Sanchez-Ramos, L.2    Duffy, D.3
  • 78
    • 0018849088 scopus 로고
    • Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone
    • Knobil E., Plant T.M., Wildt L., Belchetz P.E., Marshall G. Control of the rhesus monkey menstrual cycle: permissive role of hypothalamic gonadotropin-releasing hormone. Science 1980, 207:1371-1373.
    • (1980) Science , vol.207 , pp. 1371-1373
    • Knobil, E.1    Plant, T.M.2    Wildt, L.3    Belchetz, P.E.4    Marshall, G.5
  • 81
    • 0031054028 scopus 로고    scopus 로고
    • Prenatal androgens time neuroendocrine puberty in the sheep: effect of testosterone dose
    • Kosut S.S., Wood R.I., Herbosa-Encarnación C., Foster D.L. Prenatal androgens time neuroendocrine puberty in the sheep: effect of testosterone dose. Endocrinology 1997, 138:1072-1077.
    • (1997) Endocrinology , vol.138 , pp. 1072-1077
    • Kosut, S.S.1    Wood, R.I.2    Herbosa-Encarnación, C.3    Foster, D.L.4
  • 82
    • 33846798025 scopus 로고    scopus 로고
    • Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents
    • Kubota Y., Hatada S., Kondo S., Karube F., Kawaguchi Y. Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents. J. Neurosci. Off. J. Soc. Neurosci. 2007, 27:1139-1150. 10.1523/JNEUROSCI.3846-06.2007.
    • (2007) J. Neurosci. Off. J. Soc. Neurosci. , vol.27 , pp. 1139-1150
    • Kubota, Y.1    Hatada, S.2    Kondo, S.3    Karube, F.4    Kawaguchi, Y.5
  • 83
    • 77954895859 scopus 로고    scopus 로고
    • Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    • Lehman M.N., Coolen L.M., Goodman R.L. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 2010, 151:3479-3489. 10.1210/en.2010-0022.
    • (2010) Endocrinology , vol.151 , pp. 3479-3489
    • Lehman, M.N.1    Coolen, L.M.2    Goodman, R.L.3
  • 84
    • 34548805696 scopus 로고    scopus 로고
    • Luteinizing hormone (LH) hypersecretion and diminished LH responses to RU486 in a non human primate model for polycystic ovary syndrome (PCOS).
    • June 4, 2005, San Diego, CA.
    • Levine, J.E., Terasawa, E., Hoffman, S.M., Dobbert, M.J.W., Foecking, E.M., Abbott, D.H., 2005. Luteinizing hormone (LH) hypersecretion and diminished LH responses to RU486 in a non human primate model for polycystic ovary syndrome (PCOS). Annu. Meet. Endocr. Soc. June 4, 2005, San Diego, CA.
    • (2005) Annu. Meet. Endocr. Soc.
    • Levine, J.E.1    Terasawa, E.2    Hoffman, S.M.3    Dobbert, M.J.W.4    Foecking, E.M.5    Abbott, D.H.6
  • 85
    • 84867283326 scopus 로고    scopus 로고
    • Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis
    • Lim S.S., Davies M.J., Norman R.J., Moran L.J. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. Update 2012, 18:618-637. 10.1093/humupd/dms030.
    • (2012) Hum. Reprod. Update , vol.18 , pp. 618-637
    • Lim, S.S.1    Davies, M.J.2    Norman, R.J.3    Moran, L.J.4
  • 88
    • 0842334585 scopus 로고    scopus 로고
    • Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep
    • Manikkam M., Crespi E.J., Doop D.D., Herkimer C., Lee J.S., Yu S., Brown M.B., Foster D.L., Padmanabhan V. Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep. Endocrinology 2004, 145:790-798. 10.1210/en.2003-0478.
    • (2004) Endocrinology , vol.145 , pp. 790-798
    • Manikkam, M.1    Crespi, E.J.2    Doop, D.D.3    Herkimer, C.4    Lee, J.S.5    Yu, S.6    Brown, M.B.7    Foster, D.L.8    Padmanabhan, V.9
  • 89
    • 41549136181 scopus 로고    scopus 로고
    • Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep
    • Manikkam M., Thompson R.C., Herkimer C., Welch K.B., Flak J., Karsch F.J., Padmanabhan V. Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep. Biol. Reprod. 2008, 78:648-660. 10.1095/biolreprod.107.063347.
    • (2008) Biol. Reprod. , vol.78 , pp. 648-660
    • Manikkam, M.1    Thompson, R.C.2    Herkimer, C.3    Welch, K.B.4    Flak, J.5    Karsch, F.J.6    Padmanabhan, V.7
  • 91
    • 0033304755 scopus 로고    scopus 로고
    • Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep
    • Masek K.S., Wood R.I., Foster D.L. Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep. Endocrinology 1999, 140:3459-3466.
    • (1999) Endocrinology , vol.140 , pp. 3459-3466
    • Masek, K.S.1    Wood, R.I.2    Foster, D.L.3
  • 92
    • 33646410148 scopus 로고    scopus 로고
    • The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism
    • McCartney C.R., Prendergast K.A., Chhabra S., Eagleson C.A., Yoo R., Chang R.J., Foster C.M., Marshall J.C. The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J. Clin. Endocrinol. Metab. 2006, 91:1714-1722. 10.1210/jc.2005-1852.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1714-1722
    • McCartney, C.R.1    Prendergast, K.A.2    Chhabra, S.3    Eagleson, C.A.4    Yoo, R.5    Chang, R.J.6    Foster, C.M.7    Marshall, J.C.8
  • 94
    • 84855890276 scopus 로고    scopus 로고
    • Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome
    • McGee W.K., Bishop C.V., Bahar A., Pohl C.R., Chang R.J., Marshall J.C., Pau F.K., Stouffer R.L., Cameron J.L. Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome. Hum. Reprod. Oxf. Engl. 2012, 27:531-540. 10.1093/humrep/der393.
    • (2012) Hum. Reprod. Oxf. Engl. , vol.27 , pp. 531-540
    • McGee, W.K.1    Bishop, C.V.2    Bahar, A.3    Pohl, C.R.4    Chang, R.J.5    Marshall, J.C.6    Pau, F.K.7    Stouffer, R.L.8    Cameron, J.L.9
  • 96
    • 84055183022 scopus 로고    scopus 로고
    • Rapid nongenomic effects of oestradiol on gonadotrophin-releasing hormone neurones
    • Moenter S.M., Chu Z. Rapid nongenomic effects of oestradiol on gonadotrophin-releasing hormone neurones. J. Neuroendocrinol. 2012, 24:117-121. 10.1111/j.1365-2826.2011.02135.x.
    • (2012) J. Neuroendocrinol. , vol.24 , pp. 117-121
    • Moenter, S.M.1    Chu, Z.2
  • 97
    • 0026093587 scopus 로고
    • Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge
    • Moenter S.M., Caraty A., Locatelli A., Karsch F.J. Pattern of gonadotropin-releasing hormone (GnRH) secretion leading up to ovulation in the ewe: existence of a preovulatory GnRH surge. Endocrinology 1991, 129:1175-1182. 10.1210/endo-129-3-1175.
    • (1991) Endocrinology , vol.129 , pp. 1175-1182
    • Moenter, S.M.1    Caraty, A.2    Locatelli, A.3    Karsch, F.J.4
  • 98
    • 84872713513 scopus 로고    scopus 로고
    • Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome
    • Moore A.M., Prescott M., Campbell R.E. Estradiol negative and positive feedback in a prenatal androgen-induced mouse model of polycystic ovarian syndrome. Endocrinology 2013, 154:796-806. 10.1210/en.2012-1954.
    • (2013) Endocrinology , vol.154 , pp. 796-806
    • Moore, A.M.1    Prescott, M.2    Campbell, R.E.3
  • 99
    • 0029833087 scopus 로고    scopus 로고
    • Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features
    • Morales A.J., Laughlin G.A., Bützow T., Maheshwari H., Baumann G., Yen S.S. Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features. J. Clin. Endocrinol. Metab. 1996, 81:2854-2864.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 2854-2864
    • Morales, A.J.1    Laughlin, G.A.2    Bützow, T.3    Maheshwari, H.4    Baumann, G.5    Yen, S.S.6
  • 100
    • 77951258439 scopus 로고    scopus 로고
    • Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity
    • Morrison J.L., Duffield J.A., Muhlhausler B.S., Gentili S., McMillen I.C. Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity. Pediatr. Nephrol. 2010, 25:669-677. 10.1007/s00467-009-1407-3.
    • (2010) Pediatr. Nephrol. , vol.25 , pp. 669-677
    • Morrison, J.L.1    Duffield, J.A.2    Muhlhausler, B.S.3    Gentili, S.4    McMillen, I.C.5
  • 101
    • 3042598989 scopus 로고    scopus 로고
    • Further evidence for the role of glucose as a metabolic regulator of hypothalamic gonadotropin-releasing hormone pulse generator activity in goats
    • Ohkura S., Ichimaru T., Itoh F., Matsuyama S., Okamura H. Further evidence for the role of glucose as a metabolic regulator of hypothalamic gonadotropin-releasing hormone pulse generator activity in goats. Endocrinology 2004, 145:3239-3246. 10.1210/en.2003-1516.
    • (2004) Endocrinology , vol.145 , pp. 3239-3246
    • Ohkura, S.1    Ichimaru, T.2    Itoh, F.3    Matsuyama, S.4    Okamura, H.5
  • 102
    • 68949212460 scopus 로고    scopus 로고
    • Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance
    • Ortega H.H., Salvetti N.R., Padmanabhan V. Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance. Reproduction 2009, 137:865-877. 10.1530/REP-08-0491.
    • (2009) Reproduction , vol.137 , pp. 865-877
    • Ortega, H.H.1    Salvetti, N.R.2    Padmanabhan, V.3
  • 103
    • 79959800774 scopus 로고    scopus 로고
    • Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming
    • Padmanabhan V., Veiga-Lopez A. Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming. Semin. Reprod. Med. 2011, 29:173-186. 10.1055/s-0031-1275519.
    • (2011) Semin. Reprod. Med. , vol.29 , pp. 173-186
    • Padmanabhan, V.1    Veiga-Lopez, A.2
  • 104
    • 84891848498 scopus 로고    scopus 로고
    • Animal models of the polycystic ovary syndrome phenotype
    • Padmanabhan V., Veiga-Lopez A. Animal models of the polycystic ovary syndrome phenotype. Steroids 2013, 78:734-740. 10.1016/j.steroids.2013.05.004.
    • (2013) Steroids , vol.78 , pp. 734-740
    • Padmanabhan, V.1    Veiga-Lopez, A.2
  • 105
    • 33646029436 scopus 로고    scopus 로고
    • Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions
    • Pagán Y.L., Srouji S.S., Jimenez Y., Emerson A., Gill S., Hall J.E. Inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome: investigation of hypothalamic and pituitary contributions. J. Clin. Endocrinol. Metab. 2006, 91:1309-1316. 10.1210/jc.2005-2099.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1309-1316
    • Pagán, Y.L.1    Srouji, S.S.2    Jimenez, Y.3    Emerson, A.4    Gill, S.5    Hall, J.E.6
  • 106
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review
    • Palomba S., Falbo A., Zullo F., Orio F. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr. Rev. 2009, 30:1-50. 10.1210/er.2008-0030.
    • (2009) Endocr. Rev. , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio, F.4
  • 107
    • 33744526092 scopus 로고    scopus 로고
    • Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome
    • Panidis D., Rousso D., Koliakos G., Kourtis A., Katsikis I., Farmakiotis D., Votsi E., Diamanti-Kandarakis E. Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. Fertil. Steril. 2006, 85:1778-1783. 10.1016/j.fertnstert.2005.11.044.
    • (2006) Fertil. Steril. , vol.85 , pp. 1778-1783
    • Panidis, D.1    Rousso, D.2    Koliakos, G.3    Kourtis, A.4    Katsikis, I.5    Farmakiotis, D.6    Votsi, E.7    Diamanti-Kandarakis, E.8
  • 109
    • 0031765313 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone
    • Pastor C.L., Griffin-Korf M.L., Aloi J.A., Evans W.S., Marshall J.C. Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J. Clin. Endocrinol. Metab. 1998, 83:582-590.
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 582-590
    • Pastor, C.L.1    Griffin-Korf, M.L.2    Aloi, J.A.3    Evans, W.S.4    Marshall, J.C.5
  • 110
    • 33645959858 scopus 로고    scopus 로고
    • Effect of steroid milieu on gonadotropin-releasing hormone-1 neuron firing pattern and luteinizing hormone levels in male mice
    • Pielecka J., Moenter S.M. Effect of steroid milieu on gonadotropin-releasing hormone-1 neuron firing pattern and luteinizing hormone levels in male mice. Biol. Reprod. 2006, 74:931-937. 10.1095/biolreprod.105.049619.
    • (2006) Biol. Reprod. , vol.74 , pp. 931-937
    • Pielecka, J.1    Moenter, S.M.2
  • 111
    • 32644440014 scopus 로고    scopus 로고
    • Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback
    • Pielecka J., Quaynor S.D., Moenter S.M. Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback. Endocrinology 2006, 147:1474-1479. 10.1210/en.2005-1029.
    • (2006) Endocrinology , vol.147 , pp. 1474-1479
    • Pielecka, J.1    Quaynor, S.D.2    Moenter, S.M.3
  • 113
    • 0021189672 scopus 로고
    • Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin-releasing hormone secretion
    • Reame N., Sauder S.E., Kelch R.P., Marshall J.C. Pulsatile gonadotropin secretion during the human menstrual cycle: evidence for altered frequency of gonadotropin-releasing hormone secretion. J. Clin. Endocrinol. Metab. 1984, 59:328-337.
    • (1984) J. Clin. Endocrinol. Metab. , vol.59 , pp. 328-337
    • Reame, N.1    Sauder, S.E.2    Kelch, R.P.3    Marshall, J.C.4
  • 115
    • 0033305038 scopus 로고    scopus 로고
    • In utero exposure of female lambs to testosterone reduces the sensitivity of the gonadotropin-releasing hormone neuronal network to inhibition by progesterone
    • Robinson J.E., Forsdike R.A., Taylor J.A. In utero exposure of female lambs to testosterone reduces the sensitivity of the gonadotropin-releasing hormone neuronal network to inhibition by progesterone. Endocrinology 1999, 140:5797-5805.
    • (1999) Endocrinology , vol.140 , pp. 5797-5805
    • Robinson, J.E.1    Forsdike, R.A.2    Taylor, J.A.3
  • 118
    • 79951627782 scopus 로고    scopus 로고
    • Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood
    • Roland A.V., Moenter S.M. Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood. Endocrinology 2011, 152:618-628. 10.1210/en.2010-0823.
    • (2011) Endocrinology , vol.152 , pp. 618-628
    • Roland, A.V.1    Moenter, S.M.2
  • 119
    • 79955768198 scopus 로고    scopus 로고
    • Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase
    • Roland A.V., Moenter S.M. Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase. Mol. Endocrinol. 2011, 25:847-858. 10.1210/me.2010-0508.
    • (2011) Mol. Endocrinol. , vol.25 , pp. 847-858
    • Roland, A.V.1    Moenter, S.M.2
  • 120
    • 82455212896 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone neurons by glucose
    • Roland A.V., Moenter S.M. Regulation of gonadotropin-releasing hormone neurons by glucose. Trends Endocrinol. Metab. (TEM) 2011, 22:443-449. 10.1016/j.tem.2011.07.001.
    • (2011) Trends Endocrinol. Metab. (TEM) , vol.22 , pp. 443-449
    • Roland, A.V.1    Moenter, S.M.2
  • 121
    • 78049388028 scopus 로고    scopus 로고
    • Prenatal androgen exposure programs metabolic dysfunction in female mice
    • Roland A.V., Nunemaker C.S., Keller S.R., Moenter S.M. Prenatal androgen exposure programs metabolic dysfunction in female mice. J. Endocrinol. 2010, 207:213-223. 10.1677/JOE-10-0217.
    • (2010) J. Endocrinol. , vol.207 , pp. 213-223
    • Roland, A.V.1    Nunemaker, C.S.2    Keller, S.R.3    Moenter, S.M.4
  • 122
    • 2942653176 scopus 로고    scopus 로고
    • Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity
    • San Millán J.L., Cortón M., Villuendas G., Sancho J., Peral B., Escobar-Morreale H.F. Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. J. Clin. Endocrinol. Metab. 2004, 89:2640-2646. 10.1210/jc.2003-031252.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2640-2646
    • San Millán, J.L.1    Cortón, M.2    Villuendas, G.3    Sancho, J.4    Peral, B.5    Escobar-Morreale, H.F.6
  • 123
    • 24944498458 scopus 로고    scopus 로고
    • Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female
    • Sarma H.N., Manikkam M., Herkimer C., Dell'Orco J., Welch K.B., Foster D.L., Padmanabhan V. Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female. Endocrinology 2005, 146:4281-4291. 10.1210/en.2005-0322.
    • (2005) Endocrinology , vol.146 , pp. 4281-4291
    • Sarma, H.N.1    Manikkam, M.2    Herkimer, C.3    Dell'Orco, J.4    Welch, K.B.5    Foster, D.L.6    Padmanabhan, V.7
  • 124
    • 10944256867 scopus 로고    scopus 로고
    • Fetal programming: testosterone exposure of the female sheep during midgestation disrupts the dynamics of its adult gonadotropin secretion during the periovulatory period
    • Savabieasfahani M., Lee J.S., Herkimer C., Sharma T.P., Foster D.L., Padmanabhan V. Fetal programming: testosterone exposure of the female sheep during midgestation disrupts the dynamics of its adult gonadotropin secretion during the periovulatory period. Biol. Reprod. 2005, 72:221-229. 10.1095/biolreprod.104.031070.
    • (2005) Biol. Reprod. , vol.72 , pp. 221-229
    • Savabieasfahani, M.1    Lee, J.S.2    Herkimer, C.3    Sharma, T.P.4    Foster, D.L.5    Padmanabhan, V.6
  • 125
    • 0036198971 scopus 로고    scopus 로고
    • Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep
    • Sharma T.P., Herkimer C., West C., Ye W., Birch R., Robinson J.E., Foster D.L., Padmanabhan V. Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep. Biol. Reprod. 2002, 66:924-933.
    • (2002) Biol. Reprod. , vol.66 , pp. 924-933
    • Sharma, T.P.1    Herkimer, C.2    West, C.3    Ye, W.4    Birch, R.5    Robinson, J.E.6    Foster, D.L.7    Padmanabhan, V.8
  • 126
    • 0021847860 scopus 로고
    • Influence of perinatal androgen on the sexually dimorphic distribution of tyrosine hydroxylase-immunoreactive cells and fibers in the anteroventral periventricular nucleus of the rat
    • Simerly R.B., Swanson L.W., Handa R.J., Gorski R.A. Influence of perinatal androgen on the sexually dimorphic distribution of tyrosine hydroxylase-immunoreactive cells and fibers in the anteroventral periventricular nucleus of the rat. Neuroendocrinology 1985, 40:501-510.
    • (1985) Neuroendocrinology , vol.40 , pp. 501-510
    • Simerly, R.B.1    Swanson, L.W.2    Handa, R.J.3    Gorski, R.A.4
  • 127
    • 0036796149 scopus 로고    scopus 로고
    • Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization
    • Sir-Petermann T., Maliqueo M., Angel B., Lara H.E., Pérez-Bravo F., Recabarren S.E. Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization. Hum. Reprod. Oxf. Engl. 2002, 17:2573-2579.
    • (2002) Hum. Reprod. Oxf. Engl. , vol.17 , pp. 2573-2579
    • Sir-Petermann, T.1    Maliqueo, M.2    Angel, B.3    Lara, H.E.4    Pérez-Bravo, F.5    Recabarren, S.E.6
  • 129
    • 84934443669 scopus 로고    scopus 로고
    • Sex steroid regulation of kisspeptin circuits
    • Smith J.T. Sex steroid regulation of kisspeptin circuits. Adv. Exp. Med. Biol. 2013, 784:275-295. 10.1007/978-1-4614-6199-9_13.
    • (2013) Adv. Exp. Med. Biol. , vol.784 , pp. 275-295
    • Smith, J.T.1
  • 130
    • 62749116510 scopus 로고    scopus 로고
    • Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity - implication for polycystic ovary syndrome
    • Steckler T.L., Herkimer C., Dumesic D.A., Padmanabhan V. Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity - implication for polycystic ovary syndrome. Endocrinology 2009, 150:1456-1465. 10.1210/en.2008-1256.
    • (2009) Endocrinology , vol.150 , pp. 1456-1465
    • Steckler, T.L.1    Herkimer, C.2    Dumesic, D.A.3    Padmanabhan, V.4
  • 131
    • 0017160742 scopus 로고
    • Sexual differentiation and feedback control of luteinizing hormone secretion in the rhesus monkey
    • Steiner R.A., Clifton D.K., Spies H.G., Resko J.A. Sexual differentiation and feedback control of luteinizing hormone secretion in the rhesus monkey. Biol. Reprod. 1976, 15:206-212.
    • (1976) Biol. Reprod. , vol.15 , pp. 206-212
    • Steiner, R.A.1    Clifton, D.K.2    Spies, H.G.3    Resko, J.A.4
  • 133
    • 2342539599 scopus 로고    scopus 로고
    • Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder
    • Sullivan S.D., Moenter S.M. Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder. Proc. Natl. Acad. Sci. USA 2004, 101:7129-7134. 10.1073/pnas.0308058101.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7129-7134
    • Sullivan, S.D.1    Moenter, S.M.2
  • 134
    • 1442274659 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid neurons integrate and rapidly transmit permissive and inhibitory metabolic cues to gonadotropin-releasing hormone neurons
    • Sullivan S.D., Moenter S.M. Gamma-aminobutyric acid neurons integrate and rapidly transmit permissive and inhibitory metabolic cues to gonadotropin-releasing hormone neurons. Endocrinology 2004, 145:1194-1202. 10.1210/en.2003-1374.
    • (2004) Endocrinology , vol.145 , pp. 1194-1202
    • Sullivan, S.D.1    Moenter, S.M.2
  • 135
    • 10944261252 scopus 로고    scopus 로고
    • GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone neurons
    • Sullivan S.D., Moenter S.M. GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone neurons. Biol. Reprod. 2005, 72:33-41. 10.1095/biolreprod.104.033126.
    • (2005) Biol. Reprod. , vol.72 , pp. 33-41
    • Sullivan, S.D.1    Moenter, S.M.2
  • 136
    • 0035993003 scopus 로고    scopus 로고
    • Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction?
    • Sullivan S.D., Howard L.C., Clayton A.H., Moenter S.M. Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction?. Biol. Reprod. 2002, 66:1702-1706.
    • (2002) Biol. Reprod. , vol.66 , pp. 1702-1706
    • Sullivan, S.D.1    Howard, L.C.2    Clayton, A.H.3    Moenter, S.M.4
  • 137
    • 0141680913 scopus 로고    scopus 로고
    • Metabolic regulation of fertility through presynaptic and postsynaptic signaling to gonadotropin-releasing hormone neurons
    • Sullivan S.D., DeFazio R.A., Moenter S.M. Metabolic regulation of fertility through presynaptic and postsynaptic signaling to gonadotropin-releasing hormone neurons. J. Neurosci. Off. J. Soc. Neurosci. 2003, 23:8578-8585.
    • (2003) J. Neurosci. Off. J. Soc. Neurosci. , vol.23 , pp. 8578-8585
    • Sullivan, S.D.1    DeFazio, R.A.2    Moenter, S.M.3
  • 138
    • 78049493431 scopus 로고    scopus 로고
    • Progesterone treatment inhibits and dihydrotestosterone (DHT) treatment potentiates voltage-gated calcium currents in gonadotropin-releasing hormone (GnRH) neurons
    • Sun J., Moenter S.M. Progesterone treatment inhibits and dihydrotestosterone (DHT) treatment potentiates voltage-gated calcium currents in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology 2010, 151:5349-5358. 10.1210/en.2010-0385.
    • (2010) Endocrinology , vol.151 , pp. 5349-5358
    • Sun, J.1    Moenter, S.M.2
  • 139
    • 77949751420 scopus 로고    scopus 로고
    • Diurnal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing hormone neurons
    • Sun J., Chu Z., Moenter S.M. Diurnal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing hormone neurons. J. Neurosci. Off. J. Soc. Neurosci. 2010, 30:3912-3923. 10.1523/JNEUROSCI.6256-09.2010.
    • (2010) J. Neurosci. Off. J. Soc. Neurosci. , vol.30 , pp. 3912-3923
    • Sun, J.1    Chu, Z.2    Moenter, S.M.3
  • 140
    • 0034463048 scopus 로고    scopus 로고
    • Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology
    • Suter K.J., Song W.J., Sampson T.L., Wuarin J.P., Saunders J.T., Dudek F.E., Moenter S.M. Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology. Endocrinology 2000, 141:412-419.
    • (2000) Endocrinology , vol.141 , pp. 412-419
    • Suter, K.J.1    Song, W.J.2    Sampson, T.L.3    Wuarin, J.P.4    Saunders, J.T.5    Dudek, F.E.6    Moenter, S.M.7
  • 142
    • 1442348151 scopus 로고    scopus 로고
    • Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice
    • Tortoriello D.V., McMinn J., Chua S.C. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology 2004, 145:1238-1247. 10.1210/en.2003-1406.
    • (2004) Endocrinology , vol.145 , pp. 1238-1247
    • Tortoriello, D.V.1    McMinn, J.2    Chua, S.C.3
  • 143
    • 14044253504 scopus 로고    scopus 로고
    • Prenatal programming of reproductive neuroendocrine function: the effect of prenatal androgens on the development of estrogen positive feedback and ovarian cycles in the ewe
    • Unsworth W.P., Taylor J.A., Robinson J.E. Prenatal programming of reproductive neuroendocrine function: the effect of prenatal androgens on the development of estrogen positive feedback and ovarian cycles in the ewe. Biol. Reprod. 2005, 72:619-627. 10.1095/biolreprod.104.035691.
    • (2005) Biol. Reprod. , vol.72 , pp. 619-627
    • Unsworth, W.P.1    Taylor, J.A.2    Robinson, J.E.3
  • 144
    • 41549098869 scopus 로고    scopus 로고
    • Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep
    • Veiga-Lopez A., Ye W., Phillips D.J., Herkimer C., Knight P.G., Padmanabhan V. Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep. Biol. Reprod. 2008, 78:636-647. 10.1095/biolreprod.107.065904.
    • (2008) Biol. Reprod. , vol.78 , pp. 636-647
    • Veiga-Lopez, A.1    Ye, W.2    Phillips, D.J.3    Herkimer, C.4    Knight, P.G.5    Padmanabhan, V.6
  • 145
    • 65249183137 scopus 로고    scopus 로고
    • Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormonal dynamics in sheep
    • Veiga-Lopez A., Astapova O.I., Aizenberg E.F., Lee J.S., Padmanabhan V. Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormonal dynamics in sheep. Biol. Reprod. 2009, 80:718-725. 10.1095/biolreprod.108.074781.
    • (2009) Biol. Reprod. , vol.80 , pp. 718-725
    • Veiga-Lopez, A.1    Astapova, O.I.2    Aizenberg, E.F.3    Lee, J.S.4    Padmanabhan, V.5
  • 146
    • 0022447036 scopus 로고
    • Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection
    • Veldhuis J.D., Johnson M.L. Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am. J. Physiol. 1986, 250:E486-E493.
    • (1986) Am. J. Physiol. , vol.250 , pp. E486-E493
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 147
  • 148
    • 0023870461 scopus 로고
    • Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization
    • Waldstreicher J., Santoro N.F., Hall J.E., Filicori M., Crowley W.F. Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization. J. Clin. Endocrinol. Metab. 1988, 66:165-172.
    • (1988) J. Clin. Endocrinol. Metab. , vol.66 , pp. 165-172
    • Waldstreicher, J.1    Santoro, N.F.2    Hall, J.E.3    Filicori, M.4    Crowley, W.F.5
  • 150
    • 0019451437 scopus 로고
    • Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey
    • Wildt L., Häusler A., Marshall G., Hutchison J.S., Plant T.M., Belchetz P.E., Knobil E. Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology 1981, 109:376-385.
    • (1981) Endocrinology , vol.109 , pp. 376-385
    • Wildt, L.1    Häusler, A.2    Marshall, G.3    Hutchison, J.S.4    Plant, T.M.5    Belchetz, P.E.6    Knobil, E.7
  • 151
    • 84879656262 scopus 로고    scopus 로고
    • The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications
    • Witchel S.F., Tena-Sempere M. The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications. Fertil. Steril. 2013, 100:12-22. 10.1016/j.fertnstert.2013.05.024.
    • (2013) Fertil. Steril. , vol.100 , pp. 12-22
    • Witchel, S.F.1    Tena-Sempere, M.2
  • 152
    • 84865438211 scopus 로고    scopus 로고
    • Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice
    • Witham E.A., Meadows J.D., Shojaei S., Kauffman A.S., Mellon P.L. Prenatal exposure to low levels of androgen accelerates female puberty onset and reproductive senescence in mice. Endocrinology 2012, 153:4522-4532. 10.1210/en.2012-1283.
    • (2012) Endocrinology , vol.153 , pp. 4522-4532
    • Witham, E.A.1    Meadows, J.D.2    Shojaei, S.3    Kauffman, A.S.4    Mellon, P.L.5
  • 153
    • 0028047995 scopus 로고
    • FOS expression in the gonadotropin-releasing hormone (GnRH) neuron does not increase during the ovarian steroid-induced GnRH surge in the rhesus monkey
    • Witkin J.W., Xiao E., Popilskis S., Ferin M., Silverman A.J. FOS expression in the gonadotropin-releasing hormone (GnRH) neuron does not increase during the ovarian steroid-induced GnRH surge in the rhesus monkey. Endocrinology 1994, 135:956-961.
    • (1994) Endocrinology , vol.135 , pp. 956-961
    • Witkin, J.W.1    Xiao, E.2    Popilskis, S.3    Ferin, M.4    Silverman, A.J.5
  • 155
    • 0029081443 scopus 로고
    • Prenatal testosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in the developing sheep
    • Wood R.I., Mehta V., Herbosa C.G., Foster D.L. Prenatal testosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in the developing sheep. Neuroendocrinology 1995, 62:238-247.
    • (1995) Neuroendocrinology , vol.62 , pp. 238-247
    • Wood, R.I.1    Mehta, V.2    Herbosa, C.G.3    Foster, D.L.4
  • 156
    • 0029740180 scopus 로고    scopus 로고
    • Prenatal androgens defeminize activation of GnRH neurons in response to estradiol stimulation
    • Wood R.I., Kim S.J., Foster D.L. Prenatal androgens defeminize activation of GnRH neurons in response to estradiol stimulation. J. Neuroendocrinol. 1996, 8:617-625.
    • (1996) J. Neuroendocrinol. , vol.8 , pp. 617-625
    • Wood, R.I.1    Kim, S.J.2    Foster, D.L.3
  • 157
    • 77953647358 scopus 로고    scopus 로고
    • Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats
    • Wu X.-Y., Li Z.-L., Wu C.-Y., Liu Y.-M., Lin H., Wang S.-H., Xiao W.-F. Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats. Endocr. J. 2010, 57:201-209.
    • (2010) Endocr. J. , vol.57 , pp. 201-209
    • Wu, X.-Y.1    Li, Z.-L.2    Wu, C.-Y.3    Liu, Y.-M.4    Lin, H.5    Wang, S.-H.6    Xiao, W.-F.7
  • 158
    • 84555186997 scopus 로고    scopus 로고
    • Reproductive tissues maintain insulin sensitivity in diet-induced obesity
    • Wu S., Divall S., Wondisford F., Wolfe A. Reproductive tissues maintain insulin sensitivity in diet-induced obesity. Diabetes 2012, 61:114-123. 10.2337/db11-0956.
    • (2012) Diabetes , vol.61 , pp. 114-123
    • Wu, S.1    Divall, S.2    Wondisford, F.3    Wolfe, A.4
  • 159
    • 84897882480 scopus 로고    scopus 로고
    • Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell
    • Wu S., Divall S., Nwaopara A., Radovick S., Wondisford F., Ko C., Wolfe A. Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell. Diabetes 2013, 10.2337/db13-1514.
    • (2013) Diabetes
    • Wu, S.1    Divall, S.2    Nwaopara, A.3    Radovick, S.4    Wondisford, F.5    Ko, C.6    Wolfe, A.7
  • 160
    • 84877135079 scopus 로고    scopus 로고
    • Prenatal androgen excess programs metabolic derangements in pubertal female rats
    • Yan X., Dai X., Wang J., Zhao N., Cui Y., Liu J. Prenatal androgen excess programs metabolic derangements in pubertal female rats. J. Endocrinol. 2013, 217:119-129. 10.1530/JOE-12-0577.
    • (2013) J. Endocrinol. , vol.217 , pp. 119-129
    • Yan, X.1    Dai, X.2    Wang, J.3    Zhao, N.4    Cui, Y.5    Liu, J.6
  • 161
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E., Scott L.J., Saxena R., Voight B.F., Marchini J.L., et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat. Genet. 2008, 40:638-645. 10.1038/ng.120.
    • (2008) Nat. Genet. , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, B.F.4    Marchini, J.L.5
  • 162
    • 34548820963 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition
    • Zhang C., Bosch M.A., Levine J.E., Rønnekleiv O.K., Kelly M.J. Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J. Neurosci. Off. J. Soc. Neurosci. 2007, 27:10153-10164. 10.1523/JNEUROSCI.1657-07.2007.
    • (2007) J. Neurosci. Off. J. Soc. Neurosci. , vol.27 , pp. 10153-10164
    • Zhang, C.1    Bosch, M.A.2    Levine, J.E.3    Rønnekleiv, O.K.4    Kelly, M.J.5


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