Obesity and sex steroid changes across puberty: Evidence for marked hyperandrogenemia in pre- and early pubertal obese girls

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 2, 2007, Pages 430-436

  McCartney, Christopher R ^a,b   Blank, Susan K ^a,b   Prendergast, Kathleen A ^a,b   Chhabra, Sandhya ^a,b   Eagleson, Christine A ^a,b   Helm, Kristin D ^a,b   Yoo, Richard ^c   Chang, R Jeffrey ^c   Foster, Carol M ^d   Caprio, Sonia ^e   Marshall, John C ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; INSULIN; PROGESTERONE; SEX HORMONE; TESTOSTERONE;

ADOLESCENT; ANDROGEN BLOOD LEVEL; ARTICLE; BLOOD SALVAGE; BODY MASS; CLINICAL ARTICLE; CLINICAL RESEARCH; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIET RESTRICTION; FEMALE; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEDICAL ASSESSMENT; OBESITY; PREPUBERTY; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PUBERTY; SCHOOL CHILD; SEX HORMONE DETERMINATION; TESTOSTERONE BLOOD LEVEL;

EID: 33846999319     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2002     Document Type: Article

References (31)

1. Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC 1999 The insulin-related ovarian regulatory system in health and disease. Endocr Rev 20:535-582
2. Wabitsch M, Hauner H, Heinze E, Bockmann A, Benz R, Mayer H, Teller W 1995 Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction. J Clin Endocrinol Metab 80:3469-3475
3. Dunkel L, Sorva R, Voutilainen R 1985 Low levels of sex hormone-binding globulin in obese children. J Pediatr 107:95-97
4. De Simone M, Verrotti A, Iughetti L, Palumbo M, Farello G, Di Cesare E, Bernabei R, Rosato T, Lozzi S, Criscione S 2001 Increased visceral adipose tissue is associated with increased circulating insulin and decreased sex hormone binding globulin levels in massively obese adolescent girls. J Endocrinol Invest 24:438-444
5. van Hooff MH, Voorhorst FJ, Kaptein MB, Hirasing RA, Koppenaal C, Schoemaker J 2000 Insulin, androgen, and gonadotropin concentrations, body mass index, and waist to hip ratio in the first years after menarche in girls with regular menstrual cycles, irregular menstrual cycles, or oligomenorrhea. J Clin Endocrinol Metab 85:1394-1400
6. Reinehr T, de Sousa G, Roth CL, Andler W 2005 Androgens before and after weight loss in obese children. J Clin Endocrinol Metab 90:5588-5595
7. McCartney CR, Prendergast KA, Chhabra S, Eagleson CA, Yoo R, Chang RJ, Foster CM, Marshall JC 2006 The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 91:1714-1722
8. Goji K 1993 Twenty-four-hour concentration profiles of gonadotropin and estradiol (E2) in prepubertal and early pubertal girls: the diurnal rise of E2 is opposite the nocturnal rise of gonadotropin. J Clin Endocrinol Metab 77:1629-1635
9. Mitamura R, Yano K, Suzuki N, Ito Y, Makita Y, Okuno A 2000 Diurnal rhythms of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol secretion before the onset of female puberty in short children. J Clin Endocrinol Metab 85:1074-1080
10. Ankarberg C, Norjavaara E 1999 Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17β-estradiol and dehydroepiandrosterone sulfate. J Clin Endocrinol Metab 84:975-984
11. Norjavaara E, Ankarberg C, Albertsson-Wikland K 1996 Diurnal rhythm of 17β-estradiol secretion throughout pubertal development in healthy girls: evaluation by a sensitive radioimmunoassay. J Clin Endocrinol Metab 81: 4095-4102
12. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, Mei Z, Curtin LR, Roche AF, Johnson CL 2000 CDC growth charts: United States. Adv Data 1-27
13. Marshall WA, Tanner JM 1969 Variations in pattern of pubertal changes in girls. Arch Dis Child 44:291-303
14. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666-3672
15. Legro RS, Castracane VD, Kauffman RP 2004 Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls. Obstet Gynecol Surv 59: 141-154
16. l'Allemand D, Schmidt S, Rousson V, Brabant G, Gasser T, Gruters A 2002 Associations between body mass, leptin, IGF-I and circulating adrenal androgens in children with obesity and premature adrenarche. Eur J Endocrinol 146:537-543
17. Strauss RS 2002 Childhood obesity. Pediatr Clin North Am 49:175-201
18. Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ 1986 Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 62: 904-910
19. Arroyo A, Laughlin GA, Morales AJ, Yen SS 1997 Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. J Clin Endocrinol Metab 82:3728-3733
20. Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D, Hall JE 1997 Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab 82:2248-2256
21. Wang Y 2002 Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 110:903-910
22. Cemeroglu AP, Foster CM, Warner R, Kletter GB, Marshall JC, Kelch RP 1996 Comparison of the neuroendocrine control of pubertal maturation in girls and boys with spontaneous puberty and in hypogonadal girls. J Clin Endocrinol Metab 81:4352-4357
23. Cemeroglu AP, Kletter GB, Guo W, Brown MB, Kelch RP, Marshall JC, Padmanabhan V, Foster CM 1998 In pubertal girls, naloxone fails to reverse the suppression of luteinizing hormone secretion by estradiol. J Clin Endocrinol Metab 83:3501-3506
24. Apter D, Butzow TL, Laughlin GA, Yen SS 1993 Gonadotropin- releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins. J Clin Endocrinol Metab 76:940-949
25. Soules MR, Steiner RA, Clifton DK, Cohen NL, Aksel S, Bremner WJ 1984 Progesterone modulation of pulsatile luteinizing hormone secretion in normal women. J Clin Endocrinol Metab 58:378-383
26. Marshall JC, Eagleson CA 1999 Neuroendocrine aspects of polycystic ovary syndrome. Endocrinol Metab Clin North Am 28:295-324
27. Pastor CL, Griffin-Korf ML, Aloi JA, Evans WS, Marshall JC 1998 Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab 83:582-590
28. Daniels TL, Berga SL 1997 Resistance of gonadotropin releasing hormone drive to sex steroid-induced suppression in hyperandrogenic anovulation. J Clin Endocrinol Metab 82:4179-4183
29. Chhabra S, McCartney CR, Yoo RY, Eagleson CA, Chang RJ, Marshall JC 2005 Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girls. J Clin Endocrinol Metab 90:2810-2815
30. Eagleson CA, Gingrich MB, Pastor CL, Arora TK, Burt CM, Evans WS, Marshall JC 2000 Polycystic ovarian syndrome: evidence that flutamide restores sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab 85:4047-4052
31. Blank SK, McCartney CR, Marshall JC 2006 The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome. Hum Reprod Update 12:351-361