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Volumn 16, Issue 4, 2010, Pages 427-434

The early fracture hematoma and its potential role in fracture healing

Author keywords

[No Author keywords available]

Indexed keywords

BENEFICIAL ASPECTS; BONE TISSUE ENGINEERING; FRACTURE HEALING; FRACTURE TREATMENT; IMMUNE CELLS; IMMUNE REACTION; IMMUNE SYSTEMS; INITIAL STAGES; REGENERATIVE PROCESS; WOUND HEALING;

EID: 77955070792     PISSN: 19373368     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.teb.2009.0687     Document Type: Review
Times cited : (328)

References (69)
  • 1
    • 0018099212 scopus 로고
    • The biology of fracture healing in long bones
    • McKibbin, B. The biology of fracture healing in long bones. J Bone Joint Surg Br 60B, 150, 1978.
    • (1978) J Bone Joint Surg Br 60B , vol.150
    • McKibbin, B.1
  • 2
    • 33644877907 scopus 로고    scopus 로고
    • Overview of the fracture healing cascade
    • Phillips, A.M. Overview of the fracture healing cascade. Injury 36 Suppl 3, S5, 2005.
    • (2005) Ijury 36 Suppl , vol.3
    • Phillips, A.M.1
  • 4
    • 0030020149 scopus 로고    scopus 로고
    • Fracture healing. Morphologic and physiologic aspects
    • Braun, W., and Ruter, A. [Fracture healing. Morphologic and physiologic aspects]. Unfallchirurg 99, 59, 1996.
    • (1996) Unfallchirurg , vol.99 , pp. 59
    • Braun, W.1    Ruter, A.2
  • 7
    • 18244379581 scopus 로고    scopus 로고
    • Initial vascularization and tissue differentiation are influenced by fixation stability
    • Lienau, J., Schell, H., Duda, G.N., Seebeck, P., Muchow, S., and Bail, H.J. Initial vascularization and tissue differentiation are influenced by fixation stability. J Orthop Res 23, 639, 2005.
    • (2005) J Orthop Res , vol.23 , pp. 639
    • Lienau, J.1    Schell, H.2    Duda, G.N.3    Seebeck, P.4    Muchow, S.5    Bail, H.J.6
  • 8
    • 33645049352 scopus 로고    scopus 로고
    • CYR61 (CCN1) protein expression during fracture healing in an ovine tibial model and its relation to the mechanical fixation stability
    • Lienau, J., Schell, H., Epari, D.R., Schutze, N., Jakob, F., Duda, G.N., and Bail, H.J. CYR61 (CCN1) protein expression during fracture healing in an ovine tibial model and its relation to the mechanical fixation stability. J Orthop Res 24, 254, 2006.
    • (2006) J Orthop Res , vol.24 , pp. 254
    • Lienau, J.1    Schell, H.2    Epari, D.R.3    Schutze, N.4    Jakob, F.5    Duda, G.N.6    Bail, H.J.7
  • 10
    • 0021558149 scopus 로고
    • Principles of fracture healing; Part I: The biology of fracture repair
    • Brighton, C.T. Principles of fracture healing; part I: the biology of fracture repair. AAOS Intern Course Lect 33, 60, 1984.
    • (1984) AAOS Intern Course Lect , vol.33 , pp. 60
    • Brighton, C.T.1
  • 12
    • 0033820789 scopus 로고    scopus 로고
    • And functional relationships between coagulation and the innate immune response
    • Opal, S.M. Phylogenetic and functional relationships between coagulation and the innate immune response. Crit Care Med 28, S77, 2000.
    • (2000) Crit Care Med , vol.28
    • Opal, S.M.1    Phylogenetic2
  • 14
    • 0012429950 scopus 로고    scopus 로고
    • Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs
    • Gerstenfeld, L.C., Thiede, M., Seibert, K., Mielke, C., Phip-pard, D., Svagr, B., Cullinane, D., and Einhorn, T.A. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res 21, 670, 2003.
    • (2003) J Orthop Res , vol.21 , pp. 670
    • Gerstenfeld, L.C.1    Thiede, M.2    Seibert, K.3    Mielke, C.4    Phip-Pard, D.5    Svagr, B.6    Cullinane, D.7    Einhorn, T.A.8
  • 15
    • 0036259278 scopus 로고    scopus 로고
    • Cyclooxygenase-2 regulates mesen-chymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    • Zhang, X., Schwarz, E.M., Young, D.A., Puzas, J.E., Rosier, R.N., and O'Keefe, R.J. Cyclooxygenase-2 regulates mesen-chymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109, 1405, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1405
    • Zhang, X.1    Schwarz, E.M.2    Young, D.A.3    Puzas, J.E.4    Rosier, R.N.5    O'Keefe, R.J.6
  • 16
    • 0015400563 scopus 로고
    • Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes
    • Horton, J.E., Raisz, L.G., Simmons, H.A., Oppenheim, J.J., and Mergenhagen, S.E. Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science 177, 793, 1972.
    • (1972) Science , vol.177 , pp. 793
    • Horton, J.E.1    Raisz, L.G.2    Simmons, H.A.3    Oppenheim, J.J.4    Mergenhagen, S.E.5
  • 17
    • 33947583822 scopus 로고    scopus 로고
    • Shared mechanisms and crosstalk between the immune and bone systems
    • Takayanagi, H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7, 292, 2007.
    • (2007) Nat Rev Immunol , vol.7 , pp. 292
    • Osteoimmunology, T.H.1
  • 18
    • 0034735792 scopus 로고    scopus 로고
    • Bone versus immune system
    • Arron, J.R., and Choi, Y. Bone versus immune system. Nature 408, 535, 2000.
    • (2000) Nature , vol.408 , pp. 535
    • Arron, J.R.1    Choi, Y.2
  • 20
    • 16844377831 scopus 로고    scopus 로고
    • Mechanistic insight into osteoclast differentiation in osteoimmunology
    • Takayanagi, H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med 83, 170, 2005.
    • (2005) J Mol Med , vol.83 , pp. 170
    • Takayanagi, H.1
  • 22
    • 9244252016 scopus 로고    scopus 로고
    • The molecular triad OPG/RANK/RANKL: Involvement in the orchestration of pathophysio-logical bone remodeling
    • Theoleyre, S., Wittrant, Y., Tat, S.K., Fortun, Y., Redini, F., and Heymann, D. The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysio-logical bone remodeling. Cytokine Growth Factor Rev 15, 457, 2004.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 457
    • Theoleyre, S.1    Wittrant, Y.2    Tat, S.K.3    Fortun, Y.4    Redini, F.5    Heymann, D.6
  • 24
    • 0023806904 scopus 로고
    • Tumor necrosis factor-alpha inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxy-ribonucleic acid synthesis in osteoblast-enriched bone cell cultures
    • Centrella, M., McCarthy, T.L., and Canalis, E. Tumor necrosis factor-alpha inhibits collagen synthesis and alkaline phosphatase activity independently of its effect on deoxy-ribonucleic acid synthesis in osteoblast-enriched bone cell cultures. Endocrinology 123, 1442, 1988.
    • (1988) Endocrinology , vol.123 , pp. 1442
    • Centrella, M.1    McCarthy, T.L.2    Canalis, E.3
  • 25
  • 26
    • 0015383163 scopus 로고
    • The neutrophilic leukocyte in wound repair a study with antineutrophil serum
    • Simpson, D.M., and Ross, R. The neutrophilic leukocyte in wound repair a study with antineutrophil serum. J Clin Invest 51, 2009, 1972.
    • (1972) J Clin Invest , vol.51
    • Simpson, D.M.1    Ross, R.2
  • 28
    • 0031949259 scopus 로고    scopus 로고
    • Lymphocyte function in wound healing and following injury
    • Schaffer, M., and Barbul, A. Lymphocyte function in wound healing and following injury. Br J Surg 85, 444, 1998.
    • (1998) Br J Surg , vol.85 , pp. 444
    • Schaffer, M.1    Barbul, A.2
  • 29
    • 2442595111 scopus 로고    scopus 로고
    • Understanding the role of immune regulation in wound healing
    • Park, J.E., and Barbul, A. Understanding the role of immune regulation in wound healing. Am J Surg 187, 11S, 2004.
    • (2004) Am J Surg , vol.187
    • Park, J.E.1    Barbul, A.2
  • 30
    • 73549118560 scopus 로고    scopus 로고
    • And specific macrophage ablation is detrimental to wound healing in mice
    • Mirza, R., DiPietro, L.A., and Koh, T.J. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol 175, 2454, 2009.
    • (2009) Am J Pathol , vol.175 , pp. 2454
    • Mirza, R.1    Dipietro, L.A.2    Selective, J.K.T.3
  • 31
    • 0017092398 scopus 로고
    • Induction of collagen synthesis in rats by transplantation of allogenic macrophages
    • Casey, W.J., Peacock, E.E., Jr., and Chvapil, M. Induction of collagen synthesis in rats by transplantation of allogenic macrophages. Surg Forum 27, 53, 1976.
    • (1976) Surg Forum , vol.27 , pp. 53
    • Casey, W.J.1    Peacock Jr., E.E.2    Chvapil, M.3
  • 33
    • 0024600506 scopus 로고
    • The effect of in vivo T helper and T suppressor lymphocyte depletion on wound healing
    • Barbul, A., Breslin, R.J., Woodyard, J.P., Wasserkrug, H.L., and Efron, G. The effect of in vivo T helper and T suppressor lymphocyte depletion on wound healing. Ann Surg 209, 479, 1989.
    • (1989) Ann Surg , vol.209 , pp. 479
    • Barbul, A.1    Breslin, R.J.2    Woodyard, J.P.3    Wasserkrug, H.L.4    Efron, G.5
  • 34
    • 0032102990 scopus 로고    scopus 로고
    • Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: Competitive regulation by CD4\+ T cells correlates with Th1/Th2 phenotype
    • Munder, M., Eichmann, K., and Modolell, M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4\+ T cells correlates with Th1/Th2 phenotype. J Immunol 160, 5347, 1998.
    • (1998) J Immunol , vol.160 , pp. 5347
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 35
    • 0000186134 scopus 로고
    • A histological study of the early phases of bone repair
    • Ham, A. A histological study of the early phases of bone repair. J Bone Joint Surg Am 12, 827, 1930.
    • (1930) J Bone Joint Surg Am , vol.12 , pp. 827
    • Ham, A.1
  • 36
    • 0036436216 scopus 로고    scopus 로고
    • Effect of repeated irrigation and debridement on fracture healing in an animal model
    • Park, S.H., Silva, M., Bahk, W.J., McKellop, H., and Lieberman, J.R. Effect of repeated irrigation and debridement on fracture healing in an animal model. J Orthop Res 20, 1197, 2002.
    • (2002) J Orthop Res , vol.20 , pp. 1197
    • Park, S.H.1    Silva, M.2    Bahk, W.J.3    McKellop, H.4    Lieberman, J.R.5
  • 37
    • 0027301947 scopus 로고
    • The importance of the he-matoma for fracture healing in rats
    • Grundnes, O., and Reikeras, O. The importance of the he-matoma for fracture healing in rats. Acta Orthop Scand 64, 340, 1993.
    • (1993) Acta Orthop Scand , vol.64 , pp. 340
    • Grundnes, O.1    Reikeras, O.2
  • 38
    • 0025087997 scopus 로고
    • The osteogenetic potential of fracture haematoma. Subperiosteal and intramuscular transplantation of the haematoma
    • Mizuno, K., Mineo, K., Tachibana, T., Sumi, M., Matsubara, T., and Hirohata, K. The osteogenetic potential of fracture haematoma. Subperiosteal and intramuscular transplantation of the haematoma. J Bone Joint Surg Br 72, 822, 1990.
    • (1990) J Bone Joint Surg Br , vol.72 , pp. 822
    • Mizuno, K.1    Mineo, K.2    Tachibana, T.3    Sumi, M.4    Matsubara, T.5    Hirohata, K.6
  • 40
    • 33846864468 scopus 로고    scopus 로고
    • An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity
    • Oe, K., Miwa, M., Sakai, Y., Lee, S.Y., Kuroda, R., and Kur-osaka, M. An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity. J Bone Joint Surg Br 89, 133, 2007.
    • (2007) J Bone Joint Surg Br , vol.89 , pp. 133
    • Oe, K.1    Miwa, M.2    Sakai, Y.3    Lee, S.Y.4    Kuroda, R.5    Kur-Osaka, M.6
  • 41
    • 0027551751 scopus 로고
    • The osteogenic potential of fracture hematoma and its mechanism on bone formation\through fracture hematoma culture and transplantation of freeze-dried hematoma
    • Tsunoda, M., Mizuno, K., and Matsubara, T. The osteogenic potential of fracture hematoma and its mechanism on bone formation\through fracture hematoma culture and transplantation of freeze-dried hematoma. Kobe J Med Sci 39, 35, 1993.
    • (1993) Kobe J Med Sci , vol.39 , pp. 35
    • Tsunoda, M.1    Mizuno, K.2    Matsubara, T.3
  • 42
    • 0014780216 scopus 로고
    • The biochemical characteristics of the fracture hematoma in man
    • Wray, J.B. The biochemical characteristics of the fracture hematoma in man. Surg Gynecol Obstet 130, 847, 1970.
    • (1970) Surg Gynecol Obstet , vol.130 , pp. 847
    • Wray, J.B.1
  • 43
    • 0015301667 scopus 로고
    • Oxygen tension of healing fractures in the rabbit
    • Brighton, C.T., and Krebs, A.G. Oxygen tension of healing fractures in the rabbit. J Bone Joint Surg Am 54, 323, 1972.
    • (1972) J Bone Joint Surg Am , vol.54 , pp. 323
    • Brighton, C.T.1    Krebs, A.G.2
  • 44
    • 0015400128 scopus 로고
    • Oxygen tension of nonunion of fractured femurs in the rabbit
    • Brighton, C.T., and Krebs, A.G. Oxygen tension of nonunion of fractured femurs in the rabbit. Surg Gynecol Obstet 135, 379, 1972.
    • (1972) Surg Gynecol Obstet , vol.135 , pp. 379
    • Brighton, C.T.1    Krebs, A.G.2
  • 49
    • 0030077878 scopus 로고    scopus 로고
    • Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes
    • Ayala, A., Ertel, W., and Chaudry, I.H. Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock 5, 79, 1996.
    • (1996) Shock , vol.5 , pp. 79
    • Ayala, A.1    Ertel, W.2    Chaudry, I.H.3
  • 50
    • 0024816621 scopus 로고
    • The wound is a possible source of posttraumatic immuno-suppression
    • Lazarou, S.A., Barbul, A., Wasserkrug, H.L., and Efron, G. The wound is a possible source of posttraumatic immuno-suppression. Arch Surg 124, 1429, 1989.
    • (1989) Arch Surg , vol.124 , pp. 1429
    • Lazarou, S.A.1    Barbul, A.2    Wasserkrug, H.L.3    Efron, G.4
  • 51
    • 0030103346 scopus 로고    scopus 로고
    • The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability
    • Napolitano, L.M., Koruda, M.J., Meyer, A.A., and Baker, C.C. The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability. Shock 5, 202, 1996.
    • (1996) Shock , vol.5 , pp. 202
    • Napolitano, L.M.1    Koruda, M.J.2    Meyer, A.A.3    Baker, C.C.4
  • 53
  • 54
    • 27644458699 scopus 로고    scopus 로고
    • Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing
    • Busti, A.J., Hooper, J.S., Amaya, C.J., and Kazi, S. Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing. Pharmacotherapy 25, 1566, 2005.
    • (2005) Pharmacotherapy , vol.25 , pp. 1566
    • Busti, A.J.1    Hooper, J.S.2    Amaya, C.J.3    Kazi, S.4
  • 55
    • 0032820103 scopus 로고    scopus 로고
    • Bone abnormalities in the surgical treatment of patients with rheumatoid arthritis
    • Bogoch, E.R., and Moran, E.L. Bone abnormalities in the surgical treatment of patients with rheumatoid arthritis. Clin Orthop Relat Res 366, 8, 1999.
    • (1999) Clin Orthop Relat Res , vol.366 , pp. 8
    • Bogoch, E.R.1    Moran, E.L.2
  • 56
    • 28544439444 scopus 로고    scopus 로고
    • The role of the immune system in the pathophysiology of osteoporosis
    • Clowes, J.A., Riggs, B.L., and Khosla, S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 208, 207, 2005.
    • (2005) Immunol Rev , vol.208 , pp. 207
    • Clowes, J.A.1    Riggs, B.L.2    Khosla, S.3
  • 57
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • Riggs, B.L., Khosla, S., and Melton, L.J., 3rd. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23, 279, 2002.
    • (2002) Endocr Rev , vol.23 , pp. 279
    • Riggs, B.L.1    Khosla, S.2    Melton III, L.J.3
  • 58
    • 33845625260 scopus 로고    scopus 로고
    • Ageing is associated with a decline in peripheral blood CD56 bright NK cells
    • Chidrawar, S.M., Khan, N., Chan, Y.L., Nayak, L., and Moss, P.A. Ageing is associated with a decline in peripheral blood CD56 bright NK cells. Immun Ageing 3, 10, 2006.
    • (2006) Immun Ageing , vol.3 , pp. 10
    • Chidrawar, S.M.1    Khan, N.2    Chan, Y.L.3    Nayak, L.4    Moss, P.A.5
  • 60
    • 36549051569 scopus 로고    scopus 로고
    • Immunity trauma and the elderly
    • Smith, R.M. Immunity trauma and the elderly. Injury 38, 1401, 2007.
    • (2007) Ijury , vol.38 , pp. 1401
    • Smith, R.M.1
  • 62
    • 2442552934 scopus 로고    scopus 로고
    • Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?
    • Kang, S.C., Matsutani, T., Choudhry, M.A., Schwacha, M.G., Rue, L.W., Bland, K.I., and Chaudry, I.H. Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? Cytokine 26, 223, 2004.
    • (2004) Cytokine , vol.26 , pp. 223
    • Kang, S.C.1    Matsutani, T.2    Choudhry, M.A.3    Schwacha, M.G.4    Rue, L.W.5    Bland, K.I.6    Chaudry, I.H.7
  • 64
    • 21444445838 scopus 로고    scopus 로고
    • Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells
    • Hernigou, P., Poignard, A., Beaujean, F., and Rouard, H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am 87, 1430, 2005.
    • (2005) J Bone Joint Surg Am , vol.87 , pp. 1430
    • Hernigou, P.1    Poignard, A.2    Beaujean, F.3    Rouard, H.4
  • 69
    • 21844463276 scopus 로고    scopus 로고
    • Differentiation of osteoblasts in three-dimensional culture in processed cancellous bone matrix: Quantitative analysis of gene expression based on real-time reverse transcription-polymerase chain reaction
    • Stangenberg, L., Schaefer, D.J., Buettner, O., Ohnolz, J., Mobest, D., Horch, R.E., Stark, G.B., and Kneser, U. Differentiation of osteoblasts in three-dimensional culture in processed cancellous bone matrix: quantitative analysis of gene expression based on real-time reverse transcription-polymerase chain reaction. Tissue Eng 11, 855, 2005.
    • (2005) Int. Issue Eng , vol.11 , pp. 855
    • Stangenberg, L.1    Schaefer, D.J.2    Buettner, O.3    Ohnolz, J.4    Mobest, D.5    Horch, R.E.6    Stark, G.B.7    Kneser, U.8


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