메뉴 건너뛰기




Volumn 152, Issue 2, 2011, Pages 618-628

Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GONADORELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LUTEINIZING HORMONE; METFORMIN;

EID: 79951627782     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0823     Document Type: Article
Times cited : (72)

References (82)
  • 1
    • 0019451437 scopus 로고
    • Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey
    • Wildt L, Hausler A, Marshall G, Hutchison JS, Plant TM, Belchetz PE, Knobil E 1981 Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology 109:376-385 (Pubitemid 11040187)
    • (1981) Endocrinology , vol.109 , Issue.2 , pp. 376-385
    • Wildt, L.1    Hausler, A.2    Marshall, G.3
  • 3
    • 0023870461 scopus 로고
    • Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: Indirect evidence for partial gonadotroph desensitization
    • Waldstreicher J, Santoro NF, Hall JE, Filicori M, Crowley Jr WF 1988 Hyperfunction of the hypothalamic-pituitary axis in women with polycystic ovarian disease: indirect evidence for partial gonadotroph desensitization. J Clin Endocri Metab 66:165-172 (Pubitemid 18027747)
    • (1988) Journal of Clinical Endocrinology and Metabolism , vol.66 , Issue.1 , pp. 165-172
    • Waldstreicher, J.1    Santoro, N.F.2    Hall, J.E.3    Filicori, M.4    Crowley Jr., W.F.5
  • 4
    • 0017068476 scopus 로고
    • Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome
    • Rebar R, Judd HL, Yen SS, Rakoff J, Vandenberg G, Naftolin F 1976 Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest 57:1320-1329
    • (1976) J Clin Invest , vol.57 , pp. 1320-1329
    • Rebar, R.1    Judd, H.L.2    Yen, S.S.3    Rakoff, J.4    Vandenberg, G.5    Naftolin, F.6
  • 5
    • 33745249573 scopus 로고    scopus 로고
    • The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
    • DOI 10.1093/humupd/dml017
    • Blank SK, McCartney CR, Marshall JC 2006 The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Hum Reprod Update 12:351-361 (Pubitemid 43923410)
    • (2006) Human Reproduction Update , vol.12 , Issue.4 , pp. 351-361
    • Blank, S.K.1    McCartney, C.R.2    Marshall, J.C.3
  • 6
    • 21244500111 scopus 로고    scopus 로고
    • Androgen excess fetal programming of female reproduction: A developmental aetiology for polycystic ovary syndrome?
    • Abbott DH, Barnett DK, Bruns CM, Dumesic DA 2005 Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome? Hum Reprod Update 11:357-374
    • (2005) Hum Reprod Update , vol.11 , pp. 357-374
    • Abbott, D.H.1    Barnett, D.K.2    Bruns, C.M.3    Dumesic, D.A.4
  • 7
    • 0036796149 scopus 로고    scopus 로고
    • Maternal serum androgens in pregnant women with polycystic ovarian syndrome: Possible implications in prenatal androgenization
    • Sir-Petermann T, Maliqueo M, Angel B, Lara HE, Pérez-Bravo F, Recabarren SE 2002 Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization. Hum Reprod 17:2573-2579 (Pubitemid 35174106)
    • (2002) Human Reproduction , vol.17 , Issue.10 , pp. 2573-2579
    • Sir-Petermann, T.1    Maliqueo, M.2    Angel, B.3    Lara, H.E.4    Perez-Bravo, F.5    Recabarren, S.E.6
  • 9
    • 2342539599 scopus 로고    scopus 로고
    • Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: Implications for a common fertility disorder
    • DOI 10.1073/pnas.0308058101
    • Sullivan SD, Moenter SM 2004 Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder. Proc Natl Acad Sci USA 101:7129-7134 (Pubitemid 38596454)
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.18 , pp. 7129-7134
    • Sullivan, S.D.1    Moenter, S.M.2
  • 10
    • 78049388028 scopus 로고    scopus 로고
    • Prenatal androgen exposure programs metabolic dysfunction in female mice
    • Roland AV, Nunemaker CS, Keller SR, Moenter SM 2010 Prenatal androgen exposure programs metabolic dysfunction in female mice. J Endocrinol 207:213-223
    • (2010) J Endocrinol , vol.207 , pp. 213-223
    • Roland, A.V.1    Nunemaker, C.S.2    Keller, S.R.3    Moenter, S.M.4
  • 11
    • 12244253710 scopus 로고    scopus 로고
    • Activation of A-type γ-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons
    • DOI 10.1210/me.2002-0163
    • DeFazio RA, Heger S, Ojeda SR, Moenter SM 2002 Activation of A-type γ-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons. Mol Endocrinol 16:2872-2891 (Pubitemid 36020664)
    • (2002) Molecular Endocrinology , vol.16 , Issue.12 , pp. 2872-2891
    • DeFazio, R.A.1    Heger, S.2    Ojeda, S.R.3    Moenter, S.M.4
  • 12
    • 24944498458 scopus 로고    scopus 로고
    • Fetal programming: Excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female
    • Sarma HN, Manikkam M, Herkimer C, Dell'Orco J, Welch KB, Foster DL, Padmanabhan V 2005 Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female. Endocrinology 146:4281-4291
    • (2005) Endocrinology , vol.146 , pp. 4281-4291
    • Sarma, H.N.1    Manikkam, M.2    Herkimer, C.3    Dell'Orco, J.4    Welch, K.B.5    Foster, D.L.6    Padmanabhan, V.7
  • 13
    • 0033304755 scopus 로고    scopus 로고
    • Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep
    • Masek KS, Wood RI, Foster DL 1999 Prenatal dihydrotestosterone differentially masculinizes tonic and surge modes of luteinizing hormone secretion in sheep. Endocrinology 140:3459-3466 (Pubitemid 30645401)
    • (1999) Endocrinology , vol.140 , Issue.8 , pp. 3459-3466
    • Masek, K.S.1    Wood, R.I.2    Foster, D.L.3
  • 14
    • 18844378644 scopus 로고    scopus 로고
    • Neuroendocrine consequences of prenatal androgen exposure in the female rat: Absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator
    • DOI 10.1095/biolreprod.105.039800
    • Foecking EM, Szabo M, Schwartz NB, Levine JE 2005 Neuro-endocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator. Biol Reprod 72:1475-1483 (Pubitemid 40696090)
    • (2005) Biology of Reproduction , vol.72 , Issue.6 , pp. 1475-1483
    • Foecking, E.M.1    Szabo, M.2    Schwartz, N.B.3    Levine, J.E.4
  • 15
    • 18144395497 scopus 로고    scopus 로고
    • Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
    • DOI 10.1016/j.fertnstert.2004.11.070
    • DeUgarte CM, Bartolucci AA, Azziz R 2005 Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril 83:1454-1460 (Pubitemid 40615820)
    • (2005) Fertility and Sterility , vol.83 , Issue.5 , pp. 1454-1460
    • DeUgarte, C.M.1    Bartolucci, A.A.2    Azziz, R.3
  • 16
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome
    • Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257-1266
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Segal, K.R.2    Shelley, D.R.3    Green, G.4    Dobrjansky, A.5    Licholai, T.6
  • 17
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • DOI 10.1210/er.18.6.774
    • Dunaif A 1997 Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18:774-800 (Pubitemid 28009567)
    • (1997) Endocrine Reviews , vol.18 , Issue.6 , pp. 774-800
    • Dunaif, A.1
  • 18
    • 0031957333 scopus 로고    scopus 로고
    • Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome
    • DOI 10.1530/eje.0.1380269
    • Diamanti-Kandarakis E, Kouli C, Tsianateli T, Bergiele A 1998 Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome. Eur J Endocrinol 138:269-274 (Pubitemid 28154775)
    • (1998) European Journal of Endocrinology , vol.138 , Issue.3 , pp. 269-274
    • Diamanti-Kandarakis, E.1    Kouli, C.2    Tsianateli, T.3    Bergiele, A.4
  • 19
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
    • Palomba S, Falbo A, Zullo F, Orio Jr F 2009 Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 30:1-50
    • (2009) Endocr Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio Jr., F.4
  • 20
    • 33745481313 scopus 로고    scopus 로고
    • Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2005.12.036, PII S0015028206005565
    • Essah PA, Apridonidze T, Iuorno MJ, Nestler JE 2006 Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome. Fertil Steril 86:230-232 (Pubitemid 43962958)
    • (2006) Fertility and Sterility , vol.86 , Issue.1 , pp. 230-232
    • Essah, P.A.1    Apridonidze, T.2    Iuorno, M.J.3    Nestler, J.E.4
  • 21
    • 23044513823 scopus 로고    scopus 로고
    • Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome
    • DOI 10.1210/jc.2005-0110
    • Palomba S, Orio Jr F, Falbo A, Manguso F, Russo T, Cascella T, Tolino A, Carmina E, Colao A, Zullo F 2005 Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. J Clin Endocrinol Metab 90:4068-4074 (Pubitemid 41058174)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.7 , pp. 4068-4074
    • Palomba, S.1    Orio Jr., F.2    Falbo, A.3    Manguso, F.4    Russo, T.5    Cascella, T.6    Tolino, A.7    Carmina, E.8    Colao, A.9    Zullo, F.10
  • 22
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • DOI 10.1016/0026-0495(94)90209-7
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ 1994 Met-formin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism 43:647-654 (Pubitemid 24145474)
    • (1994) Metabolism: Clinical and Experimental , vol.43 , Issue.5 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 23
    • 77952557432 scopus 로고    scopus 로고
    • Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial
    • Romualdi D, Giuliani M, Cristello F, Fulghesu AM, Selvaggi L, Lanzone A, Guido M 2010 Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial. Fertil Steril 93:2303-2310
    • (2010) Fertil Steril , vol.93 , pp. 2303-2310
    • Romualdi, D.1    Giuliani, M.2    Cristello, F.3    Fulghesu, A.M.4    Selvaggi, L.5    Lanzone, A.6    Guido, M.7
  • 26
    • 34147119062 scopus 로고    scopus 로고
    • Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia
    • DOI 10.1080/09513590701214398, PII 776488182
    • Genazzani AD, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni VM 2007 Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia. Gynecol Endocrinol 23:146-152 (Pubitemid 46570211)
    • (2007) Gynecological Endocrinology , vol.23 , Issue.3 , pp. 146-152
    • Genazzani, A.D.1    Lanzoni, C.2    Ricchieri, F.3    Baraldi, E.4    Casarosa, E.5    Jasonni, V.M.6
  • 29
    • 33747624148 scopus 로고    scopus 로고
    • Metformin-induced stimulation of adenosine 5′ monophosphate- activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    • DOI 10.1095/biolreprod.106.050831
    • Tosca L, Solnais P, Ferré P, Foufelle F, Dupont J 2006 Metformin-induced stimulation of adenosine 5′ monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells. Biol Reprod 75:342-351 (Pubitemid 44268068)
    • (2006) Biology of Reproduction , vol.75 , Issue.3 , pp. 342-351
    • Tosca, L.1    Solnais, P.2    Ferre, P.3    Foufelle, F.4    Dupont, J.5
  • 30
    • 33847234345 scopus 로고    scopus 로고
    • Effects of metformin on bovine granulosa cells steroidogenesis: Possible involvement of adenosine 5′ monophosphate-activated protein kinase (AMPK)
    • Tosca L, Chabrolle C, Uzbekova S, Dupont J 2007 Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5′ monophosphate-activated protein kinase (AMPK). Biol Reprod 76:368-378
    • (2007) Biol Reprod , vol.76 , pp. 368-378
    • Tosca, L.1    Chabrolle, C.2    Uzbekova, S.3    Dupont, J.4
  • 32
    • 59649129909 scopus 로고    scopus 로고
    • Follicle-stimulating hormone inhibits adenosine 5′-monophosphate- activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway
    • Kayampilly PP, Menon KM 2009 Follicle-stimulating hormone inhibits adenosine 5′-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway. Endocrinology 150: 929-935
    • (2009) Endocrinology , vol.150 , pp. 929-935
    • Kayampilly, P.P.1    Menon, K.M.2
  • 33
    • 40849092830 scopus 로고    scopus 로고
    • Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes
    • DOI 10.1210/me.2007-0330
    • Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ 2008 Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LβT2 gonadotropes. Mol Endocrinol 22:760-771 (Pubitemid 351397801)
    • (2008) Molecular Endocrinology , vol.22 , Issue.3 , pp. 760-771
    • Lu, M.1    Tang, Q.2    Olefsky, J.M.3    Mellon, P.L.4    Webster, N.J.G.5
  • 34
    • 33745199458 scopus 로고    scopus 로고
    • Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain
    • DOI 10.1113/jphysiol.2006.110122
    • Ramamurthy S, Ronnett GV 2006 Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 574:85-93 (Pubitemid 43905799)
    • (2006) Journal of Physiology , vol.574 , Issue.1 , pp. 85-93
    • Ramamurthy, S.1    Ronnett, G.V.2
  • 35
    • 64349115078 scopus 로고    scopus 로고
    • AMPK in the brain: Its roles in energy balance and neuroprotection
    • Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S 2009 AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem 109(Suppl 1):17-23
    • (2009) J Neurochem , vol.109 , Issue.SUPPL. 1 , pp. 17-23
    • Ronnett, G.V.1    Ramamurthy, S.2    Kleman, A.M.3    Landree, L.E.4    Aja, S.5
  • 40
    • 0034463048 scopus 로고    scopus 로고
    • Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: Characterization of whole-cell electrophysiological properties and morphology
    • DOI 10.1210/en.141.1.412
    • Suter KJ, Song WJ, Sampson TL, Wuarin JP, Saunders JT, Dudek FE, Moenter SM 2000 Genetic targeting of green fluorescent protein to gonadotropin-releasing hormone neurons: characterization of whole-cell electrophysiological properties and morphology. Endocrinology 141:412-419 (Pubitemid 32260384)
    • (2000) Endocrinology , vol.141 , Issue.1 , pp. 412-419
    • Suter, K.J.1    Song, W.J.2    Sampson, T.L.3    Wuarin, J.-P.4    Saunders, J.T.5    Dudek, F.E.6    Moenter, S.M.7
  • 42
    • 33744537874 scopus 로고    scopus 로고
    • Metformin Prevents Alcohol-Induced Liver Injury in the Mouse: Critical Role of Plasminogen Activator Inhibitor-1
    • DOI 10.1053/j.gastro.2006.03.020, PII S0016508506005695
    • Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, Luyendyk JP, Roth RA, Arteel GE 2006 Metformin prevents alcohol- induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology 130:2099-2112 (Pubitemid 43816952)
    • (2006) Gastroenterology , vol.130 , Issue.7 , pp. 2099-2112
    • Bergheim, I.1    Guo, L.2    Davis, M.A.3    Lambert, J.C.4    Beier, J.I.5    Duveau, I.6    Luyendyk, J.P.7    Roth, R.A.8    Arteel, G.E.9
  • 45
    • 73949110359 scopus 로고    scopus 로고
    • Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by highfat diet in mice
    • Brill DS, Moenter SM 2009 Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by highfat diet in mice. Biol Reprod 81:1093-1098
    • (2009) Biol Reprod , vol.81 , pp. 1093-1098
    • Brill, D.S.1    Moenter, S.M.2
  • 46
    • 0036090391 scopus 로고    scopus 로고
    • Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neurons
    • DOI 10.1210/en.143.6.2284
    • Nunemaker CS, DeFazio RA, Moenter SM 2002 Estradiol-sensitive afferents modulate long-term episodic firing patterns of GnRH neurons. Endocrinology 143:2284-2292 (Pubitemid 34521575)
    • (2002) Endocrinology , vol.143 , Issue.6 , pp. 2284-2292
    • Nunemaker, C.S.1    Anthony, D.R.2    Moenter, S.M.3
  • 47
    • 20544440426 scopus 로고    scopus 로고
    • Endogenous activation of metabotropic glutamate receptors modulates GABAergic transmission to gonadotropin-releasing hormone neurons and alters their firing rate: A possible local feedback circuit
    • DOI 10.1523/JNEUROSCI.0913-05.2005
    • Chu Z, Moenter SM 2005 Endogenous activation of metabotropic glutamate receptors modulates GABAergic transmission to gonadotropin- releasing hormone neurons and alters their firing rate: a possible local feedback circuit. J Neurosci 25:5740-5749 (Pubitemid 40847886)
    • (2005) Journal of Neuroscience , vol.25 , Issue.24 , pp. 5740-5749
    • Chu, Z.1    Moenter, S.M.2
  • 48
    • 0346670276 scopus 로고    scopus 로고
    • A targeted extracellular approach for recording long-term firing patterns of excitable cells: A practical guide
    • DOI 10.1251/bpo46
    • Nunemaker CS, DeFazio RA, Moenter SM 2003 A targeted extracellular approach for recording long-term firing patterns of excitable cells: a practical guide. Biol Proced Online 5:53-62 (Pubitemid 38097499)
    • (2003) Biological Procedures Online , vol.5 , Issue.1 , pp. 53-62
    • Nunemaker, C.S.1    DeFazio, R.A.2    Moenter, S.M.3
  • 49
    • 0023380855 scopus 로고
    • Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian species
    • Matteri RL, Roser JF, Baldwin DM, Lipovetsky V, Papkoff H 1987 Characterization of a monoclonal antibody which detects luteinizing hormone from diverse mammalian species. Domest Anim Endocrinol 4:157-165
    • (1987) Domest Anim Endocrinol , vol.4 , pp. 157-165
    • Matteri, R.L.1    Roser, J.F.2    Baldwin, D.M.3    Lipovetsky, V.4    Papkoff, H.5
  • 51
    • 0029017420 scopus 로고
    • Regulation of rat luteinizing hormone β gene expression in transgenic mice by steroids and a gonadotropin-releasing hormone antagonist
    • Fallest PC, Trader GL, Darrow JM, Shupnik MA 1995 Regulation of rat luteinizing hormone β gene expression in transgenic mice by steroids and a gonadotropin-releasing hormone antagonist. Biol Reprod 53:103-109
    • (1995) Biol Reprod , vol.53 , pp. 103-109
    • Fallest, P.C.1    Trader, G.L.2    Darrow, J.M.3    Shupnik, M.A.4
  • 52
  • 53
    • 0018657086 scopus 로고
    • Phasic firing enhances vasopressin release from the rat neurohypophysis
    • Dutton A, Dyball RE 1979 Phasic firing enhances vasopressin release from the rat neurohypophysis. J Physiol 290:433-440 (Pubitemid 9194163)
    • (1979) Journal of Physiology , vol.VOL. 290 , pp. 433-440
    • Dutton, A.1    Dyball, R.E.J.2
  • 55
    • 0034464912 scopus 로고    scopus 로고
    • Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo
    • DOI 10.1210/en.141.1.396
    • Shim WS, Conaway M, Masamura S, Yue W, Wang JP, Kmar R, Santen RJ 2000 Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo. Endocrinology 141:396-405 (Pubitemid 32260382)
    • (2000) Endocrinology , vol.141 , Issue.1 , pp. 396-405
    • Shim, W.-S.1    Conaway, M.2    Masamura, S.3    Yue, W.4    Wang, J.-P.5    Kumar, R.6    Santen, R.J.7
  • 56
    • 39549114798 scopus 로고    scopus 로고
    • The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats
    • DOI 10.1111/j.1365-2826.2007.01643.x
    • Coyral-Castel S, Tosca L, Ferreira G, Jeanpierre E, Rame C, Lomet D, Caraty A, Monget P, Chabrolle C, Dupont J 2008 The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats. J Neuroendocrinol 20:335-346 (Pubitemid 351280097)
    • (2008) Journal of Neuroendocrinology , vol.20 , Issue.3 , pp. 335-346
    • Coyral-Castel, S.1    Tosca, L.2    Ferreira, G.3    Jeanpierre, E.4    Rame, C.5    Lomet, D.6    Caraty, A.7    Monget, P.8    Chabrolle, C.9    Dupont, J.10
  • 57
  • 58
    • 77952323191 scopus 로고    scopus 로고
    • Does metformin affect ovarian morphology in patients with polycystic ovary syndrome? A retrospective cross-sectional preliminary analysis
    • Falbo A, Orio F, Venturella R, Rania E, Materazzo C, Tolino A, Zullo F, Palomba S 2009 Does metformin affect ovarian morphology in patients with polycystic ovary syndrome? A retrospective cross-sectional preliminary analysis. J Ovarian Res 2:5
    • (2009) J Ovarian Res , vol.2 , pp. 5
    • Falbo, A.1    Orio, F.2    Venturella, R.3    Rania, E.4    Materazzo, C.5    Tolino, A.6    Zullo, F.7    Palomba, S.8
  • 59
    • 68149142726 scopus 로고    scopus 로고
    • The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome
    • Ozcimen EE, Uckuyu A, Ciftci FC, Zeyneloglu HB 2009 The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome. Arch Gynecol Obstet 280:263-269
    • (2009) Arch Gynecol Obstet , vol.280 , pp. 263-269
    • Ozcimen, E.E.1    Uckuyu, A.2    Ciftci, F.C.3    Zeyneloglu, H.B.4
  • 60
    • 33646551305 scopus 로고    scopus 로고
    • Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome
    • Palomba S, Orio Jr F, Falbo A, Russo T, Tolino A, Zullo F 2006 Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome. Fertil Steril 86:1694-1701
    • (2006) Fertil Steril , vol.86 , pp. 1694-1701
    • Palomba, S.1    Orio Jr., F.2    Falbo, A.3    Russo, T.4    Tolino, A.5    Zullo, F.6
  • 61
    • 0345505642 scopus 로고    scopus 로고
    • Metformin has direct effects on human ovarian steroidogenesis
    • DOI 10.1016/S0015-0282(02)04925-7
    • Mansfield R, Galea R, Brincat M, Hole D, Mason H 2003 Metformin has direct effects on human ovarian steroidogenesis. Fertil Steril 79:956-962 (Pubitemid 36385020)
    • (2003) Fertility and Sterility , vol.79 , Issue.4 , pp. 956-962
    • Mansfield, R.1    Galea, R.2    Brincat, M.3    Hole, D.4    Mason, H.5
  • 62
    • 0034892698 scopus 로고    scopus 로고
    • Metformin directly inhibits androgen production in human thecal cells
    • Attia GR, Rainey WE, Carr BR 2001 Metformin directly inhibits androgen production in human thecal cells. Fertil Steril 76:517-524
    • (2001) Fertil Steril , vol.76 , pp. 517-524
    • Attia, G.R.1    Rainey, W.E.2    Carr, B.R.3
  • 63
    • 32644440014 scopus 로고    scopus 로고
    • Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback
    • DOI 10.1210/en.2005-1029
    • Pielecka J, Quaynor SD, Moenter SM 2006 Androgens increase gonadotropin-releasing hormone neuron firing activity in females and interfere with progesterone negative feedback. Endocrinology 147:1474-1479 (Pubitemid 43244382)
    • (2006) Endocrinology , vol.147 , Issue.3 , pp. 1474-1479
    • Pielecka, J.1    Quaynor, S.D.2    Moenter, S.M.3
  • 64
    • 0027303172 scopus 로고
    • In vivo metformin treatment ameliorates insulin resistance: Evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes
    • Matthaei S, Reibold JP, Hamann A, Benecke H, Häring HU, Greten H, Klein HH 1993 In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes. Endocrinology 133:304-311
    • (1993) Endocrinology , vol.133 , pp. 304-311
    • Matthaei, S.1    Reibold, J.P.2    Hamann, A.3    Benecke, H.4    Häring, H.U.5    Greten, H.6    Klein, H.H.7
  • 65
    • 77949268951 scopus 로고    scopus 로고
    • Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase
    • Bourron O, Daval M, Hainault I, Hajduch E, Servant JM, Gautier JF, Ferré P, Foufelle F 2010 Biguanides and thiazolidinediones inhibit stimulated lipolysis in human adipocytes through activation of AMP-activated protein kinase. Diabetologia 53:768-778
    • (2010) Diabetologia , vol.53 , pp. 768-778
    • Bourron, O.1    Daval, M.2    Hainault, I.3    Hajduch, E.4    Servant, J.M.5    Gautier, J.F.6    Ferré, P.7    Foufelle, F.8
  • 67
    • 23644445507 scopus 로고    scopus 로고
    • Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase
    • DOI 10.1016/j.ejphar.2005.06.016, PII S0014299905006680
    • Huypens P, Quartier E, Pipeleers D, Van de Casteele M 2005 Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase. Eur J Pharmacol 518:90-95 (Pubitemid 41133630)
    • (2005) European Journal of Pharmacology , vol.518 , Issue.2-3 , pp. 90-95
    • Huypens, P.1    Quartier, E.2    Pipeleers, D.3    Van De, C.M.4
  • 68
    • 33645788973 scopus 로고    scopus 로고
    • Effects of metformin and oleic acid on adipocyte expression of resistin
    • Rea R, Donnelly R 2006 Effects of metformin and oleic acid on adipocyte expression of resistin. Diabetes Obes Metab 8:105-109
    • (2006) Diabetes Obes Metab , vol.8 , pp. 105-109
    • Rea, R.1    Donnelly, R.2
  • 69
    • 0034302911 scopus 로고    scopus 로고
    • Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes
    • Mueller WM, Stanhope KL, Gregoire F, Evans JL, Havel PJ 2000 Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obes Res 8:530-539
    • (2000) Obes Res , vol.8 , pp. 530-539
    • Mueller, W.M.1    Stanhope, K.L.2    Gregoire, F.3    Evans, J.L.4    Havel, P.J.5
  • 70
    • 9444277280 scopus 로고    scopus 로고
    • Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes
    • DOI 10.1677/joe.1.05646
    • Klein J, Westphal S, Kraus D, Meier B, Perwitz N, Ott V, Fasshauer M, Klein HH 2004 Metformin inhibits leptin secretion via a mitogen- activated protein kinase signalling pathway in brown adipocytes. J Endocrinol 183:299-307 (Pubitemid 39562712)
    • (2004) Journal of Endocrinology , vol.183 , Issue.2 , pp. 299-307
    • Klein, J.1    Westphal, S.2    Kraus, D.3    Meier, B.4    Perwitz, N.5    Ott, V.6    Fasshauer, M.7    Klein, H.H.8
  • 71
    • 0037247643 scopus 로고    scopus 로고
    • Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro
    • DOI 10.1055/s-2003-38386
    • He G, Pedersen SB, Bruun JM, Lihn AS, Richelsen B 2003 Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro. Horm Metab Res 35:18-23 (Pubitemid 36403287)
    • (2003) Hormone and Metabolic Research , vol.35 , Issue.1 , pp. 18-23
    • He, G.1    Pedersen, S.B.2    Bruun, J.M.3    Lihn, A.S.4    Richelsen, B.5
  • 72
    • 34249717231 scopus 로고    scopus 로고
    • Adipokines and the blood-brain barrier
    • DOI 10.1016/j.peptides.2007.04.023, PII S0196978107001647
    • Pan W, Kastin AJ 2007 Adipokines and the blood-brain barrier. Peptides 28:1317-1330 (Pubitemid 46843398)
    • (2007) Peptides , vol.28 , Issue.6 , pp. 1317-1330
    • Pan, W.1    Kastin, A.J.2
  • 73
    • 23944482982 scopus 로고    scopus 로고
    • Central actions of adipocyte hormones
    • DOI 10.1016/j.tem.2005.07.010, PII S104327600500158X
    • Ahima RS 2005 Central actions of adipocyte hormones. Trends Endocrinol Metab 16:307-313 (Pubitemid 41206637)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.7 , pp. 307-313
    • Ahima, R.S.1
  • 74
    • 44349194320 scopus 로고    scopus 로고
    • Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential
    • DOI 10.1016/j.bbrc.2008.04.146, PII S0006291X08008310
    • Wen JP, Lv WS, Yang J, Nie AF, Cheng XB, Yang Y, Ge Y, Li XY, Ning G 2008 Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential. Biochem Biophys Res Commun 371:756-761 (Pubitemid 351728105)
    • (2008) Biochemical and Biophysical Research Communications , vol.371 , Issue.4 , pp. 756-761
    • Wen, J.-P.1    Lv, W.-S.2    Yang, J.3    Nie, A.-F.4    Cheng, X.-B.5    Yang, Y.6    Ge, Y.7    Li, X.-Y.8    Ning, G.9
  • 77
    • 69249147344 scopus 로고    scopus 로고
    • Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/ LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways
    • Zhou L, Deepa SS, Etzler JC, Ryu J, Mao X, Fang Q, Liu DD, Torres JM, Jia W, Lechleiter JD, Liu F, Dong LQ 2009 Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/ LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem 284:22426-22435
    • (2009) J Biol Chem , vol.284 , pp. 22426-22435
    • Zhou, L.1    Deepa, S.S.2    Etzler, J.C.3    Ryu, J.4    Mao, X.5    Fang, Q.6    Liu, D.D.7    Torres, J.M.8    Jia, W.9    Lechleiter, J.D.10    Liu, F.11    Dong, L.Q.12
  • 78
    • 77955927305 scopus 로고    scopus 로고
    • Effects of metformin administration on plasma gonadotropin levels in women with infertility, with an in vitro study of the direct effects on the pituitary gonadotrophs
    • Oride A, Kanasaki H, Purwana IN, Miyazaki K 2010 Effects of metformin administration on plasma gonadotropin levels in women with infertility, with an in vitro study of the direct effects on the pituitary gonadotrophs. Pituitary 13:236-241
    • (2010) Pituitary , vol.13 , pp. 236-241
    • Oride, A.1    Kanasaki, H.2    Purwana, I.N.3    Miyazaki, K.4
  • 79
    • 0347986534 scopus 로고    scopus 로고
    • Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome
    • DOI 10.1016/j.fertnstert.2003.05.020
    • Genazzani AD, Battaglia C, Malavasi B, Strucchi C, Tortolani F, Gamba O 2004 Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril 81:114-119 (Pubitemid 38058335)
    • (2004) Fertility and Sterility , vol.81 , Issue.1 , pp. 114-119
    • Genazzani, A.D.1    Battaglia, C.2    Malavasi, B.3    Strucchi, C.4    Tortolani, F.5    Gamba, O.6
  • 80
    • 36249013118 scopus 로고    scopus 로고
    • The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome
    • DOI 10.1111/j.1365-2265.2007.02985.x
    • Sahin Y, Unluhizarci K, Yilmazsoy A, Yikilmaz A, Aygen E, AQKelestimur F 2007 The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome. Clin Endocrinol 67:904-908 (Pubitemid 350135135)
    • (2007) Clinical Endocrinology , vol.67 , Issue.6 , pp. 904-908
    • Sahin, Y.1    Unluhizarci, K.2    Yilmazsoy, A.3    Yikilmaz, A.4    Aygen, E.5    Kelestimur, F.6
  • 81
    • 34247119788 scopus 로고    scopus 로고
    • Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys
    • DOI 10.1016/j.reprotox.2006.12.009, PII S0890623807000056
    • Zhou R, Bruns CM, Bird IM, Kemnitz JW, Goodfriend TL, Dumesic DA, Abbott DH 2007 Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys. Reprod Toxicol 23:438-448 (Pubitemid 46602932)
    • (2007) Reproductive Toxicology , vol.23 , Issue.3 , pp. 438-448
    • Zhou, R.1    Bruns, C.M.2    Bird, I.M.3    Kemnitz, J.W.4    Goodfriend, T.L.5    Dumesic, D.A.6    Abbott, D.H.7
  • 82
    • 77954928402 scopus 로고    scopus 로고
    • Developmental programming: Insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep
    • Veiga-Lopez A, Lee JS, Padmanabhan V 2010 Developmental programming: insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep. Endocrinology 151:4007-4017
    • (2010) Endocrinology , vol.151 , pp. 4007-4017
    • Veiga-Lopez, A.1    Lee, J.S.2    Padmanabhan, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.