Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment

Acta Biomaterialia

Volumn 10, Issue 11, 2014, Pages 4730-4741

  Seebach, Elisabeth ^a   Freischmidt, Holger ^a   Holschbach, Jeannine ^a,b   Fellenberg, Jörg ^a   Richter, Wiltrud ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Bone healing; Fibrin hydrogel; Host cell recruitment; Macrophage; Mesenchymal stroma cells

Indexed keywords

BONE; CELL CULTURE; CELL ENGINEERING; DEFECTS; ENDOTHELIAL CELLS; FLOWCHARTING; HYDROGELS; TISSUE REGENERATION;

BONE DEFECT; BONE HEALING; ENGRAFTMENT; FIBRIN HYDROGEL; HOST CELL RECRUITMENT; HOST CELLS; LONG BONE; LONG BONE HEALING; MESENCHYMAL STROMA CELL; STROMA CELLS;

MACROPHAGES;

FIBRIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; CYTOKINE; HYDROGEL; IMMUNOLOGIC FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE MATURATION; CALLUS; CELL INVASION; CELL MIGRATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; FEMORAL BONE DEFECT; FEMUR; FIBRIN CLOT; FRACTURE HEALING; HOST CELL; HYDROGEL; IMMUNOMODULATION; MACROPHAGE; MALE; MESENCHYMAL STROMA CELL; MESENCHYMAL STROMA CELL TRANSPLANTATION; NONHUMAN; PROTEIN EXPRESSION; RAT; TISSUE REGENERATION; ANIMAL; BONE REGENERATION; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; PATHOLOGY; PHARMACOLOGY; PROSTHESIS IMPLANTATION; SPRAGUE DAWLEY RAT; TIME; WOUND HEALING;

ANIMALS; BONE REGENERATION; BONY CALLUS; CYTOKINES; ENDOTHELIAL CELLS; FEMALE; FEMUR; FIBRIN; HYDROGEL; IMMUNOLOGIC FACTORS; MACROPHAGES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; PROSTHESIS IMPLANTATION; RATS, SPRAGUE-DAWLEY; TIME FACTORS; WOUND HEALING;

EID: 84908135389     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.07.017     Document Type: Article

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