The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine

Structure

Volumn 22, Issue 10, 2014, Pages 1399-1407

  Ulens, Chris ^a   Spurny, Radovan ^a   Thompson, Andrew J ^b   Alqazzaz, Mona ^b   Debaveye, Sarah ^a   Han, Lu ^c   Price, Kerry ^b   Villalgordo, Jose M ^d   Tresadern, Gary ^e   Lynch, Joseph W ^c   Lummis, Sarah C R ^b  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d VillaPharma Research   (Spain)

^e JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND GATED ION CHANNEL; MEMANTINE; PHENYLALANINE; PROTEIN ELIC; RIMANTADINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SENSITIVITY; FLUORESCENCE; HUMAN; HUMAN CELL; NONHUMAN; PROKARYOTE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; VOLTAGE CLAMP TECHNIQUE; WILD TYPE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MOLECULAR MIMICRY; MUTATION; OOCYTE; PATCH CLAMP TECHNIQUE; PECTOBACTERIUM CHRYSANTHEMI; PHYSIOLOGY; XENOPUS;

PROKARYOTA;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGAND-GATED ION CHANNELS; MEMANTINE; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PECTOBACTERIUM CHRYSANTHEMI; PHENYLALANINE; PROTEIN CONFORMATION; RIMANTADINE; XENOPUS;

EID: 84908159544     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.07.013     Document Type: Article

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