The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts

Archives of Pharmacal Research

Volumn 35, Issue 7, 2012, Pages 1269-1278

  Kim, Do Sung ^a   Li, Bo ^a   Rhew, Ki Yon ^b   Oh, Hyo Won ^c   Lim, Hyun Dae ^c   Lee, Wan ^c   Chae, Han Jung ^a   Kim, Hyung Ryong ^c  

^a Chonbuk National University   (South Korea)

^b Dongduk Women's University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

4 Phenylbutyric acid; ER stress; Human gingival fibroblasts

Indexed keywords

4 PHENYLBUTYRIC ACID; BECLIN 1; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; INITIATION FACTOR 2ALPHA; JANUS KINASE 1; PROTEIN P46; PROTEIN P54; THAPSIGARGIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROLIFERATION; CELL VACUOLE; DRUG ACTIVITY; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

AUTOPHAGY; BIOLOGICAL MARKERS; CELL PROLIFERATION; CELLS, CULTURED; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FIBROBLASTS; GINGIVA; HEAT-SHOCK PROTEINS; HUMANS; PHENYLBUTYRATES; PROTECTIVE AGENTS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; THAPSIGARGIN; TIME FACTORS; TRANSFECTION; UNFOLDED PROTEIN RESPONSE;

EID: 84864953680     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0718-2     Document Type: Article

References (45)

1. Adachi, T., Yasuda, H., Nakamura, S., Kamiya, T., Hara, H., and Ikeda, T., Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase. Free Radic. Res., 45, 1083-1092 (2011).
2. Barber, P. A., Davis, S. M., Infeld, B., Baird, A. E., Donnan, G. A., Jolley, D., and Lichtenstein, M., Spontaneous reperfusion after ischemic stroke is associated with improved outcome. Stroke, 29, 2522-2528 (1998). (Pubitemid 28544002)
3. Basseri, S., Lhotak, S., Sharma, A. M., and Austin, R. C., The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response. J. Lipid Res., 50, 2486-2501 (2009).
4. Ben Mosbah, I., Alfany-Fernandez, I., Martel, C., Zaouali, M. A., Bintanel-Morcillo, M., Rimola, A., Rodes, J., Brenner, C., Rosello-Catafau, J., and Peralta, C., Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion. Cell Death Dis., 1, e52 (2010).
5. Bertolotti, A., Zhang, Y., Hendershot, L. M., Harding, H. P., and Ron, D., Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol., 2, 326-332 (2000).
6. Carducci, M. A., Gilbert, J., Bowling, M. K., Noe, D., Eisenberger, M. A., Sinibaldi, V., Zabelina, Y., Chen, T. L., Grochow, L. B., and Donehower, R. C., A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. Clin. Cancer Res., 7, 3047-3055 (2001). (Pubitemid 32963823)
7. Chae, H. J., Kim, H. R., Xu, C., Bailly-Maitre, B., Krajewska, M., Krajewski, S., Banares, S., Cui, J., Digicaylioglu, M., Ke, N., Kitada, S., Monosov, E., Thomas, M., Kress, C. L., Babendure, J. R., Tsien, R. Y., Lipton, S. A., and Reed, J. C., BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell, 15, 355-366 (2004). (Pubitemid 39092752)
8. Chen, Y., Azad, M. B., and Gibson, S. B., Methods for detecting autophagy and determining autophagy-induced cell death. Can. J. Physiol. Pharmacol., 88, 285-295 (2010).
9. Choi, A. Y., Choi, J. H., Yoon, H., Hwang, K. Y., Noh, M. H., Choe, W., Yoon, K. S., Ha, J., Yeo, E. J., and Kang, I., Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells. Eur. J. Pharmacol., 668, 115-126 (2011).
10. Choi, S. E., Lee, Y. J., Jang, H. J., Lee, K. W., Kim, Y. S., Jun, H. S., Kang, S. S., Chun, J., and Kang, Y., A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS). Arch. Biochem. Biophys., 475, 109-114 (2008).
11. Clarke, K. O., Ludeman, S. M., Springer, J. B., Colvin, O. M., Lea, M. A., and Harrison, L. E., Exposure to a deuterated analogue of phenylbutyrate retards S-phase progression in HT-29 colon cancer cells. J. Pharm. Sci., 91, 1054-1064 (2002). (Pubitemid 34640930)
12. Cochran, D. L., Inflammation and bone loss in periodontal disease. J. Periodontol., 79, 1569-1576 (2008).
13. Ding, W. X., Ni, H. M., Gao, W., Hou, Y. F., Melan, M. A., Chen, X., Stolz, D. B., Shao, Z. M., and Yin, X. M., Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J. Biol. Chem., 282, 4702-4710 (2007). (Pubitemid 47101001)
14. Domon, H., Takahashi, N., Honda, T., Nakajima, T., Tabeta, K., Abiko, Y., and Yamazaki, K., Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. Clin. Chim. Acta, 401, 134-140 (2009).
15. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T., LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J., 19, 5720-5728 (2000).
16. Kang, C. and Avery, L., To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy, 4, 82-84 (2008).
17. Kawakami, T., Inagi, R., Takano, H., Sato, S., Ingelfinger, J. R., Fujita, T., and Nangaku, M., Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells. Nephrol. Dial. Transplant., 24, 2665-2672 (2009).
18. Kim, D. S., Kim, J. H., Lee, G. H., Kim, H. T., Lim, J. M., Chae, S. W., Chae, H. J., and Kim, H. R., p38 Mitogen-activated protein kinase is involved in endoplasmic reticulum stressinduced cell death and autophagy in human gingival fibroblasts. Biol. Pharm. Bull., 33, 545-549 (2010).
19. Kouroku, Y., Fujita, E., Tanida, I., Ueno, T., Isoai, A., Kumagai, H., Ogawa, S., Kaufman, R. J., Kominami, E., and Momoi, T., ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death. Differ., 14, 230-239 (2007). (Pubitemid 46092226)
20. Latt, S. A. and Wohlleb, J. C., Optical studies of the interaction of 33258 Hoechst with DNA, chromatin, and metaphase chromosomes. Chromosoma, 52, 297-316 (1975).
21. Lea, M. A., Shareef, A., Sura, M., and desBordes, C., Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules. Cancer Chemother. Pharmacol., 54, 57-63 (2004). (Pubitemid 38858366)
22. Li, J., Ni, M., Lee, B., Barron, E., Hinton, D. R., and Lee, A. S., The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stressinduced autophagy in mammalian cells. Cell Death Differ., 15, 1460-1471 (2008).
23. Ma, Y. and Hendershot, L. M., The unfolding tale of the unfolded protein response. Cell, 107, 827-830 (2001). (Pubitemid 34084974)
24. Maestri, N. E., Brusilow, S. W., Clissold, D. B., and Bassett, S. S., Long-term treatment of girls with ornithine transcarbamylase deficiency. N. Engl. J. Med., 335, 855-859 (1996). (Pubitemid 26304067)
25. McGrath-Morrow, S. A. and Stahl, J. L., G(1) Phase growth arrest and induction of p21(Waf1/Cip1/Sdi1) in IB3-1 cells treated with 4-sodium phenylbutyrate. J. Pharmacol. Exp. Ther., 294, 941-947 (2000). (Pubitemid 30666844)
26. Nagai, H., Noguchi, T., Takeda, K., and Ichijo, H., Pathophysiological roles of ASK1-MAP kinase signaling pathways. J. Biochem. Mol. Biol., 40, 1-6 (2007). (Pubitemid 46182728)
27. Ogata, M., Hino, S., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., Shiosaka, S., Hammarback, J. A., Urano, F., and Imaizumi, K., Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol., 26, 9220-9231 (2006). (Pubitemid 44904418)
28. Ozcan, U., Yilmaz, E., Ozcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Gorgun, C. Z., and Hotamisligil, G. S., Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science, 313, 1137-1140 (2006). (Pubitemid 44300242)
29. Perlmutter, D. H., Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking. Pediatr. Res., 52, 832-836 (2002). (Pubitemid 35379461)
30. Qi, X., Hosoi, T., Okuma, Y., Kaneko, M., and Nomura, Y., Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol. Pharmacol., 66, 899-908 (2004). (Pubitemid 39319462)
31. Qin, L., Wang, Z., Tao, L., and Wang, Y., ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy, 6, 239-247 (2010).
32. Ron, D., Translational control in the endoplasmic reticulum stress response. J. Clin. Invest., 110, 1383-1388 (2002). (Pubitemid 35396906)
33. Settembre, C., Di Malta, C., Polito, V. A., Garcia Arencibia, M., Vetrini, F., Erdin, S., Erdin, S. U., Huynh, T., Medina, D., Colella, P., Sardiello, M., Rubinsztein, D. C., and Ballabio, A., TFEB links autophagy to lysosomal biogenesis. Science, 332, 1429-1433 (2011).
34. Strober, W., Trypan blue exclusion test of cell viability. Curr. Protoc. Immunol., Appendix 3, Appendix 3B (2001).
35. Suzuki, T., Lu, J., Zahed, M., Kita, K., and Suzuki, N., Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Arch. Biochem. Biophys., 468, 1-14 (2007). (Pubitemid 350087841)
36. Tassa, A., Roux, M. P., Attaix, D., and Bechet, D. M., Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes. Biochem. J., 376, 577-586 (2003). (Pubitemid 38058057)
37. Taunton, J., Rowning, B. A., Coughlin, M. L., Wu, M., Moon, R. T., Mitchison, T. J., and Larabell, C. A., Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J. Cell Biol., 148, 519-530 (2000).
38. Ullman, E., Fan, Y., Stawowczyk, M., Chen, H. M., Yue, Z., and Zong, W. X., Autophagy promotes necrosis in apoptosisdeficient cells in response to ER stress. Cell Death Differ., 15, 422-425 (2008).
39. Van Dyke, T. E., Control of inflammation and periodontitis. Periodontol. 2000, 45, 158-166 (2007).
40. Vilatoba, M., Eckstein, C., Bilbao, G., Smyth, C. A., Jenkins, S., Thompson, J. A., Eckhoff, D. E., and Contreras, J. L., Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulumstress mediated apoptosis. Surgery, 138, 342-351 (2005). (Pubitemid 41253820)
41. Wiley, J. C., Meabon, J. S., Frankowski, H., Smith, E. A., Schecterson, L. C., Bothwell, M., and Ladiges, W. C., Phenylbutyric acid rescues endoplasmic reticulum stressinduced suppression of APP proteolysis and prevents apoptosis in neuronal cells. PLoS One, 5, e9135 (2010).
42. Wu, J. and Kaufman, R. J., From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ., 13, 374-384 (2006).
43. Xie, H., Jung, K., and Nam, S., Overexpression of SIRT2 contributes tumor cell growth in hepatocellular carcinomas. Mol. Cell. Toxicol., 7, 367-374 (2011).
44. Yang, C., Kaushal, V., Shah, S. V., and Kaushal, G. P., Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells. Am. J. Physiol. Renal. Physiol., 294, F777-F787 (2008).
45. Yorimitsu, T., Nair, U., Yang, Z., and Klionsky, D. J., Endoplasmic reticulum stress triggers autophagy. J. Biol. Chem., 281, 30299-30304 (2006). (Pubitemid 44537037)