Persistence pays off for PCOS gene prospectors

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 7, 2012, Pages 2286-2288

  Strauss III, Jerome F ^a   McAllister, Jan M ^b   Urbanek, Margrit ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAUCASIAN; CHINESE; DENND1A GENE; EDITORIAL; ETHNIC GROUP; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; HUMAN; HYPERANDROGENISM; INCIDENCE; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RACE; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; THADA GENE;

DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MUTATION; POLYCYSTIC OVARY SYNDROME;

EID: 84863587278     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2109     Document Type: Editorial

References (9)

1. Legro RS, Driscoll D, Strauss 3rd JF, Fox J, Dunaif A 1998 Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci USA 95:14956-14960 (Pubitemid 29003738)
2. Guo M, Chen ZJ, Eijkemans MJ, Goverde AJ, Fauser BC, Macklon NS 2012 Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo/amenorrhoea. Hum Reprod 27:1481-1488
3. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, Shi Y, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y 2011 Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43:55-59
4. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K 2012 Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab 97:E1342-E1347
5. Goodarzi MO, Jones MR, Li X, Chua AK, Garcia OA, Chen YD, Krauss RM, Rotter JI, Ankener W, Legro RS, Azziz R, Strauss 3rd JF, Dunaif A, Urbanek M 2012 Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts. J Med Genet 49:90-95
6. Lerchbaum E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B 2011 Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women. Horm Metab Res 43:743-747
7. Eriksen MB, Brusgaard K, Andersen M, Tan Q, Altinok ML, Gaster M, Glintborg D 13 April 2012 Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs279106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis. Eur J Obstet Gynecol Reprod Biol doi: 10.1016/j.ejogrb.2012.03.020
8. Zhao H, Xu X, Xing X, Wang J, He L, Shi Y, Shi Y, Zhao Y, Chen ZJ 2012 Family-based analysis of susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Hum Reprod 27:294-298
9. Marat AL, Dokainish H, McPherson PS 2011 DENN domain proteins: regulators of Rab GTPases. J Biol Chem 286:13791-13800