Immune responses during healing of massive segmental femoral bone defects mediated by hybrid baculovirus-engineered ASCs

Biomaterials

Volumn 33, Issue 30, 2012, Pages 7422-7434

  Lin, Chin Yu ^a   Lin, Kun Ju ^b,c   Li, Kuei Chang ^a   Sung, Li Yu ^a   Hsueh, Swei ^b   Lu, Chia Hsin ^a   Chen, Guan Yu ^a   Chen, Chiu Ling ^a   Huang, Shiu Feng ^d   Yen, Tzu Chen ^b,e   Chang, Yu Han ^b,e   Hu, Yu Chen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Adipose derived stem cells; Baculovirus; Immune response; Inflammation; Segmental bone defect; Tissue engineering

Indexed keywords

ADIPOSE DERIVED STEM CELLS; BACULOVIRUS; IMMUNE RESPONSE; INFLAMMATION; SEGMENTAL BONE DEFECT;

CELL DEATH; DEFECTS; GENETIC ENGINEERING; IMMUNOLOGY; PATHOLOGY; STEM CELLS; TISSUE ENGINEERING;

BONE;

BONE MORPHOGENETIC PROTEIN 2; VASCULOTROPIN;

ADIPOSE DERIVED STEM CELL; ALLOTRANSPLANTATION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; APOPTOSIS; ARTICLE; BACULOVIRUS; BASOPHIL; BONE DEVELOPMENT; BONE REMODELING; BONE TURNOVER; CELL FATE; CELL INFILTRATION; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DNA MODIFICATION; EOSINOPHIL COUNT; EXPERIMENTAL RABBIT; FEMALE; FEMUR FRACTURE; FRACTURE HEALING; GENETIC ENGINEERING; INFLAMMATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MONOCYTE; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENE; TRANSIENT EXPRESSION;

ADIPOSE TISSUE; ANIMALS; ANTIBODIES; APOPTOSIS; BACULOVIRIDAE; BONE MORPHOGENETIC PROTEIN 2; BONE REMODELING; CELL MOVEMENT; CYTOTOXICITY, IMMUNOLOGIC; FEMUR; GENETIC ENGINEERING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFLAMMATION; INTERFERON-GAMMA; MACROPHAGES; MALE; RABBITS; STEM CELL TRANSPLANTATION; STEM CELLS; T-LYMPHOCYTES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; TRANSGENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

ORYCTOLAGUS CUNICULUS;

EID: 84865028651     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.06.083     Document Type: Article

References (47)

1. Virk M.S., Conduah A., Park S.H., Liu N., Sugiyama O., Cuomo A., et al. Influence of short-term adenoviral vector and prolonged lentiviral vector mediated bone morphogenetic protein-2 expression on the quality of bone repair in a rat femoral defect model. Bone 2008, 42:921-931.
2. Gamradt S.C., Lieberman J.R. Genetic modification of stem cells to enhance bone repair. Ann Biomed Eng 2004, 32:136-147.
3. Yazici C., Takahata M., Reynolds D.G., Xie C., Samulski R.J., Samulski J., et al. Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Mol Ther 2011, 19:1416-1425.
4. Dupont K.M., Sharma K., Stevens H.Y., Boerckel J.D., Garcia A.J., Guldberg R.E. Human stem cell delivery for treatment of large segmental bone defects. Proc Natl Acad Sci USA 2010, 107:3305-3310.
5. Kumar S., Wan C., Ramaswamy G., Clemens T.L., Ponnazhagan S. Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect. Mol Ther 2010, 18:1026-1034.
6. Kimelman-Bleich N., Pelled G., Zilberman Y., Kallai I., Mizrahi O., Tawackoli W., et al. Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair. Mol Ther 2011, 19:53-59.
7. Zou D., Zhang Z., He J., Zhu S., Wang S., Zhang W., et al. Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold. Biomaterials 2011, 32:9707-9718.
8. Zou D., Zhang Z., He J., Zhang K., Ye D., Han W., et al. Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs. Biomaterials 2012, 33:2097-2108.
9. Rada T., Reis R.L., Gomes M.E. Adipose tissue-derived stem cells and their application in bone and cartilage tissue engineering. Tissue Eng Part B-Rev 2009, 15:113-125.
10. Virk M.S., Sugiyama O., Park S.H., Gambhir S.S., Adams D.J., Drissi H., et al. " Same Day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair. Mol Ther 2011, 19:960-968.
11. Zachos T.A., Diggs A., Weisbrode S., Bartlett J., Bertone A.L. Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model. Mol Ther 2007, 15:1543-1550.
12. Meinel L., Hofmann S., Betz O., Fajardo R., Merkle H.P., Langer R., et al. Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials 2006, 27:4993-5002.
13. Chew S.A., Kretlow J.D., Spicer P.P., Edwards A.W., Baggett L.S., Tabata Y., et al. Delivery of plasmid DNA encoding bone morphogenetic protein-2 with a biodegradable branched polycationic polymer in a critical-size rat cranial defect model. Tissue Eng Part A 2011, 17:751-763.
14. Lee S.-J., Kang S.-W., Do H.-J., Han I., Shin D.A., Kim J.-H., et al. Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells. Biomaterials 2010, 31:5652-5659.
15. Heckl D., Schwarzer A., Haemmerle R., Steinemann D., Rudolph C., Skawran B., et al. Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia. Mol Ther 2012, 20:1187-1195.
16. Kost T.A., Condreay J.P., Jarvis D.L. Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nat Biotechnol 2005, 23:567-575.
17. Chen C.-Y., Lin C.-Y., Chen G.-Y., Hu Y.-C. Baculovirus as a gene delivery vector: recent understandings of molecular alterations in transduced cells and latest applications. Biotechnol Adv 2011, 29:618-631.
18. Liu C.Y.-Y., Chen H.-Z., Chao Y.-C. Maximizing baculovirus-mediated foreign proteins expression in mammalian cells. Curr Gene Ther 2010, 10:232-241.
19. Madhan S., Prabakaran M., Kwang J. Baculovirus as vaccine vectors. Curr Gene Ther 2010, 10:201-213.
20. He F., Madhan S., Kwang J. Baculovirus vector as a delivery vehicle for influenza vaccines. Expert Rev Vaccines 2009, 8:455-467.
21. Airenne K.J., Makkonen K.-E., Mähönen A.J., Ylä-Herttuala S. In vivo application and tracking of baculovirus. Curr Gene Ther 2010, 10:187-194.
22. Wang S., Balasundaram G. Potential cancer gene therapy by baculoviral transduction. Curr Gene Ther 2010, 10:214-225.
23. Hu Y.-C., Yao K., Wu T.-Y. Baculovirus as an expression and/or delivery vehicle for vaccine antigens. Expert Rev Vaccines 2008, 7:363-371.
24. Lin C.-Y., Lu C.-H., Luo W.-Y., Chang Y.-H., Sung L.-Y., Chiu H.-Y., et al. Baculovirus as a gene delivery vector for cartilage and bone tissue engineering. Curr Gene Ther 2010, 10:242-254.
25. Kost T.A., Condreay J.P., Ames R.S. Baculovirus gene delivery: a flexible assay development tool. Curr Gene Ther 2010, 10:168-173.
26. Chuang C.-K., Sung L.-Y., Hwang S.-M., Lo W.-H., Chen H.-C., Hu Y.-C. Baculovirus as a new gene delivery vector for stem cells engineering and bone tissue engineering. Gene Ther 2007, 14:1417-1424.
27. Lin C.-Y., Chang Y.-H., Lin K.-J., Yen T.-Z., Tai C.-L., Chen C.-Y., et al. The healing of critical-sized femoral segmental bone defects in rabbits using baculovirus-engineered mesenchymal stem cells. Biomaterials 2010, 31:3222-3230.
28. Lin C.-Y., Lin K.-J., Kao C.-Y., Chen M.-C., Yen T.-Z., Lo W.-H., et al. The role of adipose-derived stem cells engineered with the persistently expressing hybrid baculovirus in the healing of massive bone defects. Biomaterials 2011, 32:6505-6514.
29. Im G.I., Shin Y.W., Lee K.B. Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?. Osteoarthritis Cartilage 2005, 13:845-853.
30. Lo W.-H., Hwang S.-M., Chuang C.-K., Chen C.-Y., Hu Y.-C. Development of a hybrid baculoviral vector for sustained transgene expression. Mol Ther 2009, 17:658-666.
31. Lin C.-Y., Chang Y.-H., Kao C.-Y., Lu C.-H., Sung L.-Y., Yen T.-C., et al. Augmented healing of critical-size calvarial defects by baculovirus-engineered MSCs that persistently express growth factors. Biomaterials 2012, 33:3682-3692.
32. Chen C.-Y., Wu H.-H., Chen C.-P., Chern S.-R., Hwang S.-M., Huang S.-F., et al. Biosafety assessment of human mesenchymal stem cells engineered by hybrid baculovirus vectors. Mol Pharmaceut 2011, 8:1505-1514.
33. Sung L.-Y., Lo W.-H., Chiu H.-Y., Chen H.-C., Chuang C.-K., Lee H.-P., et al. Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression. Biomaterials 2007, 28:3437-3447.
34. O'Reilly D., Miller L., Luckow V. Baculovirus expression vectors: a laboratory manual 1992, W.H. Freeman and Co, New York.
35. Ma X., Hibbert B., White D., Seymour R., Whitman S.C., O'Brien E.R. Contribution of recipient-derived cells in allograft neointima formation and the response to stent implantation. PLoS One 2008, 3:e1894.
36. Sherwood E.R., Toliver-Kinsky T. Mechanisms of the inflammatory response. Best Pract Res Clin Anaesthesiol 2004, 18:385-405.
37. Cypher T.J., Grossman J.P. Biological principles of bone graft healing. J Foot Ankle Surg 1996, 35:413-417.
38. Murphy K. Janeway's immunobiology 2012, Garland Science, New York.
39. Abbas A.K., Lichtman A.H., Pillai S. Cellular and molecular immunology 2007, Elsevier, Philadelphia.
40. Xu X.L., Tang T., Dai K., Zhu Z., Guo X.E., Yu C., et al. Immune response and effect of adenovirus-mediated human BMP-2 gene transfer on the repair of segmental tibial bone defects in goats. Acta Orthop 2005, 76:637-646.
41. Liu Y., Wang L., Kikuiri T., Akiyama K., Chen C., Xu X., et al. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α. Nat Med 2011, 17:1594-1601.
42. Brune I.B., Wilke W., Hensler T., Holzmann B., Siewert J.R. Downregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery. Am J Surg 1999, 177:55-60.
43. Shegarfi H., Reikeras O. Bone transplantation and immune response. J Orthop Surg 2009, 17:206-211.
44. Prockop D.J. Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther 2009, 17:939-946.
45. Colburn N.T., Zaal K.J.M., Wang F., Tuan R.S. A role for γ/δ T cells in a mouse model of fracture healing. Arthritis Rheum 2009, 60:1694-1703.
46. Liu H., Kemeny D.M., Heng B.C., Ouyang H.W., Melendez A.J., Cao T. The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells. J Immunol 2006, 176:2864-2871.
47. Prigozhina T.B., Khitrin S., Elkin G., Eizik O., Morecki S., Slavin S. Mesenchymal stromal cells lose their immunosuppressive potential after allotransplantation. Exp Hematol 2008, 36:1370-1376.