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Volumn 83, Issue 2, 1998, Pages 582-590

Polycystic ovary syndrome: Evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE; PROLACTIN; TESTOSTERONE;

EID: 0031765313     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.2.582     Document Type: Article
Times cited : (259)

References (57)
  • 1
    • 0001698606 scopus 로고
    • Amenorrhea associated with bilateral polycystic ovaries
    • Stein IF, Leventhal ML. 1935 Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 29:181-191.
    • (1935) Am J Obstet Gynecol , vol.29 , pp. 181-191
    • Stein, I.F.1    Leventhal, M.L.2
  • 2
    • 0029095150 scopus 로고
    • The polycystic ovary syndrome
    • Franks S. 1995 The polycystic ovary syndrome. N Engl J. Med. 333:853-861.
    • (1995) N Engl J. Med , vol.333 , pp. 853-861
    • Franks, S.1
  • 3
    • 0029822278 scopus 로고    scopus 로고
    • Insulin and the polycystic ovary syndrome
    • Utiger RD. 1996 Insulin and the polycystic ovary syndrome. N Engl J Med. 335:657-658.
    • (1996) N Engl J Med , vol.335 , pp. 657-658
    • Utiger, R.D.1
  • 4
    • 0028071849 scopus 로고
    • Insulin resistance, hypersecretion of LH and a dual defect hypothesis for the pathogenesis of PCOS
    • Poretsky L, Piper B. 1994 Insulin resistance, hypersecretion of LH and a dual defect hypothesis for the pathogenesis of PCOS. Obstet Gynecol. 84:613-621.
    • (1994) Obstet Gynecol , vol.84 , pp. 613-621
    • Poretsky, L.1    Piper, B.2
  • 5
    • 85047696604 scopus 로고
    • Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
    • Ehrman DA, Barnes R, Rosenfield RL. 1995 Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev. 16:322-352.
    • (1995) Endocr Rev , vol.16 , pp. 322-352
    • Ehrman, D.A.1    Barnes, R.2    Rosenfield, R.L.3
  • 6
    • 0017068476 scopus 로고
    • Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome
    • Rebar RW, Judd HL, Yen SSC, Rakoff J, Vandenberg G, Naftolin F. 1976 Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest. 57:1320-1329.
    • (1976) J Clin Invest , vol.57 , pp. 1320-1329
    • Rebar, R.W.1    Judd, H.L.2    Yen, S.S.C.3    Rakoff, J.4    Vandenberg, G.5    Naftolin, F.6
  • 7
    • 0014767566 scopus 로고
    • Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease
    • Yen SSC, Vela P, Rankin J. 1970 Inappropriate secretion of follicle-stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab. 30:435-442.
    • (1970) J Clin Endocrinol Metab , vol.30 , pp. 435-442
    • Yen, S.S.C.1    Vela, P.2    Rankin, J.3
  • 9
    • 0027372636 scopus 로고
    • Increased LH and a subunit secretion in women with hyperandrogenemic anovulation
    • Berga SL, Guzick DS, Winters SJ. 1993 Increased LH and a subunit secretion in women with hyperandrogenemic anovulation. J Clin Endocrinol Metab 77:895-901.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 895-901
    • Berga, S.L.1    Guzick, D.S.2    Winters, S.J.3
  • 10
    • 0023187907 scopus 로고
    • Circulating LH pulse frequency in women with polycystic ovarian syndrome
    • Kazer RR, Kessel B, Yen SSC. 1987 Circulating LH pulse frequency in women with polycystic ovarian syndrome. J Clin Endocrinol Metab. 65:233-236.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 233-236
    • Kazer, R.R.1    Kessel, B.2    Yen, S.S.C.3
  • 11
    • 0030754055 scopus 로고    scopus 로고
    • Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome
    • Taylor AE, McCourt B, Martin KA, et al. 1997 Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab. 82:2248-2256.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2248-2256
    • Taylor, A.E.1    McCourt, B.2    Martin, K.A.3
  • 12
    • 0020538956 scopus 로고
    • Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist
    • Chang RJ, Laufer LR, Meldrum DR, Judd HL. 1983 Steroid secretion in polycystic ovarian disease after ovarian suppression by a long-acting gonadotropin-releasing hormone agonist J Clin Endocrinol Metab. 56:897-903.
    • (1983) J Clin Endocrinol Metab , vol.56 , pp. 897-903
    • Chang, R.J.1    Laufer, L.R.2    Meldrum, D.R.3    Judd, H.L.4
  • 14
    • 0020421953 scopus 로고
    • Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease
    • Chang RJ, Manfdel FP, Lu JK, Judd HL, 1982 Enhanced disparity of gonadotropin secretion by estrone in women with polycystic ovarian disease. J Clin Endocrinol Metab. 54:490-495.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 490-495
    • Chang, R.J.1    Manfdel, F.P.2    Lu, J.K.3    Judd, H.L.4
  • 15
    • 0029796476 scopus 로고    scopus 로고
    • Decreases in ovarian cytochrome P450 c17α activity and serum free testosterone after reduction of insulin secretion in PCOS
    • Nestler JE, Jacobowicz DJ. 1996 Decreases in ovarian cytochrome P450 c17α activity and serum free testosterone after reduction of insulin secretion in PCOS. N Engl J Med. 335:617-623.
    • (1996) N Engl J Med , vol.335 , pp. 617-623
    • Nestler, J.E.1    Jacobowicz, D.J.2
  • 16
    • 0029795871 scopus 로고    scopus 로고
    • The insulin sensitizing agent Troglitazone improves metabolic and reproductive abnormalities in PCOS
    • Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. 1996 The insulin sensitizing agent Troglitazone improves metabolic and reproductive abnormalities in PCOS. J Clin Endocrinol Metab. 81:3299-3306.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3299-3306
    • Dunaif, A.1    Scott, D.2    Finegood, D.3    Quintana, B.4    Whitcomb, R.5
  • 17
    • 0029873153 scopus 로고    scopus 로고
    • Can metformin reduce insulin resistance in PCOS
    • Acbay O, Gundogdu S. 1996 Can metformin reduce insulin resistance in PCOS. Fertil Steril. 65:946-949.
    • (1996) Fertil Steril , vol.65 , pp. 946-949
    • Acbay, O.1    Gundogdu, S.2
  • 18
    • 0028269228 scopus 로고
    • Endocrine consequences of weight loss in obese hyperandrogenic anovulatory women
    • Guzick DS, Wing R, Smith D, Berga SL, Winters SJ. 1994 Endocrine consequences of weight loss in obese hyperandrogenic anovulatory women. Fertil Steril. 61:598-604.
    • (1994) Fertil Steril , vol.61 , pp. 598-604
    • Guzick, D.S.1    Wing, R.2    Smith, D.3    Berga, S.L.4    Winters, S.J.5
  • 19
    • 0031015005 scopus 로고    scopus 로고
    • Effects of metformin on insulin secretion, insulin action and ovarian steroidogenesis in women with polycystic ovary syndrome
    • Ehrman DA, Cavaghan MK, Imperial J, Sturgis J, Rosenfield RL, Polansky KS. 1997 Effects of metformin on insulin secretion, insulin action and ovarian steroidogenesis in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 82:524-530.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 524-530
    • Ehrman, D.A.1    Cavaghan, M.K.2    Imperial, J.3    Sturgis, J.4    Rosenfield, R.L.5    Polansky, K.S.6
  • 20
    • 0028099876 scopus 로고
    • Ovarian hyperandrogenism as a result of congenital adrenal virilizing disorders: Evidence for perinatal masculinization of neuroendocrine function in women
    • Barnes RB, Rosenfield RL, Ehrman DA, et al. 1994 Ovarian hyperandrogenism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab. 79:1328-1333.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1328-1333
    • Barnes, R.B.1    Rosenfield, R.L.2    Ehrman, D.A.3
  • 21
    • 0020040414 scopus 로고
    • Effect of androgen excess on inappropriate gonadotropin secretion as found in PCOS
    • Lobo RA, Goebelsmann U. 1982 Effect of androgen excess on inappropriate gonadotropin secretion as found in PCOS. Am J Obstet Gynecol. 142:394-401.
    • (1982) Am J Obstet Gynecol , vol.142 , pp. 394-401
    • Lobo, R.A.1    Goebelsmann, U.2
  • 22
    • 0021130137 scopus 로고
    • The effect of continuous androgen secretion on the hypothalamic pituitary axis in women: Evidence from a luteinized thecoma of the ovary
    • Dunaif A, Scully RN, Wiser WL, Chapin DS, Crowley WF. 1984 The effect of continuous androgen secretion on the hypothalamic pituitary axis in women: evidence from a luteinized thecoma of the ovary. J Clin Endocrinol Metab. 59:389-393.
    • (1984) J Clin Endocrinol Metab , vol.59 , pp. 389-393
    • Dunaif, A.1    Scully, R.N.2    Wiser, W.L.3    Chapin, D.S.4    Crowley, W.F.5
  • 24
    • 0024403763 scopus 로고
    • The effect of long term testosterone administration on pulsatile LH secretion and ovarian histology in eugonadal female to male transsexuals
    • Spinder T, Spijkstra JJ, Van Den Tweel, et al. 1989 The effect of long term testosterone administration on pulsatile LH secretion and ovarian histology in eugonadal female to male transsexuals. J Clin Endocrinol Metab. 69:151-156.
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 151-156
    • Spinder, T.1    Spijkstra, J.J.2    Van Den Tweel3
  • 25
    • 0021250746 scopus 로고
    • Steroid and gonadotropin secretion in a patient with viralization due to a lipoid cell ovarian tumor
    • Barkan AL, Cassorla F, Loriaux DL, Kelch RP, Marshall JC. 1984 Steroid and gonadotropin secretion in a patient with viralization due to a lipoid cell ovarian tumor. Obstet Gynecol. 63:287-295.
    • (1984) Obstet Gynecol , vol.63 , pp. 287-295
    • Barkan, A.L.1    Cassorla, F.2    Loriaux, D.L.3    Kelch, R.P.4    Marshall, J.C.5
  • 26
    • 0028356926 scopus 로고
    • Accelerated 24-h LH pulsatile activity in adolescent girls with ovarian hyperandrogenism: Relevance to the developmental phase of PCOS
    • Apter D, Butzow T, Laughlin GA, Yen SSC. 1994 Accelerated 24-h LH pulsatile activity in adolescent girls with ovarian hyperandrogenism: relevance to the developmental phase of PCOS. J Clin Endocrinol Metab. 79:119-125.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 119-125
    • Apter, D.1    Butzow, T.2    Laughlin, G.A.3    Yen, S.S.C.4
  • 27
    • 0025183150 scopus 로고
    • Endocrine determinants of fertility: Serum androgen concentrations during follow up of adolescents into the third decade of life
    • Apter D, Vihko R. 1990 Endocrine determinants of fertility: serum androgen concentrations during follow up of adolescents into the third decade of life. J Clin Endocrinol Metab. 71:970-974.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 970-974
    • Apter, D.1    Vihko, R.2
  • 28
  • 29
    • 0023125434 scopus 로고
    • Differential control of LH and FSH secretion by LHRH pulse frequency in man
    • Gross KM, Matsumoto AM, Bremner WJ. 1987 Differential control of LH and FSH secretion by LHRH pulse frequency in man. J Clin Endocrinol Metab. 64:675-680.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 675-680
    • Gross, K.M.1    Matsumoto, A.M.2    Bremner, W.J.3
  • 30
    • 0023178020 scopus 로고
    • Corpus luteum insufficiency induced by a rapid GnRH induced gonadotropin secretion pattern in the follicular phase
    • Soules MR, Clifton DK, Bremner WJ, Steiner RA. 1987 Corpus luteum insufficiency induced by a rapid GnRH induced gonadotropin secretion pattern in the follicular phase. J Clin Endocrinol Metab. 65:457-464.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 457-464
    • Soules, M.R.1    Clifton, D.K.2    Bremner, W.J.3    Steiner, R.A.4
  • 31
    • 0025914152 scopus 로고
    • Reduction of GnRH pulse frequency is associated with subsequent selective FSH secretion in women with polycystic ovarian disease
    • Christman GM, Randolph JF, Kelch RP, Marshall JC. 1991 Reduction of GnRH pulse frequency is associated with subsequent selective FSH secretion in women with polycystic ovarian disease. J Clin Endocrinol Metab. 72:1278-1285.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1278-1285
    • Christman, G.M.1    Randolph, J.F.2    Kelch, R.P.3    Marshall, J.C.4
  • 32
    • 0022447036 scopus 로고
    • Cluster analysis: A simple, versatile and robust algorithm for endocrine pulse detection
    • Veldhuis JD, Johnson ML. 1986 Cluster analysis: a simple, versatile and robust algorithm for endocrine pulse detection. Am J Physiol. 250:E486-E493.
    • (1986) Am J Physiol , vol.250
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 34
    • 0024515617 scopus 로고
    • Opioidergic regulation of LH pulsatility in women with PCOS
    • Oxf
    • Berga SL, Yen SSC. 1989 Opioidergic regulation of LH pulsatility in women with PCOS. Clin Endocrinol (Oxf). 30:177-184.
    • (1989) Clin Endocrinol , vol.30 , pp. 177-184
    • Berga, S.L.1    Yen, S.S.C.2
  • 35
    • 0019451437 scopus 로고
    • Frequency and amplitude of GnRH stimulation and gonadotropin secretion in the rhesus monkey
    • Wildt L, Hausler A, Marshall G, et al. 1981 Frequency and amplitude of GnRH stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology. 109:376-385.
    • (1981) Endocrinology , vol.109 , pp. 376-385
    • Wildt, L.1    Hausler, A.2    Marshall, G.3
  • 36
    • 0024347630 scopus 로고
    • The frequency of gonadotropin-releasing hormone (GnRH) stimulation differentially regulates gonadotropin subunit mRNA expression
    • Dalkin AC, Haisenleder DJ, Ortolano GA, Ellis T, Marshall JC. 1989 The frequency of gonadotropin-releasing hormone (GnRH) stimulation differentially regulates gonadotropin subunit mRNA expression. Endocrinology. 125:917-924.
    • (1989) Endocrinology , vol.125 , pp. 917-924
    • Dalkin, A.C.1    Haisenleder, D.J.2    Ortolano, G.A.3    Ellis, T.4    Marshall, J.C.5
  • 37
    • 15144347091 scopus 로고
    • A pulsatile GnRH stimulus is required to increase transcription of the gonadotropin subunit genes: Evidence for differential regulation of transcription by pulse frequency in vivo
    • Haisenleder DJ, Dalkin AC, Ortolando GA, Marshall JC, Shupnik MA. 1991 A pulsatile GnRH stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology. 128:1278-1285.
    • (1991) Endocrinology , vol.128 , pp. 1278-1285
    • Haisenleder, D.J.1    Dalkin, A.C.2    Ortolando, G.A.3    Marshall, J.C.4    Shupnik, M.A.5
  • 38
    • 0021189672 scopus 로고
    • Pulsatile gonadotropin secretion during the human menstrual cycle-evidence for altered frequency of GnRH secretion
    • Reame N, Sauder SE, Kelch RP, Marshall JC. 1984 Pulsatile gonadotropin secretion during the human menstrual cycle-evidence for altered frequency of GnRH secretion. J Clin Endocrinol Metab. 59:328-338.
    • (1984) J Clin Endocrinol Metab , vol.59 , pp. 328-338
    • Reame, N.1    Sauder, S.E.2    Kelch, R.P.3    Marshall, J.C.4
  • 39
    • 0022494386 scopus 로고
    • Characterization of the physiologic pattern of episodic gonadotropin secretion throughout the human menstrual cycle
    • Filicori M, Santoro N, Merriam GR, Crowley WF. 1986 Characterization of the physiologic pattern of episodic gonadotropin secretion throughout the human menstrual cycle. J Clin Endocrinol Metab. 62:1136-1144.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 1136-1144
    • Filicori, M.1    Santoro, N.2    Merriam, G.R.3    Crowley, W.F.4
  • 41
    • 0024339548 scopus 로고
    • The roles of estradiol and progesterone in decreasing luteinizing hormone pulse frequency in the luteal phase of the menstrual cycle
    • Nippoldt TB, Reame NE, Kelch RP, Marshall JC 1989 The roles of estradiol and progesterone in decreasing luteinizing hormone pulse frequency in the luteal phase of the menstrual cycle. J Clin Endocrinol Metab. 69:67-76.
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 67-76
    • Nippoldt, T.B.1    Reame, N.E.2    Kelch, R.P.3    Marshall, J.C.4
  • 43
    • 0023235089 scopus 로고
    • Is changing hypothalamic activity important for control of ovulation
    • Clayton RN, Royston JP, Chapman J, et al. 1987 Is changing hypothalamic activity important for control of ovulation. Br Med J. 295:7-12.
    • (1987) Br Med J , vol.295 , pp. 7-12
    • Clayton, R.N.1    Royston, J.P.2    Chapman, J.3
  • 44
    • 8544243541 scopus 로고    scopus 로고
    • Resistance of GnRH drive to sex steroid-induced suppression in hyperandrogenemic anovulation
    • Abstract P2-612
    • Daniels TL, Berga SL. Resistance of GnRH drive to sex steroid-induced suppression in hyperandrogenemic anovulation [Abstract P2-612]. Proc of the 78th Annual Meet of The Endocrine Soc. 1996.
    • (1996) Proc of the 78th Annual Meet of the Endocrine Soc.
    • Daniels, T.L.1    Berga, S.L.2
  • 45
    • 0026539046 scopus 로고
    • Longitudinal evaluation of different gonadotropin pulsatile patterns in anovulatory cycles of young girls
    • Venturoli S, Porcu E, Fabri R, et al. 1992 Longitudinal evaluation of different gonadotropin pulsatile patterns in anovulatory cycles of young girls. J Clin Endocrinol Metab. 74:836-841.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 836-841
    • Venturoli, S.1    Porcu, E.2    Fabri, R.3
  • 46
    • 0021027336 scopus 로고
    • A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic ovary syndrome
    • Zumoff B, Freeman R, Coupey S. 1983 A chronobiologic abnormality in luteinizing hormone secretion in teenage girls with the polycystic ovary syndrome. N Engl J Med. 309:1206-1209.
    • (1983) N Engl J Med , vol.309 , pp. 1206-1209
    • Zumoff, B.1    Freeman, R.2    Coupey, S.3
  • 47
    • 0018882217 scopus 로고
    • Serum steroids and pituitary hormones in female puberty: A partly longitudinal study
    • Oxf
    • Apter D. 1980 Serum steroids and pituitary hormones in female puberty: a partly longitudinal study. Clin Endocrinol (Oxf). 12:107-113.
    • (1980) Clin Endocrinol , vol.12 , pp. 107-113
    • Apter, D.1
  • 48
    • 0023835915 scopus 로고
    • The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in PCOS
    • Dunaif A, Mandeli J, Fluhr H, Dobtjansky A. 1988 The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in PCOS. J Clin Endocrinol Metab. 66:131-139.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 131-139
    • Dunaif, A.1    Mandeli, J.2    Fluhr, H.3    Dobtjansky, A.4
  • 50
    • 0019443286 scopus 로고
    • Insulin enhancement of LH and FSH levels by cultured pituitary cells
    • Adashi E, Hsueh A, Yen SS. 1981 Insulin enhancement of LH and FSH levels by cultured pituitary cells. Endocrinology. 108:1441-1449.
    • (1981) Endocrinology , vol.108 , pp. 1441-1449
    • Adashi, E.1    Hsueh, A.2    Yen, S.S.3
  • 52
    • 0024590991 scopus 로고
    • Insulin administration alters gonadal steriod metabolism independent of changes in gonadotropin secretion in insulin resistant women with the polycystic ovary syndrome
    • Dunaif A, Graf M. 1989 Insulin administration alters gonadal steriod metabolism independent of changes in gonadotropin secretion in insulin resistant women with the polycystic ovary syndrome. J Clin Invest. 83:23-29.
    • (1989) J Clin Invest , vol.83 , pp. 23-29
    • Dunaif, A.1    Graf, M.2
  • 53
    • 0022647650 scopus 로고
    • Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
    • Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ. 1986 Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab. 62:904-910.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 904-910
    • Barbieri, R.L.1    Makris, A.2    Randall, R.W.3    Daniels, G.4    Kistner, R.W.5    Ryan, K.J.6
  • 54
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with PCOS
    • Nestler JE, Barlascini CO, Matt DW, et al. 1989 Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with PCOS. J Clin Endocrinol Metab. 68:1027-1032.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 1027-1032
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 55
    • 0023226202 scopus 로고
    • Steroids effect the secretory modalities of GnRH release
    • Melrose P, Gross L. 1987 Steroids effect the secretory modalities of GnRH release. Endocrinology. 121:190-199.
    • (1987) Endocrinology , vol.121 , pp. 190-199
    • Melrose, P.1    Gross, L.2
  • 56
    • 0022596436 scopus 로고
    • Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome?
    • Dunaif A. 1986 Do androgens directly regulate gonadotropin secretion in the polycystic ovary syndrome? J Clin Endocrinol Metab. 63:215-221.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 215-221
    • Dunaif, A.1
  • 57
    • 0027381113 scopus 로고
    • The effect of flutamide on pulsatile gonadotropin secretion in hyperandrogenemic women
    • Sir-Petermann T, Raberbauer B, Wildt L. 1993 The effect of flutamide on pulsatile gonadotropin secretion in hyperandrogenemic women. Hum Reprod. 8:1807-1812.
    • (1993) Hum Reprod , vol.8 , pp. 1807-1812
    • Sir-Petermann, T.1    Raberbauer, B.2    Wildt, L.3


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